Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro

Toxicology Letters

Volumn 223, Issue 2, 2013, Pages 124-138

  Das, Sreemanti ^a,b   Das, Jayeeta ^a,b   Samadder, Asmita ^a,b   Paul, Avijit ^a,b   Khuda Bukhsh, Anisur Rahman ^a,b  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

Apigenin; Apoptosis; Drug DNA interaction; Mitochondrial dysfunction; PLGA nano encapsulation; Skin melanoma

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; APIGENIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; GLUTATHIONE REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYGLACTIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER CELL CULTURE; CELL MIGRATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DRUG RELEASE; ENZYME ACTIVITY; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MELANOMA; META ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR STABILITY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHOTODEGRADATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROSCOPY; THERMOSTABILITY; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET RADIATION; ZETA POTENTIAL;

APIGENIN; APOPTOSIS; DRUG-DNA INTERACTION; MITOCHONDRIAL DYSFUNCTION; PLGA-NANO-ENCAPSULATION; SKIN MELANOMA;

APIGENIN; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; CYTOCHROMES C; DNA FRAGMENTATION; HUMANS; LACTIC ACID; MELANOMA; MITOCHONDRIA; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; REACTIVE OXYGEN SPECIES;

EID: 84886308723     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.09.012     Document Type: Article

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