Studies of skin-window exudate human neutrophils: Increased resistance to pentoxifylline of the respiratory burst in primed cells

Inflammation

Volumn 21, Issue 2, 1997, Pages 191-203

  Carletto, A ^a   Biasi, D ^a   Bambara, L M ^a   Caramaschi, P ^a   Bonazzi, M L ^a   Lussignoli, S ^a   Andrioli, G ^a   Bellavite, P ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; OXYGEN RADICAL; PENTOXIFYLLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ZYMOSAN;

AEROBIC METABOLISM; ARTICLE; CELL ISOLATION; CELL METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVATION; EXUDATE; HUMAN; HUMAN CELL; IMMUNOLOGICAL PROCEDURES; INFLAMMATION; NEUTROPHIL; NORMAL HUMAN; RESPIRATORY BURST; SKIN INFLAMMATION;

CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; HUMANS; INFLAMMATION; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PENTOXIFYLLINE; RESPIRATORY BURST; SKIN WINDOW TECHNIQUE; SUPEROXIDES; ZYMOSAN;

EID: 0030753586     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027370220810     Document Type: Article

References (64)

1. VAN EPPS, D. E., and M. L. GARCIA. 1980. Enhancement of neutrophil function as a result of prior exposure to chemotactic factor. J. Clin. Invest. 66:167-175.
2. ZIMMERLI, W., P. D. LEW, H. J. COHEN, and F. A. WALDVOGE. 1984. Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates. Infect. Immun. 46:625-630.
3. ZIMMERLI, W., B. SELIGMANN, and J. I. GALLIN. 1986. Exudation primes human and guinea pig neutrophils for subsequent responsiveness to the chemotactic peptide N-formylmethionylleucylphenylalanine and increases complement component C3bi receptor expression. J. Clin. Invest. 77:925-933.
4. BRIHEIM, G., O. STENDAHL, B. I. COBLE, and C. DAHLGREN. 1988. Exudate polymorphonuclear leukocytes isolates from skin chambers are primed for enhanced response to subsequent stimulation with the chemoattractant fMet-Leu-Phe and C3 opsonized yeast particles. Inflammation 12:141-152.
5. BIASI, D., L. M. BAMBARA, A. CARLETTO, M. CARAFFI, M. C. SERRA, S. CHIRUMBOLO, and P. BELLAVITE. 1993. Factor-specific changes of the oxidative metabolism of exudate human neutrophils. Inflammation 17:13-23.
6. ISSEKUTZ, A. C., K. Y. LEE, and W. D. BIGGAR. 1979. Enhancement of human neutrophil bactericidal activity by chemotactic factors. Infect. Immun. 24:295-301.
7. NIWA, Y., T. SAKANE, M. SHINGU, and Y. MIYACHI. 1985. Role of stimulated neutrophils from patients with syistemic lupus erythematosus in tissue injury, with special reference to serum factors and increased active oxigen species generated by neutrophils. Inflammation 9:163-172.
8. ANDERSON, B. O., and A. H. HARKEN. 1990. Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury. J. Trauma 30:S44-49.
9. SMITH, J. A. 1994. Neutrophils, host defense, and inflammation: a double-edged sword. J. Leukocyte Biol. 56:672-686.
10. HALLETT, M. B., and D. S. O. LLOYDS. 1995. Neutrophil priming: the cellular signals that say 'amber' but not 'green'. Immunol. Today. 16:264-268.
11. BELLAVITE, P. 1988. The superoxide-forming enzymatic system of phagocytes. Free Radical Biol. Med. 4:225-261.
12. 2 by lipopolysaccharide: possible mechanism of these actions. Infect. Immun. 62:922-927.
13. BARNES, C. R., G. L. MANDELL, H. T. CARPER, S. LUONG, and G. W. SULLIVAN. 1995. Adenosine modulation of tumor necrosis factor-alpha-induced neutrophil activation. Biochem. Pharmacol. 50:1851-1857.
14. BRANDT, E., PETERSEN, F., and FLAD, H. D. 1992. Recombinant tumor necrosis factor-alpha potentiates neutrophil degranulation in response to host defense cytokines neutrophil-activating peptide 2 and IL-8 by modulating intracellular cyclic AMP levels. J. Immunol. 149:1356-1364.
15. CRONSTEIN, B. N., E. D. ROSENSTEIN, S. B. KRAMER, G. WEISSMANN, and R. HIRSCHHORN. 1985. Adenosine, a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via A2 receptor on human neutrophils. J. Immunol. 135:1366-1371.
16. BELLAVITE, P., S. CHIRUMBOLO, C. MANSOLDO, G. GANDINI, and P. DRI. 1992. A simultaneous assay for oxidative metabolism and adhesion of human neutrophils. Evidence for correlations and dissociations of the two responses. J. Leukocyte Biol. 51:329-335.
17. OTTONELLO, L., M. P. MORONE, P. DAPINO, and F. DALLEGRI. 1995. Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils. Clin. Exp. Immunol. 101:502-506.
18. DANIELS, R. H., I. N. BIRD, M. E. HILL, and M. J. FINNEN. 1993. Differential regulation of early phase and late phase responses in human neutrophils by cAMP. Biochem. Pharmacol. 45:1613-1620.
19. BESSLER, H., R. GIGAL, M. DJALDETTI, and I. ZAHAVI. 1986. Effects of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J. Leukocyte Biol. 40:747-754.
20. ROBERTS, P. J., K. L. YONG, A. KHWAJA, B. V. JOHNSON, A. R. PIZZEY, J. E. CARVER, I. E. ADDISON, and D. C. LINCH. 1993. Pentoxifylline at clinically achievable levels inhibits fMLP-induced neutrophil responses, but not priming, upregulation of cell-adhesion molecules, or migration induced by GM-CSF. Eur. J. Haematol. 50:1-10.
21. DELLA BIANCA, V., P. DE TOGNI, M. GRZESKOWIAK, L. M. VICENTINI, and F. DI VIRGILIO. 1986. Cyclic AMP inhibition of phosphoinositide turnover in human neutrophils. Biochim. Biophys. Acta 886:441-447.
22. BIASI, D., M. L. BAMBARA, A. CARLETTO, P. CARAMASCHI, M. C. SERRA, P. GUZZO, C. SANTONASTASO, and P. BELLAVITE. 1993. Molecular mechanisms of priming: exudate human neutrophils are primed to fMet-Leu-Phe but have normal intracellular calcium and cAMP responses. Bull. Molec. Biol. Med. 18:225-235.
23. FOLLIN, P., M. P. WYMANN, B. DEWALD, M. CESKA, and C. DAHLGREN. 1991. Human neutrophil migration into skin chambers is associated with production of NAP-1/IL8 and C5a. Eur. J. Haematol. 47:71-76.
24. METCALF, J. A., J. I. GALLIN, W. M. NAUSEEF, and R. K. ROOT. In Laboratory manual of neutrophil function. Raven Press, New York 1986.
25. SENN, H. J., and W. F. JUNGI. 1975. Neutrophil migration in health and disease. Semin. Hematol. 12:27-45.
26. VOLKER, T. T., O. M. VIRATELLE, M. A. DELAAGE, and J. LABOUESSE. 1985. Radioimmunoassay of cyclic AMP can provide a highly sensitive assay for adenilate cyclase, even a very high ATP concentrations. Analyt. Biochem. 144:347-355.
27. BIASI, D., A. CARLETTO, P. CARAMASCHI, P. BELLAVITE, G. ANDRIOLI, M. CARAFFI, M. L. PACOR and L. M. BAMBARA. 1995. Neutrophil functions, spondylarthropathies and HLA-B27: a study of 43 patients. Clin. Exper. Rheumatol. 13:623-627.
28. TENNENBERG, S. D., and J. S. SOLOMKIN. 1990. Activation of neutrophils by cachectin/tumor necrosis factor: priming of n-formyl-methionyl-leucyl-phenylalanine-induced oxidative responsiveness via receptor mobilization without degranulation. J. Leukocyte Biol. 47:217-223.
29. FINKEL, T. H., M. J. PABST, H. SUZUKI, L. A. GUTHRIE, J. R. FOREHAND, W. A. PHILIPS, and R. B. JOHNSTON. 1987. Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin. J. Biol. Chem. 262:6643-6649.
30. AXTELL, R. A., R. R. SANDBORG, J. E. SMOLEN, P. A. WARD, and L. A. BOXER. 1990. Exposure of human neutrophils to exogenous nucleotides causes elevation in intracellular calcium, transmembrane calcium fluxes, and an alteration of a cytosolic factor result in enhanced superox. prod, in response to FMLP and arachid. acid. Blood 75:1324-1332.
31. YEE, J., and N. V. CHRISTOU. 1993. Neutrophil priming by lipopolysaccharide involves heterogeneity in calcium-mediated signal transduction. Studies using fluo-3 and flow cytometry. J. Immunol. 150:1988-1997.
32. BAULDRY, S. A., C. E. MCCALL, S. L. COUSART, and D. A. BASS. 1991. Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming. J. Immunol. 146:1277-1285.
33. FOREHAND, J. R., R. B. JOHNSTON, and J. S. BOMALASKI. 1993. Phospholipase A2 activity in human neutrophils. Stimulation by lipopolysaccharide and possible involvement in priming for an enhanced respiratory burst. J. Immunol. 151:4918-4925.
34. DOERFLER, M. E., J. WEISS, J. D. CLARK, and P. ELSBACH. 1994. Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2. J. Clin. Invest. 93:1583-1591.
35. SCHATZ-MUNDING, M., and V. ULLRICH. 1992. Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation. Eur. J. Biochem. 204:705-712.
36. PHILLIPS, W. A., M. CROATTO, and J. A. HAMILTON. 1992. Priming of the respiratory burst of bone-marrow derived macrophages is associated with an increase in protein kinase C content. J. Immunol 149:1016-1022.
37. BERKOW, R. L., D. WANG, J. W. LARRICK, R. W. DODSON, and T. H. HOWARD. 1987. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor. J. Immunol. 139:3783-3791.
38. KLEIN, J. B., V. PAYNE, T. M. SCHEPERS, and K. M. MCLEISH. 1990. Bacterial lipopolysaccharide enhances polymorphonuclear leukocyte function independent of changes in intracellular calcium. Inflammation 14:599-611.
39. KARNAD, A. B., K. L. HARTSHORN, J. WRIGHT, J. B. MYERS, J. H. SCHWARTZ, and A. I. TAUBER. 1989. Priming of human neutrophils with n-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. Blood 74:2519-2526.
40. ADACHI, S., M. KUBOTA, K. MATSUBARA, Y. WAKAZONO, H. HIROTA, K. KUWAKADO, Y. AKIYAMA, and H. MIKAWA. 1993. Role of protein kinase C in neutrophil survival enhanced by granulocyte colony-stimulating factor. Exp-Hematol. 21:1709-1713.
41. PEDRERA, C., M. LUCAS, L. BELLIDO, and M. A. LOPEZ-GONZALEZ. 1994. Receptor-independent mechanisms are involved in the priming of neutrophil's oxidase by vasoactive intestinal peptide. Regul. Pept. 54:505-511.
42. KOENDERMAN, L., M. YAZDANBAKHSH, D. ROOS, and A. J. VERHOEVEN. 1989. Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. J. Immunol. 142:623-628.
43. ELBIM, C., S. BAILLY, S. CHOLLET-MARTIN, J. HAKIM, and M. A. GOUGEROT-POCIDALO. 1994. Differential priming effects of proinflammatory cytokines on human neutrophil oxidative burst in response to bacterial N-formyl peptides. Infect. Immun. 62:2195-2201.
44. 2-generation. Biochem. Pharmacol. 47:1029-1037.
45. BADGER, A. M., D. L. OLIVERA, and K. M. ESSER. 1994. Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock. Circ. Shock. 44:188-195.
46. PARKINSON, F. E., J. A. PARKINSON, K. A. RUDOLPHI, and B. B. FREDHOLM. 1994. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen. Pharmacol. 25:1053-1058.
47. NAKAGAWA, K., F. N. MILLER, A. W. KNOTT, and M. J. EDWARDS. 1995. Pentoxifylline inhibits FMLP-induced macromolecular leakage. Am. J. Physiol. 269:239-245.
48. COTTAM, H. B., H. SHIH, L. R. TEHRANI, D. B. WASSON, and D. A. CARSON. 1996. Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J. Med. Chem. 39:2-9.
49. CHAPELIER, A., J. REIGNIER, M. MAZMANIAN, E. DULMET, J. M. LIBERT, P. DARTEVELLE, F. BARBOTIN, and P. HERVE. 1995. Amelioration of reperfusion injury by pentoxifylline after lung transplantation. The Universite Paris-Sud Lung Transplant Group. J. Heart Lung Transplant. 14:676-683.
50. VAN-LEENEN, D. T. VAN DER POLL, M. LEVI, H. TEN CATE, S. J. VAN DEVENTER, C. E. HACK, L. A. AARDEN, and J. W. TEN-CATE. 1993. Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees. J. Immunol. 151:2318-2325.
51. MANDELL, G. L. 1988. ARDS, neutrophils and pentoxifylline. Am. Rev. Resp. Dis. 138:1103-1105.
52. OISMULLER, C., N. MAYER, M. MICKSCHE, H. STELTZER, and A. F. HAMMERLE. 1995. In vivo modulation of human neutrophil function by pentoxifylline in patients with septic syndrome. Shock 4:161-165.
53. YASUI, K., K. OHTA, M. KOBAYASHI, T. AIZAWA, and A. KOMIYAMA. 1996. Successful treatment of Behcet's disease with pentoxifylline. Ann. Intern. Med. 124:891-893.
54. WARD, A., and P. CLISSOLD. 1987. Pentoxifylline. A review of its parmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34:50-97.
55. NATHAN, C. and E. SANCHEZ. 1990. Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils. J. Cell Biol. 111:2171-2181.
56. IYENGAR, R. 1996. Gating by cyclic AMP: expanded role for an old signaling pathway. Science 271:461-463.
57. BUHL, A. M., N. AVDI, G. S. WORTHEN, and G. L. JOHNSON. 1994. Mapping of the C5a receptor signal transduction network in human neutrophils. Proc. Natl. Acad. Sci. U.S.A. 91:9190-9194.
58. WORTHEN, G. S., N. AVDI, A. M. BUHL, N. SUZUKI, and G. L. JOHNSON. 1994. FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. J. Clin. Invest. 94:815-823.
59. KRAMER, I. M., R. L. VAN DER BEND, A. J. VERHOEVEN, and D. ROOS. 1988. The 47-kDa protein involved in the NADPH:O2 oxidoreductase of human neutrophils is phosphorylated by cyclic AMP-dependent and calcium dependent protein phosphorylation in rabbit peritoneal neutrophils. Biochim. Biophys. Acta 760:126-135.
60. QUILLIAM, L. A., H. MUELLER, B. P. BOHL, V. PROSSNITZ, L. A. SKLAR, C. J. DER, and G. M. BOKOCH. 1991. Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils. J. Immunol. 147:1628-1635.
61. BEERMANN, B., R. INGS, J. MANSBY, J. CHAMBERLAIN and A. MCDONALD. 1985. Kinetics of intravenous and oral pentoxifylline in healthy subjects. Clin. Pharmacol. Ther. 37:25-28.
62. RIDINGS, P. C., A. C. WINDSOR, H. J. SUGERMAN, E. KENNEDY, M. M. SHOLLEY, C. R. BLOCHER, B. J. FISHER, and A. A. FOWLER. 1994. Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established. Arch. Surg. 129:1144-1152.
63. ANDRES, D. W., G. J. KUTKOSKI, W. M. QUINLAN, N. A. DOYLE, and C. M. DOERSCHUK. 1995. Effect of pentoxifylline on changes in neutrophil sequestration and emigration in the lungs. Am. J. Physiol. 268:27-32.
64. DAVIS, C. F., MOORE, F. D., RODRICK, M. L., FEARON, D. T. and MANNICK, J. A. (1987) Neutrophil activation after burn injury: Contributions of the classic complement pathway and of endotoxin. Surgery 102:477-484.