A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents

Molecular Pharmacology

Volumn 79, Issue 2, 2011, Pages 279-289

  Phromnoi, Kanokkarn ^a   Reuter, Simone ^a   Sung, Bokyung ^a   Prasad, Sahdeo ^a   Kannappan, Ramaswamy ^b   Yadav, Vivek R ^a   Chanmahasathien, Wisinee ^b   Limtrakul, Pornngarm ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

5,3' DIHYDROXY 3,6,7,8,4' PENTAMETHOXYFLAVONE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLIN D1; CYCLOOXYGENASE 2; DNA; ESTERASE; FLAVONE DERIVATIVE; FLICE INHIBITORY PROTEIN; FLUOROURACIL; GELATINASE B; GENE PRODUCT; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PACLITAXEL; PROTEIN BCL XL; SURVIVIN; SYNAPTOTAGMIN I; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; VASCULOTROPIN; X LINKED INHIBITOR OF APOPTOSIS;

ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; GARDENIA; GARDENIA OBTUSIFOLIA; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SENSITIZATION; SIGNAL TRANSDUCTION; TUMOR CELL;

ANGIOGENESIS INDUCING AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; FLAVONOIDS; GENES, REPORTER; HUMANS; I-KAPPA B KINASE; IMMUNOHISTOCHEMISTRY; OLIGODEOXYRIBONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78751533767     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.067512     Document Type: Article

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