Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells

Molecular Carcinogenesis

Volumn 54, Issue 12, 2015, Pages 1734-1747

  Shrotriya, Sangeeta ^a   Deep, Gagan ^a,b   Lopert, Pamela ^a   Patel, Manisha ^a   Agarwal, Rajesh ^a,b   Agarwal, Chapla ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Autophagy; Bioenergetics; Grape seed extract; Head and neck squamous cell carcinoma; Oxidative stress

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ANTINEOPLASTIC AGENT; CASPASE 3; GLUTATHIONE; GRAPE SEED EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN COMPLEX III; MULTIENZYME COMPLEX; OXYGEN; SUPEROXIDE; UNCLASSIFIED DRUG; UBIQUINOL CYTOCHROME C REDUCTASE;

ACIDIFICATION; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL LYSATE; CELL METABOLISM; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFICACY; ENERGY METABOLISM; ENERGY YIELD; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; METABOLIC STRESS; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; TURNOVER TIME; ANIMAL; CARCINOMA, SQUAMOUS CELL; DRUG EFFECTS; HEAD AND NECK NEOPLASMS; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NUDE MOUSE; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CYTOPROTECTION; ELECTRON TRANSPORT COMPLEX III; GRAPE SEED EXTRACT; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, NUDE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TUMOR CELLS, CULTURED;

EID: 84944524138     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22246     Document Type: Article

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