Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo

Environmental Toxicology and Pharmacology

Volumn 37, Issue 1, 2014, Pages 300-314

  Sikdar, Sourav ^a   Mukherjee, Avinaba ^a   Ghosh, Samrat ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

Caspase 3; Condurango glycoside rich components (CGS); H460; Mitochondria membrane potential (MMP); Non small cell lung cancer (NSCLC); Reactive oxygen species (ROS)

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZO[A]PYRENE; CASPASE 3; CASPASE 9; CONDURANGOGLYCOSIDE A; CONDURANGOGLYCOSIDE A0; CONDURANGOGLYCOSIDE E2; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOSIDE; LIPOCORTIN 5; MARSDENIA CONDURANGO EXTRACT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALTERNATIVE MEDICINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DNA NICK TRANSLATION; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; ENZYME ACTIVATION; GENE EXPRESSION; H460 CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

CASPASE-3; CONDURANGO GLYCOSIDE-RICH COMPONENTS (CGS); H460; MITOCHONDRIA MEMBRANE POTENTIAL (MMP); NON SMALL CELL LUNG CANCER (NSCLC); REACTIVE OXYGEN SPECIES (ROS);

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZO(A)PYRENE; CARCINOGENS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; GLYCOSIDES; HUMANS; LEUKOCYTES, MONONUCLEAR; LUNG NEOPLASMS; MARSDENIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; PLANT BARK; PLANT EXTRACTS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84891384789     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2013.12.004     Document Type: Article

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