Cell sensitivity, non-linearity and inverse effects

Homeopathy

Volumn 104, Issue 2, 2015, Pages 139-160

  Bellavite, Paolo ^a   Signorini, Andrea ^b   Marzotto, Marta ^a   Moratti, Elisabetta ^a   Bonafini, Clara ^a   Olioso, Debora ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b Medical Office   (Italy)

Author keywords

Allosteric regulation; Cell biology; Energy landscape; High dilutions; Homeopathy; Hormesis; Pharmacodynamics; Receptors; Similia rule; Systems biology

Indexed keywords

ADENOSINE RECEPTOR; APIGENIN; ARSENIC; BENZODIAZEPINE DERIVATIVE; CAFFEINE; CALCAREA CARBONICA EXTRACT; CALENDULA EXTRACT; CARCINOSINUM EXTRACT; CEDAR LEAF OIL; CELL RECEPTOR; CHELIDONINE; CHELIDONIUM EXTRACT; CONIUM MACULATUM EXTRACT; CORTICOTROPIN; COUMARIN DERIVATIVE; DNA; ESTRADIOL; G PROTEIN COUPLED RECEPTOR; GELSEMIUM EXTRACT; HOMEOPATHIC AGENT; HYDRASTIS EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLAVONE DERIVATIVE; PLANT EXTRACT; PROTEASOME; RUTA EXTRACT; SABAL EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT; MATERIA MEDICA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AUTOREGULATION; CALCAREA CARBONICA; CARCINOSINUM; CELL COMMUNICATION; CELL VIABILITY; CELLULAR STRESS RESPONSE; CHEMICAL INTERACTION; CONFORMATIONAL TRANSITION; CYTOLOGY; DRUG BINDING SITE; DRUG DNA BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; ENZYME INHIBITION; EPIGENETICS; GELSEMIUM; GENE EXPRESSION; HOMEOPATHY; HORMESIS; HORMONAL REGULATION; HUMAN; HYDRASTIS; INTRACELLULAR SIGNALING; LYCOPODIUM; MEDICINAL PLANT; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NOCICEPTION; NONHUMAN; NONLINEAR SYSTEM; POSTMENOPAUSE OSTEOPOROSIS; PROTEIN SYNTHESIS INHIBITION; REVIEW; RUTA; TRANQUILIZING ACTIVITY; DOSE RESPONSE; DRUG EFFECTS; PROCEDURES;

CELL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEOPATHY; HORMESIS; HUMANS; MATERIA MEDICA;

EID: 84946901563     PISSN: 14754916     EISSN: 14764245     Source Type: Journal    
DOI: 10.1016/j.homp.2015.02.002     Document Type: Review

References (182)

1. Weatherall M.W. Making medicine scientific: empiricism, rationality, and quackery in mid-Victorian Britain. Soc Hist Med 1996, 9:175-194.
2. Giles J. Degrees in homeopathy slated as unscientific. Nature 2007, 446:352-353.
3. Shang A., Huwiler-Müntener K., Nartey L., Jüni P., Dörig S., Sterne J.A.C., et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet 2005, 366:726-732.
4. Kleijnen J., Knipschild P., ter Riet G. Clinical trials of homoeopathy. BMJ 1991, 302:316-323.
5. Dillon L.R. Homeopathy? Absurd [letter; comment]. Am J Health Syst Pharm 1996, 53(1336):1339.
6. Gold P.W., Novella S., Roy R., Marcus D., Bell I., Davidovitch N., et al. Homeopathy-quackery or a key to the future of medicine?. Homeopathy 2008, 97:28-33.
7. Rutten L., Mathie R.T., Fisher P., Goossens M., Van Wassenhoven M. Plausibility and evidence: the case of homeopathy. Med Health Care Philos 2013, 16:525-532.
8. de Oliveira C.C., de Oliveira S.M., Goes V.M., Probst C.M., Krieger M.A., Buchi D.F. Gene expression profiling of macrophages following mice treatment with an immunomodulator medication. J Cell Biochem 2008, 104:1364-1377.
9. Burbano R.R., Leal M.F., da Costa J.B., Bahia M.O., de Lima P.D., Khayat A.S., et al. Lymphocyte proliferation stimulated by activated human macrophages treated with Canova. Homeopathy 2009, 98:45-48.
10. Iavicoli I., Calabrese E.J., Nascarella M.A. Exposure to nanoparticles and hormesis. Dose Response 2010, 8:501-517.
11. Rattan S.I., Deva T. Testing the hormetic nature of homeopathic interventions through stress response pathways. Hum Exp Toxicol 2010, 29:551-554.
12. Van Wijk R., Wiegant F.A. Postconditioning hormesis and the similia principle. Front Biosci (Elite Ed) 2011, 3:1128-1138.
13. Demirovic D., Rattan S.I. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol 2013, 48:94-98.
14. Bell I.R., Schwartz G.E. Adaptive network nanomedicine: an integrated model for homeopathic medicine. Front Biosci (Schol Ed) 2013, 5:685-708.
15. Bellavite P., Marzotto M., Olioso D., Moratti E., Conforti A. High-dilution effects revisited. 2. Pharmacodynamic mechanisms. Homeopathy 2014, 103:22-43.
16. Bell I.R., Baldwin C.M., Schwartz G.E. Translating a nonlinear systems theory model for homeopathy into empirical tests. Altern Ther Health Med 2002, 8:58-66.
17. Bellavite P., Signorini A. The emerging science of homeopathy: complexity, biodynamics, and nanopharmacology 2002, Berkeley (CA), North Atlantic.
18. Ghosh S., Bishayee K., Paul A., Mukherjee A., Sikdar S., Chakraborty D., et al. Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase-mediated signaling via reactive oxygen species elevation. J Integr Med 2013, 11:116-124.
19. Arora S., Aggarwal A., Singla P., Jyoti S., Tandon S. Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells. Homeopathy 2013, 102:274-282.
20. Bigagli E., Luceri C., Bernardini S., Dei A., Filippini A., Dolara P. Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles. Homeopathy 2014, 103:127-132.
21. Preethi K.C., Kuttan G., Kuttan R. Anti-tumour activity of Ruta graveolens extract. Asian Pac J Cancer Prev 2006, 7:439-443.
22. Sunila E.S., Kuttan R., Preethi K.C., Kuttan G. Dynamized preparations in cell culture. Evid Based Complement Altern Med 2009, 6:257-263.
23. Preethi K., Ellanghiyil S., Kuttan G., Kuttan R. Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action. Integr Cancer Ther 2012, 11:172-182.
24. Chirumbolo S., Conforti A., Lussignoli S., Metelmann H., Bellavite P. Effects of Podophyllum peltatum compounds in various preparations dilutions on human neutrophil functions in vitro. Br Hom J 1997, 86:16-26.
25. Hostanska K., Rostock M., Melzer J., Baumgartner S., Saller R. A homeopathic remedy from arnica, marigold, St. John inverted question marks wort and comfrey accelerates in vitro wound scratch closure of NIH 3T3 fibroblasts. BMC Complement Altern Med 2012, 12:100.
26. Manduca P., Marchisio S., Astigiano S., Zanotti S., Galmozzi F., Palermo C., et al. FMS*Calciumfluor specifically increases mRNA levels and induces signaling via MAPK 42,44 and not FAK in differentiating rat osteoblasts. Cell Biol Int 2005, 29(8):629-637.
27. Palermo C., Filanti C., Poggi S., Manduca P. Osteogenesis in vitro in rat tibia-derived osteoblasts is promoted by the homeopathic preparation, FMS*Calciumfluor. Cell Biol Int 1999, 23:31-40.
28. Sainte-Laudy J., Belon P. Improvement of flow cytometric analysis of basophil activation inhibition by high histamine dilutions. A novel basophil specific marker: CD 203c. Homeopathy 2006, 95:3-8.
29. Chirumbolo S., Brizzi M., Ortolani R., Vella A., Bellavite P. Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study. Inflamm Res 2009, 58:755-764.
30. Marzotto M., Olioso D., Brizzi M., Tononi P., Cristofoletti M., Bellavite P. Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complement Altern Med 2014, 14:104.
31. Olioso D., Marzotto M., Moratti E., Brizzi M., Bellavite P. Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells. J Ethnopharmacol 2014, 153:535-539.
32. Bhattacharyya S.S., Mandal S.K., Biswas R., Paul S., Pathak S., Boujedaini N., et al. In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med (Maywood ) 2008, 233:1591-1601.
33. Chirumbolo S., Signorini A., Bianchi I., Lippi G., Bellavite P. Effects of homeopathic preparations of organic acids and of minerals on the oxidative metabolism of human neutrophils. Br Hom J 1993, 82:227-244.
34. Venard C., Boujedaini N., Mensah-Nyagan A.G., Patte-Mensah C. Comparative analysis of gelsemine and Gelsemium sempervirens activity on neurosteroid allopregnanolone formation in the spinal cord and limbic system. Evid Based Complement Altern Med 2011, 2011:407617.
35. Samadder A., Das S., Das J., Paul A., Boujedaini N., Khuda-Bukhsh A.R. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro. J Acupunct Meridian Stud 2013, 6:180-187.
36. de Oliveira S.M., de Oliveira C.C., Abud A.P., Guimaraes F.S., Di Bernardi R.P., Coletto E.L., et al. Mercurius solubilis: actions on macrophages. Homeopathy 2011, 100:228-236.
37. Pathak S., Multani A.S., Banerji P., Banerji P. Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: a novel treatment for human brain cancer. Int J Oncol 2003, 23:975-982.
38. Baumgartner S., Thurneysen A., Heusser P. Growth stimulation of dwarf peas (Pisum sativum L.) through homeopathic potencies of plant growth substances. Forsch Komplementarmed Klass Naturheilkd 2004, 11:281-292.
39. de Oliveira C.C., Abud A.P., de Oliveira S.M., Guimaraes F.S., de Andrade L.F., Di Bernardi R.P., et al. Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complement Altern Med 2011, 11:101.
40. Guedes J.R., Carrasco S., Ferreira C.M., Bonamin L.V., Souza W., Goldenstein-Schainberg C., et al. Ultra high dilution of triiodothyronine modifies cellular apoptosis in Rana catesbeiana tadpole tail in vitro. Homeopathy 2011, 100:220-227.
41. Hofbauer R., Pasching E., Moser D., Frass M. Heparin-binding epidermal growth factor expression in KATO-III cells after Helicobacter pylori stimulation under the influence of strychnos Nux vomica and Calendula officinalis. Homeopathy 2010, 99:177-182.
42. Huh Y.H., Kim M.J., Yeo M.G. Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase-2 in primary cultured mouse chondrocytes. Homeopathy 2013, 102:248-253.
43. Mannaioni P.F., Mastroianni R., Mastrangelo D. Adrenaline inhibits the immunological activation of human basophils at pharmacological and ultra-low doses. Med Sci Monit 2010, 16:BR227-BR232.
44. Walchli C., Baumgartner S., Bastide M. Effect of low doses and high homeopathic potencies in normal and cancerous human lymphocytes: an in vitro isopathic study. J Altern Complement Med 2006, 12:421-427.
45. 3 high dilution effects on the rate and variability of wheat seedling growth. Forsch Komplementarmed Klass Naturheilkd 2005, 12:277-283.
46. Marotti I., Betti L., Bregola V., Bosi S., Trebbi G., Borghini G., et al. Transcriptome profiling of wheat seedling following treatment with ultrahigh diluted arsenic trioxide. Evid Based Complement Altern Med 2014, 2014:851263.
47. Das S., Saha S.K., De A., Das D., Khuda-Bukhsh A.R. Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes. Zhong Xi Yi Jie He Xue Bao 2012, 10:337-346.
48. De A., Das D., Dutta S., Chakraborty D., Boujedaini N., Khuda-Bukhsh A.R. Potentiated homeopathic drug Arsenicum Album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenite-exposed bacteria Escherichia coli. Zhong Xi Yi Jie He Xue Bao 2012, 10:210-227.
49. Das D., De A., Dutta S., Biswas R., Boujedaini N., Khuda-Bukhsh A.R. Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate. Zhong Xi Yi Jie He Xue Bao 2011, 9:752-760.
50. Mukherjee A., Boujedaini N., Khuda-Bukhsh A.R. Homeopathic Thuja 30C ameliorates benzo(a)pyrene-induced DNA damage, stress and viability of perfused lung cells of mice in vitro. J Integr Med 2013, 11:397-404.
51. Sikdar S., Mukherjee A., Ghosh S., Khuda-Bukhsh A.R. Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo. Environ Toxicol Pharmacol 2014, 37:300-314.
52. MacLaughlin B.W., Gutsmuths B., Pretner E., Jonas W.B., Ives J., Kulawardane D.V., et al. Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models. Integr Cancer Ther 2006, 5:362-372.
53. Davenas E., Beauvais F., Amara J., Robinson M., Miadonna A., Tedeschi A., et al. Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 1988, 333:816-818.
54. Poitevin B., Davenas E., Benveniste J. In vitro immunological degranulation of human basophils is modulated by lung histamine and Apis mellifica. Br J Clin Pharmacol 1988, 25:439-444.
55. Belon P., Cumps J., Ennis M., Mannaioni P., Roberfroid M., Sainte-Laudy J., et al. Histamine dilutions modulate basophil activation. Inflamm Res 2004, 53:181-188.
56. Endler P., Thieves K., Reich C., Matthiessen P., Bonamin L., Scherr C., et al. Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study. Homeopathy 2010, 99:25-36.
57. Tay S., Hughey J.J., Lee T.K., Lipniacki T., Quake S.R., Covert M.W. Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 2010, 466:267-271.
58. Ashall L., Horton C.A., Nelson D.E., Paszek P., Harper C.V., Sillitoe K., et al. Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science 2009, 324:242-246.
59. Saha S., Hossain D.M., Mukherjee S., Mohanty S., Mazumdar M., Mukherjee S., et al. Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit. BMC Complement Altern Med 2013, 13:230.
60. Jonas W.B., Gaddipati J.P., Rajeshkumar N.V., Sharma A., Thangapazham R.L., Warren J., et al. Can homeopathic treatment slow prostate cancer growth?. Integr Cancer Ther 2006, 5:343-349.
61. Bigagli E., Luceri C., Bernardini S., Dei A., Dolara P. Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact 2010, 188:214-219.
62. Ramo P., Kesseli J., Yli-Harja O. Perturbation avalanches and criticality in gene regulatory networks. J Theor Biol 2006, 242:164-170.
63. Balleza E., varez-Buylla E.R., Chaos A., Kauffman S., Shmulevich I., Aldana M. Critical dynamics in genetic regulatory networks: examples from four kingdoms. PLoS ONE 2008, 3:e2456.
64. Paul A., Das S., Das J., Samadder A., Khuda-Bukhsh A.R. Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo. Toxicol Lett 2013, 222(1):10-22.
65. Das S., Das J., Samadder A., Paul A., Khuda-Bukhsh A.R. Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. Toxicol Lett 2013, 223:124-138.
66. Bhattacharyya S.S., Paul S., Dutta S., Boujedaini N., Khuda-Bukhsh A.R. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Zhong Xi Yi Jie He Xue Bao 2010, 8:645-654.
67. Das S., Das J., Samadder A., Bhattacharyya S.S., Das D., Khuda-Bukhsh A.R. Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells. Colloids Surf B Biointerfaces 2013, 101:325-336.
68. Rao M.L., Roy R., Bell I.R., Hoover R. The defining role of structure (including epitaxy) in the plausibility of homeopathy. Homeopathy 2007, 96:175-182.
69. Chikramane P.S., Suresh A.K., Bellare J.R., Kane S.G. Extreme homeopathic dilutions retain starting materials: a nanoparticulate perspective. Homeopathy 2010, 99:231-242.
70. Czerlinski G., Ypma T. Homeopathic potentization based on nanoscale domains. J Altern Complement Med 2011, 17:1165-1173.
71. Upadhyay R.P., Nayak C. Homeopathy emerging as nano medicine. Int J High Dilution Res 2011, 10:299-310.
72. Chikramane P.S., Kalita D., Suresh A.K., Kane S.G., Bellare J.R. Why extreme dilutions reach non-zero asymptotes: a nanoparticulate hypothesis based on froth flotation. Langmuir 2012, 28:15864-15875.
73. Bhattacharyya S.S., Paul S., Khuda-Bukhsh A.R. Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp Biol Med (Maywood) 2010, 235:678-688.
74. Bhattacharyya S.S., Das J., Das S., Samadder A., Das D., De A., et al. Rapid green synthesis of silver nanoparticles from silver nitrate by a homeopathic mother tincture Phytolacca decandra. Zhong Xi Yi Jie He Xue Bao 2012, 10:546-554.
75. Sarkar S., Zhang L., Subramaniam P., Lee K.B., Garfunkel E., Strickland P.A., et al. Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells. PLoS ONE 2014, 9:e97304.
76. Dayem A.A., Kim B., Gurunathan S., Choi H.Y., Yang G., Saha S.K., et al. Biologically synthesized silver nanoparticles induce neuronal differentiation of SH-SY5Y cells via modulation of reactive oxygen species, phosphatases, and kinase signaling pathways. Biotechnol J 2014, 9:934-943.
77. de Ligt R.A., Kourounakis A.P., IJzerman A.P. Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery. Br J Pharmacol 2000, 130:1-12.
78. Lutz W.K., Lutz R.W., Andersen M.E. Dose-incidence relationships derived from superposition of distributions of individual susceptibility on mechanism-based dose responses for biological effects. Toxicol Sci 2006, 90:33-38.
79. Rothman J.S., Silver R.A. Data-driven modeling of synaptic transmission and integration. Prog Mol Biol Transl Sci 2014, 123:305-350.
80. Dessirier J.M., O'Mahony M., Iodi-Carstens M., Yao E., Carstens E. Oral irritation by sodium chloride: sensitization, self-desensitization, and cross-sensitization to capsaicin. Physiol Behav 2001, 72:317-324.
81. Bellavite P., Lussignoli S., Semizzi M., Ortolani R., Signorini A. The similia principle. From cellular models to regulation of homeostasis. Br Hom J 1997, 86:73-85.
82. Signorini A., Andrioli G., Ortolani R., Conforti A., Bellavite P. The similia principle revisited. Theoretical bases and experimental evidence for a physio-pathological model based on the reactivation of homeostatic communication. Homeopath Links 2001, 13:227-233.
83. Bellavite P., Ortolani R., Pontarollo F., Pitari G., Conforti A. Immunology and homeopathy. 5. The rationale of the 'simile'. Evid Based Complement Altern Med 2007, 4:149-163.
84. Uusi-Oukari M., Korpi E.R. Regulation of GABA(A) receptor subunit expression by pharmacological agents. Pharmacol Rev 2010, 62:97-135.
85. Martini L., Whistler J.L. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol 2007, 17:556-564.
86. Wermerskirchen A.S., LaTocha D.H., Clarke B.L. Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production. Life Sci 2000, 67:2177-2187.
87. Nielsen T.F., Ravn P., Bagger Y.Z., Warming L., Christiansen C. Pulsed estrogen therapy in prevention of postmenopausal osteoporosis. A 2-year randomized, double blind, placebo-controlled study. Osteoporos Int 2004, 15:168-174.
88. Devissaguet J.P., Brion N., Lhote O., Deloffre P. Pulsed estrogen therapy: pharmacokinetics of intranasal 17-beta-estradiol (S21400) in postmenopausal women and comparison with oral and transdermal formulations. Eur J Drug Metab Pharmacokinet 1999, 24:265-271.
89. Millar R.P., Newton C.L. The year in G protein-coupled receptor research. Mol Endocrinol 2010, 24:261-274.
90. Bellavite P., Chirumbolo S., Lippi G., Andrioli G., Bonazzi L., Ferro I. Dual effects of formylpeptides on the adhesion of endotoxin-primed human neutrophils. Cell Biochem Funct 1993, 11:231-239.
91. Carletto A., Biasi D., Bambara L.M., Caramaschi P., Bonazzi M.L., Lussignoli S., et al. Studies of skin-window exudate human neutrophils: increased resistance to pentoxifylline of the respiratory burst in primed cells. Inflammation 1997, 21:191-203.
92. Bellavite P., Chirumbolo S., Santonastaso C., Biasi D., Lussignoli S., Andrioli G. Dose-dependence of the various functional responses of neutrophils to formylpeptides. Activation, regulation, and inverse effects according to the agonist dose and cell condition. Signals and Images 1997, 111-119. Kluwer Acad. Publ., Dordrecht. M. Bastide (Ed.).
93. Bellavite P., Andrioli G., Lussignoli S., Signorini A., Ortolani R., Conforti A. Scientific reappraisal of the "Principle of Similarity". Med Hypotheses 1997, 49:203-212.
94. Lichtenstein L.M., Gillespie E. The effects of the H1 and H2 antihistamines on "allergic" histamine release and its inhibition by histamine. J Pharmacol Exp Ther 1975, 192:441-450.
95. Bateson P., Barker D., Clutton-Brock T., Deb D., D'Udine B., Foley R.A., et al. Developmental plasticity and human health. Nature 2004, 430:419-421.
96. Tobi E.W., Lumey L.H., Talens R.P., Kremer D., Putter H., Stein A.D., et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009, 18:4046-4053.
97. Heijmans B.T., Tobi E.W., Lumey L.H., Slagboom P.E. The epigenome: archive of the prenatal environment. Epigenetics 2009, 4:526-531.
98. Wolff G.L., Kodell R.L., Moore S.R., Cooney C.A. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J 1998, 12:949-957.
99. Szyf M. The early life environment and the epigenome. Biochim Biophys Acta 2009, 1790:878-885.
100. Ji L.L., Dickman J.R., Kang C., Koenig R. Exercise-induced hormesis may help healthy aging. Dose Response 2010, 8:73-79.
101. Schroeder E.A., Raimundo N., Shadel G.S. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab 2013, 17:954-964.
102. Formenti S.C., Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009, 10:718-726.
103. Vaiserman A.M. Hormesis and epigenetics: is there a link?. Ageing Res Rev 2011, 10:413-421.
104. Scott B.R., Belinsky S.A., Leng S., Lin Y., Wilder J.A., Damiani L.A. Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer. Dose Response 2009, 7:104-131.
105. Daxinger L., Whitelaw E. Transgenerational epigenetic inheritance: more questions than answers. Genome Res 2010, 20:1623-1628.
106. Crews D., Gillette R., Scarpino S.V., Manikkam M., Savenkova M.I., Skinner M.K. Epigenetic transgenerational inheritance of altered stress responses. Proc Natl Acad Sci U S A 2012, 109:9143-9148.
107. Schmidt R.J., Tancredi D.J., Krakowiak P., Hansen R.L., Ozonoff S. Maternal intake of supplemental iron and risk of autism spectrum disorder. Am J Epidemiol 2014, 180:890-900.
108. Siow R.C., Mann G.E. Dietary isoflavones and vascular protection: activation of cellular antioxidant defenses by SERMs or hormesis?. Mol Asp Med 2010, 31:468-477.
109. Calabrese E.J., Bachmann K.A., Bailer A.J., Bolger P.M., Borak J., Cai L., et al. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol 2007, 222:122-128.
110. Luna-Lopez A., Gonzalez-Puertos V.Y., Romero-Ontiveros J., Ventura-Gallegos J.L., Zentella A., Gomez-Quiroz L.E., et al. A noncanonical NF-kappaB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response. Free Radic Biol Med 2013, 63:41-50.
111. Wiegant F.A., Prins H.A., Van W.R. Postconditioning hormesis put in perspective: an overview of experimental and clinical studies. Dose Response 2011, 9:209-224.
112. Van Wijk R., Wiegant F.A. Postconditioning hormesis and the homeopathic Similia principle: molecular aspects. Hum Exp Toxicol 2010, 29:561-565.
113. Bell I.R., Koithan M. A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system. BMC Complement Altern Med 2012, 12:191.
114. Bellavite P., Pettigrew A. Miasms and modern pathology. Homeopathy 2004, 93:65-66.
115. Mathur M. The concept of miasm-evolution and present day perspective. Homeopathy 2009, 98:177-180.
116. Gulati R. The concept of miasm. Homeopathy 2010, 99:150.
117. Hahnemann C.F.S. Organon of Medicine 1842, Homeopress Ltd (ed. 1994), Haifa. 5th and 6th edn. J. Reves (Ed.).
118. Smith S.W., Hauben M., Aronson J.K. Paradoxical and bidirectional drug effects. Drug Saf 2012, 35:173-189.
119. Chirumbolo S., Marzotto M., Conforti A., Vella A., Ortolani R., Bellavite P. Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets. Clin Mol Allergy 2010, 8:13.
120. Wiegant F., Van Wijk R. The similia principle: results obtained in a cellular model system. Homeopathy 2010, 99:3-14.
121. Bildet J., Guere J.M., Saurel J., Aubin M., Demerque D., Quilichini R. E'tude de l'action de differentes diluitions de Phosphorus sur l'hepatite toxique du rat. Ann Homéop Fr 1975, 4:425-432.
122. Palmerini C.A., Codini M., Floridi A., Mattoli P., Buffetti S., Di Leginio E. The use of Phosphorus 30 CH in the experimental treatment of hepatic fibrosis in rats. Omeomed92 1993, 219-226. Editrice Compositori, Bologna. C. Bornoroni (Ed.).
123. Rajkumar R., Srivastava S.K., Yadav M.C., Varshney V.P., Varshney J.P., Kumar H. Effect of a Homeopathic complex on oestrus induction and hormonal profile in anoestrus cows. Homeopathy 2006, 95:131-135.
124. de Almeida L.R., Campos M.C., Herrera H.M., Bonamin L.V., da Fonseca A.H. Effects of homeopathy in mice experimentally infected with Trypanosoma cruzi. Homeopathy 2008, 97:65-69.
125. Mishra N., Muraleedharan K.C., Paranjpe A.S., Munta D.K., Singh H., Nayak C. An exploratory study on scientific investigations in homeopathy using medical analyzer. J Altern Complement Med 2011, 17:705-710.
126. Frass M., Zagorchev P., Yurukova V., Wulkersdorfer B., Thieves K., Zedtwitz-Liebenstein K., et al. Two cases of fulminant hepatic failure from Amanita phalloides poisoning treated additively by homeopathy. Ochsner J 2014, 14:252-258.
127. Betti L., Brizzi M., Nani D., Peruzzi M. Effect of high dilutions of Arsenicum album on wheat seedlings from seed poisoned with the same substance. Br Hom J 1997, 86:86-89.
128. Cazin J.C., Cazin M., Gaborit J.L., Chaoui A., Boiron J., Belon P., et al. A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilisation of Arsenic in the rat. Hum Toxicol 1987, 6:315-320.
129. Brizzi M., Nani D., Peruzzi M., Betti L. Statistical analysis of the effect of high dilutions of arsenic in a large dataset from a wheat germination model. Br Hom J 2000, 89:63-67.
130. Kundu S.N., Mitra K., Bukhsh A.R. Efficacy of a potentized homoeopathic drug (Arsenicum-album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver. Complement Ther Med 2000, 8:76-81.
131. Kundu S.N., Mitra K., Khuda Bukhsh A.R. Efficacy of a potentized homeopathic drug (Arsenicum-Aalbum-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Complement Ther Med 2000, 8:157-165.
132. Datta S., Mallick P., Bukhsh A.R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: comparative studies of pre-, post- and combined pre- and post-oral administration and comparative efficacy of two microdoses. Complement Ther Med 1999, 7:62-75.
133. Mitra K., Kundu S.N., Khuda Bukhsh A.R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations in body weight, tissue weight and total protein. Complement Ther Med 1999, 7:24-34.
134. Datta S., Mallick P., Bukhsh A.R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses. Complement Ther Med 1999, 7:156-163.
135. Belon P., Banerjee P., Choudhury S.C., Banerjee A., Biswas S.J., Karmakar S.R., et al. Can administration of potentized homeopathic remedy, Arsenicum album, alter antinuclear antibody (ANA) titer in people living in high-risk arsenic contaminated areas? I. A correlation with certain hematological parameters. Evid Based Complement Altern Med 2006, 3:99-107.
136. Banerjee P., Biswas S.J., Belon P., Khuda-Bukhsh A.R. A potentized homeopathic drug, Arsenicum Album 200, can ameliorate genotoxicity induced by repeated injections of arsenic trioxide in mice. J Vet Med A Physiol Pathol Clin Med 2007, 54:370-376.
137. Belon P., Banerjee A., Karmakar S.R., Biswas S.J., Choudhury S.C., Banerjee P., et al. Homeopathic remedy for arsenic toxicity? Evidence-based findings from a randomized placebo-controlled double blind human trial. Sci Total Environ 2007, 384:141-150.
138. Kokornaczyk M.O., Trebbi G., Dinelli G., Marotti I., Bregola V., Nani D., et al. Droplet evaporation method as a new potential approach for highlighting the effectiveness of ultra high dilutions. Complement Ther Med 2014, 22:333-340.
139. Khuda-Bukhsh A.R., Banerjee A., Biswas S.J., Karmakar S.R., Banerjee P., Pathak S., et al. An initial report on the efficacy of a millesimal potency Arsenicum Album LM 0/3 in ameliorating arsenic toxicity in humans living in a high-risk arsenic village. Zhong Xi Yi Jie He Xue Bao 2011, 9:596-604.
140. Bode A.M., Dong Z. The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit Rev Oncol Hematol 2002, 42:5-24.
141. Varani K., Portaluppi F., Gessi S., Merighi S., Vincenzi F., Cattabriga E., et al. Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors. Cell Mol Life Sci 2005, 62:2350-2358.
142. Gaytan S.P., Pasaro R. Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothalamic cardio-respiratory related nuclei of rat pups. Exp Neurol 2012, 237:247-259.
143. Laurienti P.J., Field A.S., Burdette J.H., Maldjian J.A., Yen Y.F., Moody D.M. Dietary caffeine consumption modulates fMRI measures. Neuroimage 2002, 17:751-757.
144. Schultz K.D., Fritschka E., Kribben A., Rothschild M., Thiede H.M., Distler A., et al. Alpha 2- and beta 2-adrenoceptor downregulation in marathon runners. J Hypertens Suppl 1989, 7:S48-S49.
145. Rengo G., Leosco D., Zincarelli C., Marchese M., Corbi G., Liccardo D., et al. Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. Am J Physiol Heart Circ Physiol 2010, 298:H2032-H2038.
146. Bernstein D., Fajardo G., Zhao M. The role of beta-adrenergic receptors in heart failure: differential regulation of cardiotoxicity and cardioprotection. Prog Pediatr Cardiol 2011, 31:35-38.
147. Bond R.A. Is paradoxical pharmacology a strategy worth pursuing?. Trends Pharmacol Sci 2001, 22:273-276.
148. Heilbrunn S.M., Shah P., Bristow M.R., Valantine H.A., Ginsburg R., Fowler M.B. Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation 1989, 79:483-490.
149. Bond R.A., Spina D., Parra S., Page C.P. Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?. Pharmacol Ther 2007, 115:360-374.
150. Loffing J. Paradoxical antidiuretic effect of thiazides in diabetes insipidus: another piece in the puzzle. J Am Soc Nephrol 2004, 15:2948-2950.
151. Page C. Paradoxical pharmacology: turning our pharmacological models upside down. Trends Pharmacol Sci 2011, 32:197-200.
152. Yun A.J., Lee P.Y., Bazar K.A. Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effect. Med Hypotheses 2005, 64:1050-1059.
153. Teixeira M.Z. Homeopathic use of modern medicines: utilisation of the curative rebound effect. Med Hypotheses 2003, 60:276-283.
154. Nussinov R., Tsai C.J. Unraveling structural mechanisms of allosteric drug action. Trends Pharmacol Sci 2014, 35:256-264.
155. Bu Z., Callaway D.J. Proteins move! Protein dynamics and long-range allostery in cell signaling. Adv Protein Chem Struct Biol 2011, 83:163-221.
156. Nussinov R., Ma B., Tsai C.J., Csermely P. Allosteric conformational barcodes direct signaling in the cell. Structure 2013, 21:1509-1521.
157. Nussinov R., Tsai C.J. Allostery in disease and in drug discovery. Cell 2013, 153:293-305.
158. Bellavite P., Corso F., Dusi S., Grzeskowiak M., Della-Bianca V., Rossi F. Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid. J Biol Chem 1988, 263:8210-8214.
159. Swardfager W., Herrmann N., McIntyre R.S., Mazereeuw G., Goldberger K., Cha D.S., et al. Potential roles of zinc in the pathophysiology and treatment of major depressive disorder. Neurosci Biobehav Rev 2013, 37:911-929.
160. Ciolek J., Maiga A., Marcon E., Servent D., Gilles N. Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor. Eur J Pharmacol 2011, 655:1-8.
161. del S.A., Tsai C.J., Ma B., Nussinov R. The origin of allosteric functional modulation: multiple pre-existing pathways. Structure 2009, 17:1042-1050.
162. Nussinov R., Tsai C.J., Csermely P. Allo-network drugs: harnessing allostery in cellular networks. Trends Pharmacol Sci 2011, 32:686-693.
163. Nussinov R., Tsai C.J., Ma B. The underappreciated role of allostery in the cellular network. Annu Rev Biophys 2013, 42:169-189.
164. Kolomytkin O.V., Dunn S., Hart F.X., Frilot C., Kolomytkin D., Marino A.A. Glycoproteins bound to ion channels mediate detection of electric fields: a proposed mechanism and supporting evidence. Bioelectromagnetics 2007, 28:379-385.
165. Vincze G., Szasz A., Liboff A.R. New theoretical treatment of ion resonance phenomena. Bioelectromagnetics 2008, 29:380-386.
166. Fesenko E.E., Gluvstein A.Y. Changes in the state of water, induced by radiofrequency electromagnetic fields. FEBS Lett 1995, 367:53-55.
167. Del Giudice E., Tedeschi A. Water and autocatalysis in living matter. Electromagn Biol Med 2009, 28:46-52.
168. Khesbak H., Savchuk O., Tsushima S., Fahmy K. The role of water H-bond imbalances in B-DNA substate transitions and peptide recognition revealed by time-resolved FTIR spectroscopy. J Am Chem Soc 2011, 133:5834-5842.
169. Fuxreiter M., Mezei M., Simon I., Osmany R. Interfacial water as a 'hydration fingerprint' in the noncognate complex of BamHI. Biophys J 2005, 89:903-911.
170. Freier E., Wolf S., Gerwert K. Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc Natl Acad Sci U S A 2011, 108:11435-11439.
171. Szolnoki Z. A dynamically changing intracellular water network serves as a universal regulator of the cell: the water-governed cycle. Biochem Biophys Res Commun 2007, 357:331-334.
172. Rimratchada S., McLeish T.C., Radford S.E., Paci E. The role of high-dimensional diffusive search, stabilization, and frustration in protein folding. Biophys J 2014, 106:1729-1740.
173. Tsai C.J., Nussinov R. The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?. Phys Chem Chem Phys 2014, 16:6332-6341.
174. Strohle A., Holsboer F. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry 2003, 36(suppl. 3):S207-S214.
175. Muchmore D.B. Raloxifene: a selective estrogen receptor modulator (SERM) with multiple target system effects. Oncologist 2000, 5:388-392.
176. Venard C., Boujedaini N., Belon P., Mensah-Nyagan A.G., Patte-Mensah C. Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience 2008, 153:154-161.
177. Marzotto M., Conforti A., Magnani P., Zanolin M.E., Bellavite P. Effects of Ignatia amara in mouse behavioural models. Homeopathy 2012, 101:57-67.
178. Bellavite P., Marzotto M., Olioso D., Moratti E., Conforti A. High-dilution effects revisited. 1. Physicochemical aspects. Homeopathy 2014, 103:4-21.
179. Van Wijk R., Wiegant F.A. The similia principle as a therapeutic strategy: a research program on stimulation of self-defense in disordered mammalian cells. Altern Ther Health Med 1997, 3:33-38.
180. Bellavite P., Olioso D., Marzotto M., Moratti E., Conforti A. A dynamic network model of the similia principle. Complement Ther Med 2013, 21:750-761.
181. Zhang Q., Bhattacharya S., Andersen M.E. Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol 2013, 3:130031.
182. Bellavite P. Complexity science and homeopathy. A synthetic overview. Homeopathy 2003, 92:203-212.