Codeposition of cystatin C with amyloid-β protein in the brain of alzheimer disease patients

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 1, 2001, Pages 94-104

  Levy, Efrat ^a   Sastre, Magdalena ^a   Kumar, Asok ^a   Gallo, Gloria ^a   Piccardo, Pedro ^b   Ghetti, Bernardino ^b   Tagliavini, Fabrizio ^c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Alzheimer disease (AD); Amyloid protein (A ); Cerebral amyloid angiopathy (CAA); Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA D); Hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA I); amyloid precursor protein ( APP)

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYSTATIN C; CYSTATIN C ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROPIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; TISSUE DISTRIBUTION; VASCULAR AMYLOIDOSIS;

EID: 0035140013     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.1.94     Document Type: Article

References (59)

1. Amyloid plaque core protein in Alzheimer disease and Down syndrome
2. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
3. Different processing of Alzheimer's β-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
4. Familial cerebral amyloid angiopathy presenting as recurrent cerebral hemorrhage
5. Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease
6. Hereditary cerebral haemorrhage caused by cortical amyloid angiopathy
7. Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls
8. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
9. An Italian type of HCHWA
10. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β amyloid precursor protein gene
11. Familial cerebral hemorrhage as a result of cerebral amyloid angiopathy
12. Apoplexie und ihre Vererbung
13. Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastrenteropancreatic neuroendocrine protein, γ trace
14. Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis is a variant of γ trace basic protein (cystatin C)
15. Post-γ-globulin: Isolation and physicochemical characterization
16. The place of human γ trace (cystatin C) amongst the cysteine proteinase inhibitors
17. Cystatins-inhibitors of cysteine proteinases
18. Hereditary cerebral amyloid angiopathy: The amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases
19. Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage
20. Immunoreactive A4 and γ trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease
21. Immunohistochemical study of cerebral amyloid angiopathy III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with γ trace in patients with leukoencephalopathy
22. Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to β protein and cystatin C
23. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
24. Apolipoprotein E genotyping by one-stage PCR
25. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's Disease
26. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
27. High frequency of apolipoprotein E ε2 allele in hemorrhage due to cerebral amyloid angiopathy
28. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy
29. Apolipoprotein E alleles and brain vascular pathology in Alzheimer's disease
30. Association of apolipoprotein E ε2 and vasculopathy in cerebral amyloid angiopathy
31. Icelandic-like mutation in an animal model of cerebrovascular β amyloisosis
32. Cerebral hemorrhage with biopsy-proved amyloid angiopathy
33. Dementia with non-hereditary cystatin C angiopathly
34. Cerebral amyloid angiopathy with the deposition of γ trace (cystatin C) and β protein
35. Co-localization of γ'A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis
36. Cerebral amyloid angiopathy: A significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly
37. Progression of cerebral amyloid angiopathy: Accumulation of amyloid- β40 in affected vessels
38. The, apolipoprotein E ε2 allele and the pathological features in cerebral amyloid angiopathyrelated hemorrhage
39. Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia
40. Intraneuronal Aβ42 accumulation in human brain
41. Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease
42. Immunochemical identification of the serine protease inhibitor α1-antichymocrypsin in the brain amyloid deposits of Alzheimer's disease
43. Isolation and characterization of amyloid P component from Alzheimer disease and other types of cerebral amyloidosis
44. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and syatemic amyloid
45. SP-40,40 is a constituent of Alzheimer's amyloid
46. Distribution of clusterin in Alzheimer brain tissue
47. Sulfated glycosaminoglycans: A common constituent of all amyloids?
48. Cellular cofactors for amyloid β-peptide-induced cell stress. Moving from cell culture to in vivo
49. Inflammatory pathogenesis in Alzheimer's disease: Biological mechanisms and cognitive sequeli
50. The role of the immune system in neurodegenerative disorders
51. Up-regulated production and activation of the complement system in Alzheimer's disease brain
52. Pro-inflammatory complement activation by the Aβ peptide of Alzheimer's disease is biologically significant and can be blocked by vaccinia virus complement control protein
53. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
54. Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
55. Amyloid β-pepfide and oxidative cellular injury in Alzheimer's disease
56. Free radicals and disruption of neuronal ion homeostasis in Alzheimer disease: A role for amyloid β-peptide?
57. Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged
58. The possible place of cathepsins and cystatins in the puzzle of Alzheimer disease: A review
59. Microvascular degeneration in hereditary cystatin C amyloid angiopathy of the brain