Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothalamic cardio-respiratory related nuclei of rat pups

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 247-259

  Gaytan, Susana P ^a   Pasaro, Rosario ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Adenosine A 1 receptor; Adenosine A 2A receptor; Caffeine; Central nervous system; Neonatal therapy

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; CAFFEINE; HEMOGLOBIN; PROTEIN C FOS;

ADENOSINERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BRAIN MATURATION; BRAIN STEM; BREATHING RATE; CONTROLLED STUDY; GENE EXPRESSION; HEART RATE; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOHISTOCHEMISTRY; MEDULLA OBLONGATA; NERVOUS SYSTEM; NEWBORN; NONHUMAN; PARABRACHIAL NUCLEUS; PONS; PONTOMEDULLARY NUCLEUS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION; VENTROLATERAL MEDULLA;

ANIMALS; ANIMALS, NEWBORN; BRAIN STEM; CAFFEINE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM STIMULANTS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, PURINERGIC P1; RESPIRATORY SYSTEM; UP-REGULATION;

EID: 84864957311     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.06.028     Document Type: Article

References (55)

1. Alexander S.P., Reddington M. The cellular localization of adenosine receptors in rat neostriatum. Neuroscience 1989, 28:645-651.
2. Bairam A., Boutroy M.J., Badonnel Y., Vert P. Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant. J. Pediatr. 1987, 110(4):636-639.
3. Bairam A., Joseph V., Lajeunesse Y., Kinkead R. Altered expression of adenosine A1 and A2A receptors in the carotid body and nucleus tractus solitarius of adult male and female rats following neonatal caffeine treatment. Brain Res. 2009, 1287:74-83.
4. Bhatt-Mehta V., Schumacher R.E. Treatment of apnea of prematurity. Paediatr. Drugs 2003, 5(3):195-210.
5. Bruder E.D., Taylor J.K., Kamer K.J., Raff H. Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 295(4):R1195-R1203.
6. Burnstock G., Fredholm B.B., North R.A., Verkhratsky A. The birth and postnatal development of purinergic signalling. Acta Physiol. (Oxf.) 2010, 199(2):93-147.
7. Cai J., Tuong C.M., Gozal D. A neonatal mouse model of intermittent hypoxia associated with features of apnea in premature infants. Respir Physiol Neurobiol. 2011, 15(178(2)):210-217.
8. Cao Y., Fujito Y., Matsuyama K., Aoki M. Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2006, 192(5):497-505.
9. Clancy B., Finlay B.L., Darlington R.B., Anand K.J. Extrapolating brain development from experimental species to humans. Neurotoxicology 2007, 28(5):931-937.
10. Cunha R.A., Constantino M.D., Fonseca E., Ribeiro J.A. Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids. Eur. J. Biochem. 2001, 268(10):2939-2947.
11. Darnall R.A., Ariagno R.L., Kinney H.C. The late preterm infant and the control of breathing, sleep, and brainstem development: a review. Clin. Perinatol. 2006, 33(4):883-914.
12. Davis P.G., Schmidt B., Roberts R.S., Doyle L.W., Asztalos E., Haslam R., Sinha S., Tin W., Caffeine for Apnea of Prematurity Trial Group Caffeine for apnea of prematurity trial: benefits may vary in subgroups. J. Pediatr. 2010, 156(3):382-387.
13. Depuy S.D., Kanbar R., Coates M.B., Stornetta R.L., Guyenet P.G. Control of breathing by raphe obscurus serotonergic neurons in mice. J. Neurosci. 2011, 31(6):1981-1990.
14. Deurveilher S., Lo H., Murphy J.A., Burns J., Semba K. Differential c-Fos immunoreactivity in arousal-promoting cell groups following systemic administration of caffeine in rats. J. Comp. Neurol. 2006, 498(5):667-689.
15. Dixon A.K., Gubitz A.K., Sirinathsinghji D.J., Richardson P.J., Freeman T.C. Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol. 1996, 118(6):1461-1468.
16. Doyle L.W., Cheong J., Hunt R.W., Lee K.J., Thompson D.K., Davis P.G., Rees S., Anderson P.J., Inder T.E. Caffeine and brain development in very preterm infants. Ann. Neurol. 2010, 68(5):734-742.
17. Dunwiddie T.V., Masino S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 2001, 24:31-55.
18. Eldridge F.L., Millhorn D.E., Kiley J.P. Antagonism by theophylline of respiratory inhibition induced by adenosine. J. Appl. Physiol. 1985, 59(5):1428-1433.
19. Etzel B.A., Guillet R. Effects of neonatal exposure to caffeine on adenosine A1 receptor ontogeny using autoradiography. Brain Res. Dev. Brain Res. 1994, 82:223-230.
20. Fastbom J., Pazos A., Palacios J.M. The distribution of adenosine A1 receptors and 5'-nucleotidase in the brain of soma commonly used experimental rats. Neuroscience 1987, 22:813-826.
21. Festing M.F. Design and statistical methods in studies using animal models of development. ILAR J. 2006, 47(1):5-14.
22. Fredholm B.B., Dunwiddie T.V. How does adenosine inhibit transmitter release?. Trends Pharmacol. Sci. 1988, 9:130-134.
23. Fredholm B.B., Bättig K., Holmén J., Nehlig A., Zvartau E.E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 1999, 51(1):83-133.
24. Fredholm B.B., Chen J.F., Cunha R.A., Svenningsson P., Vougeois J.M. Adenosine and brain function. Int. Rev. Neurobiol. 2005, 63:191-270.
25. Gaytán S.P., Pásaro R. Connections of the rostral ventral respiratory neuronal cell group: an anterograde and retrograde tracing study in the rat. Brain Res. Bull. 1998, 47:625-642.
26. Gaytan S.P., Saadani-Makki F., Bodineau L., Frugière A., Larnicol N., Pásaro R. Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. Auton. Neurosci. 2006, 126-127:339-346.
27. Gaytan S.P., Giraldez-Perez R.M., Pasaro R. Characterization of enhanced c-Fos expression and redistribution of the adenosinergic receptors in the respiratory related-areas of the rat after neonatal exposure to caffeine. XXXV Congress of the Spanish Society of Physiological Sciences. Acta Physiol. 2009, 195(667):45-46.
28. Glotzbach S.F., Tansey P.A., Baldwin R.B., Ariagno R.L. Periodic breathing in preterm infants, influence of bronchopulmonary dysplasia and theophylline. Pediatr. Pulmonol. 1989, 7(2):78-81.
29. Guillet R. Neonatal caffeine exposure alters adenosine receptor control of locomotor activity. Dev. Pharmacol. Ther. 1990, 15:94-100.
30. Guillet R., Kellogg C. Neonatal exposure to therapeutic caffeine alters the ontogeny of adenosine A1 receptors in brain of rats. Neuropharmacology 1991, 30(5):489-496.
31. Han T.H., Jang S.H., Lee S.Y., Ryu P.D. Adenosine reduces GABAergic IPSC frequency via presynaptic A1 receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla. Neurosci. Lett. 2011, 490:63-67.
32. Hascoet J.M., Hamon I., Boutroy M.J. Risks and benefits of therapies for apnoea in premature infants. Drug Saf. 2000, 23(5):363-379.
33. Herlenius E., Ådén U., Tang L.Q., Lagercrantz H. Perinatal respiratory control and its modulation by adenosine and caffeine in the rat. Pediatr. Res. 2002, 51:4-12.
34. Higuchi R., Dollinger G., Walsh P.S., Griffith R. Simultaneous amplification and detection of specific DNA sequences. Biotechnology 1992, 10:413-417.
35. Jégou S., El Yacoubi M., Mounien L., Ledent C., Parmentier M., Costentin J., Vaugeois J.M., Vaudry H. Adenosine A2A receptor gene disruption provokes marked changes in melanocortin content and pro-opiomelanocortin gene expression. J. Neuroendocrinol. 2003, 15(12):1171-1177.
36. Lagercrantz H., Yamamoto Y., Fredholm B.B., Prabhakar N.R., von Euler C. Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors?. Pediatr. Res. 1984, 18(4):387-390.
37. León D., Albasanz J.L., Ruiz M.A., Fernandez M., Martin M. Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. J. Neurochem. 2002, 82:625-634.
38. Leon A.E., Michienzi K., Ma C.X., Hutchison A.A. Serum caffeine concentrations in preterm neonates. Am. J. Perinatol. 2007, 24(1):39-47.
39. Li D.P., Chen S.R., Pan H.L. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J. Neurochem. 2010, 113:530-542.
40. Lorenzo A.M., León D., Castillo C.A., Ruiz M.A., Albasanz J.L., Martín M. Maternal caffeine intake during gestation and lactation down-regulates adenosine A1 receptor in rat brain from mothers and neonates. J. Neurosci. Res. 2010, 88(6):1252-1261.
41. Marchal F., Bairam A., Vert P. Neonatal apnea and apneic syndromes. Clin. Perinatol. 1987, 14(3):509-529.
42. Mayer C.A., Haxhiu M.A., Martin R.J., Wilson C.G. Adenosine A2A receptors mediate GABAergic inhibition of respiration in premature rats. J. Appl. Physiol. 2006, 100(1):91-97.
43. Mayfield R.D., Suzuki F., Zahniser N.R. Adenosine A2a receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus. J. Neurochem. 1993, 60:2334-2337.
44. Montandon G., Kinkead R., Bairam A. Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292(4):R1621-R1631.
45. Montandon G., Kinkead R., Bairam A. Adenosinergic modulation of respiratory activity: developmental plasticity induced by perinatal caffeine administration. Respir. Physiol. Neurobiol. 2008, 164(1-2):87-95.
46. Oliet S.H.R., Poulain D.A. Adenosine induced presynaptic inhibition of IPSCs and EPSCs in rat hypothalamic supraoptic nucleus neurones. J. Physiol. 1999, 520(3):815-825.
47. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2009, Elsevier, Amsterdam. 6th ed.
48. Ribeiro J.A. Adenosine A2a receptor interactions with receptors for other neurotransmitters and neuromodulators. Eur. J. Pharmacol. 1999, 375:101-113.
49. Saadani-Makki F., Frugière A., Gros F., Gaytan S., Bodineau L. Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. A study on brainstem-spinal cord preparations isolated from newborn rats. Neuroscience 2004, 127(2):505-518.
50. Schmidt B., Roberts R.S., Davis P., Doyle L.W., Barrington K.J., Ohlsson A., Solimano A., Tin W. Long-term effects of caffeine therapy for apnea of prematurity. N. Engl. J. Med. 2007, 357(19):1893-1902.
51. Svenningsson P., Nomikos G.G., Ongini E., Fredholm B.B. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience 1997, 79(3):753-764.
52. Thomas T., Spyer K.M. A novel influence of adenosine on ongoing activity in rat rostral ventrolateral medulla. Neuroscience 1999, 88(4):1213-1223.
53. Thomas T., St Lambert J.H., Dashwood M.R., Spyer K.M. Localization and action of adenosine A2a receptors in regions of the brainstem important in cardiovascular control. Neuroscience 2000, 95(2):513-518.
54. Zaidi S.I., Jafri A., Martin R.J., Haxhiu M.A. Adenosine A2A receptors are expressed by GABAergic neurons of medulla oblongata in developing rat. Brain Res. 2006, 1071(1):42-53.
55. Zorrilla E.P. Multiparous species present problems (and possibilities) to developmentalists. Dev. Psychobiol. 1997, 30(2):141-150.