Translational Homeostasis via the mRNA Cap-Binding Protein, eIF4E

Molecular Cell

Volumn 46, Issue 6, 2012, Pages 847-858

  Yanagiya, Akiko ^a   Suyama, Eigo ^b   Adachi, Hironori ^a   Svitkin, Yuri V ^a   Aza Blanc, Pedro ^b   Imataka, Hiroaki ^c   Mikami, Satoshi ^d   Martineau, Yvan ^a,e   Ronai, Ze'ev A ^b   Sonenberg, Nahum ^a  

^a MCGILL UNIVERSITY   (Canada)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF HYOGO   (Japan)

^d RIKEN   (Japan)

^e CANCER RESEARCH CENTER OF TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TRANSLATION INITIATION; TRANSLATION REGULATION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; EUKARYOTIC INITIATION FACTOR-4E; HEK293 CELLS; HELA CELLS; HOMEOSTASIS; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS; RNA CAP-BINDING PROTEINS; TRANSFECTION; UBIQUITIN;

EID: 84862979524     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.04.004     Document Type: Article

References (36)

1. Braunstein S., Karpisheva K., Pola C., Goldberg J., Hochman T., Yee H., Cangiarella J., Arju R., Formenti S.C., Schneider R.J. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol. Cell 2007, 28:501-512.
2. Cormier P., Pyronnet S., Morales J., Mulner-Lorillon O., Sonenberg N., Bellé R. eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin. Dev. Biol. 2001, 232:275-283.
3. Dowling R.J., Topisirovic I., Alain T., Bidinosti M., Fonseca B.D., Petroulakis E., Wang X., Larsson O., Selvaraj A., Liu Y., et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010, 328:1172-1176.
4. Duncan R., Milburn S.C., Hershey J.W. Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J. Biol. Chem. 1987, 262:380-388.
5. Elia A., Constantinou C., Clemens M.J. Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1. Oncogene 2008, 27:811-822.
6. Feldman M.E., Apsel B., Uotila A., Loewith R., Knight Z.A., Ruggero D., Shokat K.M. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009, 7:e38.
7. Furukawa M., He Y.J., Borchers C., Xiong Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 2003, 5:1001-1007.
8. García-Martínez J.M., Moran J., Clarke R.G., Gray A., Cosulich S.C., Chresta C.M., Alessi D.R. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem. J. 2009, 421:29-42.
9. Geyer R., Wee S., Anderson S., Yates J., Wolf D.A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 2003, 12:783-790.
10. Gingras A.C., Kennedy S.G., O'Leary M.A., Sonenberg N., Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 1998, 12:502-513.
11. Gingras A.C., Raught B., Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 1999, 68:913-963.
12. Gingras A.C., Raught B., Gygi S.P., Niedzwiecka A., Miron M., Burley S.K., Polakiewicz R.D., Wyslouch-Cieszynska A., Aebersold R., Sonenberg N. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 2001, 15:2852-2864.
13. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001, 15:807-826.
14. Graff J.R., Konicek B.W., Vincent T.M., Lynch R.L., Monteith D., Weir S.N., Schwier P., Capen A., Goode R.L., Dowless M.S., et al. Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J. Clin. Invest. 2007, 117:2638-2648.
15. Graff J.R., Konicek B.W., Carter J.H., Marcusson E.G. Targeting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res. 2008, 68:631-634.
16. Gross J.D., Moerke N.J., von der Haar T., Lugovskoy A.A., Sachs A.B., McCarthy J.E., Wagner G. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell 2003, 115:739-750.
17. Hiremath L.S., Webb N.R., Rhoads R.E. Immunological detection of the messenger RNA cap-binding protein. J. Biol. Chem. 1985, 260:7843-7849.
18. Hitchcock A.L., Auld K., Gygi S.P., Silver P.A. A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc. Natl. Acad. Sci. USA 2003, 100:12735-12740.
19. Khaleghpour K., Pyronnet S., Gingras A.C., Sonenberg N. Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Mol. Cell. Biol. 1999, 19:4302-4310.
20. Kremer C.L., Klein R.R., Mendelson J., Browne W., Samadzedeh L.K., Vanpatten K., Highstrom L., Pestano G.A., Nagle R.B. Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate 2006, 66:1203-1212.
21. Lavoie C.A., Lachance P.E., Sonenberg N., Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. J. Biol. Chem. 1996, 271:16393-16398.
22. Lazaris-Karatzas A., Montine K.S., Sonenberg N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 1990, 345:544-547.
23. Lin T.A., Kong X., Saltiel A.R., Blackshear P.J., Lawrence J.C. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J. Biol. Chem. 1995, 270:18531-18538.
24. Mader S., Lee H., Pause A., Sonenberg N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 1995, 15:4990-4997.
25. Martín M.E., Pérez M.I., Redondo C., Alvarez M.I., Salinas M., Fando J.L. 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers. Int. J. Biochem. Cell Biol. 2000, 32:633-642.
26. Murata T., Shimotohno K. Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E. J. Biol. Chem. 2006, 281:20788-20800.
27. Pause A., Belsham G.J., Gingras A.C., Donzé O., Lin T.A., Lawrence J.C., Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature 1994, 371:762-767.
28. Pear W.S., Nolan G.P., Scott M.L., Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 1993, 90:8392-8396.
29. Pei Y., Tuschl T. On the art of identifying effective and specific siRNAs. Nat. Methods 2006, 3:670-676.
30. Pintard L., Willis J.H., Willems A., Johnson J.L., Srayko M., Kurz T., Glaser S., Mains P.E., Tyers M., Bowerman B., Peter M. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 2003, 425:311-316.
31. Poulin F., Gingras A.C., Olsen H., Chevalier S., Sonenberg N. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 1998, 273:14002-14007.
32. Rong L., Livingstone M., Sukarieh R., Petroulakis E., Gingras A.C., Crosby K., Smith B., Polakiewicz R.D., Pelletier J., Ferraiuolo M.A., Sonenberg N. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 2008, 14:1318-1327.
33. Spence J., Gali R.R., Dittmar G., Sherman F., Karin M., Finley D. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell 2000, 102:67-76.
34. Tsukiyama-Kohara K., Poulin F., Kohara M., DeMaria C.T., Cheng A., Wu Z., Gingras A.C., Katsume A., Elchebly M., Spiegelman B.M., et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 2001, 7:1128-1132.
35. Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J., Harper J.W. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 2003, 425:316-321.
36. Yoshida M., Yoshida K., Kozlov G., Lim N.S., De Crescenzo G., Pang Z., Berlanga J.J., Kahvejian A., Gehring K., Wing S.S., Sonenberg N. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J. 2006, 25:1934-1944.