Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Nature Communications

Volumn 6, Issue , 2015, Pages

  Zhang, Zhentao ^a,b   Song, Mingke ^a   Liu, Xia ^a   Su Kang, Seong ^a   Duong, Duc M ^a   Seyfried, Nicholas T ^a   Cao, Xuebing ^c   Cheng, Liming ^d   Sun, Yi E ^d,e   Ping Yu, Shan ^a   Jia, Jianping ^f   Levey, Allan I ^a   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d TONGJI UNIVERSITY   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; ASPARAGINE ENDOPEPTIDASE; BETA SECRETASE 1; CYSTEINE PROTEINASE; DELTA SECRETASE; SECRETASE; SYNAPSIN I; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; LEGUMAIN;

AGING; AMINO ACID; ENZYME ACTIVITY; MENTAL HEALTH; PATHOGENICITY; PROTEIN; RISK FACTOR; RODENT;

AGED; AGING; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LONG TERM POTENTIATION; MALE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SENILE PLAQUE; SYNAPSE; UPREGULATION; AMYLOID PLAQUE; ANIMAL; BRAIN; ELECTRICAL SYNAPSE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HEK293 CELL LINE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; MASS SPECTROMETRY; MEMORY; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; TRANSGENIC MOUSE; VERY ELDERLY; WESTERN BLOTTING;

MUS; MUS MUSCULUS;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; BRAIN; CYSTEINE ENDOPEPTIDASES; ELECTRICAL SYNAPSES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LONG-TERM POTENTIATION; MALE; MASS SPECTROMETRY; MEMORY; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MIDDLE AGED; PLAQUE, AMYLOID;

EID: 84946781429     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9762     Document Type: Article

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