5-Demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis

Molecular Nutrition and Food Research

Volumn 57, Issue 12, 2013, Pages 2103-2111

  Charoensinphon, Noppawat ^a   Qiu, Peiju ^a,b   Dong, Ping ^a   Zheng, Jinkai ^a   Ngauv, Pearline ^a   Cao, Yong ^c   Li, Shiming ^d   Ho, Chi Tang ^d   Xiao, Hang ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b OCEAN UNIVERSITY OF CHINA   (China)

^c SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

5 Demethyltangeretin; 5 Hydroxy 6,7,8,4 tetramethoxyflavone; Apoptosis; Lung cancer; Tangeretin

Indexed keywords

5 DEMETHYLTANGERETIN; 5-DEMETHYLTANGERETIN; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; FLAVONE DERIVATIVE; PROTEIN BAX; TANGERETIN;

5-HYDROXY-6,7,8,4′-TETRAMETHOXYFLAVONE; APOPTOSIS; ARTICLE; CELL CYCLE CHECKPOINT; DRUG EFFECT; HUMAN; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

5-DEMETHYLTANGERETIN; 5-HYDROXY-6,7,8,4′-TETRAMETHOXYFLAVONE; APOPTOSIS; LUNG CANCER; TANGERETIN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLAVONES; HUMANS; LUNG NEOPLASMS;

EID: 84889063108     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300136     Document Type: Article

References (34)

1. Li, S., Lo, C. Y., Ho, C. T., Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. J. Agric. Food Chem. 2006, 54, 4176-4185.
2. Li, S. M., Pan, M. H., Lo, C. Y., Tan, D. et al., Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones. J. Funct. Food 2009, 1, 2-12.
3. Li, S., Pan, M. H., Lai, C. S., Lo, C. Y. et al., Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg. Med. Chem. 2007, 15, 3381-3389.
4. Xiao, H., Yang, C. S., Li, S., Jin, H. et al., Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol. Nutr. Food Res. 2009, 53, 398-406.
5. Qiu, P., Dong, P., Guan, H., Li, S. et al., Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol. Nutr. Food Res. 2010, 54, S244-S252.
6. Qiu, P., Guan, H., Dong, P., Guo, S. et al., The inhibitory effects of 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone on human colon cancer cells. Mol. Nutr. Food Res. 2011, 55, 1523-1532.
7. Qiu, P., Guan, H., Dong, P., Li, S. et al., The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. Mol. Nutr. Food Res. 2011, 55, 613-622.
8. Sergeev, I. N., Ho, C. T., Li, S., Colby, J., Dushenkov, S., Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells. Mol. Nutr. Food Res. 2007, 51, 1478-1484.
9. Pan, M. H., Lai, Y. S., Lai, C. S., Wang, Y. J. et al., 5-Hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. J. Agric. Food Chem. 2007, 55, 5081-5091.
10. Jemal, A., Siegel, R., Ward, E., Hao, Y. et al. Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59, 225-249.
11. McCracken, M., Olsen, M., Chen, M. S., Jr., Jemal, A. et al., Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J. Clin. 2007, 57, 190-205.
12. Erridge, S. C., Moller, H., Price, A., Brewster, D., International comparisons of survival from lung cancer: pitfalls and warnings. Nat. Clin. Pract. Oncol. 2007, 4, 570-577.
13. Wang, Z., Li, S., Jonca, M., Lambros, T. et al., Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases. Biomed. Chromatogr. 2006, 20, 1206-1215.
14. Dong, P., Qiu, P., Zhu, Y., Li, S. et al., Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection. J. Chromatogr. A 2010, 1217, 642-647.
15. Nutakul, W., Sobers, H. S., Qiu, P., Dong, P. et al., Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. J. Agric. Food Chem. 2011, 59, 10964-10970.
16. Kandaswami, C., Perkins, E., Soloniuk, D. S., Drzewiecki, G., Middleton, E., Jr., Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. Cancer Lett. 1991, 56, 147-152.
17. Rodriguez, J., Yanez, J., Vicente, V., Alcaraz, M. et al., Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity. Melanoma Res. 2002, 12, 99-107.
18. Manthey, J. A., Guthrie, N., Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J. Agr. Food Chem. 2002, 50, 5837-5843.
19. Benavente-Garcia, O., Castillo, J., Alcaraz, M., Vicente, V. et al., Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways. Curr. Cancer Drug Tar. 2007, 7, 795-809.
20. Hanahan, D., Weinberg, R. A., The hallmarks of cancer. Cell 2000, 100, 57-70.
21. Hanahan, D., Weinberg, R. A., Hallmarks of cancer: the next generation. Cell 2011, 144, 646-674.
22. Eymin, B., Gazzeri, S., Role of cell cycle regulators in lung carcinogenesis. Cell Adh. Migr. 2010, 4, 114-123.
23. Malumbres, M., Barbacid, M., Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 2009, 9, 153-166.
24. Molinari, M., Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif. 2000, 33, 261-274.
25. Taylor, W. R., Stark, G. R., Regulation of the G2/M transition by p53. Oncogene 2001, 20, 1803-1815.
26. Charrier-Savournin, F. B., Chateau, M. T., Gire, V., Sedivy, J. et al., p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol. Biol. Cell 2004, 15, 3965-3976.
27. Taylor, W. R., Schonthal, A. H., Galante, J., Stark, G. R., p130/E2F4 binds to and represses the cdc2 promoter in response to p53. J. Biol. Chem. 2001, 276, 1998-2006.
28. Vousden, K. H., Ryan, K. M., p53 and metabolism. Nat. Rev. Cancer 2009, 9, 691-700.
29. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., Vogelstein, B., A model for p53-induced apoptosis. Nature 1997, 389, 300-305.
30. Liu, Y., Kulesz-Martin, M., p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding. Carcinogenesis 2001, 22, 851-860.
31. Taylor, W. R., DePrimo, S. E., Agarwal, A., Agarwal, M. L. et al., Mechanisms of G2 arrest in response to overexpression of p53. Mol. Biol. Cell 1999, 10, 3607-3622.
32. Innocente, S. A., Abrahamson, J. L., Cogswell, J. P., Lee, J. M., p53 regulates a G2 checkpoint through cyclin B1. Proc. Natl. Acad. Sci. USA 1999, 96, 2147-2152.
33. Abbas, T., Dutta, A., p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer 2009, 9, 400-414.
34. Scagliotti, G. V., Novello, S., Selvaggi, G., Multidrug resistance in non-small-cell lung cancer. Ann. Oncol. 1999, 10, S83-86.