A model for homeopathic remedy effects: Low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system

BMC Complementary and Alternative Medicine

Volumn 12, Issue , 2012, Pages

  Bell, Iris R ^a,b   Koithan, Mary ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF NURSING   (United States)

Author keywords

Allostasis; Complex adaptive system; Cross adaptation; Epitaxy; Homeopathy; Hormesis; Metaplasticity; Nanomedicine; Nanoparticles; Resilience; Silica; Stress response network; Time dependent sensitization

Indexed keywords

ALCOHOL; CYTOKINE; DNA; HEAT SHOCK PROTEIN; MINERAL; NANOPARTICLE; SILICON DIOXIDE; WATER;

ADSORPTION; ALTERNATIVE MEDICINE; ARTICLE; BASIC RESEARCH; CHEMICAL INTERACTION; COLLOID; CRYSTAL STRUCTURE; DILUTION; ELECTROMAGNETIC FIELD; HOMEOPATHY; HOMEOSTASIS; HUMAN; NANOTECHNOLOGY; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PATIENT SATISFACTION; PLANT; ULTRASOUND;

ADAPTATION, PHYSIOLOGICAL; ALLOSTASIS; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MATERIA MEDICA; MODELS, THEORETICAL; NANOPARTICLES; PLANT EXTRACTS; TIME FACTORS;

EID: 84867629714     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-12-191     Document Type: Article

References (249)

1. Bhattacharyya SS, Mandal SK, Biswas R, Paul S, Pathak S, Boujedaini N, Belon P, Khuda-Bukhsh AR. In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med (Maywood) 2008, 233(12):1591-1601.
2. Chikramane PS, Suresh AK, Bellare JR, Kane SG. Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy 2010, 99(4):231-242.
3. Upadhyay RP, Nayak C. Homeopathy emerging as nanomedicine. International Journal of High Dilution Research 2011, 10(37):299-310.
4. Ives JA, Moffett JR, Arun P, Lam D, Todorov TI, Brothers AB, Anick DJ, Centeno J, Namboodiri MA, Jonas WB. Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions. Homeopathy 2010, 99(1):15-24.
5. Karatsoreos IN, McEwen BS. Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci 2011, 15(12):576-584.
6. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 2008, 583(2-3):174-185.
7. Van Wijk R, Wiegant FA. Postconditioning hormesis and the homeopathic Similia principle: molecular aspects. Hum Exp Toxicol 2010, 29(7):561-565.
8. Van Wijk R, Wiegant FA. Postconditioning hormesis and the similia principle. Front Biosci (Elite Ed) 2011, 3:1128-1138.
9. Khuda-Bukhsh AR, Bhattacharyya SS, Paul S, Dutta S, Boujedaini N, Belon P. Modulation of signal proteins: a plausible mechanism to explain how a potentized drug secale cor 30C diluted beyond avogadro's limit combats skin papilloma in mice. Evid Based Complement Alternat Med 2011, 2011:286320.
10. Bellavite P, Ortolani R, Pontarollo F, Pitari G, Conforti A. Immunology and Homeopathy. 5. The Rationale of the 'Simile'. Evid Based Complement Alternat Med 2007, 4(2):149-163.
11. Bertani S, Lussignoli S, Andrioli G, Bellavite P, Conforti A. Dual effects of a homeopathic mineral complex on carrageenan-induced oedema in rats. Br Homeopath J 1999, 88(3):101-105.
12. Malarczyk E, Pazdzioch-Czochra M, Graz M, Kochmanska-Rdest J, Jarosz-Wilkolazka A. Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde. Nonlinear Biomed Phys 2011, 5(1):9.
13. Hyland ME, Lewith GT. Oscillatory effects in a homeopathic clinical trial: an explanation using complexity theory, and implications for clinical practice. Homeopathy 2002, 91(3):145-149.
14. Bell IR, Brooks AJ, Howerter A, Jackson N, Schwartz GE. Acute electroencephalographic effects from repeated olfactory administration of homeopathic remedies in individuals with self-reported chemical sensitivity. Altern Ther Health Med 2012, in press..
15. Bell IR, Howerter A, Jackson N, Aickin M, Bootzin RR. Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia. Homeopathy 2012, 101(3):182-192.
16. Iavicoli I, Calabrese EJ, Nascarella MA. Exposure to nanoparticles and hormesis. Dose Response 2010, 8(4):501-517.
17. Wiegant F, Van Wijk R. The similia principle: results obtained in a cellular model system. Homeopathy 2010, 99(1):3-14.
18. Bell IR, Howerter A, Jackson N, Brooks AJ, Schwartz GE. Multi-week resting EEG cordance change patterns from repeated olfactory activation with two constitutionally-salient homeopathic remedies in healthy young adults. J Alternative and Complementary Medicine 2012, 18(5):445-453.
19. Bellavite P, Signorini A. The Emerging Science of Homeopathy. Complexity, Biodynamics, and Nanopharmacology 2002, Berkeley: North Atlantic Books, 2.
20. Bellavite P. Complexity science and homeopathy: a synthetic overview. Homeopathy: the Journal of the Faculty of Homeopathy 2003, 92(4):203-212.
21. Koithan M, Bell IR, Niemeyer K, Pincus D. A complex systems science perspective for whole systems of CAM research. Forsch Komplementarmed Klass Naturheilkd 2012, 19(Supplement 1):7-14.
22. Bell IR, Koithan M, Pincus D. Research methodological implications of nonlinear dynamical systems models for whole systems of complementary and alternative medicine. Forsch Komplementarmed Klass Naturheilkd 2012, 19(Supplement 1):15-21.
23. Pincus D, Metten A. Nonlinear dynamics in biopsychosocial resilience. Nonlinear Dynamics Psychol Life Sci 2010, 14(4):353-380.
24. Rao ML, Roy R, Bell IR. The defining role of structure (including epitaxy) in the plausibility of homeopathy. Homeopathy 2007, 96(3):175-182.
25. Chaplin MF. The Memory of Water: an overview. Homeopathy 2007, 96(3):143-150.
26. Elia V, Napoli E, Germano R. The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions. Homeopathy 2007, 96(3):163-169.
27. Elia V, Niccoli M. Thermodynamics of extremely diluted aqueous solutions. Ann N Y Acad Sci 1999, 879:241-248.
28. Elia V, Niccoli M. New physico-chemical properties of extremely diluted aqueous solutions. Journal of Thermal Analysis and Calorimetry 2004, 75:815-836.
29. Rey L, Physica A. Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride. Statistical mechanics and its applications 2003, 323:67-74.
30. Rey L. Can low-temperature thermoluminescence cast light on the nature of ultra-high dilutions?. Homeopathy 2007, 96(3):170-174.
31. Roy R, Tiller W, Bell IR, Hoover MR. The structure of liquid water: novel insights from materials research and potential relevance to homeopathy. Materials Research Innovation 2005, 9(4):557-608.
32. Demangeat JL. NMR relaxation evidence for solute-induced nanosized superstructures in ultramolecular aqueous dilutions of silica-lactose. Journal of Molecular Liquids 2010, 155:71-79.
33. Montagnier L, Aissa J, Ferris S, Montagnier J-L, Lavallee C. Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences. Interdisciplinary Sci Comput Life Sci 2009, 1:81-90.
34. Walach H. Entanglement model of homeopathy as an example of generalised entanglement predicted by weak quantum theory. Forschende Komplementarmedizin/Research in Complementary Medicine 2003, 10(4):192-200.
35. Milgrom LR. A new geometrical description of entanglement and the curative homeopathic process. J Altern Complement Med 2008, 14(3):329-339.
36. Calabrese EJ. Hormesis and homeopathy: introduction. Hum Exp Toxicol 2010, 29(7):527-529.
37. Rattan SI, Deva T. Testing the hormetic nature of homeopathic interventions through stress response pathways. Hum Exp Toxicol 2010, 29(7):551-554.
38. Calabrese EJ, Jonas WB. Homeopathy: clarifying its relationship to hormesis. Hum Exp Toxicol 2010, 29(7):531-6. 29(7):531-536..
39. Bell IR, Schwartz GE. Adaptive network nanomedicine: an integrated model for homeopathic medicine. Frontiers in Bioscience (Elite Ed) 2012, in press..
40. Hahnemann S. Organon of the Medical Art 1843, Redmond, WA: Birdcage Books, 6.
41. Clarke JH. A Dictionary of Practical Materia Medica 1977, Bradford, UK: Health Science Press.
42. Steinsbekk A, Ludtke R. Patients' assessments of the effectiveness of homeopathic care in Norway: a prospective observational multicentre outcome study. Homeopathy 2005, 94(1):10-16.
43. Kliems H, Witt CM. The good doctor: a qualitative study of German homeopathic physicians. J Altern Complement Med 2011, 17(3):265-270.
44. New Directions in Homeopathy Research 2009, Essen, Germany: KVC Verlag, Witt C, Albrecht H.
45. Bornhoft G, Matthiessen PF. Homeopathy in Healthcare - Effectiveness 2011, Appropriateness, Safety, Costs: Springer.
46. Jutte R, Riley D. A review of the use and role of low potencies in homeopathy. Complement Ther Med 2005, 13(4):291-296.
47. Loftsson T. Aqueous solubility and true solutions. Pharmazie 2010, 65(6):404-407.
48. Roduner E. Size matters: why nanomaterials are different. Chem Soc Rev 2006, 35(7):583-592.
49. DeCastro CL, Mitchell BS. Nanoparticles from mechanical attrition. Synthesis, Functionalization, and Surface Treatment of Nanoparticles 2002, 1-15. Valencia, CA: American Scientific Publisher, Baraton MI.
50. Merisko-Liversidge E, Liversidge GG. Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv Drug Deliv Rev 2011, 63(6):427-440.
51. Keck CM, Muller RH. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm 2006, 62(1):3-16.
52. Liu G, Zhang D, Jiao Y, Zheng D, Liu Y, Duan C, Jia L, Zhang Q, Lou H. Comparison of different methods for preparation of a stable riccardin D formulation via nano-technology. Int J Pharm 2012, 422(1-2):516-522.
53. Ruan B, Jacobi M. Ultrasonication effects on thermal and rheological properties of carbon nanotube suspensions. Nanoscale Res Lett 2012, 7(1):127.
54. Tang C, Zhou T, Yang J, Zhang Q, Chen F, Fu Q, Yang L. Wet-grinding assisted ultrasonic dispersion of pristine multi-walled carbon nanotubes (MWCNTs) in chitosan solution. Colloids Surf B Biointerfaces 2011, 86(1):189-197.
55. Chan HK, Kwok PC. Production methods for nanodrug particles using the bottom-up approach. Adv Drug Deliv Rev 2011, 63(6):406-416.
56. Liu L, Randolph TW, Carpenter JF. Particles shed from syringe filters and their effects on agitation-induced protein aggregation. J Pharm Sci 2012, 101(8):2952-2959.
57. Fratini E, Page MG, Giorgi R, Colfen H, Baglioni P, Deme B, Zemb T. Competitive surface adsorption of solvent molecules and compactness of agglomeration in calcium hydroxide nanoparticles. Langmuir 2007, 23(5):2330-2338.
58. Abbasi AR, Morsali A. Influence of solvents on the morphological properties of AgBr nano-structures prepared using ultrasound irradiation. Ultrason Sonochem 2012, 19(3):540-545.
59. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci 2005, 94(2):256-274.
60. Buzea C, Pacheco II, Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2(4):MR17-71.
61. Yao P, Hughes S. Macroscopic entanglement and violation of Bell's inequalities between two spatially separated quantum dots in a planar photonic crystal system. Opt Express 2009, 17(14):11505-11514.
62. Bhattacharyya SS, Paul S, Khuda-Bukhsh AR. Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp Biol Med (Maywood) 2010, 235(6):678-688.
63. Prakash DJ, Arulkumar S, Sabesan M. Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress induced behavioral and biochemical alteration in male albino mice. Pharmacognosy Res 2010, 2(6):330-334.
64. Das S, Das J, Samadder A, Bhattacharyya S, Das D, Khuda-Bukhsh AR. Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells. Colloids Surf B Biointerfaces 2013, 101:325-336.
65. Song L, Yang K, Jiang W, Du P, Xing B. Adsorption of bovine serum albumin on nano and bulk oxide particles in deionized water. Colloids Surf B Biointerfaces 2012, 94:341-346.
66. Tavares Cardoso MA, Talebi M, Soares PA, Yurteri CU, van Ommen JR. Functionalization of lactose as a biological carrier for bovine serum albumin by electrospraying. Int J Pharmaceutics 2011, 414(1-2):1-5.
67. Belton DJ, Deschaume O, Perry CC. An overview of the fundamentals of the chemistry of silica with relevance to biosilicification and technological advances. FEBS J 2012, 279(10):1710-1720.
68. Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol 2010, 80(12):1833-1843.
69. Bhattacharyya SS, Das J, Das S, Samadder A, Das D, De A, Paul S, Khuda-Bukhsh AR. Rapid green synthesis of silver nanoparticles from silver nitrate by a homeopathic mother tincture Phytolacca Decandra. Zhong Xi Yi Jie He Xue Bao 2012, 10(5):546-554.
70. Patil SV, Borase HP, Patil CD, Salunke BK. Biosynthesis of silver nanoparticles using latex from few euphorbian plants and their antimicrobial potential. Appl Biochem Biotechnol 2012, 167(4):776-790.
71. Perry CC, Keeling-Tucker T. Crystalline silica prepared at room temperature from aqueous solution in the presence of intrasilica bioextracts. Chem Commun (Camb) 1998, 1998(23):2587-2588.
72. Perry CC, Keeling-Tucker T. Model studies of colloidal silica precipitation using biosilica extracts from Equisetum telmateia. Colloid Polym Sci 2003, 281(7):652-664.
73. Daisy P, Saipriya K. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. Int J Nanomedicine 2012, 7:1189-1202.
74. Witt CM, Ludtke R, Weisshuhn TE, Quint P, Willich SN. The role of trace elements in homeopathic preparations and the influence of container material, storage duration, and potentisation. Forsch Komplementarmed 2006, 13(1):15-21.
75. Khripin CY, Pristinski D, Dunphy DR, Brinker CJ, Kaehr B. Protein-directed assembly of arbitrary three-dimensional nanoporous silica architectures. ACS Nano 2011, 5(2):1401-1409.
76. Wang DC, Chen GY, Chen KY, Tsai CH. DNA as a template in self-assembly of Au nano-structure. IET Nanobiotechnol 2011, 5(4):132-135.
77. Baca HK, Carnes EC, Ashley CE, Lopez DM, Douthit C, Karlin S, Brinker CJ. Cell-directed-assembly: directing the formation of nano/bio interfaces and architectures with living cells. Biochim Biophys Acta 2011, 1810(3):259-267.
78. Neville F, Broderick MJ, Gibson T, Millner PA. Fabrication and activity of silicate nanoparticles and nanosilicate-entrapped enzymes using polyethyleneimine as a biomimetic polymer. Langmuir 2011, 27(1):279-285.
79. Caron V, Willart JF, Lefort R, Derollez P, Danede F, Descamps M. Solid state amorphization kinetic of alpha lactose upon mechanical milling. Carbohydr Res 2011, 346(16):2622-2628.
80. Schroder HC, Wang X, Tremel W, Ushijima H, Muller WE. Biofabrication of biosilica-glass by living organisms. Nat Prod Rep 2008, 25(3):455-474.
81. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008, 9(8):847-856.
82. Winter M, Beer HD, Hornung V, Kramer U, Schins RP, Forster I. Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells. Nanotoxicology 2011, 5(3):326-340.
83. Relaix S, Leheny RL, Reven L, Sutton M. Memory effect in composites of liquid crystal and silica aerosil. Phys Rev E Stat Nonlin Soft Matter Phys 2011, 84(6-1):061705.
84. de Jonge N, Ross FM. Electron microscopy of specimens in liquid. Nat Nanotechnol 2011, 6(11):695-704.
85. Ponce A, Mejia-Rosales S, Jose-Yacaman M. Scanning transmission electron microscopy methods for the analysis of nanoparticles. Methods Mol Biol 2012, 906:453-471.
86. Anick DJ. High sensitivity 1H-NMR spectroscopy of homeopathic remedies made in water. BMC Complement Altern Med 2004, 4(1):1.
87. White ER, Mecklenburg M, Shevitski B, Singer SB, Regan BC. Charged nanoparticle dynamics in water induced by scanning transmission electron microscopy. Langmuir 2012, 28(8):3695-3698.
88. Bell NC, Minelli C, Tompkins J, Stevens MM, Shard AG. Emerging techniques for submicrometer particle sizing applied to stober silica. Langmuir 2012, 28(29):10860-10872.
89. Soo CY, Song Y, Zheng Y, Campbell EC, Riches AC, Gunn-Moore F, Powis SJ. Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 2012, 136(2):192-197.
90. Armstead AL, Li B. Nanomedicine as an emerging approach against intracellular pathogens. Int J Nanomedicine 2011, 6:3281-3293.
91. Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, Irvine DJ. Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release 2012, 157(3):354-365.
92. Barabasi AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet 2011, 12(1):56-68.
93. Szalay MS, Kovacs IA, Korcsmaros T, Bode C, Csermely P. Stress-induced rearrangements of cellular networks: Consequences for protection and drug design. FEBS Lett 2007, 581(19):3675-3680.
94. Brodsky SV, Goligorsky MS. Endothelium under stress: local and systemic messages. Semin Nephrol 2012, 32(2):192-198.
95. Danese A, McEwen BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav 2012, 106(1):29-39.
96. Demirovic D, Rattan SI. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol 2012, In press..
97. Antelman SM, Caggiula AR, Gershon S, Edwards DJ, Austin MC, Kiss S, Kocan D. Stressor-induced oscillation. A possible model of the bidirectional symptoms in PTSD. Ann N Y Acad Sci 1997, 821:296-304.
98. Antelman SM, Caggiula AR, Kocan D, Knopf S, Meyer D, Edwards DJ, Barry H. One experience with 'lower' or 'higher' intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Res 1991, 566(1-2):276-283.
99. West B. Where Medicine Went Wrong: Rediscovering the Path to Complexity (Studies of Nonlinear Phenomena in Life Science) 2006, 283-314. New Jersey: World Scientific Publishing Company.
100. Goldberger AL, Amaral LAN, Hausdorff JM, Ivanov PC, Peng CK, Stanley HE. Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci 2002, 99(Suppl 1):2466-2472.
101. Vidal M, Cusick ME, Barabasi AL. Interactome networks and human disease. Cell 2011, 144:986-998.
102. Yoo JW, Yun DS, Kim HJ. Influence of reaction parameters on size and shape of silica nanoparticles. J Nanosci Nanotechnol 2006, 6(11):3343-3346.
103. Song M, Yuan S, Yin J, Wang X, Meng Z, Wang H, Jiang G. Size-dependent toxicity of nano-C60 aggregates: more sensitive indication by apoptosis-related Bax translocation in cultured human cells. Environ Sci Technol 2012, 46(6):3457-3464.
104. Yang X, Liu J, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, et al. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol 2010, 7:1.
105. Napierska D, Thomassen LC, Rabolli V, Lison D, Gonzalez L, Kirsch-Volders M, Martens JA, Hoet PH. Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 2009, 5(7):846-853.
106. Passagne I, Morille M, Rousset M, Pujalte I, L'Azou B. Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. Toxicology 2012, 299(2-3):112-124.
107. Shi Z, Huang X, Liu B, Tao H, Cai Y, Tang R. Biological response of osteosarcoma cells to size-controlled nanostructured hydroxyapatite. J Biomater Appl 2010, 25(1):19-37.
108. Pathak S, Multani AS, Banerji P, Banerji P. Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol 2003, 23(4):975-982.
109. Nandy P, Bhandary S, Das S, Basu R, Bhattacharya S. Nanoparticles and membrane anisotropy. Homeopathy 2011, 100(3):194.
110. O'Connor TL, Greenberg SA. The kinetics for the solution of silica in aqueous solutions. J Phys Chem 1958, 62(10):1195-1198.
111. Konakanchi H, Vajjha R, Misra D, Das D. Electrical conductivity measurements of nanofluids and development of new correlations. J Nanosci Nanotechnol 2011, 11(8):6788-6795.
112. Liu Y, Kathan K, Saad W, Prudhomme RK. Ostwald ripening of B-carotene nanoparticles. Phys Rev Lett 2007, 98(035102):1-4.
113. Mahesh S, Gopal A, Thirumalai R, Ajayaghosh A. Light-induced Ostwald ripening of organic nanodots to rods. J Am Chem Soc 2012, 134(17):7227-7230.
114. Xin HL, Zheng H. In situ Observation of Oscillatory Growth of Bismuth Nanoparticles. Nano Lett 2012, 12(3):1470-1474.
115. Wang Y, Wu X, Yang W, Zhai Y, Xie B, Yang M. Aggregate of nanoparticles: rheological and mechanical properties. Nanoscale Res Lett 2011, 6(1):114.
116. Wolf U, Wolf M, Heusser P, Thurneysen A, Baumgartner S. Homeopathic preparations of quartz. sulfur and copper sulfate assessed by uv-spectroscopy. Evid Based Complement Alternat Med 2011, 2011:692798.
117. Witt C, Ludtke R, Weisshuhn TE, Willich SN. High homeopathic potencies are different from potentized solvent when investigated with the REDEM technology. Forsch Komplementarmed Klass Naturheilkd 2005, 12(1):6-13.
118. Bell IR, Lewis D, Brooks AJ, Lewis S, Schwartz GE. Gas discharge visualization evaluation of ultramolecular doses of homeopathic medicines under blinded, controlled conditions. J Altern Complement Med 2003, 9(1):25-38.
119. Sukul NC, Ghosh S, Sukul A, Sinhababu SP. Variation in Fourier transform infrared spectra of some homeopathic potencies and their diluent media. J Altern Complement Med 2005, 11(5):807-812.
120. Ive EC, Couchman IM, Reddy L. Therapeutic effect of Arsenicum album on leukocytes. Int J Mol Sci 2012, 13(3):3979-3987.
121. Gariboldi S, Palazzo M, Zanobbio L, Dusio GF, Mauro V, Solimene U, Cardani D, Mantovani M, Rumio C. Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther 2009, 22(6):497-510.
122. Samal A, Geckeler KE. Unexpected solute aggregation in water on dilution. Chem Commun 2001, 2001(21):2224-2225.
123. Baumgartner S. The State of Basic Research on Homeopathy. New Directions in Homeopathy Research 2009, 107-130. Essen, Germany: KVC Verlag, Witt C, Albrecht H.
124. Baumgartner S, Shah D, Schaller J, Kampfer U, Thurneysen A, Heusser P. Reproducibility of dwarf pea shoot growth stimulation by homeopathic potencies of gibberellic acid. Complement Ther Med 2008, 16(4):183-191.
125. Dantas F, Rampes H. Do homeopathic medicines provoke adverse effects? A systematic review. Br Homeopath J 2000, 89(Suppl 1):S35-S38.
126. Tesson B, Hildebrand M. Dynamics of silica cell wall morphogenesis in the diatom Cyclotella cryptica: substructure formation and the role of microfilaments. J Struct Biol 2010, 169(1):62-74.
127. Li X, Zhang J, Gu H. Study on the adsorption mechanism of DNA with mesoporous silica nanoparticles in aqueous solution. Langmuir 2012, 28(5):2827-2834.
128. Mohamed BM, Verma NK, Prina-Mello A, Williams Y, Davies AM, Bakos G, Tormey L, Edwards C, Hanrahan J, Salvati A, et al. Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity. J Nanobiotechnology 2011, 9:29.
129. Han B, Guo J, Abrahaley T, Qin L, Wang L, Zheng Y, Li B, Liu D, Yao H, Yang J, et al. Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization. PLoS One 2011, 6(2):e17236.
130. Zhu M, Li Y, Shi J, Feng W, Nie G, Zhao Y. Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small 2012, 8(3):404-412.
131. Khuda-Bukhsh AR, De A, Das D, Dutta S, Boujedaini N. Analysis of the capability of ultra-highly diluted glucose to increase glucose uptake in arsenite-stressed bacteria Escherichia coli. Zhong Xi Yi Jie He Xue Bao 2011, 9(8):901-912.
132. Sunila ES, Hamsa TP, Kuttan G. Effect of Thuja occidentalis and its polysaccharide on cell-mediated immune responses and cytokine levels of metastatic tumor-bearing animals. Pharm Biol 2011, 49(10):1065-1073.
133. Sunila ES, Kuttan R, Preethi KC, Kuttan G. Dynamized preparations in cell culture. Evid Based Complement Alternat Med 2009, 6(2):257-263.
134. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007, 87(3):873-904.
135. Gadek-Michalska A, Bugajski J. Interleukin-1 (IL-1) in stress-induced activation of limbic-hypothalamic-pituitary adrenal axis. Pharmacol Rep 2010, 62(6):969-982.
136. Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP. Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 2005, 12(5):255-269.
137. Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T, Baba Y. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity 2011, 34(5):703-714.
138. Scharpf KR, Wendt J, Lotze M, Hamm AO. The brain's relevance detection network operates independently of stimulus modality. Behav Brain Res 2010, 210(1):16-23.
139. Bell IR, Lewis DA, Schwartz GE, Lewis SE, Caspi O, Scott A, Brooks AJ, Baldwin CM. Electroencephalographic cordance patterns distinguish exceptional clinical responders with fibromyalgia to individualized homeopathic medicines. J Alternative & Complementary Medicine 2004, 10(2):285-299.
140. Soboloff J, Madesh M, Gill DL. Sensing cellular stress through STIM proteins. Nat Chem Biol 2011, 7(8):488-492.
141. Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta 2012, 1822(5):753-783.
142. Mihalik A, Csermely P. Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. PLoS Comput Biol 2011, 7(10):e1002187.
143. Vasquez A, Dobrin R, Sergi D, Eckmann JP, Oltvai ZN, Barabasi AL. The topological relationship between the large-scale attributes and local interaction patterns of complex networks. Proc Natl Acad Sci USA 2004, 101(52):17940-17945.
144. Csermely P. Chaperone overload is a possible contributor to 'civilization diseases'. Trends Genet 2001, 17(12):701-704.
145. Koithan M, Verhoef M, Bell IR, Ritenbaugh C, White M, Mulkins A. The process of whole person healing: "unstuckness" and beyond. J Altern Complement Med 2007, 13(6):659-668.
146. Van Wijk R, Wiegant FA. The similia principle as a therapeutic strategy: a research program on stimulation of self-defense in disordered mammalian cells. Altern Ther Health Med 1997, 3(2):33-38.
147. Ramachandran C, Nair PK, Clement RT, Melnick SJ. Investigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations. J Altern Complement Med 2007, 13(4):403-407.
148. Glatthaar-Saalmuller B. In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. Can J Physiol Pharmacol 2007, 85(11):1084-1090.
149. Roeska K, Seilheimer B. Antiviral activity of Engystol(R) and Gripp-Heel(R): an in-vitro assessment. J Immune Based Ther Vaccines 2010, 8:6.
150. Pereira WK, Lonardoni MV, Grespan R, Caparroz-Assef SM, Cuman RK, Bersani-Amado CA. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. J Infect 2005, 51(2):157-164.
151. Burbano RR, Leal MF, da Costa JB, Bahia Mde O, de Lima PD, Khayat AS, Seligman IC, de Assumpcao PP, Buchi Dde F, Smith Mde A. Lymphocyte proliferation stimulated by activated human macrophages treated with Canova. Homeopathy 2009, 98(1):45-48.
152. Smit E, Oberholzer HM, Pretorius E. A review of immunomodulators with reference to Canova. Homeopathy 2009, 98(3):169-176.
153. Bellavite P, Marzotto M, Chirumbolo S, Conforti A. Advances in homeopathy and immunology: a review of clinical research. Front Biosci (Schol Ed) 2011, 3:1363-1389.
154. Bell IR, Lewis DA, Lewis SE, Schwartz GE, Brooks AJ, Scott A, Baldwin CM. EEG alpha sensitization in individualized homeopathic treatment of fibromyalgia. Int J Neurosci 2004, 114(9):1195-1220.
155. Bell IR, Howerter A, Jackson N, Aickin M, Baldwin CM, Bootzin RR. Effects of homeopathic medicines on polysomnographic sleep of young adults with histories of coffee-related insomnia. Sleep Med 2011, 12(5):505-511.
156. Bell IR, Brooks AJ, Howerter A, Jackson N, Schwartz GE. Short term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults. Homeopathy 2011, 100(4):203-211.
157. Ruiz-Vega G, Poitevin B, Perez-Ordaz L. Histamine at high dilution reduces spectral density in delta band in sleeping rats. Homeopathy 2005, 94(2):86-91.
158. Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P. Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology (Berl) 2010, 210(4):533-545.
159. Bellavite P, Magnani P, Zanolin E, Conforti A. Homeopathic doses of Gelsemium sempervirens improve the behavior of mice in response to novel environments. Evid Based Complement Alternat Med 2011, 2011:362517.
160. Jonas W, Lin Y, Tortella F. Neuroprotection from glutamate toxicity with ultra-low dose glutamate. Neuroreport 2001, 12(2):335-339.
161. Marotta D, Marini A, Banaudha K, Maharaj SV, Jonas WB. Nonlinear effects of glutamate and KCl on glutamate toxicity in cultured rat cerebellar neurons. Int J Neurosci 2003, 113(4):491-502.
162. Mishra N, Muraleedharan KC, Paranjpe AS, Munta DK, Singh H, Nayak C. An exploratory study on scientific investigations in homeopathy using medical analyzer. J Altern Complement Med 2011, 17(8):705-710.
163. Das D, De A, Dutta S, Biswas R, Boujedaini N, Khuda-Bukhsh AR. Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate. Zhong Xi Yi Jie He Xue Bao 2011, 9(7):752-760.
164. de Oliveira CC, de Oliveira SM, Goes VM, Probst CM, Krieger MA, Buchi Dde F. Gene expression profiling of macrophages following mice treatment with an immunomodulator medication. J Cell Biochem 2008, 104(4):1364-1377.
165. Tai W, Roberts L, Seryshev A, Gubatan JM, Bland CS, Zabriskie R, Kulkarni S, Soong L, Mbawuike I, Gilbert B, et al. Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic. Mucosal Immunol 2011, 4(2):197-207.
166. Marano F, Hussain S, Rodrigues-Lima F, Baeza-Squiban A, Boland S. Nanoparticles: molecular targets and cell signalling. Arch Toxicol 2011, 85(7):733-741.
167. Hanley C, Thurber A, Hanna C, Punnoose A, Zhang J, Wingett DG. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale Res Lett 2009, 4:1409-1420.
168. Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev 2009, 89(2):535-606.
169. Sabban EL, Serova LI. Influence of prior experience with homotypic or heterotypic stressor on stress reactivity in catecholaminergic systems. Stress 2007, 10(2):137-143.
170. Hayley S, Merali Z, Anisman H. Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness. Stress 2003, 6(1):19-32.
171. Lorton D, Lubahn CL, Estus C, Millar BA, Carter JL, Wood CA, Bellinger DL. Bidirectional communication between the brain and the immune system: implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation 2006, 13(5-6):357-374.
172. Zhang H, He X, Zhang Z, Zhang P, Li Y, Ma Y, Kuang Y, Zhao Y, Chai Z. Nano-CeO2 exhibits adverse effects at environmental relevant concentrations. Environ Sci Technol 2011, 45(8):3725-3730.
173. Wiegant FA, Prins HA, Van Wijk R. Postconditioning hormesis put in perspective: an overview of experimental and clinical studies. Dose Response 2011, 9(2):209-224.
174. Lewin SR, Ribeiro RM, Walters T, Lau GK, Bowden S, Locarnini S, Perelson AS. Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed. Hepatology 2001, 34(5):1012-1020.
175. Zilinskas J, Zekonis J, Zekonis G, Sadzeviciene R, Sapragoniene M, Navickaite J, Barzdziukaite I. Inhibition of peripheral blood neutrophil oxidative burst in periodontitis patients with a homeopathic medication Traumeel S. Med Sci Monit 2011, 17(5):CR284-CR291.
176. Wang T, Jiang H, Zhao Q, Wang S, Zou M, Cheng G. Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: Effect of silica architecture on immunological properties. Int J Pharm 2012, 436(1-2):351-358.
177. Davies PC. Does quantum mechanics play a non-trivial role in life?. Biosystems 2004, 78(1-3):69-79.
178. McGuinness LP, Yan Y, Stacey A, Simpson DA, Hall LT, Maclaurin D, Prawer S, Mulvaney P, Wrachtrup J, Caruso F, et al. Quantum measurement and orientation tracking of fluorescent nanodiamonds inside living cells. Nat Nanotechnol 2011, 6(6):358-363.
179. Karmali PP, Simberg D. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opin Drug Deliv 2011, 8(3):343-357.
180. Antelman SM, Caggiula AR, Edwards DJ, Gershon S, Kucinski BJ, Kiss S, Kocan D. Long-term oscillation of corticosterone following intermittent cocaine. J Neural Transm Gen Sect 2000, 107(3):369-375.
181. Abraham WC. Metaplasticity: tuning synapses and networks for plasticity. Nat Rev Neurosci 2008, 9(5):387.
182. Hale HB. Cross-adaptation. Environ Res 1969, 2:423-434.
183. Loscalzo J, Barabasi AL. Systems biology and the future of medicine. Wiley Interdiscip Rev Syst Biol Med 2011, 3(6):619-627.
184. Stebbing AR. A mechanism for hormesis-a problem in the wrong discipline. Crit Rev Toxicol 2003, 33(3-4):463-467.
185. Artola A. Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex-the same metaplastic process?. Eur J Pharmacol 2008, 585(1):153-162.
186. Antelman SM, Caggiula AR. Oscillation follows drug sensitization: implications. Crit Rev Neurobiol 1996, 10(1):101-117.
187. Antelman SM, Levine J, Gershon S. Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic. Mol Psychiatry 2000, 5(4):350-356.
188. Mattson MP. Hormesis defined. Aging Research Rev 2008, 7(1):1-7.
189. Calabrese EJ, Mattson MP. Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal 2011, 5(1):25-38.
190. Nascarella MA, Calabrese EJ. A method to evaluate hormesis in nanoparticle dose-responses. Dose Response 2012, 10(3):344-354.
191. Vaiserman AM. Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity. Dose Response 2010, 8(1):16-21.
192. Stebbing AR. Adaptive responses account for the beta-curve-hormesis is linked to acquired tolerance. Nonlinearity Biol Toxicol Med 2003, 1(4):493-511.
193. Launay JC, Besnard Y, Guinet-Lebreton A, Savourey G. Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level. Aviat Space Environ Med 2006, 77(12):1230-1235.
194. Lunt HC, Barwood MJ, Corbett J, Tipton MJ. 'Cross-adaptation': habituation to short repeated cold-water immersions affects the response to acute hypoxia in humans. J Physiol 2010, 588(Pt 18):3605-3613.
195. Adolph EF. General and specific characteristics of physiological adaptations. Am J Physiol 1956, 184:18-28.
196. Frei H. Polarity analysis, a new approach to increase the precision of homeopathic prescriptions. Homeopathy 2009, 98(1):49-55.
197. Win-Shwe TT, Yamamoto S, Fujitani Y, Hirano S, Fujimaki H. Spatial learning and memory function-related gene expression in the hippocampus of mouse exposed to nanoparticle-rich diesel exhaust. Neurotoxicology 2008, 29(6):940-947.
198. Wiegant FA, Spieker N, van Wijk R. Stressor-specific enhancement of hsp induction by low doses of stressors in conditions of self- and cross-sensitization. Toxicology 1998, 127(1-3):107-119.
199. Karst H, Berger S, Erdmann G, Schutz G, Joels M. Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci USA 2010, 107(32):14449-14454.
200. Bliem B, Muller-Dahlhaus JF, Dinse HR, Ziemann U. Homeostatic metaplasticity in the human somatosensory cortex. J Cogn Neurosci 2008, 20(8):1517-1528.
201. Potter-Nerger M, Fischer S, Mastroeni C, Groppa S, Deuschl G, Volkmann J, Quartarone A, Munchau A, Siebner HR. Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. J Neurophysiol 2009, 102(6):3180-3190.
202. Garcia R, Spennato G, Nilsson-Todd L, Moreau JL, Deschaux O. Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats. Neurobiol Learn Mem 2008, 89(4):560-566.
203. Marotta D, Marini A, Banaudha K, Maharaj S, Jonas WB. Nonlinear effects of glutamate and KCl on glutamate toxicity in cultured rat cerebellar neurons. Int J Neurosci 2003, 113:45-56.
204. Antal A, Begemeier S, Nitsche MA, Paulus W. Prior state of cortical activity influences subsequent practicing of a visuomotor coordination task. Neuropsychologia 2008, 46(13):3157-3161.
205. Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 2008, 32(1):20-39.
206. Antelman SM, Eichler AJ, Black CA, Kocan D. Interchangeability of stress and amphetamine in sensitization. Science 1980, 207(4428):329-331.
207. Frank MG, Watkins LR, Maier SF. Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse. Brain Behav Immun 2011, 25(Suppl1):S21-28.
208. Sorg B, Bailie T, Tschirgi M, Li N, Wu W. Exposure to repeated low-level formaldehyde in rats increases basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde. Brain Res 2001, 898(2):314-320.
209. Prasad BM, Ulibarri C, Sorg BA. Stress-induced cross-sensitization to cocaine: effect of adrenalectomy and corticosterone after short- and long-term withdrawal. Psychopharmacology 1998, 136(1):24-33.
210. Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience 2005, 134(3):737-744.
211. Avena NM, Hoebel BG. Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia. Pharmacol Biochem Behav 2003, 74(3):635-639.
212. Sorg BA, Tschirgi ML, Swindell S, Chen L, Fang J. Repeated formaldehyde effects in an animal model for multiple chemical sensitivity. [Review] [56 refs]. Ann N Y Acad Sci 2001, 933:57-67.
213. Xu GP, Van Bockstaele E, Reyes B, Bethea T, Valentino RJ. Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stress. J Neurosci 2004, 24(38):8193-8197.
214. Antelman SM, Knopf S, Kocan D, Edwards DJ, Ritchie JC, Nemeroff CB. One stressful event blocks multiple actions of diazepam for up to at least a month. Brain Res 1988, 445(2):380-385.
215. Bortolotto ZA, Collett VJ, Conquet F, Jia Z, Collingridge GL. An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity. Neuropharmacology 2008, 55(4):454-458.
216. Antelman S. Stress and its timing: critical factors in determining the consequences of dopaminergic agents. Pharmacol Biochem Behav 1982, 17(Suppl 1):21-23.
217. Antelman SM, Caggiula AR, Kiss S, Edwards DJ, Kocan D, Stiller R. Neurochemical and physiological effects of cocaine oscillate with sequential drug treatment: possibly a major factor in drug variability. Neuropsychopharmacology 1995, 12(4):297-306.
218. Antelman SM, Caggiula AR, Knopf S, Kocan DJ, Edwards DJ. Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs. Psychopharmacology 1992, 107(2-3):331-336.
219. Stub T, Salamonsen A, Alraek T. Is it possible to distinguish homeopathic aggravation from adverse effects? A qualitative study. Forsch Komplementmed 2012, 19(1):13-19.
220. Oberbaum M, Singer SR, Vithoulkas G. The colour of the homeopathic improvement: the multidimensional nature of the response to homeopathic therapy. Homeopathy 2005, 94(3):196-199.
221. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain 2011, 152(3 Suppl):S2-S15.
222. Bell IR, Lewis DAI, Brooks AJ, Schwartz GE, Lewis SE, Walsh BT, Baldwin CM. Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo. Rheumatology 2004, 43:577-582.
223. Bell IR, Lewis DA, Schwartz GE, Lewis SE, Caspi O, Scott A, Brooks AJ, Baldwin CM. Electroencephalographic cordance patterns distinguish exceptional clinical responders with fibromyalgia to individualized homeopathic medicines. J Altern Complement Med 2004, 10(2):285-299.
224. Vithoulkas G. The Science of Homeopathy 1980, N.Y.: Grove Weidenfeld.
225. Singh SK, Srinivasan KK, Gowthamarajan K, Singare DS, Prakash D, Gaikwad NB. Investigation of preparation parameters of nanosuspension by top-down media milling to improve the dissolution of poorly water-soluble glyburide. Eur J Pharm Biopharm 2011, 78(3):441-446.
226. Schiff SJ, Jerger K, Duong DH, Chang T, Spano ML, Ditto WL. Controlling chaos in the brain. Nature 1994, 370:615-620.
227. Garfinkel A, Spano ML, Ditto WL, Weiss JN. Controlling cardiac chaos. Science 1992, 257(5074):1230-1235.
228. Coffey DS. Self-organization, complexity, and chaos: the new biology for medicine. Nat Med 1998, 4(8):882-885.
229. Avena NM, Rada P, Moise N, Hoebel BG. Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neuroscience 2006, 139(3):813-820.
230. Chae Y, Yang CH, Kwon YK, Kim MR, Pyun KH, Hahm DH, Lee HJ, Shim I. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Neurosci Lett 2004, 358:87-90.
231. Curran EJ, Akil H, Watson SJ. Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals. Neurochem Res 1996, 21(11):1425-1435.
232. Day HE, Badiani A, Uslaner JM, Oates MM, Vittoz NM, Robinson TE, Watson SJ, Akil H. Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala. J Neurosci 2001, 21(2):732-740.
233. Lee BR, Dong Y. Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond. Neuropharmacology 2011, 61(7):1060-1069.
234. Seery MD, Leo RJ, Holman EA, Silver RC. Lifetime exposure to adversity predicts functional impairment and healthcare utilization among individuals with chronic back pain. Pain 2010, 150(3):507-515.
235. Kauffman S. At Home in the Universe. The Search for the Laws of Self-Organization and Complexity 1995, NY: Oxford University Press.
236. Fredrickson BL, Losada MF. Positive affect and the complex dynamics of human flourishing. Am Psychol 2005, 60(7):678-686.
237. Bell IR, Koithan M. Models for the study of whole systems. Integr Cancer Ther 2006, 5(4):293-307.
238. Brien SB, Harrison H, Daniels J, Lewith G. Monitoring improvement in health during homeopathic intervention. Development of an assessment tool based on Hering's Law of Cure: the Hering's Law Assessment Tool (HELAT). Homeopathy 2012, 101(1):28-37.
239. Besinis A, van Noort R, Martin N. Infiltration of demineralized dentin with silica and hydroxyapatite nanoparticles. Dental materials: official publication of the Academy of Dental Materials 2012, 28(9):1012-1023.
240. Randolph T. Specific adaptation. Ann Allergy 1978, 40:333-345.
241. Bar-Yam Y, Epstein IR. Response of complex networks to stimuli. Proc Natl Acad Sci USA 2004, 101(13):4341-4345.
242. Kim J, Arola DD, Gu L, Kim YK, Mai S, Liu Y, Pashley DH, Tay FR. Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach. Acta Biomater 2010, 6(7):2740-2750.
243. Sukul NC, Bala SK, Bhattacharyya B. Prolonged cataleptogenic effects of potentized homoeopathic drugs. Psychopharmacology 1986, 89:338-339.
244. Verma S, Gokhale R, Burgess DJ. A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int J Pharm 2009, 380(1-2):216-222.
245. Liu Y, Lou C, Yang H, Shi M, Miyoshi H. Silica nanoparticles as promising drug/gene delivery carriers and fluorescent nano-probes: recent advances. Curr Cancer Drug Targets 2011, 11(2):156-163.
246. Hardy CL, LeMasurier JS, Belz GT, Scalzo-Inguanti K, Yao J, Xiang SD, Kanellakis P, Bobik A, Strickland DH, Rolland JM, et al. Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation. J Immunol 2012, 188(3):1431-1441.
247. Zhang Q, Pi J, Woods CG, Andersen ME. Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses. Toxicol Appl Pharmacol 2009, 237(3):345-356.
248. Rozman KK, Doull J. Scientific foundations of hormesis. Part 2. Maturation, strengths, limitations, and possible applications in toxicology, pharmacology, and epidemiology. Crit Rev Toxicol 2003, 33(3-4):451-462.
249. Gersten O. The path traveled and the path ahead for the allostatic framework: A rejoinder on the framework's importance and the need for further work related to theory, data, and measurement. Soc Sci Med 2008, 66(3):531-535.