-
1
-
-
0034987968
-
New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization
-
DOI 10.1002/path.862
-
Hermsen M, et al. New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization. J Pathol. 2001;194(2):177-182. (Pubitemid 32519967)
-
(2001)
Journal of Pathology
, vol.194
, Issue.2
, pp. 177-182
-
-
Hermsen, M.1
Guervs, M.A.2
Meijer, G.3
Baak, J.4
Van Diest, P.5
Marcos, C.A.6
Sampedro, A.7
-
3
-
-
32944464047
-
Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma
-
DOI 10.1158/1078-0432.CCR-05-2017
-
Slebos RJ, et al. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res. 2006;12(3 pt 1):701-709. (Pubitemid 43259848)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.3 I
, pp. 701-709
-
-
Slebos, R.J.C.1
Yi, Y.2
Ely, K.3
Carter, J.4
Evjen, A.5
Zhang, X.6
Shyr, Y.7
Murphy, B.M.8
Cmelak, A.J.9
Burkey, B.B.10
Netterville, J.L.11
Levy, S.12
Yarbrough, W.G.13
Chung, C.H.14
-
4
-
-
32644444748
-
Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus
-
Smeets SJ, et al. Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene. 2006;25(17):2558-2564.
-
(2006)
Oncogene
, vol.25
, Issue.17
, pp. 2558-2564
-
-
Smeets, S.J.1
-
5
-
-
39649109915
-
Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial
-
DOI 10.1093/jnci/djn011
-
Fakhry C, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100(4):261-269. (Pubitemid 351480538)
-
(2008)
Journal of the National Cancer Institute
, vol.100
, Issue.4
, pp. 261-269
-
-
Fakhry, C.1
Westra, W.H.2
Li, S.3
Cmelak, A.4
Ridge, J.A.5
Pinto, H.6
Forastiere, A.7
Gillison, M.L.8
-
6
-
-
70350656518
-
Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129
-
Gillison ML, et al. Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129. J Clin Oncol. 2009;27(suppl):15S.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Gillison, M.L.1
-
7
-
-
34247331367
-
High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma
-
DOI 10.1200/JCO.2005.04.6136
-
Licitra L, et al. High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol. 2006;24(36):5630-5636. (Pubitemid 46631302)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.36
, pp. 5630-5636
-
-
Licitra, L.1
Perrone, F.2
Bossi, P.3
Suardi, S.4
Mariani, L.5
Artusi, R.6
Oggionni, M.7
Rossini, C.8
Cantu, G.9
Squadrelli, M.10
Quattrone, P.11
Locati, L.D.12
Bergamini, C.13
Olmi, P.14
Pierotti, M.A.15
Pilotti, S.16
-
8
-
-
35548972994
-
Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
-
DOI 10.1056/NEJMoa070956
-
Posner MR, et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007;357(17):1705-1715. (Pubitemid 350005152)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.17
, pp. 1705-1715
-
-
Posner, M.R.1
Hershock, D.M.2
Blajman, C.R.3
Mickiewicz, E.4
Winquist, E.5
Gorbounova, V.6
Tjulandin, S.7
Shin, D.M.8
Cullen, K.9
Ervin, T.J.10
Murphy, B.A.11
Raez, L.E.12
Cohen, R.B.13
Spaulding, M.14
Tishler, R.B.15
Roth, B.16
Viroglio, R.D.C.17
Venkatesan, V.18
Romanov, I.19
Agarwala, S.20
Harter, K.W.21
Dugan, M.22
Cmelak, A.23
Markoe, A.M.24
Read, P.W.25
Steinbrenner, L.26
Colevas, A.D.27
Norris Jr., C.M.28
Haddad, R.I.29
more..
-
9
-
-
80052565730
-
Human papillomavirus and rising oropharyngeal cancer incidence in the United States
-
Chaturvedi AK, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294-4301.
-
(2011)
J Clin Oncol
, vol.29
, Issue.32
, pp. 4294-4301
-
-
Chaturvedi, A.K.1
-
10
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal N, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333(6046):1154-1157.
-
(2011)
Science
, vol.333
, Issue.6046
, pp. 1154-1157
-
-
Agrawal, N.1
-
11
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky N, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333(6046):1157-1160.
-
(2011)
Science
, vol.333
, Issue.6046
, pp. 1157-1160
-
-
Stransky, N.1
-
12
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
DOI 10.1016/j.cell.2004.11.006, PII S0092867404010487
-
Lang GA, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004;119(6):861-872. (Pubitemid 40017691)
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.-A.3
Liu, G.4
Rao, V.A.5
Parant, J.M.6
Valentin-Vega, Y.A.7
Terzian, T.8
Caldwell, L.C.9
Strong, L.C.10
El-Naggar, A.K.11
Lozano, G.12
-
13
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
DOI 10.1016/j.cell.2004.11.004, PII S0092867404010463
-
Olive KP, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004;119(6):847-860. (Pubitemid 40017690)
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
Crowley, D.7
Jacks, T.8
-
14
-
-
77955363995
-
TP53 mutations in human cancers: Origins, consequences, and clinical use
-
Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2(1):a001008.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, Issue.1
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
15
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
-
DOI 10.1002/humu.20495
-
Petitjean A, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Human Mutation. 2007;28(6):622-629. (Pubitemid 46744292)
-
(2007)
Human Mutation
, vol.28
, Issue.6
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
Hainaut, P.6
Olivier, M.7
-
16
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer. 2009;9(12):862-873.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.12
, pp. 862-873
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
17
-
-
0034814203
-
Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance
-
DOI 10.1016/S1368-8375(00)00122-6, PII S1368837500001226
-
Millon R, et al. Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance. Oral Oncol. 2001;37(8):620-631. (Pubitemid 32925196)
-
(2001)
Oral Oncology
, vol.37
, Issue.8
, pp. 620-631
-
-
Millon, R.1
Muller, D.2
Schultz, I.3
Salvi, R.4
Ghnassia, J.P.5
Frebourg, T.6
Wasylyk, B.7
Abecassis, J.8
-
18
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63(6):1129-1136. (Pubitemid 120035062)
-
(1990)
Cell
, vol.63
, Issue.6
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
19
-
-
0025271203
-
Association of human papillomavirus types 16 and 18 E6 proteins with p53
-
Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science. 1990;248(4951):76-79.
-
(1990)
Science
, vol.248
, Issue.4951
, pp. 76-79
-
-
Werness, B.A.1
Levine, A.J.2
Howley, P.M.3
-
21
-
-
0027853193
-
Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: A possible molecular basis for the development of multiple tumors
-
Nees M, et al. Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res. 1993;53(18):4189-4196. (Pubitemid 24146765)
-
(1993)
Cancer Research
, vol.53
, Issue.18
, pp. 4189-4196
-
-
Nees, M.1
Homann, N.2
Discher, H.3
Andl, T.4
Enders, C.5
Herold-Mende, C.6
Schuhmann, A.7
Bosch, F.X.8
-
22
-
-
79957879059
-
Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma
-
Lindenbergh-van der Plas M, et al. Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 2009;17(11):3733-3741.
-
(2009)
Clin Cancer Res
, vol.17
, Issue.11
, pp. 3733-3741
-
-
Lindenbergh-van Der Plas, M.1
-
23
-
-
37349055876
-
TP53 mutations and survival in squamous-cell carcinoma of the head and neck
-
DOI 10.1056/NEJMoa073770
-
Poeta ML, et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007;357(25):2552-2561. (Pubitemid 350294222)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.25
, pp. 2552-2561
-
-
Poeta, M.L.1
Manola, J.2
Goldwasser, M.A.3
Forastiere, A.4
Benoit, N.5
Califano, J.A.6
Ridge, J.A.7
Goodwin, J.8
Kenady, D.9
Saunders, J.10
Westra, W.11
Sidransky, D.12
Koch, W.M.13
-
24
-
-
79955467261
-
p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?
-
Perez-Sayans M, Suarez-Penaranda JM, Gayoso-Diz P, Barros-Angueira F, Gandara-Rey JM, Garcia-Garcia A. p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough? Cancer Lett. 2009;306(2):134-141.
-
(2009)
Cancer Lett
, vol.306
, Issue.2
, pp. 134-141
-
-
Perez-Sayans, M.1
Suarez-Penaranda, J.M.2
Gayoso-Diz, P.3
Barros-Angueira, F.4
Gandara-Rey, J.M.5
Garcia-Garcia, A.6
-
25
-
-
9444255067
-
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
-
Reed AL, et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res. 1996;56(16):3630-3633. (Pubitemid 26272001)
-
(1996)
Cancer Research
, vol.56
, Issue.16
, pp. 3630-3633
-
-
Reed, A.L.1
Califano, J.2
Cairns, P.3
Westra, W.H.4
Jones, R.M.5
Koch, W.6
Ahrendt, S.7
Eby, Y.8
Sewell, D.9
Nawroz, H.10
Bartek, J.11
Sidransky, D.12
-
26
-
-
67650737329
-
Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis
-
Smeets SJ, et al. Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis. Cell Oncol. 2009;31(4):291-300.
-
(2009)
Cell Oncol
, vol.31
, Issue.4
, pp. 291-300
-
-
Smeets, S.J.1
-
27
-
-
0141961918
-
Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors
-
DOI 10.1016/S0027-5107(03)00133-7
-
Dominguez G, et al. Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors. Mutat Res. 2003;530(1-2):9-17. (Pubitemid 37237504)
-
(2003)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.530
, Issue.1-2
, pp. 9-17
-
-
Dominguez, G.1
Silva, J.2
Garcia, J.M.3
Silva, J.M.4
Rodriguez, R.5
Munoz, C.6
Chacon, I.7
Sanchez, R.8
Carballido, J.9
Colas, A.10
Espana, P.11
Bonilla, F.12
-
28
-
-
0036793885
-
Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma
-
Ogi K, et al. Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Clin Cancer Res. 2002;8(10):3164-3171. (Pubitemid 35155026)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.10
, pp. 3164-3171
-
-
Ogi, K.1
Toyota, M.2
Ohe-Toyota, M.3
Tanaka, N.4
Noguchi, M.5
Sonoda, T.6
Kohama, G.7
Tokino, T.8
-
29
-
-
39449086075
-
ARF genes in prognosis of oral carcinoma
-
DOI 10.1158/1055-9965.EPI-07-0284
-
Sailasree R, Abhilash A, Sathyan KM, Nalinakumari KR, Thomas S, Kannan S. Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17(2):414-420. (Pubitemid 351272795)
-
(2008)
Cancer Epidemiology Biomarkers and Prevention
, vol.17
, Issue.2
, pp. 414-420
-
-
Sailasree, R.1
Abhilash, A.2
Sathyan, K.M.3
Nalinakumari, K.R.4
Thomas, S.5
Kannan, S.6
-
30
-
-
80053520906
-
Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: Sensitivity, specificity, and prognostic discrimination
-
Schache AG, et al. Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clin Cancer Res. 2011;17(19):6262-6271.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.19
, pp. 6262-6271
-
-
Schache, A.G.1
-
31
-
-
65549155414
-
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma
-
Sheu JJ, et al. Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res. 2009;69(6):2568-2576.
-
(2009)
Cancer Res
, vol.69
, Issue.6
, pp. 2568-2576
-
-
Sheu, J.J.1
-
32
-
-
20444439929
-
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment
-
DOI 10.1074/jbc.M500403200
-
Fu M, et al. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem. 2005;280(17):16934-16941. (Pubitemid 41389153)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.17
, pp. 16934-16941
-
-
Fu, M.1
Rao, M.2
Bouras, T.3
Wang, C.4
Wu, K.5
Zhang, X.6
Li, Z.7
Yao, T.-P.8
Pestell, R.G.9
-
33
-
-
79958254560
-
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
-
Jirawatnotai S, et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011;474(7350):230- 234.
-
(2011)
Nature
, vol.474
, Issue.7350
, pp. 230-234
-
-
Jirawatnotai, S.1
-
34
-
-
79960836823
-
Cyclin D as a therapeutic target in cancer
-
Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL. Cyclin D as a therapeutic target in cancer. Nat Rev Cancer. 2011;11(8):558-572.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.8
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
35
-
-
0032589742
-
Cyclin D1 and p16(INK4A) expression predict reduced survival in carcinoma of the anterior tongue
-
Bova RJ, et al. Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. Clin Cancer Res. 1999;5(10):2810-2819. (Pubitemid 29493956)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.10
, pp. 2810-2819
-
-
Bova, R.J.1
Quinn, D.I.2
Nankervis, J.S.3
Cole, I.E.4
Sheridan, B.F.5
Jensen, M.J.6
Morgan, G.J.7
Hughes, C.J.8
Sutherland, R.L.9
-
36
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;66(4):649-661. (Pubitemid 121001701)
-
(1991)
Cell
, vol.66
, Issue.4
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
Soreng, A.L.4
Reynolds, T.C.5
Smith, S.D.6
Sklar, J.7
-
37
-
-
65349090671
-
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
-
Lee SY, et al. Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci. 2009;100(5):920-926.
-
(2009)
Cancer Sci
, vol.100
, Issue.5
, pp. 920-926
-
-
Lee, S.Y.1
-
38
-
-
33745045658
-
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
-
DOI 10.1128/MCB.01655-05
-
Malecki MJ, et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol. 2006;26(12):4642-4651. (Pubitemid 43877581)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.12
, pp. 4642-4651
-
-
Malecki, M.J.1
Sanchez-Irizarry, C.2
Mitchell, J.L.3
Histen, G.4
Xu, M.L.5
Aster, J.C.6
Blacklow, S.C.7
-
39
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente XS, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101-105.
-
(2011)
Nature
, vol.475
, Issue.7354
, pp. 101-105
-
-
Puente, X.S.1
-
40
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
DOI 10.1126/science.1102160
-
Weng AP, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306(5694):269-271. (Pubitemid 39336870)
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris IV, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
41
-
-
79955915582
-
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
-
Klinakis A, et al. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011;473(7346):230-233.
-
(2011)
Nature
, vol.473
, Issue.7346
, pp. 230-233
-
-
Klinakis, A.1
-
42
-
-
33847211457
-
NOTCH1-induced T-cell leukemia in transgenic zebrafish
-
Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD. NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia. 2007;21(3):462-471.
-
(2007)
Leukemia
, vol.21
, Issue.3
, pp. 462-471
-
-
Chen, J.1
Jette, C.2
Kanki, J.P.3
Aster, J.C.4
Look, A.T.5
Griffin, J.D.6
-
43
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
DOI 10.1038/ng1099
-
Nicolas M, et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet. 2003;33(3):416-421. (Pubitemid 36278861)
-
(2003)
Nature Genetics
, vol.33
, Issue.3
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
Kummer, J.A.4
Mill, P.5
Van Noort, M.6
Hui, C.-C.7
Clevers, H.8
Dotto, G.P.9
Radtke, F.10
-
44
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
DOI 10.1084/jem.183.5.2283
-
Pear WS, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183(5):2283-2291. (Pubitemid 26158919)
-
(1996)
Journal of Experimental Medicine
, vol.183
, Issue.5
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
Hasserjian, R.P.4
Soffer, B.5
Sklar, J.6
Baltimore, D.7
-
45
-
-
50849104230
-
Notch tumor suppressor function
-
Dotto GP. Notch tumor suppressor function. Oncogene. 2008;27(38):5115- 5123.
-
(2008)
Oncogene
, vol.27
, Issue.38
, pp. 5115-5123
-
-
Dotto, G.P.1
-
46
-
-
22344436360
-
WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
-
DOI 10.1101/gad.341405
-
Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP. p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 2005;19(12):1485-1495. (Pubitemid 41003015)
-
(2005)
Genes and Development
, vol.19
, Issue.12
, pp. 1485-1495
-
-
Devgan, V.1
Mammucari, C.2
Millar, S.E.3
Brisken, C.4
Dotto, G.P.5
-
47
-
-
33847403486
-
Notch signaling is necessary for epithelial growth arrest by TGF-beta
-
DOI 10.1083/jcb.200612129
-
Niimi H, Pardali K, Vanlandewijck M, Heldin CH, Moustakas A. Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol. 2007;176(5):695-707. (Pubitemid 46333983)
-
(2007)
Journal of Cell Biology
, vol.176
, Issue.5
, pp. 695-707
-
-
Niimi, H.1
Pardali, K.2
Vanlandewijck, M.3
Heldin, C.-H.4
Moustakas, A.5
-
48
-
-
17844384528
-
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
-
DOI 10.1093/emboj/20.13.3427
-
Rangarajan A, et al. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 2001;20(13):3427-3436. (Pubitemid 32634350)
-
(2001)
EMBO Journal
, vol.20
, Issue.13
, pp. 3427-3436
-
-
Rangarajan, A.1
Talora, C.2
Okuyama, R.3
Nicolas, M.4
Mammucari, C.5
Oh, H.6
Aster, J.C.7
Krishna, S.8
Metzger, D.9
Chambon, P.10
Miele, L.11
Aguet, M.12
Radtke, F.13
Dotto, G.P.14
-
49
-
-
0036024023
-
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
-
Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002;9(8):842-855.
-
(2002)
Cell Death Differ
, vol.9
, Issue.8
, pp. 842-855
-
-
Nickoloff, B.J.1
Qin, J.Z.2
Chaturvedi, V.3
Denning, M.F.4
Bonish, B.5
Miele, L.6
-
50
-
-
0345166971
-
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
-
DOI 10.1083/jcb.200305112
-
Blokzijl A, et al. Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 2003;163(4):723-728. (Pubitemid 37517880)
-
(2003)
Journal of Cell Biology
, vol.163
, Issue.4
, pp. 723-728
-
-
Blokzijl, A.1
Dahlqvist, C.2
Reissmann, E.3
Falk, A.4
Moliner, A.5
Lendahl, U.6
Ibanez, C.F.7
-
51
-
-
33747014859
-
Growth suppression induced by Notch1 activation involves Wnt - beta-catenin down-regulation in human tongue carcinoma cells
-
DOI 10.1042/BC20060020
-
Duan L, Yao J, Wu X, Fan M. Growth suppression induced by Notch1 activation involves Wnt-betacatenin down-regulation in human tongue carcinoma cells. Biol Cell. 2006;98(8):479-490. (Pubitemid 44203907)
-
(2006)
Biology of the Cell
, vol.98
, Issue.8
, pp. 479-490
-
-
Duan, L.1
Yao, J.2
Wu, X.3
Fan, M.4
-
52
-
-
16244418366
-
Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways
-
DOI 10.1016/j.yexcr.2005.01.015
-
Talora C, et al. Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. Exp Cell Res. 2005;305(2):343-354. (Pubitemid 40462545)
-
(2005)
Experimental Cell Research
, vol.305
, Issue.2
, pp. 343-354
-
-
Talora, C.1
Cialfi, S.2
Segatto, O.3
Morrone, S.4
Kim, C.J.5
Frati, L.6
Dotto, G.P.7
Gulino, A.8
Screpanti, I.9
-
53
-
-
0036713311
-
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
-
DOI 10.1101/gad.988902
-
Talora C, Sgroi DC, Crum CP, Dotto GP. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 2002;16(17):2252-2263. (Pubitemid 35013088)
-
(2002)
Genes and Development
, vol.16
, Issue.17
, pp. 2252-2263
-
-
Talora, C.1
Sgroi, D.C.2
Crum, C.P.3
Paolo, D.G.4
-
54
-
-
0033594491
-
p63 is a p53 homologue required for limb and epidermal morphogenesis
-
DOI 10.1038/19531
-
Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999; 398(6729):708-713. (Pubitemid 29197649)
-
(1999)
Nature
, vol.398
, Issue.6729
, pp. 708-713
-
-
Mills, A.A.1
Zheng, B.2
Wang, X.-J.3
Vogel, H.4
Roop, D.R.5
Bradley, A.6
-
55
-
-
0033594485
-
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
-
DOI 10.1038/19539
-
Yang A, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999;398(6729):714-718. (Pubitemid 29197650)
-
(1999)
Nature
, vol.398
, Issue.6729
, pp. 714-718
-
-
Yang, A.1
Schweitzer, R.2
Sun, D.3
Kaghad, M.4
Walker, N.5
Bronson, R.T.6
Tabin, C.7
Sharpe, A.8
Caput, D.9
Crum, C.10
McKeon, F.11
-
56
-
-
34248175814
-
Regulation of Notch1 gene expression by p53 in epithelial cells
-
DOI 10.1128/MCB.02119-06
-
Yugawa T, Handa K, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T. Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol. 2007;27(10):3732-3742. (Pubitemid 46726180)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.10
, pp. 3732-3742
-
-
Yugawa, T.1
Handa, K.2
Narisawa-Saito, M.3
Ohno, S.-I.4
Fujita, M.5
Kiyono, T.6
-
57
-
-
67749093259
-
Crosstalk of Notch with p53 and p63 in cancer growth control
-
Dotto GP. Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer. 2009; 9(8):587-595.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.8
, pp. 587-595
-
-
Dotto, G.P.1
-
58
-
-
0042856236
-
Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray
-
DOI 10.1007/s00428-003-0859-2
-
Reis-Filho JS, Simpson PT, Martins A, Preto A, Gartner F, Schmitt FC. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch. 2003; 443(2):122-132. (Pubitemid 37056135)
-
(2003)
Virchows Archiv
, vol.443
, Issue.2
, pp. 122-132
-
-
Reis-Filho, J.S.1
Simpson, P.T.2
Martins, A.3
Preto, A.4
Gartner, F.5
Schmitt, F.C.6
-
59
-
-
17444390129
-
Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
-
DOI 10.1016/j.ccr.2005.02.019
-
Flores ER, et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell. 2005;7(4):363-373. (Pubitemid 40544653)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 363-373
-
-
Flores, E.R.1
Sengupta, S.2
Miller, J.B.3
Newman, J.J.4
Bronson, R.5
Crowley, D.6
Yang, A.7
McKeon, F.8
Jacks, T.9
-
60
-
-
33744830912
-
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
-
DOI 10.1073/pnas.0602477103
-
Keyes WM, et al. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A. 2006; 103(22):8435-8440. (Pubitemid 43838473)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.22
, pp. 8435-8440
-
-
Keyes, W.M.1
Vogel, H.2
Koster, M.I.3
Guo, X.4
Qi, Y.5
Petherbridge, K.M.6
Roop, D.R.7
Bradley, A.8
Mills, A.A.9
-
61
-
-
80055035200
-
DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance
-
Danilov AV, et al. DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance. PLoS One. 2011;6(10):e26815.
-
(2011)
PLoS One
, vol.6
, Issue.10
-
-
Danilov, A.V.1
-
62
-
-
33646385922
-
p63 and p73: Life and death in squamous cell carcinoma
-
Rocco JW, Ellisen LW. p63 and p73: life and death in squamous cell carcinoma. Cell Cycle. 2006; 5(9):936-940.
-
(2006)
Cell Cycle
, vol.5
, Issue.9
, pp. 936-940
-
-
Rocco, J.W.1
Ellisen, L.W.2
-
63
-
-
30344450404
-
p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
-
DOI 10.1016/j.ccr.2005.12.013, PII S1535610805003946
-
Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell. 2006;9(1):45-56. (Pubitemid 43069510)
-
(2006)
Cancer Cell
, vol.9
, Issue.1
, pp. 45-56
-
-
Rocco, J.W.1
Leong, C.-O.2
Kuperwasser, N.3
DeYoung, M.P.4
Ellisen, L.W.5
-
64
-
-
67650461955
-
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
-
Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J. 2009;28(13):1904-1915.
-
(2009)
EMBO J
, vol.28
, Issue.13
, pp. 1904-1915
-
-
Su, X.1
Cho, M.S.2
Gi, Y.J.3
Ayanga, B.A.4
Sherr, C.J.5
Flores, E.R.6
-
65
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
DOI 10.1126/science.275.5308.1943
-
Li J, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943-1947. (Pubitemid 27148818)
-
(1997)
Science
, vol.275
, Issue.5308
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
66
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
DOI 10.1038/ng0497-356
-
Steck PA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997;15(4):356-362. (Pubitemid 27147102)
-
(1997)
Nature Genetics
, vol.15
, Issue.4
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.A.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.F.14
Tavtigian, S.V.15
-
67
-
-
0032006029
-
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors
-
Okami K, et al. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res. 1998;58(3):509-511. (Pubitemid 28087415)
-
(1998)
Cancer Research
, vol.58
, Issue.3
, pp. 509-511
-
-
Okami, K.1
Wu, L.2
Riggins, G.3
Cairns, P.4
Goggins, M.5
Evron, E.6
Halachmi, N.7
Ahrendt, S.A.8
Reed, A.L.9
Hilgers, W.10
Kern, S.E.11
Koch, W.M.12
Sidransky, D.13
Jen, J.14
-
68
-
-
0031822378
-
Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma
-
DOI 10.1002/(SICI)1097-0215(19980831)77:5<684::AID-IJC4>3.0.CO;2-R
-
Shao X, et al. Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma. Int J Cancer. 1998;77(5):684-688. (Pubitemid 28341383)
-
(1998)
International Journal of Cancer
, vol.77
, Issue.5
, pp. 684-688
-
-
Shao, X.1
Tandon, R.2
Samara, G.3
Kanki, H.4
Yano, H.5
Close, L.G.6
Parsons, R.7
Sato, T.8
-
69
-
-
80051680291
-
A continuum model for tumour suppression
-
Berger AH, Knudson AG, Pandolfi PP. A continuum model for tumour suppression. Nature. 2011; 476(7359):163-169.
-
(2011)
Nature
, vol.476
, Issue.7359
, pp. 163-169
-
-
Berger, A.H.1
Knudson, A.G.2
Pandolfi, P.P.3
-
70
-
-
33645084781
-
PIK3CA mutations in head and neck squamous cell carcinoma
-
Qiu W, et al. PIK3CA mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 2006; 12(5):1441-1446.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.5
, pp. 1441-1446
-
-
Qiu, W.1
-
71
-
-
38749089046
-
Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer
-
DOI 10.1002/ijc.23217
-
Qiu W, Tong GX, Manolidis S, Close LG, Assaad AM, Su GH. Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer. Int J Cancer. 2008;122(5):1189-1194. (Pubitemid 351214020)
-
(2008)
International Journal of Cancer
, vol.122
, Issue.5
, pp. 1189-1194
-
-
Qiu, W.1
Tong, G.-X.2
Manolidis, S.3
Close, L.G.4
Assaad, A.M.5
Su, G.H.6
-
72
-
-
79958132520
-
PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
-
Henken FE, et al. PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro. Mol Cancer. 2011;10:71.
-
(2011)
Mol Cancer
, vol.10
, pp. 71
-
-
Henken, F.E.1
-
73
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009;9(8):550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.8
, pp. 550-562
-
-
Engelman, J.A.1
-
74
-
-
0025732716
-
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India
-
Saranath D, et al. High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. Br J Cancer. 1991;63(4):573-578.
-
(1991)
Br J Cancer
, vol.63
, Issue.4
, pp. 573-578
-
-
Saranath, D.1
-
75
-
-
0026474705
-
Prevalence of RAS oncogene mutation in head and neck carcinomas
-
Anderson JA, Irish JC, Ngan BY. Prevalence of RAS oncogene mutation in head and neck carcinomas. J Otolaryngol. 1992;21(5):321-326.
-
(1992)
J Otolaryngol
, vol.21
, Issue.5
, pp. 321-326
-
-
Anderson, J.A.1
Irish, J.C.2
Ngan, B.Y.3
-
76
-
-
0028278057
-
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas
-
Anderson JA, Irish JC, McLachlin CM, Ngan BY. H-ras oncogene mutation and human papillomavirus infection in oral carcinomas. Arch Otolaryngol Head Neck Surg. 1994;120(7):755-760. (Pubitemid 24217590)
-
(1994)
Archives of Otolaryngology - Head and Neck Surgery
, vol.120
, Issue.7
, pp. 755-760
-
-
Anderson, J.A.1
Irish, J.C.2
McLachlin, C.M.3
Ngan, B.Y.4
-
77
-
-
33749354957
-
Mouse models for human head and neck squamous cell carcinomas
-
DOI 10.1002/hed.20397
-
Lu S-L, Herrington H, Wang X-J. Mouse models for human head and neck squamous cell carcinomas. Head Neck. 2006;28(10):945-954. (Pubitemid 44497871)
-
(2006)
Head and Neck
, vol.28
, Issue.10
, pp. 945-954
-
-
Lu, S.-L.1
Herrington, H.2
Wang, X.-J.3
-
78
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie DA, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009;462(7269):108-112.
-
(2009)
Nature
, vol.462
, Issue.7269
, pp. 108-112
-
-
Barbie, D.A.1
-
79
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
Scholl C, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 2009; 137(5):821-834.
-
(2009)
Cell
, vol.137
, Issue.5
, pp. 821-834
-
-
Scholl, C.1
-
80
-
-
65649108558
-
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
-
Singh A, et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell. 2009;15(6):489-500.
-
(2009)
Cancer Cell
, vol.15
, Issue.6
, pp. 489-500
-
-
Singh, A.1
-
81
-
-
78649469283
-
Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck
-
Sharafinski ME, Ferris RL, Ferrone S, Grandis JR. Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck. Head Neck. 2010;32(10):1412-1421.
-
(2010)
Head Neck
, vol.32
, Issue.10
, pp. 1412-1421
-
-
Sharafinski, M.E.1
Ferris, R.L.2
Ferrone, S.3
Grandis, J.R.4
-
82
-
-
77954706620
-
Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer
-
Taoudi Benchekroun M, et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila). 2010;3(7):800-809.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, Issue.7
, pp. 800-809
-
-
Taoudi Benchekroun, M.1
-
83
-
-
34250155320
-
Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
-
DOI 10.1200/JCO.2006.06.6605
-
Temam S, et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol. 2007;25(16):2164-2170. (Pubitemid 46954638)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.16
, pp. 2164-2170
-
-
Temam, S.1
Kawaguchi, H.2
El-Naggar, A.K.3
Jelinek, J.4
Tang, H.5
Liu, D.D.6
Lang, W.7
Issa, J.-P.8
Lee, J.J.9
Mao, L.10
-
84
-
-
33748653109
-
Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
-
DOI 10.1200/JCO.2006.07.2587
-
Chung CH, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol. 2006;24(25):4170-4176. (Pubitemid 46622295)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.25
, pp. 4170-4176
-
-
Chung, C.H.1
Ely, K.2
McGavran, L.3
Varella-Garcia, M.4
Parker, J.5
Parker, N.6
Jarrett, C.7
Carter, J.8
Murphy, B.A.9
Netterville, J.10
Burkey, B.B.11
Sinard, R.12
Cmelak, A.13
Levy, S.14
Yarbrough, W.G.15
Slebos, R.J.C.16
Hirsch, F.R.17
-
85
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
DOI 10.1056/NEJMoa053422
-
Bonner JA, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567-578. (Pubitemid 43209104)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.6
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
Jones, C.U.7
Sur, R.8
Raben, D.9
Jassem, J.10
Ove, R.11
Kies, M.S.12
Baselga, J.13
Youssoufian, H.14
Amellal, N.15
Rowinsky, E.K.16
Ang, K.K.17
-
86
-
-
79955496795
-
Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study
-
Licitra L, et al. Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study. Ann Oncol. 2011;22(5):1078-1087.
-
(2011)
Ann Oncol
, vol.22
, Issue.5
, pp. 1078-1087
-
-
Licitra, L.1
-
87
-
-
28144437798
-
Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR
-
Cohen EE, et al. Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR. Clin Cancer Res. 2005;11(22):8105-8108.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.22
, pp. 8105-8108
-
-
Cohen, E.E.1
-
88
-
-
0037674062
-
Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
-
DOI 10.1200/JCO.2003.10.051
-
Cohen EE, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2003;21(10):1980- 1987. (Pubitemid 46606387)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.10
, pp. 1980-1987
-
-
Cohen, E.E.W.1
Rosen, F.2
Stadler, W.M.3
Recant, W.4
Stenson, K.5
Huo, D.6
Vokes, E.E.7
-
89
-
-
33644842102
-
Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer
-
DOI 10.1038/sj.bjc.6602999, PII 6602999
-
Kirby AM, et al. Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer. Br J Cancer. 2006;94(5):631-636. (Pubitemid 43361892)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.5
, pp. 631-636
-
-
Kirby, A.M.1
A'Hern, R.P.2
D'Ambrosio, C.3
Tanay, M.4
Syrigos, K.N.5
Rogers, S.J.6
Box, C.7
Eccles, S.A.8
Nutting, C.M.9
Harrington, K.J.10
-
90
-
-
1842772526
-
Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
-
DOI 10.1200/JCO.2004.06.075
-
Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol. 2004;22(1):77-85. (Pubitemid 41095117)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.1
, pp. 77-85
-
-
Soulieres, D.1
Senzer, N.N.2
Vokes, E.E.3
Hidalgo, M.4
Agarvala, S.S.5
Siu, L.L.6
-
91
-
-
27244432279
-
Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Wirth LJ, et al. Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2005;23(28):6976-6981.
-
(2005)
J Clin Oncol
, vol.23
, Issue.28
, pp. 6976-6981
-
-
Wirth, L.J.1
-
92
-
-
33749035470
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
-
DOI 10.1158/1078-0432.CCR-06-0913
-
Sok JC, et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006;12(17):5064-5073. (Pubitemid 44453332)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.17
, pp. 5064-5073
-
-
Sok, J.C.1
Coppelli, F.M.2
Thomas, S.M.3
Lango, M.N.4
Xi, S.5
Hunt, J.L.6
Freilino, M.L.7
Graner, M.W.8
Wikstrand, C.J.9
Bigner, D.D.10
Gooding, W.E.11
Furnari, F.B.12
Grandis, J.R.13
-
93
-
-
70349436013
-
Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
-
Hama T, et al. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist. 2009;14(9):900-908.
-
(2009)
Oncologist
, vol.14
, Issue.9
, pp. 900-908
-
-
Hama, T.1
-
94
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
DOI 10.1056/NEJMoa051918
-
Mellinghoff IK, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005;353(19):2012-2024. (Pubitemid 41609094)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.19
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
Haas-Kogan, D.A.4
Zhu, S.5
Dia, E.Q.6
Lu, K.V.7
Yoshimoto, K.8
Huang, J.H.Y.9
Chute, D.J.10
Riggs, B.L.11
Horvath, S.12
Liau, L.M.13
Cavenee, W.K.14
Nagesh, R.P.15
Beroukhim, R.16
Peck, T.C.17
Lee, J.C.18
Sellers, W.R.19
Stokoe, D.20
Prados, M.21
Cloughesy, T.F.22
Sawyers, C.L.23
Mischel, P.S.24
more..
-
95
-
-
66149135285
-
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
-
Seiwert TY, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009;69(7):3021-3031.
-
(2009)
Cancer Res
, vol.69
, Issue.7
, pp. 3021-3031
-
-
Seiwert, T.Y.1
-
96
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman JA, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316(5827):1039-1043. (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
97
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693-1703.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1693-1703
-
-
Kwak, E.L.1
-
98
-
-
0041323118
-
Inactivating mutations of caspase-8 gene in colorectal carcinomas
-
DOI 10.1016/S0016-5085(03)01059-X
-
Kim HS, et al. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology. 2003;125(3):708-715. (Pubitemid 37070689)
-
(2003)
Gastroenterology
, vol.125
, Issue.3
, pp. 708-715
-
-
Kim, H.S.1
Lee, J.W.2
Soung, Y.H.3
Park, W.S.4
Kim, S.Y.5
Lee, J.H.6
Park, J.Y.7
Cho, Y.G.8
Kim, C.J.9
Jeong, S.W.10
Nam, S.W.11
Kim, S.H.12
Lee, J.Y.13
Yoo, N.J.14
Lee, S.H.15
-
99
-
-
13444309090
-
CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas
-
Soung YH, et al. CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res. 2005;65(3):815-821.
-
(2005)
Cancer Res
, vol.65
, Issue.3
, pp. 815-821
-
-
Soung, Y.H.1
-
100
-
-
30944444113
-
Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
-
DOI 10.1016/j.cytogfr.2005.09.009, PII S1359610105001139
-
Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 2006; 17(1-2):41-58. (Pubitemid 43117515)
-
(2006)
Cytokine and Growth Factor Reviews
, vol.17
, Issue.1-2
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
101
-
-
0031410093
-
Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck
-
DOI 10.1093/carcin/18.11.2285
-
Wang D, Song H, Evans JA, Lang JC, Schuller DE, Weghorst CM. Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck. Carcinogenesis. 1997;18(11):2285-2290. (Pubitemid 28134761)
-
(1997)
Carcinogenesis
, vol.18
, Issue.11
, pp. 2285-2290
-
-
Wang, D.1
Song, H.2
Evans, J.A.3
Lang, J.C.4
Schuller, D.E.5
Weghorst, C.M.6
-
102
-
-
33845683318
-
Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4
-
DOI 10.1016/j.canlet.2006.01.003, PII S0304383506000279
-
Qiu W, Schonleben F, Li X, Su GH. Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4. Cancer Lett. 2007;245(1-2):163-170. (Pubitemid 44959352)
-
(2007)
Cancer Letters
, vol.245
, Issue.1-2
, pp. 163-170
-
-
Qiu, W.1
Schonleben, F.2
Li, X.3
Su, G.H.4
-
103
-
-
70449338760
-
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
-
Bornstein S, et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009;119(11):3408-3419.
-
(2009)
J Clin Invest
, vol.119
, Issue.11
, pp. 3408-3419
-
-
Bornstein, S.1
-
104
-
-
33646537475
-
Loss of transforming growth factorbeta type II receptor promotes metastatic headand-neck squamous cell carcinoma
-
Lu SL, et al. Loss of transforming growth factorbeta type II receptor promotes metastatic headand-neck squamous cell carcinoma. Genes Dev. 2006;20(10):1331-1342.
-
(2006)
Genes Dev
, vol.20
, Issue.10
, pp. 1331-1342
-
-
Lu, S.L.1
-
105
-
-
22144490495
-
1-mediated epithelial-to- mesenchymal transition and metastasis during skin carcinogenesis
-
DOI 10.1172/JCI24399
-
Han G, et al. Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest. 2005;115(7):1714-1723. (Pubitemid 40979710)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.7
, pp. 1714-1723
-
-
Han, G.1
Lu, S.-L.2
Li, A.G.3
He, W.4
Corless, C.L.5
Kulesz-Martin, M.6
Wang, X.-J.7
-
106
-
-
34547101487
-
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
-
DOI 10.1038/sj.onc.1210330, PII 1210330
-
Nakaya K, et al. Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene. 2007;26(36):5300-5308. (Pubitemid 47237625)
-
(2007)
Oncogene
, vol.26
, Issue.36
, pp. 5300-5308
-
-
Nakaya, K.1
Yamagata, H.D.2
Arita, N.3
Nakashiro, K.-I.4
Nose, M.5
Miki, T.6
Hamakawa, H.7
-
107
-
-
77950280030
-
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
-
Rothenberg SM, et al. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010;70(6):2158-2164.
-
(2010)
Cancer Res
, vol.70
, Issue.6
, pp. 2158-2164
-
-
Rothenberg, S.M.1
-
108
-
-
80052029516
-
Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma
-
Morin RD, et al. Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma. Nature. 2011;476(7360):298-303.
-
(2011)
Nature
, vol.476
, Issue.7360
, pp. 298-303
-
-
Morin, R.D.1
-
109
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009;41(5):521-523.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 521-523
-
-
Van Haaften, G.1
-
110
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela I, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 2011;469(7331):539-542.
-
(2011)
Nature
, vol.469
, Issue.7331
, pp. 539-542
-
-
Varela, I.1
-
111
-
-
4444291843
-
Detection of large-scale variation in the human genome
-
DOI 10.1038/ng1416
-
Iafrate AJ, et al. Detection of large-scale variation in the human genome. Nat Genet. 2004;36(9):949-951. (Pubitemid 39167488)
-
(2004)
Nature Genetics
, vol.36
, Issue.9
, pp. 949-951
-
-
Iafrate, A.J.1
Feuk, L.2
Rivera, M.N.3
Listewnik, M.L.4
Donahoe, P.K.5
Qi, Y.6
Scherer, S.W.7
Lee, C.8
-
112
-
-
51649107126
-
Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas
-
Marme A, et al. Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas. Int J Cancer. 2008;123(9):2048-2056.
-
(2008)
Int J Cancer
, vol.123
, Issue.9
, pp. 2048-2056
-
-
Marme, A.1
-
113
-
-
79959873016
-
Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival
-
Masica DL, Karchin R. Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival. Cancer Res. 2011;71(13):4550-4561.
-
(2011)
Cancer Res
, vol.71
, Issue.13
, pp. 4550-4561
-
-
Masica, D.L.1
Karchin, R.2
-
114
-
-
58149265465
-
Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers
-
Yonesaka K, et al. Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers. Clin Cancer Res. 2008;14(21):6963-6973.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.21
, pp. 6963-6973
-
-
Yonesaka, K.1
-
116
-
-
79955514313
-
Survival and human papillomavirus in oropharynx cancer in TAX 324: A subset analysis from an international phase III trial
-
Posner MR, et al. Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol. 2011;22(5):1071-1077.
-
(2011)
Ann Oncol
, vol.22
, Issue.5
, pp. 1071-1077
-
-
Posner, M.R.1
-
117
-
-
33644840089
-
Bexarotene and erlotinib for aerodigestive tract cancer
-
DOI 10.1200/JCO.2005.01.9521
-
Dragnev KH, et al. Bexarotene and erlotinib for aerodigestive tract cancer. J Clin Oncol. 2005; 23(34):8757-8764. (Pubitemid 46211521)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.34
, pp. 8757-8764
-
-
Dragnev, K.H.1
Petty, W.J.2
Shah, S.3
Biddle, A.4
Desai, N.B.5
Memoli, V.6
Rigas, J.R.7
Dmitrovsky, E.8
-
118
-
-
70449105984
-
Suppression of cancer cell growth by promoting cyclin D1 degradation
-
Shan J, Zhao W, Gu W. Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell. 2009;36(3):469-476.
-
(2009)
Mol Cell
, vol.36
, Issue.3
, pp. 469-476
-
-
Shan, J.1
Zhao, W.2
Gu, W.3
-
119
-
-
65449144050
-
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
-
Lambert JM, et al. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell. 2009;15(5):376-388.
-
(2009)
Cancer Cell
, vol.15
, Issue.5
, pp. 376-388
-
-
Lambert, J.M.1
-
120
-
-
37549040575
-
The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
-
Verdine GL, Walensky LD. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. Clin Cancer Res. 2007;13(24):7264-7270.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.24
, pp. 7264-7270
-
-
Verdine, G.L.1
Walensky, L.D.2
|