HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves

Molecules

Volumn 15, Issue 6, 2010, Pages 4452-4466

  Yam, Mun Fei ^a,b   Lim, Vuanghao ^a   Salman, Ibrahim Muhammad ^a   Ameer, Omar Ziad ^a   Ang, Lee Fung ^a   Rosidah, Noersal ^c   Abdulkarim, Muthanna Fawzy ^a   Abdullah, Ghassan Zuhair ^a   Basir, Rusliza ^b   Sadikun, Amirin ^a   Asmawi, Mohd Zaini ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c UNIVERSITY OF SUMATERA UTARA   (Indonesia)

Author keywords

3' Hydroxy 5,6,7,4' tetramethoxyflavone; Anti inflammatory activity; Eupatorin; Orthosiphon stamineus; Peritoneal capillary permeability; Sinensetin

Indexed keywords

ANTIINFLAMMATORY AGENT; CARRAGEENAN; CHLOROFORM; FLAVONOID; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; EDEMA; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; ORTHOSIPHON; PLANT LEAF; RAT; CHEMICALLY INDUCED; TOXICITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CHLOROFORM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EDEMA; FEMALE; FLAVONOIDS; MALE; ORTHOSIPHON; PLANT EXTRACTS; PLANT LEAVES; RATS;

EID: 77954290401     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15064452     Document Type: Article

References (30)

1. Perry, L. M. Medicinal plants of East and Southeast Asia: Attributed Properties and Uses; The MIT Press: Cambridge, MA/London, UK, 1980.
2. Olah, N. K.; Radu, L.; Mogosan, C.; Hanganu D, Gocan S. Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts. J. Pharm. Biomed. Anal. 2003, 33, 117-123.
3. Tezuka, Y.; Stampoulis, P.; Banskota, A. H.; Awale, S.; Tran, K. Q.; Saiki, I.; Kadota, S. Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. Chem. Pharm. Bull. 2000, 48, 1711-1719.
4. Hollman, P. C.; Katan, M. B. Dietary flavonoids: intake, health effects and bioavailability. Food. Chem. Toxicol. 1999, 37, 937-942.
5. Lyckander, I. M.; Malterud, K. E. Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. Prostag. Leukot. Essent. Fatty acids 1996, 54, 239-246.
6. Schut, G. A.; Zwaving, J. H. Pharmacological investigation of some lipophilic flavonoids from Orthosiphon aristatus. Fitoterapia 1993, LXIV 2, 99-102.
7. Loon, Y. T.; Wong, J. W.; Yap, S. P.; Yuen, K. Y. Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection. J. Chromatogr. B 2005, 816, 161-166.
8. Awale, S.; Tezuka, Y.; Banskota, A. H.; Kouda, K.; Tun, K. M.; Kadota, S. Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar. J. Nat. Prod. 2001, 64, 592-596.
9. Awale, A.; Tezuka, Y.; Banskota, A. H.; Kouda, K.; Tun, K. M.; Kadota, S. Four Highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus. Planta Med. 2002, 68, 286-288. (Pubitemid 34271005)
10. Awale, S.; Tezuka, Y.; Banskota, A. H.; Shimoji, S.; Taira, K.; Kadota S. Norstaminane-and isopimarane-type diterpenes of Orthosiphon stamineus from Okinawa. Tetrahedron 2002, 58, 5503-5512. (Pubitemid 34671231)
11. Awale, A.; Tezuka, Y.; Kobayashi, M.; Ueda, J.; Kadota, S. Neoorthosiphonone A; a nitric oxide (NO) inhibitory diterpene with new carbon skeleton from Orthosiphon stamineus. Tetrahedron Lett. 2004, 45, 1359-1362.
12. Hussein, A. A.; Meyer, J. J. M.; Jimeno, M. L.; Rodríguez, B. Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea. J. Nat. Prod. 2007, 70, 293-295.
13. Masuda, T.; Masuda, K.; Shiragami, S.; Jitoe, A.; Nakatani, N. Orthosiphol A and B, novel diterpenoid inhibitors of TPA (12-O- tetradecanoylphorbol-13-acetate)-induced inflammation, from Orthosiphon stamineus. Tetrahedron 1992, 48, 6787-6792.
14. Yam, M. F.; Basir, R.; Asmawi, M. Z.; Ismail, Z. Antioixdant and hepatoprotective effects of Orthosiphon stamineus Benth standardized extract. Am. J. Chin. Med. 2007, 35, 117-128.
15. Sriplang, K.; Adisakwattana, S.; Rungsipipat, A.; Yibchok-anun, S. Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. J. Ethnopharm. 2007, 109, 510-514.
16. Abdullah, N. R.; Ismail, Z.; Ismail, Z. Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats. Phytomedicine 2009, 16, 222-226.
17. Di Rosa, M. Biological properties of carrageenan. J. Pharmacy Pharmacol. 1972, 24, 89-102.
18. Ozaki, Y. Anti-inflammatory effects of Curcuma xanthorrhiza Roxb, and its active principle. Chem. Pharm. Bull. 1990, 38, 1045-1048.
19. Di Rosa, M.; Giroud, J. P.; Willoughby, D. A. Study of the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine. J. Path. 1971, 104, 15-29.
20. Morris, C. J. Carrageenan-induced paw edema in the rat and mouse. Meth. Mol. Bio. 2003, 225, 115-121.
21. Demello, S. V. B.; Novaes, G. S.; Laurindo, I. M. M.; Muscará, M. N.; Maciel, F. M.; Cossermelli, W.; Nitric oxide synthase inhibitor influences prostaglandin and interleukin-1 production in experimental arthritis joints. Inflamm. Res. 1997, 46, 72-77.
22. Sautebin, L.; Ialenti, A.; Ianaro, A.; Di Rosa, M. Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema. Eur. J. Pharmacol. 1995, 286, 219-222.
23. Cuzzocrea, S.; Zingarelli, B.; Costantino, G.; Szabó, A.; Salzman, A. L.; Caputi, A. P.; Szabó, C. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br. J. Pharmacol. 1997, 121, 1065-1074.
24. van Acker, S. A. B. E.; van den Berg, D. J.; Tromp, M. N. J. L.; Griffioen, D. H.; van Bennekom, W. P.; van der Vijgh, W. J.; Bast, A. Structural aspects of antioxidant activity of flavonoids. Free Radical Bio. Med. 1996, 20, 331-342.
25. Sharp, J. T.; Gosney, I.; Rowley, A. G., Practical Organic Chemistry: A Student Handbook of Technique; Chapman and Hall: London, UK, 1989.
26. Winter, C. A.; Risley, E. A.; Nus, G. V. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drug. Proc. Soc. Exp. Biol. Med. 1962, 111, 544-547.
27. Whittle, B. A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Br. J. Pharmacol. Chemother. 1964, 22, 246-253.
28. Rockett, K. A.; Awburn, M. M.; Rockett, E. J.; Cowden, W. B.; Clark, I. A. Possible role of nitric oxide in malarial immunosuppression. Parasite Immunology 1994, 16, 243-249.
29. Ravishankara, M. N.; Shrivastava, N.; Padh, H.; Rajani, M. Evaluation of antioxidant properties of root bark of Hemidesmus indicus R. Br. (Anantmul) Phytomedicine 2002, 9, 153-160.
30. Szepesi, G. HPLC in Pharmaceutical Analysis; CRC Press Inc.: Boca Raton, FL, USA, 1990. Volume I.