Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17495-17507

  Basurto Islas, Gustavo ^a   Grundke Iqbal, Inge ^a   Tung, Yunn Chyn ^a   Liu, Fei ^a   Iqbal, Khalid ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; C-TERMINAL FRAGMENTS; CATALYTIC SUBUNITS; HYPERPHOSPHORYLATED; HYPERPHOSPHORYLATION; PROTEIN PHOSPHATASE 2A; TAU HYPERPHOSPHORYLATION; THERAPEUTIC TARGETS;

AMINO ACIDS; CYTOLOGY;

NEURODEGENERATIVE DISEASES;

LEGUMAIN; PHOSPHOPROTEIN PHOSPHATASE 2; TAU PROTEIN;

ACIDOSIS; AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT;

ACIDOSIS; ALZHEIMER DISEASE; I2PP2A; LEGUMAIN; LYSOSOMES; PP2A; SET; TAU; TAU HYPERPHOSPHORYLATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; CASE-CONTROL STUDIES; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; ENZYME ACTIVATION; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEOLYSIS; RATS; RATS, WISTAR; TAU PROTEINS;

EID: 84879047960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.446070     Document Type: Article

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