Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 361-377

  Takrouri, Khuloud ^a   Chen, Ting ^a   Papadopoulos, Evangelos ^b   Sahoo, Rupam ^a   Kabha, Eihab ^b   Chen, Han ^b   Cantel, Sonia ^b   Wagner, Gerhard ^b   Halperin, Jose A ^a   Aktas, Bertal H ^a   Chorev, Michael ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

4EGI 1; E Z isomerization; eIF4F; Florescence polarization assay; Hydrazones; Inhibitors of protein protein interaction; Thiazol 2 yl hydrazones; Translation initiation

Indexed keywords

2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (3 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (4 FLUOROPHENYL)PROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (4 HYDROXYPHENYL)PROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 PHENYLPROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 [4 (TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID; 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO] 3(4 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (4 AMINOPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (4 CYCLOHEXYLPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (4 HYDROXYPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 (4 MORPHOLINOPHENYL)THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [4 [(1,1' BIPHENYL) 4 YL]THIAZOL 2 YL]HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC ACID; 2 [2 [5 (3,4 DICHLOROPHENYL)THIAZOL 2 YL] HYDRAZONO] 3 (2 NITROPHENYL)PROPANOIC AICD; 3 (2 NITROPHENYL) 2 [2 (4 PHENYLTHIAZOL 2 YL)HYDRAZONO]PROPANOIC ACID; 3 (2 NITROPHENYL) 2 [2 [4 [4 (PYRROLIDIN 1 YL)PHENYL] THIAZOL 2 YL]HYDRAZONO]PROPANOIC ACID; 3 (4 AMINOPHENYL) 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]PROPANOIC ACID; 3 (4 CHLOROPHENYL) 2 [2 [4 (3,4 DICHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]PROPANOIC ACID; 3 AMINO 3 PHENYLPROPIONIC ACID; 4 PHENYLTHIAZOLIDINE; 4 [2 CARBOXY 2 [2 [5 (3,4 DICHLOROPHENYL)THIAZOL 2 YL] HYDRAZONO]ETHYL]BENZOIC ACID; 4 [2 [2 [1 CARBOXY 2 (2 NITROPHENYL)ETHYLIDENE]HYDRAZINYL]THIAZOL 4 YL]BENZOIC ACID; HYDRAZONE DERIVATIVE; HYDROCINNAMIC ACID; INITIATION FACTOR; INITIATION FACTOR 4G; PHENYL GROUP; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 4EGI-1 COMPOUND; EIF4ENIF1 PROTEIN, HUMAN; EIF4G1 PROTEIN, HUMAN; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; PROTEIN BINDING; THIAZOLE DERIVATIVE;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOMER; ISOMERIZATION; LATITUDE; MOLECULAR LIBRARY; PHARMACOPHORE; PHYSICAL CHEMISTRY; POLARIZATION; PROTEIN PROTEIN INTERACTION; SCREENING; STRUCTURE ACTIVITY RELATION; TRANSLATION INITIATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-4G; HUMANS; HYDRAZONES; MOLECULAR STRUCTURE; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84897080920     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.034     Document Type: Article

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