Noncanonical activation of Notch1 protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) controls melanoma cell proliferation

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8442-8449

  Ma, Jun ^a   Tang, Xiaoying ^a   Wong, Poki ^a   Jacobs, Barbara ^b   Borden, Ernest C ^b   Bedogni, Barbara ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; CHEMICAL ACTIVATION; ENZYME ACTIVITY; ONCOLOGY; STEM CELLS;

CLEAVAGE MECHANISM; INTRACELLULAR DOMAIN; MATRIX METALLOPROTEINASES; MELANOMA CELLS; MELANOMA TUMORS; MEMBRANE TYPE-1 MATRIX METALLOPROTEINASE; SECRETASES; SIGNALING MOLECULES;

DERMATOLOGY;

ADAM10 ENDOPEPTIDASE; MATRIX METALLOPROTEINASE 14; NOTCH1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

CELL PROLIFERATION; MATRIX METALLOPROTEINASE (MMP); MELANOMA; NOTCH RECEPTOR; PROTEIN-PROTEIN INTERACTIONS;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 14; MELANOCYTES; MELANOMA; MEMBRANE PROTEINS; MICE; RECEPTOR, NOTCH1;

EID: 84896914323     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.516039     Document Type: Article

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