4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

Oncotarget

Volumn 5, Issue 15, 2014, Pages 6028-6037

  Yi, Tingfang ^a   Kabha, Eihab ^a   Papadopoulos, Evangelos ^a   Wagner, Gerhard ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

4EGI 1; Cancer stem cells; eIF4E; Translation

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CHEMOKINE RECEPTOR CXCR4; COMPOUND 4EGI 1; INITIATION FACTOR; INITIATION FACTOR 4E1; INITIATION FACTOR 4G1; KI 67 ANTIGEN; MESSENGER RNA; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; VASCULOTROPIN; 4EGI-1 COMPOUND; HYDRAZONE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER SIZE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SPECIFICITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; TRANSLATION REGULATION; TREATMENT DURATION; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; BREAST NEOPLASMS; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; HUMANS; HYDRAZONES; MICE; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; THIAZOLES;

EID: 84906265523     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2112     Document Type: Article

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