Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo

Toxicology Letters

Volumn 222, Issue 1, 2013, Pages 10-22

  Paul, Avijit ^a   Das, Sreemanti ^a   Das, Jayeeta ^a   Samadder, Asmita ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

Apoptosis; Atomic force microscopy; Bioavailability; Chelidonine; PLGA nanoparticles; Signalling cascade

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CHELIDONINE; CHELIDONINE NANOPARTICLE; CYCLIN D1; CYTOCHROME C; POLYGLACTIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIODEGRADABILITY; BRAIN TISSUE; CELL CYCLE M PHASE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MOUSE; NANOANALYSIS; NANOENCAPSULATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION;

APOPTOSIS; ATOMIC FORCE MICROSCOPY; BIOAVAILABILITY; CHELIDONINE; PLGA NANOPARTICLES; SIGNALLING CASCADE;

ANIMALS; APOPTOSIS; BENZOPHENANTHRIDINES; BIOLOGICAL AVAILABILITY; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOSOL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EXCIPIENTS; LACTIC ACID; MICE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NANOPARTICLES; NUCLEOSOMES; PARTICLE SIZE; POLYGLYCOLIC ACID; SIGNAL TRANSDUCTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STATIC ELECTRICITY;

EID: 84881021276     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.07.006     Document Type: Article

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