3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

Neurochemistry International

Volumn 70, Issue 1, 2014, Pages 30-38

  Okuyama, Satoshi ^a   Morita, Mayu ^a   Miyoshi, Kazuhiro ^a   Nishigawa, Yuki ^a   Kaji, Miki ^a   Sawamoto, Atsushi ^a   Terugo, Tsukasa ^a   Toyoda, Nobuki ^a   Makihata, Nahomi ^a   Amakura, Yoshiaki ^a   Yoshimura, Morio ^a   Nakajima, Mitsunari ^a   Furukawa, Yoshiko ^a  

^a MATSUYAMA UNIVERSITY   (Japan)

Author keywords

Anti inflammation; BDNF; Global cerebral ischemia; Heptamethoxyflavone; Hippocampus; Neuronal cell protection

Indexed keywords

3,5,6,7,8,3' ,4' HEPTAMETHOXYFLAVONE; BIOFLAVONOID; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; FLAVONE DERIVATIVE; UNCLASSIFIED DRUG; 3,3',4',5,6,7,8-HEPTAMETHOXYFLAVONE; FLAVONOID; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CELL ACTIVATION; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPAL CA1 REGION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SHORT TERM MEMORY; SUBVENTRICULAR ZONE; Y-MAZE TEST; ANIMAL; C57BL MOUSE; CELL DEATH; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; HIPPOCAMPUS; MEMORY DISORDERS; METABOLISM; NERVE CELL;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; DISEASE MODELS, ANIMAL; FLAVONOIDS; HIPPOCAMPUS; MALE; MEMORY DISORDERS; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS;

EID: 84898767578     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.03.008     Document Type: Article

References (44)

1. M. Al Rahim, A. Nakajima, D. Saigusa, N. Tetsu, Y. Maruyama, M. Shibuya, H. Yamakoshi, Y. Tomioka, Y. Iwabuchi, Y. Ohizumi, and T. Yamakuni 4′-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade Biochemistry 48 2009 7713 7721
2. Y. Béjot, A. Prigent-Tessier, C. Cachia, M. Giroud, C. Mossiat, N. Bertrand, P. Garnier, and C. Marie Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats Neurochem. Int. 58 2011 102 111
3. P.R. Blanquet, and Y. Lamour Brain-derived neurotrophic factor increases Ca2+/calmodulin-dependent protein kinase 2 activity in hippocampus J. Biol. Chem. 272 1997 24133 24136 (Pubitemid 27418607)
4. P.J. Bobyn, D. Corbett, D.M. Saucier, M.H. Noyan-Ashraf, B.H.J. Juurlink, and P.G. Paterson Protein-energy malnutrition impairs functional outcome in global ischemia Exp. Neurol. 196 2005 308 315 (Pubitemid 41607819)
5. B.R.S. Broughton, D.C. Reutens, and C.G. Sobey Apoptotic mechanisms after cerebral ischemia Stroke 40 2009 e331 e339
6. Y. Cui, J. Wu, S.C. Jung, D.B. Park, Y.H. Maeng, J.Y. Hong, S.J. Kim, S.R. Lee, and S.Y. Eun Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation Biol. Pharm. Bull. 33 2010 1814 1821
7. U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 1999 391 397 (Pubitemid 29453643)
8. 2+/calmodulin-dependent protein kinase in rat brain J. Neurosci. 5 1985 3270 3277 (Pubitemid 16182607)
9. 2+/calmodulin-dependent protein kinase II in cerebellar granule cells J. Biol. Chem. 264 1989 21830 21836 (Pubitemid 20028755)
10. Y. Furukawa, S. Okuyama, Y. Amakura, S. Watanabe, T. Fukata, M. Nakajima, M. Yoshimura, and T. Yoshida Isolation and characterization of activators of ERK/MAPK from citrus plants Int. J. Mol. Sci. 13 2012 1832 1845
11. S.K. Hanson, J.C. Grotta, M.N. Waxham, J. Aronowski, and P. Ostrow Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats Stroke 25 1994 466 473 (Pubitemid 24047278)
12. I. Harukuni, and A. Bhardwaj Mechanisms of brain injury after global cerebral ischemia Neurol. Clin. 24 2006 1 21 (Pubitemid 43144627)
13. M. Horn, and W. Schlote Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia Acta Neuropathol. 85 1992 79 87
14. M. Imer, B. Omay, A. Uzunkol, T. Erdem, P.A. Sabanci, A. Karasu, S.B. Albayrak, A. Sencer, K. Hepgul, and M. Kaya Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury Neurol. Res. 31 2009 977 981
15. B.H. Juurlink, and M.I. Sweeney Mechanisms that result in damage during and following cerebral ischemia Neurosci. Biobehav. Rev. 21 1997 121 128 (Pubitemid 27102557)
16. N.J. Kee, E. Preston, and J.M. Wojtowicz Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat Exp. Brain Res. 136 2001 313 320
17. D.H. Kim, S. Kim, W.Y. Jung, S.J. Park, D.H. Park, J.M. Kim, J.H. Cheong, and J.H. Ryu The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice Food Chem. Toxicol. 47 2009 1473 1479
18. C.R. Kuhlmann, C.M. Zehendner, M. Gerigk, D. Closhen, B. Bender, P. Friedl, and H.J. Luhmann MK801 blocks hypoxic blood-brain barrier disruption and leukocyte adhesion Neurosci. Lett. 449 2009 168 172
19. J.W. Lampe, and L.B. Becker State of the art in therapeutic hypothermia Annu. Rev. Med. 62 2011 79 93
20. E. Larsson, A. Nanobashvili, Z. Kokaia, and O. Lindvall Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats J. Cereb. Blood Flow Metab. 19 1999 1220 1228 (Pubitemid 30176450)
21. B. Li, Y. Arime, F.S. Hall, G.R. Uhl, and I. Sora Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice Eur. J. Pharmacol. 628 2010 104 107
22. J. Liu, K. Solway, R.O. Messing, and F.R. Sharp Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils J. Neurosci. 18 1998 7768 7778 (Pubitemid 28441018)
23. F. Lu, T. Nakamura, T. Toyoshima, Y. Liu, K. Hirooka, N. Kawai, N. Okabe, F. Shiraga, T. Tamiya, O. Miyamoto, R.F. Keep, and T. Itano Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils Neurosci. Lett. 506 2012 28 32
24. J.A. Manthey, and P. Bendele Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3′,4′,3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays J. Agric. Food Chem. 56 2008 9399 9403
25. J.A. Manthey, K. Grohmann, A. Montanari, K. Ash, and C.L. Manthey Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-α expression by human monocytes J. Nat. Prod. 62 1999 441 444 (Pubitemid 29165220)
26. K. Matsuzaki, M. Kenichi, S. Sakai, H. Yawo, N. Nakata, S. Moriguchi, K. Fukunaga, A. Yokosuka, Y. Sashida, Y. Mimaki, T. Yamakuni, and Y. Ohizumi Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus Eur. J. Pharmacol. 578 2008 194 200 (Pubitemid 350309590)
27. G. Neves, S.F. Cooke, and T.V. Bliss Synaptic plasticity, memory and the hippocampus: a neural network approach to causality Nat. Rev. Neurosci. 9 2008 65 75 (Pubitemid 350295694)
28. T. Olsson, T. Wieloch, and M.L. Smith Brain damage in a mouse model of global cerebral ischemia. Effect of NMDA receptor blockade Brain Res. 982 2003 260 269 (Pubitemid 37281422)
29. S. Okuyama, S. Minami, N. Shimada, N. Makihata, M. Nakajima, and Y. Furukawa Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice Eur. J. Pharmacol. 699 2013 118 123
30. S. Okuyama, T. Fukata, Y. Nishigawa, Y. Amakura, M. Yoshimura, T. Yoshida, M. Nakajima, and Y. Furukawa Citrus flavonoid improves MK-801-induced locomotive hyperactivity: possible relevance to schizophrenia J. Funct. Food 5 2013 2002 2006
31. S. Okuyama, N. Shimada, M. Kaji, M. Morita, K. Miyoshi, S. Minami, Y. Amakura, M. Yoshimura, T. Yoshida, S. Watanabe, M. Nakajima, and Y. Furukawa Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice Neurosci. Lett. 528 2012 190 195
32. D. Saigusa, M. Shibuya, D. Jinno, H. Yamakoshi, Y. Iwabuchi, A. Yokosuka, Y. Mimaki, A. Naganuma, Y. Ohizumi, Y. Tomioka, and T. Yamakuni High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound Anal. Bioanal. Chem. 400 2011 3635 3641
33. S. Sato, J. Xu, S. Okuyama, L.B. Martinez, S.M. Walsh, M.T. Jacobsen, R.J. Swan, J.D. Schlautman, P. Ciborowski, and T. Ikezu Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing Tau-tubulin kinase 1 J. Neurosci. 28 2008 14511 14521
34. W.R. Schabitz, S. Schwab, M. Spranger, and W. Hacke Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats J. Cereb. Blood Flow Metab. 17 1997 500 506 (Pubitemid 27250976)
35. J. Semmler, H. Wachtel, and S. Endres The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells Int. J. Immunopharmacol. 15 1993 409 413 (Pubitemid 23153552)
36. F.R. Sharp, A. Lu, Y. Tang, and D.E. Millhorn Multiple molecular penumbras after focal cerebral ischemia J. Cereb. Blood Flow Metab. 20 2000 1011 1032 (Pubitemid 30445613)
37. H. Takeda, S. Muto, T. Hattori, C. Sadakane, K. Tsuchiya, T. Katsurada, T. Ohkawara, N. Oridate, and M. Asaka Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition Endocrinology 151 2009 244 252
38. Y. Tanaka, R. Tanaka, M. Liu, N. Hattori, and T. Urabe Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia Neuroscience 171 2010 1367 1376
39. H. Uno, T. Matsuyama, H. Akita, H. Nishimura, and M. Sugita Induction of tumor necrosis factor-alpha in the mouse hippocampus following transient forebrain ischemia J. Cereb. Blood Flow Metab. 17 1997 491 499 (Pubitemid 27250975)
40. Q. Wang, X.N. Tang, and M.A. Yenari The inflammatory response in stroke J. Neuroimmunol. 184 2007 53 68 (Pubitemid 46365991)
41. J. Xu, S. Sato, S. Okuyama, R.J. Swan, M.T. Jacobsen, E. Strunk, and T. Ikezu Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice FASEB J. 24 2010 2904 2915
42. Y. Yamamoto, N. Shioda, F. Han, S. Moriguchi, A. Nakajima, A. Yokosuka, Y. Mimaki, Y. Sashida, T. Yamakuni, Y. Ohizumi, and K. Fukunaga Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation Brain Res. 1295 2009 218 229
43. I. Yonekura, N. Kawahara, H. Nakatomi, K. Furuya, and T. Kirino A model of global cerebral ischemia in C57 BL/6 mice J. Cereb. Blood Flow Metab. 24 2004 151 158 (Pubitemid 38199108)
44. S. Zola-Morgan, L.R. Squire, and D.G. Amaral Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus J. Neurosci. 6 1986 2950 2967 (Pubitemid 16026076)