메뉴 건너뛰기




Volumn 41, Issue 5, 2015, Pages 301-313

Disease chemopreventive effects and molecular mechanisms of hydroxylated polymethoxyflavones

Author keywords

Chemoprevention; HPMFs

Indexed keywords

3' DEMETHYLNOBILETIN; 3',4' DIDEMETHYLNOBILETIN; 3,5,6,7,3',4' HEXAMETHOXYFLAVONE; 3,5,6,7,8,3',4' HEPTAMETHOXYFLAVONE; 4' DEMETHYLNOBILETIN; 4' DEMETHYLTANGERETIN; 5 DEMETHYLNOBILETIN; 5 DEMETHYLSINENSETIN; 5 DEMETHYLTANGERETIN; 5 HYDROXY(5 HYDROXY 6,7,8,3',4' HEXAMETHOXYFLAVONE; 5,4' DIDEMETHYLTANGERETIN; 5,6,7,4' TETRAMETHOXYFLAVONE; 5,6,7,8,3',4',5' HEPTAMETHOXYFLAVONE; 5,7 DIMETHOXYFLAVONE; 5,7,4' TRIMETHOXYFLAVONE; APIGENIN; CHRYSIN; FLAVONE DERIVATIVE; HYDROXYLATED POLYMETHOXYFLAVONE DERIVATIVE; NOBILETIN; SINENSETIN; TANGERETIN; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; PLANT EXTRACT;

EID: 84945493627     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1236     Document Type: Review
Times cited : (52)

References (100)
  • 1
    • 84875129497 scopus 로고    scopus 로고
    • Flavonoids: biosynthesis, biological functions, and biotechnological applications
    • Falcone Ferreyra, M. L., Rius, S. P., and Casati, P. (2012) Flavonoids: biosynthesis, biological functions, and biotechnological applications. Front Plant Sci. 3, 222.
    • (2012) Front Plant Sci. , vol.3 , pp. 222
    • Falcone Ferreyra, M.L.1    Rius, S.P.2    Casati, P.3
  • 2
    • 78651067589 scopus 로고    scopus 로고
    • Anti-inflammatory activity of natural dietary flavonoids
    • Pan, M. H., Lai, C. S., and Ho, C. T. (2010) Anti-inflammatory activity of natural dietary flavonoids. Food Funct. 1, 15-31.
    • (2010) Food Funct. , vol.1 , pp. 15-31
    • Pan, M.H.1    Lai, C.S.2    Ho, C.T.3
  • 3
    • 0016906546 scopus 로고
    • The flavonoids. A class of semi-essential food components: their role in human nutrition
    • Kuhnau, J. (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet. 24, 117-191.
    • (1976) World Rev. Nutr. Diet. , vol.24 , pp. 117-191
    • Kuhnau, J.1
  • 4
    • 0032819772 scopus 로고    scopus 로고
    • Dietary flavonoids: intake, health effects and bioavailability
    • Hollman, P. C. and Katan, M. B. (1999) Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 37, 937-942.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 937-942
    • Hollman, P.C.1    Katan, M.B.2
  • 5
    • 84896281851 scopus 로고    scopus 로고
    • Chemistry and biological activities of flavonoids: an overview
    • Kumar, S. and Pandey, A. K. (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013, 162750.
    • (2013) Sci World J. , vol.2013 , pp. 162750
    • Kumar, S.1    Pandey, A.K.2
  • 6
    • 84904324976 scopus 로고    scopus 로고
    • Flavones: an important scaffold for medicinal chemistry
    • Singh, M., Kaur, M., and Silakari, O. (2014) Flavones: an important scaffold for medicinal chemistry. Eur. J. Med. Chem. 84, 206-239.
    • (2014) Eur. J. Med. Chem. , vol.84 , pp. 206-239
    • Singh, M.1    Kaur, M.2    Silakari, O.3
  • 7
    • 77956174553 scopus 로고    scopus 로고
    • Relationships between structures of hydroxyflavones and their antioxidative effects
    • Hyun, J., Woo, Y., Hwang, D. S., Jo, G., Eom, S., et al. (2010) Relationships between structures of hydroxyflavones and their antioxidative effects. Bioorg. Med. Chem. Lett. 20, 5510-5513.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5510-5513
    • Hyun, J.1    Woo, Y.2    Hwang, D.S.3    Jo, G.4    Eom, S.5
  • 8
    • 4043089112 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of dietary flavonoids in humans
    • Manach, C. and Donovan, J. L. (2004) Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic. Res. 38, 771-785.
    • (2004) Free Radic. Res. , vol.38 , pp. 771-785
    • Manach, C.1    Donovan, J.L.2
  • 9
    • 77953713797 scopus 로고    scopus 로고
    • Bioavailability challenges associated with development of anti-cancer phenolics
    • Gao, S. and Hu, M. (2010) Bioavailability challenges associated with development of anti-cancer phenolics. Mini. Rev. Med. Chem. 10, 550-567.
    • (2010) Mini. Rev. Med. Chem. , vol.10 , pp. 550-567
    • Gao, S.1    Hu, M.2
  • 10
    • 84883430076 scopus 로고    scopus 로고
    • Flavonoid bioavailability and attempts for bioavailability enhancement
    • Thilakarathna, S. H. and Rupasinghe, H. P. (2013) Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients 5, 3367-3387.
    • (2013) Nutrients , vol.5 , pp. 3367-3387
    • Thilakarathna, S.H.1    Rupasinghe, H.P.2
  • 11
    • 37549024168 scopus 로고    scopus 로고
    • Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption
    • Walle, T. (2007) Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol. Pharm. 4, 826-832.
    • (2007) Mol. Pharm. , vol.4 , pp. 826-832
    • Walle, T.1
  • 12
    • 34548423695 scopus 로고    scopus 로고
    • Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
    • Walle, T. (2007) Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? Semin.Cancer Biol. 17, 354-362.
    • (2007) Semin.Cancer Biol. , vol.17 , pp. 354-362
    • Walle, T.1
  • 13
    • 34047185899 scopus 로고    scopus 로고
    • Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines
    • Li, S., Pan, M. H., Lai, C. S., Lo, C. Y., Dushenkov, S., et al. (2007) Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg. Med. Chem. 15, 3381-3389.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 3381-3389
    • Li, S.1    Pan, M.H.2    Lai, C.S.3    Lo, C.Y.4    Dushenkov, S.5
  • 14
    • 77956237570 scopus 로고    scopus 로고
    • Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong
    • Han, S., Kim, H. M., Lee, J. M., Mok, S. Y., and Lee, S. (2010) Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong. J. Agric. Food Chem. 58, 9488-9491.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 9488-9491
    • Han, S.1    Kim, H.M.2    Lee, J.M.3    Mok, S.Y.4    Lee, S.5
  • 15
    • 65249099157 scopus 로고    scopus 로고
    • Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones
    • Li, S., Pan, M. H., Lo, C. Y., Tan, D., Wang, Y., et al. (2009) Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones. J. Funct. Food 1, 2-12.
    • (2009) J. Funct. Food , vol.1 , pp. 2-12
    • Li, S.1    Pan, M.H.2    Lo, C.Y.3    Tan, D.4    Wang, Y.5
  • 16
    • 33745757014 scopus 로고    scopus 로고
    • Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel
    • Li, S., Lo, C. Y., and Ho, C. T. (2006) Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. J Agric. Food Chem. 54, 4176-4185.
    • (2006) J Agric. Food Chem. , vol.54 , pp. 4176-4185
    • Li, S.1    Lo, C.Y.2    Ho, C.T.3
  • 17
    • 71649098481 scopus 로고    scopus 로고
    • Methylation of dietary flavones increases their metabolic stability and chemopreventive effects
    • Walle, T. (2009) Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. Int. J. Mol. Sci. 10, 5002-5019.
    • (2009) Int. J. Mol. Sci. , vol.10 , pp. 5002-5019
    • Walle, T.1
  • 18
    • 33947359919 scopus 로고    scopus 로고
    • Cancer chemopreventive properties of orally bioavailable flavonoids-methylated versus unmethylated flavones
    • Walle, T., Ta, N., Kawamori, T., Wen, X., Tsuji, P. A., et al. (2007) Cancer chemopreventive properties of orally bioavailable flavonoids-methylated versus unmethylated flavones. Biochem. Pharmacol. 73, 1288-1296.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1288-1296
    • Walle, T.1    Ta, N.2    Kawamori, T.3    Wen, X.4    Tsuji, P.A.5
  • 19
    • 0033883861 scopus 로고    scopus 로고
    • Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus
    • Nielsen, S. E., Breinholt, V., Cornett, C., and Dragsted, L. O. (2000) Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. Food Chem. Toxicol. 38, 739-746.
    • (2000) Food Chem. Toxicol. , vol.38 , pp. 739-746
    • Nielsen, S.E.1    Breinholt, V.2    Cornett, C.3    Dragsted, L.O.4
  • 20
    • 33645463556 scopus 로고    scopus 로고
    • Identification of nobiletin metabolites in mouse urine
    • Li, S., Wang, Z., Sang, S., Huang, M. T., and Ho, C. T. (2006) Identification of nobiletin metabolites in mouse urine. Mol. Nutr. Food Res. 50, 291-299.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 291-299
    • Li, S.1    Wang, Z.2    Sang, S.3    Huang, M.T.4    Ho, C.T.5
  • 22
    • 0035221389 scopus 로고    scopus 로고
    • In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits
    • Murakami, A., Kuwahara, S., Takahashi, Y., Ito, C., Furukawa, H., et al. (2001) In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci. Biotechnol. Biochem. 65, 194-197.
    • (2001) Biosci. Biotechnol. Biochem. , vol.65 , pp. 194-197
    • Murakami, A.1    Kuwahara, S.2    Takahashi, Y.3    Ito, C.4    Furukawa, H.5
  • 23
    • 0038683676 scopus 로고    scopus 로고
    • In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s
    • Breinholt, V. M., Rasmussen, S. E., Brosen, K., and Friedberg, T. H. (2003) In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. Pharmacol. Toxicol. 93, 14-22.
    • (2003) Pharmacol. Toxicol. , vol.93 , pp. 14-22
    • Breinholt, V.M.1    Rasmussen, S.E.2    Brosen, K.3    Friedberg, T.H.4
  • 24
    • 36849013519 scopus 로고    scopus 로고
    • Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450
    • Koga, N., Matsuo, M., Ohta, C., Haraguchi, K., Matsuoka, M., et al. (2007) Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450. Biol. Pharm. Bull. 30, 2317-2323.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 2317-2323
    • Koga, N.1    Matsuo, M.2    Ohta, C.3    Haraguchi, K.4    Matsuoka, M.5
  • 25
    • 84889063108 scopus 로고    scopus 로고
    • 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis
    • Charoensinphon, N., Qiu, P., Dong, P., Zheng, J., Ngauv, P., et al. (2013) 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. Mol. Nutr. Food Res. 57, 2103-2111.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 2103-2111
    • Charoensinphon, N.1    Qiu, P.2    Dong, P.3    Zheng, J.4    Ngauv, P.5
  • 26
    • 80155168613 scopus 로고    scopus 로고
    • Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships
    • Xiao, J., Zhao, Y., Wang, H., Yuan, Y., Yang, F., et al. (2011) Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. Integr. Biol. (Camb.) 3, 1087-1094.
    • (2011) Integr. Biol. (Camb.) , vol.3 , pp. 1087-1094
    • Xiao, J.1    Zhao, Y.2    Wang, H.3    Yuan, Y.4    Yang, F.5
  • 27
    • 55549098939 scopus 로고    scopus 로고
    • Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
    • Zhang, L., Kong, Y., Wu, D., Zhang, H., Wu, J., et al. (2008) Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci. 17, 1971-1978.
    • (2008) Protein Sci. , vol.17 , pp. 1971-1978
    • Zhang, L.1    Kong, Y.2    Wu, D.3    Zhang, H.4    Wu, J.5
  • 28
    • 63149133819 scopus 로고    scopus 로고
    • Adenosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus
    • Yuliana, N. D., Khatib, A., Link-Struensee, A. M., Ijzerman, A. P., Rungkat-Zakaria, F., et al. (2009) Adenosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus. Planta Med. 75, 132-136.
    • (2009) Planta Med. , vol.75 , pp. 132-136
    • Yuliana, N.D.1    Khatib, A.2    Link-Struensee, A.M.3    Ijzerman, A.P.4    Rungkat-Zakaria, F.5
  • 29
    • 78650456545 scopus 로고    scopus 로고
    • Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives
    • Shimada, T., Tanaka, K., Takenaka, S., Murayama, N., Martin, M. V., et al. (2010) Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem. Res. Toxicol. 23, 1921-1935.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 1921-1935
    • Shimada, T.1    Tanaka, K.2    Takenaka, S.3    Murayama, N.4    Martin, M.V.5
  • 30
    • 84880300172 scopus 로고    scopus 로고
    • Cancer chemoprevention: a rapidly evolving field
    • Steward, W. P. and Brown, K. (2013) Cancer chemoprevention: a rapidly evolving field. Br. J Cancer 109, 1-7.
    • (2013) Br. J Cancer , vol.109 , pp. 1-7
    • Steward, W.P.1    Brown, K.2
  • 31
    • 0017136711 scopus 로고
    • Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)
    • Sporn, M. B., Dunlop, N. M., Newton, D. L., and Smith, J. M. (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed. Proc. 35, 1332-1338.
    • (1976) Fed. Proc. , vol.35 , pp. 1332-1338
    • Sporn, M.B.1    Dunlop, N.M.2    Newton, D.L.3    Smith, J.M.4
  • 32
    • 84872015119 scopus 로고    scopus 로고
    • Cancer chemoprevention: successes and failures
    • Patterson, S. L., Colbert, M. K., and Hawk, E. (2013) Cancer chemoprevention: successes and failures. Clin. Chem. 59, 94-101.
    • (2013) Clin. Chem. , vol.59 , pp. 94-101
    • Patterson, S.L.1    Colbert, M.K.2    Hawk, E.3
  • 33
    • 84928582571 scopus 로고    scopus 로고
    • Cancer chemoprevention: much has been done, but there is still much to do. State of the art and possible new approaches
    • Serrano, D., Lazzeroni, M., and Bonanni, B. (2015) Cancer chemoprevention: much has been done, but there is still much to do. State of the art and possible new approaches. Mol. Oncol. 9, 1008-1017.
    • (2015) Mol. Oncol. , vol.9 , pp. 1008-1017
    • Serrano, D.1    Lazzeroni, M.2    Bonanni, B.3
  • 34
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D. and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 36
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh, Y. J. (2003) Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3, 768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 37
    • 79952315641 scopus 로고    scopus 로고
    • Chemical composition and biological activity of Citrus jambhiri Lush
    • Hamdan, D., El-Readi, M. Z., Tahrani, A., Herrmann, F., Kaufmann, D., et al. (2011) Chemical composition and biological activity of Citrus jambhiri Lush. Food Chem. 127, 394-403.
    • (2011) Food Chem. , vol.127 , pp. 394-403
    • Hamdan, D.1    El-Readi, M.Z.2    Tahrani, A.3    Herrmann, F.4    Kaufmann, D.5
  • 38
    • 77955050876 scopus 로고    scopus 로고
    • Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract
    • Kim, H., Moon, J. Y., Mosaddik, A., and Cho, S. K. (2010) Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. Food Chem. Toxicol. 48, 2435-2442.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2435-2442
    • Kim, H.1    Moon, J.Y.2    Mosaddik, A.3    Cho, S.K.4
  • 40
    • 15244350125 scopus 로고    scopus 로고
    • Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 cells
    • Watanabe, J., Shinmoto, H., and Tsushida, T. (2005) Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 cells. Biosci. Biotechnol. Biochem. 69, 1-6.
    • (2005) Biosci. Biotechnol. Biochem. , vol.69 , pp. 1-6
    • Watanabe, J.1    Shinmoto, H.2    Tsushida, T.3
  • 41
    • 78650889928 scopus 로고    scopus 로고
    • Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells
    • Qiu, P., Dong, P., Guan, H., Li, S., Ho, C. T., et al. (2010) Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol. Nutr. Food Res. 54(Suppl 2), S244-S252.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. S244-S252
    • Qiu, P.1    Dong, P.2    Guan, H.3    Li, S.4    Ho, C.T.5
  • 42
    • 79953315359 scopus 로고    scopus 로고
    • The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones
    • Qiu, P., Guan, H., Dong, P., Li, S., Ho, C. T., et al. (2011) The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. Mol. Nutr. Food Res. 55, 613-622.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 613-622
    • Qiu, P.1    Guan, H.2    Dong, P.3    Li, S.4    Ho, C.T.5
  • 43
    • 84928276234 scopus 로고    scopus 로고
    • 5-Demethylnobiletin promotes the formation of polymerized tubulin, leads to G2/M phase arrest and induces autophagy via JNK activation in human lung cancer cells
    • Chen, Y. K., Wang, H. C., Ho, C. T., Chen, H. Y., Li, S., et al. (2015) 5-Demethylnobiletin promotes the formation of polymerized tubulin, leads to G2/M phase arrest and induces autophagy via JNK activation in human lung cancer cells. J. Nutr. Biochem. 26, 484-504.
    • (2015) J. Nutr. Biochem. , vol.26 , pp. 484-504
    • Chen, Y.K.1    Wang, H.C.2    Ho, C.T.3    Chen, H.Y.4    Li, S.5
  • 44
    • 0037975662 scopus 로고    scopus 로고
    • Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin
    • Gupta, M. L. J., Bode, C. J., Georg, G. I., and Himes, R. H. (2003) Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proc. Natl. Acad. Sci. USA 100, 6394-6397.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6394-6397
    • Gupta, M.L.J.1    Bode, C.J.2    Georg, G.I.3    Himes, R.H.4
  • 45
    • 78650893286 scopus 로고    scopus 로고
    • Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice
    • Lai, C. S., Tsai, M. L., Cheng, A. C., Li, S., Lo, C. Y., et al. (2011) Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mol. Nutr. Food Res. 55, 278-290.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 278-290
    • Lai, C.S.1    Tsai, M.L.2    Cheng, A.C.3    Li, S.4    Lo, C.Y.5
  • 46
    • 85035816539 scopus 로고    scopus 로고
    • 5-Demethylnobiletin inhibits colon carcinogenesis in azoxymethane/dextran sulfate sodium-treated mice
    • Supplement 123.3.
    • Song, M., Wu, X., Zheng, J., and Xiao, H. (2014) 5-Demethylnobiletin inhibits colon carcinogenesis in azoxymethane/dextran sulfate sodium-treated mice. FASEB J. 28, Supplement 123.3.
    • (2014) FASEB J. , vol.28
    • Song, M.1    Wu, X.2    Zheng, J.3    Xiao, H.4
  • 47
    • 84945487052 scopus 로고    scopus 로고
    • Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin
    • Meeting Abstract Supplement 125.3.
    • Wang, M., Zheng, J., Zhong, Z., Song, M., and Wu, X. (2013) Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin. FASEB J. 27, Meeting Abstract Supplement 125.3.
    • (2013) FASEB J. , vol.27
    • Wang, M.1    Zheng, J.2    Zhong, Z.3    Song, M.4    Wu, X.5
  • 48
    • 10044243544 scopus 로고    scopus 로고
    • Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4′-hydroxy-5,6,7,8,3′-pentamethoxyflavone
    • Okuno, Y. and Miyazawa, M. (2004) Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4′-hydroxy-5, 6, 7, 8, 3′-pentamethoxyflavone. J. Nat. Prod. 67, 1876-1878.
    • (2004) J. Nat. Prod. , vol.67 , pp. 1876-1878
    • Okuno, Y.1    Miyazawa, M.2
  • 49
    • 82255179053 scopus 로고    scopus 로고
    • Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS
    • Chen, H. F., Zhang, W. G., Yuan, J. B., Li, Y. G., Yang, S. L., et al. (2012) Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. J. Pharm. Biomed. Anal. 59, 90-95.
    • (2012) J. Pharm. Biomed. Anal. , vol.59 , pp. 90-95
    • Chen, H.F.1    Zhang, W.G.2    Yuan, J.B.3    Li, Y.G.4    Yang, S.L.5
  • 50
    • 84898767578 scopus 로고    scopus 로고
    • 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model
    • Okuyama, S., Morita, M., Miyoshi, K., Nishigawa, Y., Kaji, M., et al. (2014) 3, 5, 6, 7, 8, 3′, 4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model. Neurochem. Int. 70, 30-38.
    • (2014) Neurochem. Int. , vol.70 , pp. 30-38
    • Okuyama, S.1    Morita, M.2    Miyoshi, K.3    Nishigawa, Y.4    Kaji, M.5
  • 51
    • 84943224351 scopus 로고    scopus 로고
    • 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus
    • Okuyama, S., Miyoshi, K., Tsumura, Y., Amakura, Y., Yoshimura, M., et al. (2015) 3, 5, 6, 7, 8, 3′, 4′-Heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus. Brain Sci. 5, 118-129.
    • (2015) Brain Sci. , vol.5 , pp. 118-129
    • Okuyama, S.1    Miyoshi, K.2    Tsumura, Y.3    Amakura, Y.4    Yoshimura, M.5
  • 52
    • 0028015681 scopus 로고
    • Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri
    • Lichius, J. J., Thoison, O., Montagnac, A., Pais, M., Gueritte-Voegelein, F., et al. (1994) Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri. J. Nat. Prod. 57, 1012-1016.
    • (1994) J. Nat. Prod. , vol.57 , pp. 1012-1016
    • Lichius, J.J.1    Thoison, O.2    Montagnac, A.3    Pais, M.4    Gueritte-Voegelein, F.5
  • 53
    • 34447315867 scopus 로고    scopus 로고
    • 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells
    • Pan, M. H., Lai, Y. S., Lai, C. S., Wang, Y. J., Li, S., et al. (2007) 5-Hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. J. Agric. Food Chem. 55, 5081-5091.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 5081-5091
    • Pan, M.H.1    Lai, Y.S.2    Lai, C.S.3    Wang, Y.J.4    Li, S.5
  • 54
    • 62749087811 scopus 로고    scopus 로고
    • Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis
    • Xiao, H., Yang, C. S., Li, S., Jin, H., Ho, C. T., et al. (2009) Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol. Nutr. Food Res. 53, 398-406.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 398-406
    • Xiao, H.1    Yang, C.S.2    Li, S.3    Jin, H.4    Ho, C.T.5
  • 55
    • 80053912923 scopus 로고    scopus 로고
    • The inhibitory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on human colon cancer cells
    • Qiu, P., Guan, H., Dong, P., Guo, S., Zheng, J., et al. (2011) The inhibitory effects of 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone on human colon cancer cells. Mol. Nutr. Food Res. 55, 1523-1532.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1523-1532
    • Qiu, P.1    Guan, H.2    Dong, P.3    Guo, S.4    Zheng, J.5
  • 56
    • 0029008941 scopus 로고
    • Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra
    • Shi, Q., Chen, K., Li, L., Chang, J. J., Autry, C., et al. (1995) Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. J. Nat. Prod. 58, 475-482.
    • (1995) J. Nat. Prod. , vol.58 , pp. 475-482
    • Shi, Q.1    Chen, K.2    Li, L.3    Chang, J.J.4    Autry, C.5
  • 57
    • 77958572996 scopus 로고    scopus 로고
    • A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways
    • Phromnoi, K., Reuter, S., Sung, B., Limtrakul, P., and Aggarwal, B. B. (2010) A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways. Anticancer Res. 30, 3599-3610.
    • (2010) Anticancer Res. , vol.30 , pp. 3599-3610
    • Phromnoi, K.1    Reuter, S.2    Sung, B.3    Limtrakul, P.4    Aggarwal, B.B.5
  • 58
    • 78751533767 scopus 로고    scopus 로고
    • A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IkappaB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents
    • Phromnoi, K., Reuter, S., Sung, B., Prasad, S., Kannappan, R., et al. (2011) A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IkappaB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. Mol. Pharmacol. 79, 279-289.
    • (2011) Mol. Pharmacol. , vol.79 , pp. 279-289
    • Phromnoi, K.1    Reuter, S.2    Sung, B.3    Prasad, S.4    Kannappan, R.5
  • 59
    • 80054782411 scopus 로고    scopus 로고
    • Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1
    • Phromnoi, K., Prasad, S., Gupta, S. C., Kannappan, R., Reuter, S., et al. (2011) Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. Mol. Pharmacol. 80, 889-899.
    • (2011) Mol. Pharmacol. , vol.80 , pp. 889-899
    • Phromnoi, K.1    Prasad, S.2    Gupta, S.C.3    Kannappan, R.4    Reuter, S.5
  • 60
    • 84878414762 scopus 로고    scopus 로고
    • Identification of sinensetin metabolites in rat urine by an isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization mass spectrometry
    • Wei, G. J., Sheen, J. F., Lu, W. C., Hwang, L. S., Ho, C. T., et al. (2013) Identification of sinensetin metabolites in rat urine by an isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization mass spectrometry. J. Agric. Food Chem. 61, 5016-5021.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 5016-5021
    • Wei, G.J.1    Sheen, J.F.2    Lu, W.C.3    Hwang, L.S.4    Ho, C.T.5
  • 61
    • 84865812665 scopus 로고    scopus 로고
    • Bioactivity evaluations of ingredients extracted from the flowers of Citrus aurantium L. var. amara Engl
    • Zhao, H. Y., Yang, L., Wei, J., Huang, M., and Jiang, J. G. (2012) Bioactivity evaluations of ingredients extracted from the flowers of Citrus aurantium L. var. amara Engl. Food Chem. 135, 2175-2181.
    • (2012) Food Chem. , vol.135 , pp. 2175-2181
    • Zhao, H.Y.1    Yang, L.2    Wei, J.3    Huang, M.4    Jiang, J.G.5
  • 62
    • 0022413031 scopus 로고
    • 5, 6, 4′-Trihydroxy-7, 3′-dimethoxyflavone and other methoxylated flavonoids isolated from Thymus satureiodes
    • Voirin, B., Viricel, M. R., Favre-Bonvin, J., Van Den Broucke, C. O., and Lemli, J. (1985) 5, 6, 4′-Trihydroxy-7, 3′-dimethoxyflavone and other methoxylated flavonoids isolated from Thymus satureiodes. Planta Med. 51, 523-525.
    • (1985) Planta Med. , vol.51 , pp. 523-525
    • Voirin, B.1    Viricel, M.R.2    Favre-Bonvin, J.3    Van Den Broucke, C.O.4    Lemli, J.5
  • 63
    • 84886424782 scopus 로고    scopus 로고
    • Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne
    • Lone, S. H., Bhat, K. A., Naseer, S., Rather, R. A., Khuroo, M. A., et al. (2013) Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 940, 135-141.
    • (2013) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.940 , pp. 135-141
    • Lone, S.H.1    Bhat, K.A.2    Naseer, S.3    Rather, R.A.4    Khuroo, M.A.5
  • 65
    • 33845199356 scopus 로고    scopus 로고
    • Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells
    • Sergeev, I. N., Li, S., Colby, J., Ho, C. T., and Dushenkov, S. (2006) Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells. Life Sci. 80, 245-253.
    • (2006) Life Sci. , vol.80 , pp. 245-253
    • Sergeev, I.N.1    Li, S.2    Colby, J.3    Ho, C.T.4    Dushenkov, S.5
  • 66
    • 0033977339 scopus 로고    scopus 로고
    • A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts
    • Ishiwa, J., Sato, T., Mimaki, Y., Sashida, Y., Yano, M., et al. (2000) A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J Rheumatol. 27, 20-25.
    • (2000) J Rheumatol. , vol.27 , pp. 20-25
    • Ishiwa, J.1    Sato, T.2    Mimaki, Y.3    Sashida, Y.4    Yano, M.5
  • 67
    • 33644528432 scopus 로고    scopus 로고
    • Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum
    • Bas, E., Recio, M. C., Giner, R. M., Manez, S., Cerda-Nicolas, M., et al. (2006) Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 72, 136-142.
    • (2006) Planta Med. , vol.72 , pp. 136-142
    • Bas, E.1    Recio, M.C.2    Giner, R.M.3    Manez, S.4    Cerda-Nicolas, M.5
  • 68
    • 36949011859 scopus 로고    scopus 로고
    • Demethylnobiletin inhibits delayed-type hypersensitivity reactions, human lymphocyte proliferation and cytokine production
    • Bas, E., Recio, M. C., Giner, R. M., Manez, S., Lopez-Gines, C., et al. (2007) Demethylnobiletin inhibits delayed-type hypersensitivity reactions, human lymphocyte proliferation and cytokine production. Br. J. Pharmacol. 152, 1272-1282.
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 1272-1282
    • Bas, E.1    Recio, M.C.2    Giner, R.M.3    Manez, S.4    Lopez-Gines, C.5
  • 69
    • 34547866464 scopus 로고    scopus 로고
    • Anti-inflammatory property of the urinary metabolites of nobiletin in mouse
    • Li, S., Sang, S., Pan, M. H., Lai, C. S., Lo, C. Y., et al. (2007) Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. Bioorg. Med. Chem. Lett. 17, 5177-5181.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5177-5181
    • Li, S.1    Sang, S.2    Pan, M.H.3    Lai, C.S.4    Lo, C.Y.5
  • 70
    • 57349086146 scopus 로고    scopus 로고
    • Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3′,4′-didemethylnobiletin, derived from nobiletin
    • Lai, C. S., Li, S., Chai, C. Y., Lo, C. Y., Dushenkov, S., et al. (2008) Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3′, 4′-didemethylnobiletin, derived from nobiletin. Carcinogenesis 29, 2415-2424.
    • (2008) Carcinogenesis , vol.29 , pp. 2415-2424
    • Lai, C.S.1    Li, S.2    Chai, C.Y.3    Lo, C.Y.4    Dushenkov, S.5
  • 71
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer
    • Middleton, E. J., Kandaswami, C., and Theoharides, T. C. (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 52, 673-751.
    • (2000) Pharmacol Rev. , vol.52 , pp. 673-751
    • Middleton, E.J.1    Kandaswami, C.2    Theoharides, T.C.3
  • 72
    • 0032998638 scopus 로고    scopus 로고
    • Flavonoids from Cleome droserifolia suppress NO production in activated macrophages in vitro
    • Fushiya, S., Kishi, Y., Hattori, K., Batkhuu, J., Takano, F., et al. (1999) Flavonoids from Cleome droserifolia suppress NO production in activated macrophages in vitro. Planta Med. 65, 404-407.
    • (1999) Planta Med. , vol.65 , pp. 404-407
    • Fushiya, S.1    Kishi, Y.2    Hattori, K.3    Batkhuu, J.4    Takano, F.5
  • 73
    • 84926421206 scopus 로고    scopus 로고
    • 5Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis
    • Maa, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., et al. (2014) 5Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis. J. Funct. Foods 11, 528-537.
    • (2014) J. Funct. Foods , vol.11 , pp. 528-537
    • Maa, N.1    Lai, C.S.2    Chung, C.H.3    Yang, J.M.4    Hsu, K.C.5
  • 74
    • 36949006565 scopus 로고    scopus 로고
    • Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice
    • Lai, C. S., Li, S., Chai, C. Y., Lo, C. Y., Ho, C. T., et al. (2007) Inhibitory effect of citrus 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. Carcinogenesis 28, 2581-2588.
    • (2007) Carcinogenesis , vol.28 , pp. 2581-2588
    • Lai, C.S.1    Li, S.2    Chai, C.Y.3    Lo, C.Y.4    Ho, C.T.5
  • 75
    • 84896510750 scopus 로고    scopus 로고
    • Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone via NF-kappaB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage
    • Kim, M. J., Lee, H. H., Jeong, J. W., Seo, M. J., Kang, B. W., et al. (2014) Anti-inflammatory effects of 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone via NF-kappaB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Mol. Med. Rep. 9, 1197-1203.
    • (2014) Mol. Med. Rep. , vol.9 , pp. 1197-1203
    • Kim, M.J.1    Lee, H.H.2    Jeong, J.W.3    Seo, M.J.4    Kang, B.W.5
  • 76
    • 84876426789 scopus 로고    scopus 로고
    • 5-Hydroxy-3,6,7,8,3′4′-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-kappaB suppression and Nrf-2-dependent heme oxygenase-1 induction
    • Kang, C. H., Kim, M. J., Seo, M. J., Choi, Y. H., Jo, W. S., et al. (2013) 5-Hydroxy-3, 6, 7, 8, 3′4′-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-kappaB suppression and Nrf-2-dependent heme oxygenase-1 induction. Food Chem. Toxicol. 57, 119-125.
    • (2013) Food Chem. Toxicol. , vol.57 , pp. 119-125
    • Kang, C.H.1    Kim, M.J.2    Seo, M.J.3    Choi, Y.H.4    Jo, W.S.5
  • 77
    • 84919673608 scopus 로고    scopus 로고
    • Inhibition of xanthine oxidase activity by gnaphalium affine extract
    • Lin, W. Q., Xie, J. X., Wu, X. M., Yang, L., and Wang, H. D. (2014) Inhibition of xanthine oxidase activity by gnaphalium affine extract. Chin Med. Sci. J. 29, 225-230.
    • (2014) Chin Med. Sci. J. , vol.29 , pp. 225-230
    • Lin, W.Q.1    Xie, J.X.2    Wu, X.M.3    Yang, L.4    Wang, H.D.5
  • 78
    • 77954290401 scopus 로고    scopus 로고
    • HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves
    • Yam, M. F., Lim, V., Salman, I. M., Ameer, O. Z., Ang, L. F., et al. (2010) HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves. Molecules 15, 4452-4466.
    • (2010) Molecules , vol.15 , pp. 4452-4466
    • Yam, M.F.1    Lim, V.2    Salman, I.M.3    Ameer, O.Z.4    Ang, L.F.5
  • 79
  • 81
    • 84862994947 scopus 로고    scopus 로고
    • The role of bioactive compounds on the promotion of neurite outgrowth
    • More, S. V., Koppula, S., Kim, I. S., Kumar, H., Kim, B. W., et al. (2012) The role of bioactive compounds on the promotion of neurite outgrowth. Molecules 17, 6728-6753.
    • (2012) Molecules , vol.17 , pp. 6728-6753
    • More, S.V.1    Koppula, S.2    Kim, I.S.3    Kumar, H.4    Kim, B.W.5
  • 82
    • 27144554955 scopus 로고    scopus 로고
    • Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities
    • Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., et al. (2005) Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. Biochem. Biophys. Res. Commun. 337, 1330-1336.
    • (2005) Biochem. Biophys. Res. Commun. , vol.337 , pp. 1330-1336
    • Nagase, H.1    Omae, N.2    Omori, A.3    Nakagawasai, O.4    Tadano, T.5
  • 83
    • 84892951326 scopus 로고    scopus 로고
    • Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells
    • Chiu, S. P., Wu, M. J., Chen, P. Y., Ho, Y. R., Tai, M. H., et al. (2013) Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J. Agric. Food Chem. 61, 9453-9463.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 9453-9463
    • Chiu, S.P.1    Wu, M.J.2    Chen, P.Y.3    Ho, Y.R.4    Tai, M.H.5
  • 84
    • 68849106033 scopus 로고    scopus 로고
    • 4′-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade
    • Al, R. M., Nakajima, A., Saigusa, D., Tetsu, N., Maruyama, Y., et al. (2009) 4′-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry 48, 7713-7721.
    • (2009) Biochemistry , vol.48 , pp. 7713-7721
    • Al, R.M.1    Nakajima, A.2    Saigusa, D.3    Tetsu, N.4    Maruyama, Y.5
  • 85
    • 84655167653 scopus 로고    scopus 로고
    • 3′,4′-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells
    • Su, J. D., Yen, J. H., Li, S., Weng, C. Y., Lin, M. H., et al. (2012) 3′, 4′-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic. Biol. Med. 52, 126-141.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 126-141
    • Su, J.D.1    Yen, J.H.2    Li, S.3    Weng, C.Y.4    Lin, M.H.5
  • 86
    • 82255170572 scopus 로고    scopus 로고
    • Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells
    • Lai, H. C., Wu, M. J., Chen, P. Y., Sheu, T. T., Chiu, S. P., et al. (2011) Neurotrophic effect of citrus 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. PLoS. One. 6, e28280.
    • (2011) PLoS. One. , vol.6 , pp. e28280
    • Lai, H.C.1    Wu, M.J.2    Chen, P.Y.3    Sheu, T.T.4    Chiu, S.P.5
  • 87
    • 84867045678 scopus 로고    scopus 로고
    • A new highly hydroxylated triterpene from Salvia atropatana Bunge
    • Habibi, Z., Cheraghi, Z., Ghasemi, S., and Yousefi, M. (2012) A new highly hydroxylated triterpene from Salvia atropatana Bunge. Nat. Prod. Res. 26, 1910-1913.
    • (2012) Nat. Prod. Res. , vol.26 , pp. 1910-1913
    • Habibi, Z.1    Cheraghi, Z.2    Ghasemi, S.3    Yousefi, M.4
  • 88
    • 84930410941 scopus 로고    scopus 로고
    • Beneficial effect of flavone derivatives on abeta-induced memory deficit is mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha: a comparative study
    • Arsalandeh, F., Ahmadian, S., Foolad, F., Khodagholi, F., Farimani, M. M., et al. (2015) Beneficial effect of flavone derivatives on abeta-induced memory deficit is mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha: a comparative study. Int. J. Toxicol. 34, 274-283.
    • (2015) Int. J. Toxicol. , vol.34 , pp. 274-283
    • Arsalandeh, F.1    Ahmadian, S.2    Foolad, F.3    Khodagholi, F.4    Farimani, M.M.5
  • 89
    • 0036852744 scopus 로고    scopus 로고
    • The macrophage foam cell as a target for therapeutic intervention
    • Li, A. C. and Glass, C. K. (2002) The macrophage foam cell as a target for therapeutic intervention. Nat. Med. 8, 1235-1242.
    • (2002) Nat. Med. , vol.8 , pp. 1235-1242
    • Li, A.C.1    Glass, C.K.2
  • 90
    • 79955636222 scopus 로고    scopus 로고
    • Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells
    • Yen, J. H., Weng, C. Y., Li, S., Lo, Y. H., Pan, M. H., et al. (2011) Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. Mol. Nutr. Food Res. 55, 733-748.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 733-748
    • Yen, J.H.1    Weng, C.Y.2    Li, S.3    Lo, Y.H.4    Pan, M.H.5
  • 91
    • 52449092192 scopus 로고    scopus 로고
    • Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells
    • Eguchi, A., Murakami, A., Li, S., Ho, C. T., and Ohigashi, H. (2007) Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. Biofactors 31, 107-116.
    • (2007) Biofactors , vol.31 , pp. 107-116
    • Eguchi, A.1    Murakami, A.2    Li, S.3    Ho, C.T.4    Ohigashi, H.5
  • 92
    • 84884184241 scopus 로고    scopus 로고
    • Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone and 3,5,6,7,8,3′,4′-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor
    • Kou, M. C., Fu, S. H., Yen, J. H., Weng, C. Y., Li, S., et al. (2013) Effects of citrus flavonoids, 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone and 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food Funct. 4, 602-609.
    • (2013) Food Funct. , vol.4 , pp. 602-609
    • Kou, M.C.1    Fu, S.H.2    Yen, J.H.3    Weng, C.Y.4    Li, S.5
  • 93
    • 84887076166 scopus 로고    scopus 로고
    • Suppression of adipogenesis and obesity in high-fat induced mouse model by hydroxylated polymethoxyflavones
    • Lai, C. S., Ho, M. H., Tsai, M. L., Li, S., Badmaev, V., et al. (2013) Suppression of adipogenesis and obesity in high-fat induced mouse model by hydroxylated polymethoxyflavones. J. Agric. Food Chem. 61, 10320-10328.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 10320-10328
    • Lai, C.S.1    Ho, M.H.2    Tsai, M.L.3    Li, S.4    Badmaev, V.5
  • 94
    • 57649165278 scopus 로고    scopus 로고
    • Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer
    • Hirata, T., Fujii, M., Akita, K., Yanaka, N., Ogawa, K., et al. (2009) Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer. Bioorg. Med. Chem. 17, 25-28.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 25-28
    • Hirata, T.1    Fujii, M.2    Akita, K.3    Yanaka, N.4    Ogawa, K.5
  • 95
    • 67649884282 scopus 로고    scopus 로고
    • Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes
    • Sergeev, I. N., Li, S., Ho, C. T., Rawson, N. E., and Dushenkov, S. (2009) Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes. J. Agric. Food Chem. 57, 5771-5776.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 5771-5776
    • Sergeev, I.N.1    Li, S.2    Ho, C.T.3    Rawson, N.E.4    Dushenkov, S.5
  • 96
    • 84926347826 scopus 로고    scopus 로고
    • 5O-Demethylnobiletin, a polymethoxylated flavonoid, from Citrus depressa Hayata peel prevents protein glycation
    • Upadhyay, A., Tuenter, E., Amin, A., Exarchou, V., Hermans, N., et al. (2014) 5O-Demethylnobiletin, a polymethoxylated flavonoid, from Citrus depressa Hayata peel prevents protein glycation. J. Funct. Foods 11, 243-249.
    • (2014) J. Funct. Foods , vol.11 , pp. 243-249
    • Upadhyay, A.1    Tuenter, E.2    Amin, A.3    Exarchou, V.4    Hermans, N.5
  • 97
    • 84884706279 scopus 로고    scopus 로고
    • Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury
    • Lu, Q., Yang, L., Zhao, H. Y., Jiang, J. G., and Xu, X. L. (2013) Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury. Food Chem. Toxicol. 62, 432-435.
    • (2013) Food Chem. Toxicol. , vol.62 , pp. 432-435
    • Lu, Q.1    Yang, L.2    Zhao, H.Y.3    Jiang, J.G.4    Xu, X.L.5
  • 98
    • 84886789774 scopus 로고    scopus 로고
    • Identification of novel bioactive metabolites of 5-demethylnobiletin in mice
    • Zheng, J., Song, M., Dong, P., Qiu, P., Guo, S., et al. (2013) Identification of novel bioactive metabolites of 5-demethylnobiletin in mice. Mol. Nutr. Food Res. 57, 1999-2007.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1999-2007
    • Zheng, J.1    Song, M.2    Dong, P.3    Qiu, P.4    Guo, S.5
  • 99
    • 84883318899 scopus 로고    scopus 로고
    • Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity
    • Ting, Y., Li, C. C., Pan, M. H., Ho, C. T., and Huang, Q. (2013) Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. J. Agric. Food Chem. 61, 8090-8097.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 8090-8097
    • Ting, Y.1    Li, C.C.2    Pan, M.H.3    Ho, C.T.4    Huang, Q.5
  • 100
    • 84896282886 scopus 로고    scopus 로고
    • Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions
    • Zheng, J., Li, Y., Song, M., Fang, X., McClements, D. J., et al. (2015) Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions. Food Res. Int. 62, 98-103.
    • (2015) Food Res. Int. , vol.62 , pp. 98-103
    • Zheng, J.1    Li, Y.2    Song, M.3    Fang, X.4    McClements, D.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.