eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.

Nature

Volumn 513, Issue 7516, 2014, Pages 105-109

  Boussemart, Lise ^a   Malka Mahieu, Hélène ^a   Girault, Isabelle ^a   Allard, Delphine ^a   Hemmingsson, Oskar ^a   Tomasic, Gorana ^a   Thomas, Marina ^a   Basmadjian, Christine ^a   Ribeiro, Nigel ^a   Thuaud, Frédéric ^a   Mateus, Christina ^a   Routier, Emilie ^a   Kamsu Kom, Nyam ^a   Agoussi, Sandrine ^a   Eggermont, Alexander M ^a   Désaubry, Laurent ^a   Robert, Caroline ^a   Vagner, Stéphan ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BRAF PROTEIN, HUMAN; INDOLE DERIVATIVE; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4F; INITIATION FACTOR 4G; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE INHIBITOR; SILVESTROL; SULFONAMIDE; TRITERPENE; VEMURAFENIB;

ANIMAL; ARTICLE; CELL DEATH; CHEMISTRY; COLON TUMOR; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENETICS; HUMAN; MELANOMA; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; THYROID TUMOR; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4F; EUKARYOTIC INITIATION FACTOR-4G; FEMALE; HUMANS; INDOLES; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; SULFONAMIDES; THYROID NEOPLASMS; TRITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907216956     PISSN: None     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13572     Document Type: Article

References (0)