Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1

Molecular Pharmacology

Volumn 80, Issue 5, 2011, Pages 889-899

  Phromnoi, Kanokkarn ^a,b   Prasad, Sahdeo ^a   Gupta, Subash ^a   Kannappan, Ramaswamy ^a   Reuter, Simone ^a   Limtrakul, Pornngarm ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

5,3' DIHYDROXY 3,6,7,8,4' PENTAMETHOXYFLAVONE; BORTEZOMIB; CASPASE 3; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; FLAVONE DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PERVANADATE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN CIAP 2; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; STAT3 PROTEIN; SURVIVIN; THALIDOMIDE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; DNA BINDING; DOWN REGULATION; DRUG ISOLATION; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; MYELOMA CELL; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; FLAVONOIDS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR;

EID: 80054782411     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073676     Document Type: Article

References (40)

1. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, and Sung B (2009) Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?. Ann NY Acad Sci 1171:59-76.
2. Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunnumakkara AB, Sung B, and Ichikawa H (2006) Targeting signal-transducer-and-activator-of- transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann NY Acad Sci 1091:151-169. (Pubitemid 47092233)
3. Banville D, Stocco R, and Shen SH (1995) Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts. Genomics 27:165-173.
4. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, and Darnell JE Jr (1999) Stat3 as an oncogene. Cell 98:295-303. (Pubitemid 29380565)
5. Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP, and Gescher AJ (2009) Flavones as colorectal cancer chemopreventive agents-phenol-o-methylation enhances efficacy. Cancer Prev Res (Phila) 2:743-750.
6. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernández-Luna JL, Nuñez G, Dalton WS, and Jove R (1999) Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10:105-115. (Pubitemid 29077388)
7. Cavo M (2006) Proteasome inhibitor bortezomib for the treatment of multiple myeloma. Leukemia 20:1341-1352.
8. Chatterjee M, Hönemann D, Lentzsch S, Bommert K, Sers C, Herrmann P, Mathas S, Dörken B, and Bargou RC (2002) In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway. Blood 100:3311-3318. (Pubitemid 35217082)
9. Choi CH, Sun KH, An CS, Yoo JC, Hahm KS, Lee IH, Sohng JK, and Kim YC (2002) Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3′,4′-pentamethoxyflavone (Sinensetin). Biochem Biophys Res Commun 295:832-840.
10. Chung J, Uchida E, Grammer TC, and Blenis J (1997) STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17:6508-6516. (Pubitemid 27451197)
11. Glasmacher A, Hahn C, Hoffmann F, Naumann R, Goldschmidt H, von Lilienfeld-Toal M, Orlopp K, Schmidt-Wolf I, and Gorschlüter M (2006) A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma. Br J Haematol 132:584-593. (Pubitemid 43381591)
12. Han Y, Amin HM, Franko B, Frantz C, Shi X, and Lai R (2006) Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. Blood 108:2796-2803.
13. Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, Buettner R, Proia D, Kowolik CM, Xin H, Armstrong B, Bebernitz G, Weng S, Wang L, Ye M, McEachern K, Chen H, Morosini D, Bell K, Alimzhanov M, Ioannidis S, McCoon P, Cao ZA, Yu H, Jove R, and Zinda M (2009) The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16:487-497.
14. Ihle JN (1996) STATs: signal transducers and activators of transcription. Cell 84:331-334.
15. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, and Tanaka H (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83-85.
16. Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, and Yu H (2005) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11:1314-1321. (Pubitemid 41752912)
17. Kunnumakkara AB, Nair AS, Sung B, Pandey MK, and Aggarwal BB (2009) Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. Mol Cancer Res 7:118-128.
18. Laurens A, Mboup S, Tignokpa M, Sylla O, and Masquelier J (1985) [Antimicrobial activity of some medicinal species from the Dakar markets]. Die Pharmazie 40:482-484.
19. Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, and Yu H (2010) STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 16:1421-1428.
20. Lichius JJ, Thoison O, Montagnac A, Païs M, Guéritte- Voegelein F, Sévenet T, Cosson JP, and Hadi AH (1994) Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri. J Nat Prod 57:1012-1016. (Pubitemid 24271342)
21. Luechtefeld NW, Cambre RC, and Wang WL (1981) Isolation of Campylobacter fetus subsp jejuni from zoo animals. J Am Vet Med Assoc 179:1119-1122.
22. Martin A, Tsui HW, Shulman MJ, Isenman D, and Tsui FW (1999) Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1. J Biol Chem 274:21725-21734.
23. 1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 23:1677-1684.
24. Pandey MK, Sung B, Ahn KS, and Aggarwal BB (2009) Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol Pharmacol 75:525-533.
25. Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, and Aggarwal BB (2011) A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of activation of IκB kinase and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. Mol Pharmacol 79:279-289.
26. Ram PT, Horvath CM, and Iyengar R (2000) Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science 287:142-144. (Pubitemid 30033239)
27. Schreiner SJ, Schiavone AP, and Smithgall TE (2002) Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem 277:45680-45687. (Pubitemid 36159180)
28. 2+-mediated apoptosis in breast cancer cells. Life Sci 80:245-253.
29. Shi Q, Chen K, Li L, Chang JJ, Autry C, Kozuka M, Konoshima T, Estes JR, Lin CM, and Hamel E (1995) Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. J Nat Prod 58:475-482.
30. Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, and Sawada Y (2000) Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 293:230-236. (Pubitemid 30180944)
31. Takase H, Imanishi K, Miura O, Yumioka E, and Watanabe H (1989) Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs. Japan J Pharmacol 49:301-308. (Pubitemid 19084173)
32. Tuchinda P, Saiai A, Pohmakotr M, Yoosook C, Kasisit J, Napaswat C, Santisuk T, and Reutrakul V (2004) Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica. Planta Medica 70:366-370. (Pubitemid 38594611)
33. Verma NK, Dourlat J, Davies AM, Long A, Liu WQ, Garbay C, Kelleher D, and Volkov Y (2009) STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem 284:12349-12362.
34. Xiao H, Yang CS, Li S, Jin H, Ho CT, and Patel T (2009) Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol Nutr Food Res 53:398-406.
35. Yang F, Brown C, Buettner R, Hedvat M, Starr R, Scuto A, Schroeder A, Jensen M, and Jove R (2010a) Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Mol Cancer Ther 9:953-962.
36. Yang F, Jove V, Xin H, Hedvat M, Van Meter TE, and Yu H (2010b) Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. Mol Cancer Res 8:35-45.
37. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, and Jove R (1995) Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
38. Yu H, Pardoll D, and Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9:798-809.
39. Zhang SX, Bastow KF, Tachibana Y, Kuo SC, Hamel E, Mauger A, Narayanan VL, and Lee KH (1999) Antitumor agents. 196. Substituted 2-thienyl-1,8- naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 42:4081-4087. (Pubitemid 29483025)
40. Zheng G, Yang D, Wang D, Zhou F, Yang X, and Jiang L (2009) Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. J Agric Food Chem 57:6552-6557.