Exercise-induced hormesis may help healthy aging

Dose-Response

Volumn 8, Issue 1, 2010, Pages 73-79

  Ji, Li Li ^a   Dickman, Jonathan R ^a   Kang, Chounghun ^a   Koenig, Ryan ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aging; Exercise; Hormesis; Muscle; Reactive oxygen species

Indexed keywords

EID: 77949554748     PISSN: None     EISSN: 15593258     Source Type: Journal    
DOI: 10.2203/dose-response.09-048.Ji     Document Type: Article

References (25)

1. Alamdari N, O'Neal P, Hasselgren PO. 2009. Curcumin and muscle wasting: a new role for an old drug? Nutrition. 25(2):125-9.
2. Allen RG, Tresini M. 2000. Oxidative stress and gene regulation. Free Radic Biol Med. 28(3):463-99.
3. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, Holloszy JO. 2002. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 16: 1879-1886
4. Chan DC. 2006. Mitochondria: dynamic organelles in disease, aging, and development. Cell 125: 1241-1252.
5. Corton JC and Brown-Borg HM. 2005. Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J Gerontol A Biol Sci Med Sci. 60(12): 1494-509.
6. Feng H, Awoyinka L, Kang C, Dickman JR, Koenig R, Church, Gu L and Ji LL. 2009. Nuclear factor kappa B, beta-adrenergic system and mitochondrial biogenesis in skeletal muscle: effect of endurance training. Med. Sci. Sports Exer. 41(5): S45.
7. Fries JF. Physical activity, the compression of morbidity, and the health of the elderly. 1996. J. Royal Soc. Med., 89: 64-68.
8. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Vina J. 2008. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 87(1):142-9.
9. Goodyear LJ, Chang PY, Sherwood DJ, Dufresne SD, Moller DE. 1996. Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am J Physiol. 271(2 Pt 1):E403-8.
10. Handschin C, Spiegelman BM. 2008. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 454:463-9.
11. Hollander J, Fiebig R, Gore M, Ookawara T, Ohno H, Ji LL. 2001. Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle. Pflugers Arch. 442:426-34.
12. Holloszy JO. 1993. Exercise Increases Average Longevity of Female Rats Despite Increased Food Intake and No Growth Retardation. J Geront. 48(3):B97-B100
13. Ji LL. 2008. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med. 44:142-52.
14. Ji LL, Gomez-Cabrera MC, Vina J. 2009. Role of free radicals and antioxidant signaling in muscle health and pathology. Infect. Disord. Drug Targets. 9(4):428-444.
15. Jiménez-Jiménez R, Cuevas MJ, Almar M, Lima E, García-López D, De Paz JA, González-Gallego J. 2008. Eccentric training impairs NF-kappaB activation and over-expression of inflammationrelated genes induced by acute eccentric exercise in the elderly. Mech Ageing Dev. 129:313-21.
16. Kang C, O'Moore KM, Dickman JR, Ji LL. 2009a. Exercise activation of muscle peroxisome proliferator-activated receptor-γ coactivator-1α signaling is redox sensitive, Free Radic. Biol. Med. doi:10.1016/j.freeradbiomed.2009.08.007
17. Kang C, Chung E, Diffee G, Ji LL. 2009b. Exercise training attenuates aging-associated reduction in mitochondrial biogenesis in rat skeletal muscle. Med. Sci. Sports Exer. 41(5): S44.
18. Kelly DP, Scarpulla RC. 2004. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18: 357-368
19. Maruhashi Y, Kitaoka K, Yoshiki Y, Nakamura R, Okano A, Nakamura K, Tsuyama T, Shima Y, Tomita K. 2007. ROS scavenging activity and muscle damage prevention in eccentric exercise in rats. J Physiol Sci. 57:211-6.
20. Morley, JE, Baumgartner RN, Roubenoff R, and Nair KS. Sarcopenia. 2001. J. Lab. Clin. Med. 137: 231-243.
21. Paffenbarger RS, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JBG. 1993. The association of changes in physical activity level and other lifestyle characteristics with mortality among men. N. Eng. J. Med. 328:538-545.
22. Powers SK, Jackson MJ. 2008. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev.;88(4):1243-76.
23. Reid MB. 2001. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol. 90(2):724-31.
24. Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, Stumvoll, Hahn CR, Bluher M. 2009. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA. 106(21):8665-70.
25. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. 2006. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 127:397-408.