Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4′-hydroxy-5,6,7,8,3′-pentamethoxyflavone

Journal of Natural Products

Volumn 67, Issue 11, 2004, Pages 1876-1878

  Okuno, Yoshiharu ^a   Miyazawa, Mitsuo ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXY 5,6,7,8,3' PENTAMETHOXYFLAVONE; ANTIMUTAGENIC AGENT; CHEMICAL MUTAGEN; DRUG METABOLITE; FLAVONE DERIVATIVE; FURYLFURAMIDE; NOBILETIN; SOS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIGER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG ACTIVITY; DRUG INHIBITION; DRUG TRANSFORMATION; GENE EXPRESSION; NONHUMAN; SALMONELLA TYPHIMURIUM;

ASPERGILLUS NIGER; BIOTRANSFORMATION; CITRUS; FLAVONES; FLAVONOIDS; FURYLFURAMIDE; MOLECULAR STRUCTURE; MUTAGENICITY TESTS; PLANTS, MEDICINAL; SALMONELLA TYPHIMURIUM; SOS RESPONSE (GENETICS);

ASPERGILLUS; ASPERGILLUS NIGER; NEGIBACTERIA; SALMONELLA TYPHIMURIUM;

EID: 10044243544     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np034007g     Document Type: Article

References (22)

1. Laughton, M. J.; Haliwell, B.; Evans. P.; Hoult, J. R. Biochem. Pharmacol. 1989, 38, 2859-2865.
2. Verma, A. K.; Johnson, J. A.; Gould, M. N.; Tanner, M. A. Cancer Res. 1988, 48, 5754-5758.
3. Kanazawa, K.; Kawasaki, H.; Samejima, K.; Ashida, H.; Danno, G. J. Agric. Food Chem. 1995, 43, 404-409.
4. Kandaswami, C.; Perkins, E., Soloniuk, D. S.; Drzewiecki, G.; Middleton, E., Jr. Cancer Lett. 1991, 56, 147-152.
5. Kawaii, S.; Tomono, Y.; Katase, E.; Ogawa, K.; Yano, M. J. Agric. Food Chem. 1999, 47, 128-135.
6. Sasaki, K. Yoshizaki, F. Biol. Pharm. Bull. 2002, 25, 806-808.
7. Wall, M. E.; Wani, M. C.; Manikumar, G.; Abraham, P.; Taylor, H.; Hughes, T. J.; Wanner, J.; MacGivney, R. J. Nat. Prod. 1988, 51, 1084-1091.
8. Miyazawa, M.; Okuno, Y.; Fukuyama, M.; Nakamura, S. Kosaka, H. J. Agric. Food Chem. 1999, 47, 5239-5244.
9. Ibrahim, A.-R.; Abul-Hajj, Y. J. J. Nat. Prod. 1990, 53, 1471-1478.
10. Ibrahim, A.-R. S.; Galal, A. M.; Ahmed, M. S.; Mossa, G. S. Chem. Pharm. Bull. 2003, 51, 203-206.
11. Ibrahim, A.-R. S. Phytochemistry 2000, 53, 209-212.
12. Vyas, A. V.; Mulchandani, N. B. Phytochemistry 1986, 25, 2625-2627.
13. Herz, W.; Kulanthaivel, P. Phytochemistry 1982, 21, 2363-2366.
14. Horie, T.; Tsukayama, M.; Nakayama, M. Bull. Chem. Soc. Jpn. 1982, 55, 2928-2932.
15. Murakami, A.; Kuwahara, S.; Takahashi, Y.; Ito C.; Furukawa, H.; Ju-ichi M.; Koshimura, K.; Ohigashi, H. Biosci. Biotechnol. Biochem. 2001, 65, 194-197.
16. Nielsen, S. E.; Breinholt, V.; Cornett, C.; Dragsted, L. O. Food Chem. Toxicol, 2000, 38, 739-746.
17. Nielsen S. E.; Breinholt V.; Justesen, U.; Cornett C.; Dragsted, L. O. Xenobiotica 1998, 28, 389-401.
18. Miyazawa, M.; Kasahara, H. Kameoka, H. Phytochemistry 1993, 34, 1501-1507.
19. Oda, Y.; Nakamura, S.; Oki, I. Mutat. Res. 1985, 147, 219-229.
20. Yahagi, T.; Nagao, M.; Seino, T. Mutat. Res. 1977, 48, 121-130.
21. Miller, J. H. In Experiments in Molecular Genotics; Cold Spring Harbor Laboratory: Cold Spring Habor, NY, 1972; pp 352-355.
22. Arimoto, S.; Ohara, Y.; Namba, T.; Negishi, T.; Hayatsu, H. Biochem. Biophys. Res. Commun. 1980, 92, 662-668