Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: Synthesis, SAR analysis and biological evaluation

ChemMedChem

Volumn 9, Issue 5, 2014, Pages 962-972

  Diab, Sarah ^a   Teo, Theodosia ^a   Kumarasiri, Malika ^a   Li, Peng ^a   Yu, Mingfeng ^a   Lam, Frankie ^a   Basnet, Sunita K C ^a   Sykes, Matthew J ^a   Albrecht, Hugo ^a   Milne, Robert ^a   Wang, Shudong ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

anticancer drug discovery; apoptosis; CGP57380; eIF4E phosphorylation; Mnk inhibitors

Indexed keywords

5 (2 (PHENYLAMINO)PYRIMIDIN 4 YL)THIAZOL 2(3H) ONE; BENZENE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INTERACTING KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE INTERACTING KINASE 2 INHIBITOR; PHOSPHOTRANSFERASE; PROTEIN MCL 1; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; CGP 57380; MKNK2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PURINE DERIVATIVE; SIGNAL PEPTIDE;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL SPECIFICITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; HCT116 CELL LINE; LEUKEMIA, MYELOID, ACUTE; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOID, ACUTE; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PURINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84899994001     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300552     Document Type: Article

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