Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

Cancer Research

Volumn 71, Issue 5, 2011, Pages 1849-1857

  Konicek, Bruce W ^a   Stephens, Jennifer R ^a   McNulty, Ann M ^a   Robichaud, Nathaniel ^b   Peery, Robert B ^a   Dumstorf, Chad A ^a   Dowless, Michele S ^a   Iversen, Philip W ^a   Parsons, Stephen ^a   Ellis, Karen E ^a   McCann, Denis J ^a   Pelletier, Jerry ^b   Furic, Luc ^b   Yingling, Jonathan M ^a   Stancato, Louis F ^a   Sonenberg, Nahum ^b   Graff, Jeremy R ^a  

^a ELI LILLY AND COMPANY   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CERCOSPORAMIDE; INITIATION FACTOR 4E BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INTERACTING KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; CELL PROLIFERATION; CELL SURVIVAL; CLONING; DRUG STRUCTURE; ENZYME INHIBITION; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 79952223149     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-3298     Document Type: Article

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