메뉴 건너뛰기




Volumn 30, Issue 9, 2010, Pages 3599-3610

A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways

Author keywords

AKT; CDK inhibitor; GSK3beta; Natural products; Plant extract

Indexed keywords

5,3' DIHYDROXY 3,6,7,8,4' PENTAMETHOXYFLAVONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FLAVONE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN KINASE B; UNCLASSIFIED DRUG; 5,3'-DIHYDROXY-3,6,7,8,4'-PENTAMETHOXYFLAVONE; FLAVONOID; PLANT EXTRACT;

EID: 77958572996     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (52)
  • 2
    • 0019762398 scopus 로고
    • Isolation of Campylobacter fetus subsp jejuni from zoo animals
    • Luechtefeld NW, Cambre RC and Wang WL: Isolation of Campylobacter fetus subsp jejuni from zoo animals. J Am Vet Med Assoc 179: 1119-1122, 1981.
    • (1981) J Am Vet Med Assoc , vol.179 , pp. 1119-1122
    • Luechtefeld, N.W.1    Cambre, R.C.2    Wang, W.L.3
  • 3
    • 0024577444 scopus 로고
    • Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs
    • Takase H, Imanishi K, Miura O, Yumioka E and Watanabe H: Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs. Jpn J Pharmacol 49: 301-308, 1989.
    • (1989) Jpn J Pharmacol , vol.49 , pp. 301-308
    • Takase, H.1    Imanishi, K.2    Miura, O.3    Yumioka, E.4    Watanabe, H.5
  • 4
    • 0021796031 scopus 로고
    • Antimicrobial activity of some medicinal species from the Dakar markets
    • in French
    • Laurens A, Mboup S, Tignokpa M, Sylla O and Masquelier J: Antimicrobial activity of some medicinal species from the Dakar markets. Pharmazie 40: 482-484, 1985 (in French).
    • (1985) Pharmazie , vol.40 , pp. 482-484
    • Laurens, A.1    Mboup, S.2    Tignokpa, M.3    Sylla, O.4    Masquelier, J.5
  • 5
    • 0025762696 scopus 로고
    • Pharmacological effects of Gardenia erubescens in mice, rats and cats
    • Hussain MM, Sokomba EN and Shok M: Pharmacological effects of Gardenia erubescens in mice, rats and cats. Int J Pharmacogn 29: 94-100, 1991.
    • (1991) Int J Pharmacogn , vol.29 , pp. 94-100
    • Hussain, M.M.1    Sokomba, E.N.2    Shok, M.3
  • 6
    • 0014786841 scopus 로고
    • Drug plants of the Sudan Republic in native medicine
    • el-Hamidi A: Drug plants of the Sudan Republic in native medicine. Planta Med 18: 279-280, 1970.
    • (1970) Planta Med , vol.18 , pp. 279-280
    • El-Hamidi, A.1
  • 10
    • 0033533865 scopus 로고    scopus 로고
    • Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization
    • Zhang SX, Bastow KF, Tachibana Y, Kuo SC, Hamel E, Mauger A, Narayanan VL and Lee KH: Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4- ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 42: 4081-4087, 1999.
    • (1999) J Med Chem , vol.42 , pp. 4081-4087
    • Zhang, S.X.1    Bastow, K.F.2    Tachibana, Y.3    Kuo, S.C.4    Hamel, E.5    Mauger, A.6    Narayanan, V.L.7    Lee, K.H.8
  • 12
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumorigenesis
    • Testa JR and Bellacosa A: AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98: 10983-10985, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 13
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- Intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME: AKT phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997. (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 14
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 15
    • 0033851276 scopus 로고    scopus 로고
    • GSK3, a master switch regulating cell-fate specification and tumorigenesis
    • Kim L and Kimmel AR: GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 10: 508-514, 2000.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 508-514
    • Kim, L.1    Kimmel, A.R.2
  • 16
    • 4544341116 scopus 로고    scopus 로고
    • Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, AKT, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    • Takada Y, Fang X, Jamaluddin MS, Boyd DD and Aggarwal BB: Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, AKT, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem 279: 39541-39554, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 39541-39554
    • Takada, Y.1    Fang, X.2    Jamaluddin, M.S.3    Boyd, D.D.4    Aggarwal, B.B.5
  • 17
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/AKT signalling pathway in human malignancy
    • Nicholson KM and Anderson NG: The protein kinase B/AKT signalling pathway in human malignancy. Cell Signal 14: 381-395, 2002.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 18
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    • Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O and Woodgett JR: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90, 2000.
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.S.4    Jin, O.5    Woodgett, J.R.6
  • 19
    • 33845883544 scopus 로고    scopus 로고
    • Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products
    • DOI 10.1124/mol.106.028787
    • Ahn KS, Sethi G and Aggarwal BB: Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol 71: 209-219, 2007. (Pubitemid 46020991)
    • (2007) Molecular Pharmacology , vol.71 , Issue.1 , pp. 209-219
    • Kwang, S.A.1    Sethi, G.2    Aggarwal, B.B.3
  • 20
    • 69249083578 scopus 로고    scopus 로고
    • Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species
    • Yodkeeree S, Sung B, Limtrakul P and Aggarwal BB: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res 69: 6581-6589, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6581-6589
    • Yodkeeree, S.1    Sung, B.2    Limtrakul, P.3    Aggarwal, B.B.4
  • 23
    • 35848962271 scopus 로고    scopus 로고
    • c-MYC blazing a trail of death: Coupling of the mitochondrial and death receptor apoptosis pathways by c-MYC
    • Nieminen AI, Partanen JI and Klefstrom J: c-MYC blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-MYC. Cell Cycle 6: 2464-2472, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 2464-2472
    • Nieminen, A.I.1    Partanen, J.I.2    Klefstrom, J.3
  • 25
    • 0033557805 scopus 로고    scopus 로고
    • Rel-dependent induction of Al transcription is required to protect B-cells from antigen receptor ligation-induced apoptosis
    • Grumont RJ, Rourke IJ and Gerondakis S: Rel-dependent induction of Al transcription is required to protect B-cells from antigen receptor ligation-induced apoptosis. Genes Dev 13: 400-411, 1999.
    • (1999) Genes Dev , vol.13 , pp. 400-411
    • Grumont, R.J.1    Rourke, I.J.2    Gerondakis, S.3
  • 26
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bc12 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a Bc12 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 27
    • 0035941083 scopus 로고    scopus 로고
    • Antiapoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning
    • Zhu L, Fukuda S, Cordis G, Das DK and Maulik N: Antiapoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett 508: 369-374, 2001.
    • (2001) FEBS Lett , vol.508 , pp. 369-374
    • Zhu, L.1    Fukuda, S.2    Cordis, G.3    Das, D.K.4    Maulik, N.5
  • 28
    • 0034650523 scopus 로고    scopus 로고
    • BAX oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
    • Antonsson B, Montessuit S, Lauper S, Eskes R and Martinou JC: BAX oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 345 Pt 2: 271-278, 2000.
    • (2000) Biochem J , vol.345 , Issue.PART 2 , pp. 271-278
    • Antonsson, B.1    Montessuit, S.2    Lauper, S.3    Eskes, R.4    Martinou, J.C.5
  • 29
    • 0242407049 scopus 로고    scopus 로고
    • Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy
    • DOI 10.1038/sj.bjc.6601298
    • Chiu SM, Xue LY, Usuda J, Azizuddin K and Oleinick NL: Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy. Br J Cancer 89: 1590-1597, 2003. (Pubitemid 37386619)
    • (2003) British Journal of Cancer , vol.89 , Issue.8 , pp. 1590-1597
    • Chiu, S.-M.1    Xue, L.-Y.2    Usuda, J.3    Azizuddin, K.4    Oleinick, N.L.5
  • 30
    • 0030963602 scopus 로고    scopus 로고
    • Cytosol-to-membrane redistribution of BAX and Bcl-X(L) during apoptosis
    • Hsu YT, Wolter KG and Youle RJ: Cytosol-to-membrane redistribution of BAX and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA 94: 3668-3672, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3668-3672
    • Hsu, Y.T.1    Wolter, K.G.2    Youle, R.J.3
  • 31
    • 0036195104 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of BCL-2 and BCL-xL
    • Anto RJ, Mukhopadhyay A, Denning K and Aggarwal BB: Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of BCL-2 and BCL-xL. Carcinogenesis 23: 143-150, 2002.
    • (2002) Carcinogenesis , vol.23 , pp. 143-150
    • Anto, R.J.1    Mukhopadhyay, A.2    Denning, K.3    Aggarwal, B.B.4
  • 33
    • 55949095542 scopus 로고    scopus 로고
    • SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation
    • Sethi G, Ahn KS, Sung B, Kunnumakkara AB, Chaturvedi MM and Aggarwal BB: SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol 76: 1404-1416, 2008.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1404-1416
    • Sethi, G.1    Ahn, K.S.2    Sung, B.3    Kunnumakkara, A.B.4    Chaturvedi, M.M.5    Aggarwal, B.B.6
  • 34
    • 0032008099 scopus 로고    scopus 로고
    • Novel therapeutic strategies to selectively kill cancer cells
    • Panchal RG: Novel therapeutic strategies to selectively kill cancer cells. Biochem Pharmacol 55: 247-252, 1998.
    • (1998) Biochem Pharmacol , vol.55 , pp. 247-252
    • Panchal, R.G.1
  • 36
    • 62749087811 scopus 로고    scopus 로고
    • Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis
    • Xiao H, Yang CS, Li S, Jin H, Ho CT and Patel T: Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol Nutr Food Res 53: 398-406, 2009.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 398-406
    • Xiao, H.1    Yang, C.S.2    Li, S.3    Jin, H.4    Ho, C.T.5    Patel, T.6
  • 37
    • 68249106297 scopus 로고    scopus 로고
    • Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection
    • Zheng G, Yang D, Wang D, Zhou F, Yang X and Jiang L: Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. J Agric Food Chem 57: 6552-6557, 2009.
    • (2009) J Agric Food Chem , vol.57 , pp. 6552-6557
    • Zheng, G.1    Yang, D.2    Wang, D.3    Zhou, F.4    Yang, X.5    Jiang, L.6
  • 38
    • 19344377564 scopus 로고    scopus 로고
    • Isolation and purification of four flavonoid constituents from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography
    • DOI 10.1016/j.chroma.2005.04.017, PII S0021967305007703
    • Wang X, Cheng C, Sun Q, Li F, Liu J and Zheng C: Isolation and purification of four flavonoid constituents from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography. J Chromatogr A 1075: 127-131, 2005. (Pubitemid 40719082)
    • (2005) Journal of Chromatography a , vol.1075 , Issue.1-2 , pp. 127-131
    • Wang, X.1    Cheng, C.2    Sun, Q.3    Li, F.4    Liu, J.5    Zheng, C.6
  • 41
    • 15244350125 scopus 로고    scopus 로고
    • Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 cells
    • Watanabe J, Shinmoto H and Tsushida T: Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 cells. Biosci Biotechnol Biochem 69: 1-6, 2005.
    • (2005) Biosci Biotechnol Biochem , vol.69 , pp. 1-6
    • Watanabe, J.1    Shinmoto, H.2    Tsushida, T.3
  • 42
    • 0029597877 scopus 로고
    • Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes
    • Hirano T, Abe K, Gotoh M and Oka K: Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72: 1380-1388, 1995.
    • (1995) Br J Cancer , vol.72 , pp. 1380-1388
    • Hirano, T.1    Abe, K.2    Gotoh, M.3    Oka, K.4
  • 43
    • 33845199356 scopus 로고    scopus 로고
    • 2+-mediated apoptosis in breast cancer cells
    • DOI 10.1016/j.lfs.2006.09.006, PII S0024320506007132
    • Sergeev IN, Li S, Colby J, Ho CT and Dushenkov S: Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells. Life Sci 80: 245-253, 2006. (Pubitemid 44853992)
    • (2006) Life Sciences , vol.80 , Issue.3 , pp. 245-253
    • Sergeev, I.N.1    Li, S.2    Colby, J.3    Ho, C.-T.4    Dushenkov, S.5
  • 44
    • 0036799151 scopus 로고    scopus 로고
    • Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating CDK inhibitors p21 and p27 in human colorectal carcinoma cells
    • Pan MH, Chen WJ, Lin-Shiau SY, Ho CT and Lin JK: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating CDK inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 23: 1677-1684, 2002.
    • (2002) Carcinogenesis , vol.23 , pp. 1677-1684
    • Pan, M.H.1    Chen, W.J.2    Lin-Shiau, S.Y.3    Ho, C.T.4    Lin, J.K.5
  • 45
    • 70350014642 scopus 로고    scopus 로고
    • Flavones as colorectal cancer chemopreventive agents - Phenol-o-methylation enhances efficacy
    • Phila Pa
    • Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP and Gescher AJ: Flavones as colorectal cancer chemopreventive agents - phenol-o-methylation enhances efficacy. Cancer Prev Res (Phila Pa) 2: 743-750, 2009.
    • (2009) Cancer Prev Res , vol.2 , pp. 743-750
    • Cai, H.1    Sale, S.2    Schmid, R.3    Britton, R.G.4    Brown, K.5    Steward, W.P.6    Gescher, A.J.7
  • 46
    • 34047185899 scopus 로고    scopus 로고
    • Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines
    • Li S, Pan MH, Lai CS, Lo CY, Dushenkov S and Ho CT: Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg Med Chem 15: 3381-3389, 2007.
    • (2007) Bioorg Med Chem , vol.15 , pp. 3381-3389
    • Li, S.1    Pan, M.H.2    Lai, C.S.3    Lo, C.Y.4    Dushenkov, S.5    Ho, C.T.6
  • 47
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC: The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 48
    • 17644415297 scopus 로고    scopus 로고
    • Cell biology. GSK-3beta and microtubule assembly in axons
    • Zhou FQ and Snider WD: Cell biology. GSK-3beta and microtubule assembly in axons. Science 308: 211-214, 2005.
    • (2005) Science , vol.308 , pp. 211-214
    • Zhou, F.Q.1    Snider, W.D.2
  • 49
    • 38949128693 scopus 로고    scopus 로고
    • Novel tubulin-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: Possible anti-myeloma mechanism of thalidomide
    • Iguchi T, Yachide-Noguchi T, Hashimoto Y, Nakazato S, Sagawa M, Ikeda Y and Kizaki M: Novel tubulin-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide. Int J Mol Med 21: 163-168, 2008.
    • (2008) Int J Mol Med , vol.21 , pp. 163-168
    • Iguchi, T.1    Yachide-Noguchi, T.2    Hashimoto, Y.3    Nakazato, S.4    Sagawa, M.5    Ikeda, Y.6    Kizaki, M.7
  • 50
    • 53149138204 scopus 로고    scopus 로고
    • Mechanisms of platelet-derived growth factor-mediated neuroprotection - Implications in HIV dementia
    • Peng F, Dhillon NK, Yao H, Zhu X, Williams R and Buch S: Mechanisms of platelet-derived growth factor-mediated neuroprotection - implications in HIV dementia. Eur J Neurosci 28: 1255-1264, 2008.
    • (2008) Eur J Neurosci , vol.28 , pp. 1255-1264
    • Peng, F.1    Dhillon, N.K.2    Yao, H.3    Zhu, X.4    Williams, R.5    Buch, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.