A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways

Anticancer Research

Volumn 30, Issue 9, 2010, Pages 3599-3610

  Phromnoi, Kanokkarn ^a,b   Reuter, Simone ^a   Sung, Bokyung ^a   Limtrakul, Pornngarm ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

AKT; CDK inhibitor; GSK3beta; Natural products; Plant extract

Indexed keywords

5,3' DIHYDROXY 3,6,7,8,4' PENTAMETHOXYFLAVONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FLAVONE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN KINASE B; UNCLASSIFIED DRUG; 5,3'-DIHYDROXY-3,6,7,8,4'-PENTAMETHOXYFLAVONE; FLAVONOID; PLANT EXTRACT;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GARDENIA; GARDENIA OBTUSIFOLIA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THAILAND; TUMOR CELL; CELL SEPARATION; CHEMISTRY; DRUG EFFECTS; FLOW CYTOMETRY; METABOLISM; NEOPLASM; NICK END LABELING; ORIENTAL MEDICINE; PATHOLOGY; PHYTOTHERAPY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; FLAVONOIDS; FLOW CYTOMETRY; GARDENIA; HUMANS; IN SITU NICK-END LABELING; MEDICINE, EAST ASIAN TRADITIONAL; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; SIGNAL TRANSDUCTION; THAILAND;

EID: 77958572996     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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