Efficacy of a potentized homoeopathic drug (Arsenicum-Album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver

Complementary Therapies in Medicine

Volumn 8, Issue 2, 2000, Pages 76-81

  Kundu, S N ^a   Mitra, K ^a   Bukhsh, A R Khuda ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ALCOHOL; ALKALINE PHOSPHATASE; ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; ARSENICUM ALBUM 30; BIOCHEMICAL MARKER; EOSIN; GLUTATHIONE; HEMATOXYLIN; HOMEOPATHIC AGENT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; HOMEOPATHY; LIPID PEROXIDATION; LIVER SLICE; LIVER TOXICITY; MOUSE; NONHUMAN; TISSUE INJURY; TISSUE REPAIR; TREATMENT OUTCOME;

EID: 0033911089     PISSN: 09652299     EISSN: None     Source Type: Journal    
DOI: 10.1054/ctim.2000.0367     Document Type: Article

References (18)

1. Mitra K., Kundu S. N., Khuda-Bukhsh A. R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: I. On rate of accumulation of arsenic in certain vital organs. Complementary Therapies in Medicine. 6:1998;178-184.
2. Mitra K., Kundu S. N., Khuda-Bukhsh A. R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alternations of body weight, tissue weight and total protein. Complementary Therapies in Medicine. 7:1999;24-34.
3. Datta S., Mallick P., Khuda-Bukhsh A. R. Efficacy of a potentized homoeopathic drug in reducing genotoxic effects of arsenic trioxide in mice: I. Comparative studies of Pre-, Post- and combined pre- and post- oral administration of two potencies of Arsenicum Album. Complement Ther Med. 7:1999;62-75.
4. Datta S., Mallick P., Khuda-Bukhsh A. R. Efficacy of potentized homoeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses. Complement Ther Med. 7:1999;156-163.
5. Zimmerman H. J. Hepatotoxicity. 1978;Appleton Century Crofts, New York.
6. Plaa G. L., Amdun A. M., Doull J., Klasser C. D. Toxicology, the basic science of poisons, 4th edn. 1991;Pergamon Press.
7. Tomokuni K. Studies on hepatotoxicity induced by chlorinated hydrocarbons. II. Lipid metabolism and absorption spectrum of microsomal lipid in mice exposed to 1.1.2.2-tetra chloroethane. Acta Med Okayama. 24:1970;315-322.
8. Walter K., Schutt C. Acid and alkaline phosphatase in serum (two point method). Bergmeyer H. U. Methods of enzymatic analysis, 1974;856-864 London Academic Press.
9. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:1979;351-358.
10. Ellman G. L. Tissue Sulfhydril groups. Arch Biochem Biophys. 82:1959;70-77.
11. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with Folin-Phenol reagent. J Biol Chem. 193:1951;265-275.
12. Davidson C. S., Leevy C. M., Chamerlayne E. C. Guidelines for detection of hepatotoxicity due to drugs and chemicals. NIH publication No. 79-313, 1979.
13. Srivastava D. K., Pandey K. C. Effect of copper on tissue acid and alkaline phosphatases in the green snakehead, Ophiocephalus punctatus (bloch). Toxicology Letters, 11:1982;237-241.
14. Comporti M. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest. 53:1985;599-623.
15. Dranzani M. U., Popper H., Schllner F. (eds). Toxic liver injury by protein synthesis inhibitors. Progress in liver diseases, 1976;Grane & Strutton, New York. p. 232-245.
16. Deboyser D., Goethals F., Krack G., Robertroid M. Investigation into the mechanism of tetracycline induced steatosis study in isolated hepatocytes. Toxicol Appl Pharmacol, 97:1989;473-479.
17. Bannerjee K., Bishayee A., Chatterjee M. Elevated lipid peroxidation, decreased glutathione levels and changes in glutathione-related enzymes in rats treated with human placental extract. Acta Med Okayama. 47:1993;223-227.
18. Khuda-Bukhsh A. R. Potentized homoeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vivo. Complement Ther Med. 5:1997;43-46.