Immunology and homeopathy. 5. The rationale of the 'Simile'

Evidence-based Complementary and Alternative Medicine

Volumn 4, Issue 2, 2007, Pages 149-163

  Bellavite, Paolo ^a   Ortolani, Riccardo ^b   Pontarollo, Francesco ^a   Pitari, Giuseppina ^b   Conforti, Anita ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Action; Biologic networks; Homeopathic medicine; Hormesis; Inverse effects; Paradoxical pharmacology; Reaction principle; Response to stress; Self organization; Similia principle; Wilder's rule

Indexed keywords

ADRENALIN; CORTICOTROPIN; CYCLIC AMP; ENDORPHIN; INTERLEUKIN 1; INTERLEUKIN 6; STEROID; TUMOR NECROSIS FACTOR;

CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFECT; ELECTROMAGNETIC FIELD; HOMEOPATHY; HORMESIS; IMMUNOLOGY; INVERSION OF EFFECTS; NEUROENDOCRINE SYSTEM; PHARMACODYNAMICS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STRESS;

EID: 52449090246     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nel117     Document Type: Conference Paper

References (108)

1. Hahnemann CFS. Versuch über ein neues Princip zur Auffindung der Heilkrafte der Arzneisubstanzen (Essay on a new principle for ascertaining the curative powers of drugs). Hufeland's J 1796;2:391-439.
2. Boyd LJ. A Study of the Simile in Medicine. Philadelphia: Boericke and Tafel, 1936.
3. Bellavite P, Conforti A, Piasere V, Ortolani R. Immunology and homeopathy. 1. Historical background. Evid Based Complement Alternat Med 2005;2:441-52.
4. Bellavite P, Conforti A, Pontarollo F, Ortolani R. Immunology and homeopathy. 2. Cells of the immune system and inflammation. Evid Based Complement Alternat Med 2006;3:13-24.
5. Bellavite P, Conforti A, Ortolani R. Immunology and homeopathy. 3. Experimental studies on animal models. Evid Based Complement Alternat Med 2006;3:171-86.
6. Bellavite P, Ortolani R, Pontarollo F, Piasere V, Benato G, Conforti A. Immunology and homeopathy. 4. Clinical studies - part 1. Evid Based Complement Alternat Med 2006;3:293-301.
7. Bellavite P, Ortolani R, Pontarollo F, Piasere V, Benato G, Conforti A. Immunology and homeopathy. 4. Clinical studies - part 2. Evid. Based. Complement Alternat. Med 2006;3:397-409.
8. Kleijnen J, Knipschild P, ter Riet G. Clinical trials of homoeopathy. Br Med J 1991;302:316-23.
9. Bellavite P, Signorini A. Physiopathological models of the similia principle. In: Proceedings of the 51st L. M. H. I. International Congress Capri 2-6 October 1996, 1996, 98-106.
10. Bellavite P, Signorini A. The Emerging Science of Homeopathy. Berkeley (CA): North Atlantic, 2002.
11. Bellavite P. Complexity science and homeopathy. A synthetic overview. Homeopathy 2003;92:203-12.
12. Townsend JF, Luckey TD. Hormoligosis in pharmacology. J Am Med Ass 1960;173:44-8.
13. Sagan LA. On radiation, paradigms and hormesis. Science 1989;245:574.
14. Macklis RM, Beresford B. Radiation hormesis. J Nucl Med 1991;32:350-9.
15. Von Zglinicki T, Edwall C, Ostlund E, Lind B, Nordberg M, Ringertz NR, et al. Very low cadmium concentrations stimulate DNA synthesis cell growth. J Cell Sci 1992;103:1073-81.
16. Stebbing AR. A theory for growth hormesis. Mutat Res 1998;403:249-58.
17. Olivieri G. Adaptive response and its relationship to hormesis and low dose cancer risk estimation. Hum Exp Toxicol 1999;18:440-2.
18. Calabrese EJ, Baldwin LA. Hormesis as a biological hypothesis. Environ Health Perspect 1998;106 (Suppl 1): 357-62.
19. Renn O. Implications of the hormesis hypothesis for risk perception and communication. Hum Exp Toxicol 1998;17:431-8.
20. Rozman KK, Doull J. Scientific foundations of hormesis. Part 2. Maturation, strengths, limitations, and possible applications in toxicology, pharmacology, and epidemiology. Crit Rev Toxicol 2003;33:451-62.
21. Schulz H. Uber die Theorie der Arzneimittelwirkung. Virchow's Archiv 1877;108:423-34.
22. Schulz H. Uber Hefegifte. Arch Fuer Physiol 1888;42:517-41.
23. Martius F. Das Arndt-Schulz Grundgesetz. Muench Med Wschr 1923;70:1005-6.
24. Heine H, Schmolz M. Immunoregulation via 'bystander suppression' needs minute amounts of substances - a basis for homeopathic therapy? Med Hypotheses 2000;54:392-3.
25. Calabrese EJ, Baldwin LA. The marginalization of hormesis. Hum Exp Toxicol 2000;19:32-40.
26. Bellavite P, Chirumbolo S, Santonastaso C, Biasi D, Lussignoli S, Andrioli G. Dose-dependence of the various functional responses of neutrophils to formylpeptides. Activation, regulation, and inverse effects according to the agonist dose and cell condition. In: Bastide M (ed). Signals and Images. Dordrecht: Kluwer Academic Publishers, 1997, 111-9.
27. Bellavite P, Lussignoli S, Semizzi M, Ortolani R, Signorini A. The similia principle. From cellular models to regulation of homeostasis. Brit Hom J 1997;86:73-85.
28. Bellavite P, Chirumbolo S, Lippi G, Andrioli G, Bonazzi L, Ferro I. Dual effects of formylpeptides on the adhesion of endotoxin-primed human neutrophils. Cell Biochem Funct 1993;11:231-9.
29. Bellavite P, Carletto A, Biasi D, Caramaschi P, Poli F, Suttora F, et al. Studies of skin-window exudate human neutrophils: complex patterns of adherence to serum-coated surfaces in dependence on FMLP doses. Inflammation 1994;18:575-87.
30. Dennig D, Mecheri S, Bourhis JH, Hoffman MK. Interleukin-2 may enhance or inhibit antibody production by B cells depending on intracellular cAMP concentration. Immunology 1992;77:251-5.
31. Masini E, Blandina P, Brunelleschi S, Mannaioni PF. Evidence for H2-receptor-mediated inhibition of histamine release from isolated rat mast cells. Agents Actions 1982;12:85-8.
32. Belon P, Cumps J, Ennis M, Mannaioni P, Roberfroid M, Sainte-Laudy J, et al. Histamine dilutions modulate basophil activation. Inflamm Res 2004;53:181-8.
33. Widakowich J. Pharmacodynamic principles of homeopathy. Med Hypotheses 2000;54:721-2.
34. Oberbaum M, Cambar J. Hormesis: dose-dependent reverse effects of low and very low doses. In: Endler PC, Schulte J (eds). Ultra High Dilution. Dordrecht: Kluwer Academic Publishers, 1994, 5-18.
35. Van Wijk R, Wiegant FA. The similia principle as a therapeutic strategy: a research program on stimulation of self-defense in disordered mammalian cells. Altern Ther Health Med 1997;3:33-8.
36. Van Wijk R, Wiegant FAC, Souren JEM, Ovelgonne JH, van Aken JM, Bol AWJM. A molecular basis for understanding the benefits from subharmful doses of toxicants. Biomed Ther 1997;15:4-13.
37. Wiegant FA, Souren JEM, Van Wijk R. Stimulation of survival capacity in heat shocked cells by subsequent exposure to minute amounts of chemical stressors; role of similarity in hsp-inducing effects. Hum Exp Toxicol 1999;18:460-70.
38. Chattopadhyay S. Proposition of a new system of medicine based on tolerance principle. Med Hypotheses 2002;59:191-203.
39. Bernardini S, Dei A. Hormesis may provide a central concept for homeopathy development. Toxicol Appl Pharmacol 2006;211:84.
40. Solomon GF. Stress, hormones, immunity, the complexity of interwined systems, and the simplicity of humanism. J Intensive Care Med 1997;12:219-22.
41. Cohen S, Tyrrel DAJ, Smith AP. Psychological stress and the susceptibility to the common cold. New Engl J Med 1991;325:606-12.
42. Ader R, Cohen N, Felten D. Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet 1995;345:99-103.
43. Leonard BE. The HPA and immune axes in stress: the involvement of the serotonergic system. Eur Psychiatry 2005;20:S302-6.
44. Hyland ME, Lewith GT. Oscillatory effects in a homeopathic clinical trial: an explanation using complexity theory, and implications for clinical practice. Brit Hom J 2002;91:145-9.
45. Guajardo G, Bellavite P, Wynn S, Searcy R, Fernandez R, Kayne S. Homeopathic terminology: a consensus quest. Brit Hom J 1999; 88:135-41.
46. Bellavite P, Pettigrew A. Miasms and modern pathology. Homeopathy 2004;93:65-6.
47. Milgrom LR. Patient-practitioner-remedy (PPR) entanglement. Part 6. Miasms revisited: non-linear quantum theory as a model for the homeopathic process. Homeopathy 2004;93:154-8.
48. Bousta D, Soulimani R, Jarmouni I, Belon P, Falla J, Foment N, et al. Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice. J Ethnopharmacol 2001;74:205-15.
49. Ruiz-Vega G, Poitevin B, Perez-Ordaz L. Histamine at high dilution reduces spectral density in delta band in sleeping rats. Homeopathy 2005;94:86-91.
50. Adams DO, Hamilton TA. Macrophages as destructive cells in host defense. In: Gallin JI (ed). Inflammation, 2nd edn. New York: Raven Press, 1992, 637-62.
51. Wilder J. Das 'Ausgangswert-Gesetz', ein unbeachtes biologisches Gesetz und seine Bedeutung fur Forschung und Praxis. Zeit d Gesamte Neur u Psych 1931;137:317.
52. Wilder J. Stimulus and Response: The Law Of Initial Value. Bristol: Wright, 1967.
53. Eskinazi D. Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Arch Intern Med 1999;159:1981-7.
54. Teixeira MZ. Similitude in modern pharmacology. Brit Hom J 1999;88:112-20.
55. Milgrom LR. Patient-Practitioner-Remedy (PPR) entanglement, Part 7: a gyroscopic metaphor for the vital force and its use to illustrate some of the empirical laws of homeopathy. Forsch Komplementarmed Klass Naturheilkd 2004;11:212-23.
56. Bond RA. Is paradoxical pharmacology a strategy worth pursuing? Trends Pharmacol Sci 2001;22:273-6.
57. Xu XJ, Colpaert F, Wiesenfeld-Hallin Z. Paradoxical opioid hyperalgesia and inverse tolerance. Trends Pharmacol Sci 2003;24:634-9.
58. Genton P. When antiepileptic drugs aggravate epilepsy. Brain Dev 2000;22:75-80.
59. Doux JD, Bazar KA, Lee PY, Yun AJ. Can chronic use of anti-inflammatory agents paradoxically promote chronic inflammation through compensatory host response? Med Hypotheses 2005;65:389-91.
60. Yun AJ, Lee PY, Bazar KA. Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effect. Med Hypotheses 2005;64:1050-9.
61. Yun AJ. The intellectual lineage of paradoxical pharmacology strategy. Med Hypotheses 2005;65:815.
62. Teixeira MZ. Homeopathic use of modern medicines: utilisation of the curative rebound effect. Med Hypotheses 2003;60:276-83.
63. Bellavite P, Andrioli G, Lussignoli S, Signorini A, Ortolani R, Conforti A. Scientific reappraisal of the 'Principle of Similarity'. Med Hypotheses 1997;49:203-12.
64. Cannon WB. Stresses and strains of homeostasis. Am J Med Sci 1935;1-14.
65. Bellavite P, Chirumbolo S, Lippi G, Guzzo P, Santonastaso C. Homologous priming in chemotactic peptide-stimulated neutrophils. Cell Biochem Funct 1993;11:93-100.
66. Stroebel CF. Somatization and alexithymia as aspects of mind-body intelligence. Advances-J. Body-Mind Health 1998;14:113-7.
67. Denollet J. Type D personality. A potential risk factor refined. J Psychosom Res 2000;49:255-66.
68. Duncko R, Makatsori A, Fickova E, Selko D, Jezova D. Altered coordination of the neuroendocrine response during psychosocial stress in subjects with high trait anxiety. Prog 2006;30:1058-66.
69. Biasi D, Bambara LM, Carletto A, Caraffi M, Serra MC, Chirumbolo S, et al. Factor-specific changes of the oxidative metabolism of exudate human neutrophils. Inflammation 1993;17:13-23.
70. Bastide M. Information and communication in living organisms. In: Schulte J, Endler PC (eds). Fundamental Research in Ultra High Dilution and Homeopathy. Dordrecht: Kluwer Academic Publishers, 1998, 229-39.
71. Schulte J. Effects of potentization in aqueous solutions. Brit Hom J 1999;88:155-60.
72. Endler PC, Schulte J. Homoopathie und Bioresonanztherapie. In: Physiologiche und Physikalische Voraussetzungen Grundlagenforchung. Wien: Medizinverlag Maudrich, 1997.
73. Smith CW. Quanta and coherence effects in water and living systems. J Altern Complement Med 2004;10:69-78.
74. Bonamin LV. Experimental illustrations of body signifiers theory. In: Halm RP (ed). Les Médecines Non-conventionelles: une nouvelle approche de la santé. Monaco: Les Entretiens Internationaux, 2005, 195-207.
75. Tschulakow AV, Yan Y, Klimek W. A new approach to the memory of water. Homeopathy 2005;94:241-7.
76. Anagnostatos GS. Small water clusters clathrates in the preparation process of homoeopathy. In: Endler PC, Schulte J (eds). Ultra High Dilution. Dordrecht: Kluwer Acadermic Publishsers, 1994, 121-8.
77. Sukul NC, Sukul A. High Dilution Effects: Physical and Biochemical Basis. Dordrecht: Kluwer, 2003.
78. Roy R, Tiller W, Bell IR, Hoover MR. The structure of liquid water. Novel insights from materials research; potential relevance to homeopathy. Mat Res Innovat 2005;9:98-103.
79. Garner C, Hock N. Chaos theory and homoeopathy. Berlin J Res Hom 1991;1:236-42.
80. Shepperd J. Chaos theory: implications for homeopathy. J Am Inst Homeopathy 1994;87:22-9.
81. Elia V, Napoli E, Niccoli M, Nonatelli L, Ramaglia A, Ventimiglia E. New physico-chemical properties of extremely diluted aqueous solutions. A calorimetric and conductivity study at 25°C. J Thermal Anal Calorim 2004;78:331-42.
82. Elia V, Niccoli M. New physico-chemical properties of extremely diluted aqueous solutions. J Thermal Anal Calorim 2004;75:815-36.
83. Demangeat JL, Gries P, Poitevin B, Droesbeke JJ, Zahaf T, Maton F, et al. Low-field NMR water proton longitudinal relaxation in ultrahighly diluted aqueous solutions of silica-lactose prepared in glass material for pharmaceutical use. Appl Magn Reson 2004;26:465-81.
84. Bell IR, Lewis DA, Brooks AJ, Lewis SE, Schwartz GE. Gas discharge visualization evaluation of ultramolecular doses of homeopathic medicines under blinded, controlled conditions. J Altern Complement Med 2003;9:25-38.
85. Rey LR. Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride. Physica 2003;A323:67-74.
86. Preparata G. Quantum Electrodynamic Coherence in Matter. Singapore: World Scientific, 1995.
87. Preparata G. Regimi coerenti in Fisica e Biologia. Il problema della forma. Biology Forum. Biologv Forum 1997;90:434-6.
88. Del Giudice E, Preparata G. Coherence electrodynamics in water. In: Schulte J, Endler C (eds). Fundamental Research in Ultrahigh Dilution and Homeopathy. Dordrecht: Kluwer, 1998, 89-100.
89. Ho MW, Popp FA, Warnke U. Bioelectrodynamics and Biocommunication. Singapore: World Scientific, 1994.
90. Vallee P, Lafait J, Mentre P, Monod MO, Thomas Y. Effects of pulsed low frequency electromagnetic fields on water using photoluminescence spectroscopy: role of bubble/water interface. J Chem Phys 2005;122:114513.
91. Fesenko EE, Gluvstein AY. Changes in the state of water, induced by radiofrequency electromagnetic fields. FEBS Lett 1995;367:53-5.
92. Fesenko EE, Geletyuk VI, Kazachenko VN, Chemeris NK. Preliminary microwave irradiation of water solutions changes their channel-modifying activity. FEBS Lett 1995;366:49-52.
93. Fesenko EE, Popov VI, Novikov VV, Khutsian SS. Water structure formation by weak magnetic fields and xenon. Electron microscopic analysis. Biofizika 2002;47:389-94.
94. Elbert T, Ray WJ, Kowalik ZJ, Skinner JE, Graf KE, Birbaumer N. Chaos and physiology: deterministic chaos in excitable cell assemblies. Physiol Rev 1994;74:1-47.
95. Bellavite P. Disease as information disorder. Advances-J. Body-Mind Health 1997;13:4-7.
96. Bellavite P, Semizzi M, Lussignoli S, Andrioli G, Bartocci U. A computer model of the five elements theory of traditional Chinese medicine. Complem Ther Med 1998;6:133-40.
97. Callard R, George AJ, Stark J. Cytokines, chaos, and complexity. Immunity 1999;11:507-13.
98. Mainzer K. Thinking in Complexity. In: The Complex Dynamics of Matter, Mind, and Mankind. Berlin-Heidelberg: Springer-Verlag, 1994.
99. Holland JH. Emergence. From Chaos to Order. Reading (MA): Addison-Wesley, 2000.
100. Shinbrot T, Grebogi C, Ott E, Yorke JA. Using small perturbations to control chaos. Nature 1993;363:411-7.
101. Garfinkel A, Spano ML, Ditto WL, Weiss JN. Controlling cardiac chaos. Science 1992;257:1230-5.
102. Germain RN. The art of probable: system control in the adaptive immune system. Science 2001;293:240-5.
103. van Rossum JM, de Bie JEGM. Chaos and illusion. Trends Pharmacol Sci 1991;12:379-83.
104. Ruiz G, Torres JL, Michel O, Navarro R. Homeopathic effect on heart rate variability. Brit Hom J 1999;88:106-11.
105. Torres JL, Ruiz G. Stochastic resonance and the homoeopathic effect. Brit Hom J 1996;85:134-40.
106. Schwartz GE, Russek LG, Bell IR, Riley D. Plausibility of homeopathy and conventional chemical therapy: the systemic memory resonance hypothesis. Med Hypotheses 2000;54:634-7.
107. Bell IR, Baldwin CM, Schwartz GE. Translating a nonlinear systems theory model for homeopathy into empirical tests. Altern Ther Health Med 2002;8:58-66.
108. Bell IR, Koithan M, Gorman MM, Baldwin CM. Homeopathic practitioner views of changes in patients undergoing constitutional treatment for chronic disease. J Altern Complement Med 2003;9:39-50.