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Volumn 122, Issue 6, 2012, Pages 1951-1957

The molecular pathogenesis of head and neck squamous cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CETUXIMAB; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P16; PROTEIN P21; PROTEIN P53; PROTEIN P63; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3;

EID: 84861805678     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59889     Document Type: Review
Times cited : (299)

References (120)
  • 1
    • 0034987968 scopus 로고    scopus 로고
    • New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization
    • DOI 10.1002/path.862
    • Hermsen M, et al. New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization. J Pathol. 2001;194(2):177-182. (Pubitemid 32519967)
    • (2001) Journal of Pathology , vol.194 , Issue.2 , pp. 177-182
    • Hermsen, M.1    Guervs, M.A.2    Meijer, G.3    Baak, J.4    Van Diest, P.5    Marcos, C.A.6    Sampedro, A.7
  • 4
    • 32644444748 scopus 로고    scopus 로고
    • Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus
    • Smeets SJ, et al. Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene. 2006;25(17):2558-2564.
    • (2006) Oncogene , vol.25 , Issue.17 , pp. 2558-2564
    • Smeets, S.J.1
  • 6
    • 70350656518 scopus 로고    scopus 로고
    • Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129
    • Gillison ML, et al. Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129. J Clin Oncol. 2009;27(suppl):15S.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Gillison, M.L.1
  • 9
    • 80052565730 scopus 로고    scopus 로고
    • Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    • Chaturvedi AK, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294-4301.
    • (2011) J Clin Oncol , vol.29 , Issue.32 , pp. 4294-4301
    • Chaturvedi, A.K.1
  • 10
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333(6046):1154-1157.
    • (2011) Science , vol.333 , Issue.6046 , pp. 1154-1157
    • Agrawal, N.1
  • 11
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • Stransky N, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333(6046):1157-1160.
    • (2011) Science , vol.333 , Issue.6046 , pp. 1157-1160
    • Stransky, N.1
  • 14
    • 77955363995 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: Origins, consequences, and clinical use
    • Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2(1):a001008.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.1
    • Olivier, M.1    Hollstein, M.2    Hainaut, P.3
  • 15
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • DOI 10.1002/humu.20495
    • Petitjean A, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Human Mutation. 2007;28(6):622-629. (Pubitemid 46744292)
    • (2007) Human Mutation , vol.28 , Issue.6 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6    Olivier, M.7
  • 18
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63(6):1129-1136. (Pubitemid 120035062)
    • (1990) Cell , vol.63 , Issue.6 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 19
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science. 1990;248(4951):76-79.
    • (1990) Science , vol.248 , Issue.4951 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 21
    • 0027853193 scopus 로고
    • Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: A possible molecular basis for the development of multiple tumors
    • Nees M, et al. Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res. 1993;53(18):4189-4196. (Pubitemid 24146765)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4189-4196
    • Nees, M.1    Homann, N.2    Discher, H.3    Andl, T.4    Enders, C.5    Herold-Mende, C.6    Schuhmann, A.7    Bosch, F.X.8
  • 22
    • 79957879059 scopus 로고    scopus 로고
    • Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma
    • Lindenbergh-van der Plas M, et al. Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 2009;17(11):3733-3741.
    • (2009) Clin Cancer Res , vol.17 , Issue.11 , pp. 3733-3741
    • Lindenbergh-van Der Plas, M.1
  • 26
    • 67650737329 scopus 로고    scopus 로고
    • Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis
    • Smeets SJ, et al. Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis. Cell Oncol. 2009;31(4):291-300.
    • (2009) Cell Oncol , vol.31 , Issue.4 , pp. 291-300
    • Smeets, S.J.1
  • 30
    • 80053520906 scopus 로고    scopus 로고
    • Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: Sensitivity, specificity, and prognostic discrimination
    • Schache AG, et al. Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clin Cancer Res. 2011;17(19):6262-6271.
    • (2011) Clin Cancer Res , vol.17 , Issue.19 , pp. 6262-6271
    • Schache, A.G.1
  • 31
    • 65549155414 scopus 로고    scopus 로고
    • Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma
    • Sheu JJ, et al. Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res. 2009;69(6):2568-2576.
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2568-2576
    • Sheu, J.J.1
  • 32
    • 20444439929 scopus 로고    scopus 로고
    • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment
    • DOI 10.1074/jbc.M500403200
    • Fu M, et al. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem. 2005;280(17):16934-16941. (Pubitemid 41389153)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 16934-16941
    • Fu, M.1    Rao, M.2    Bouras, T.3    Wang, C.4    Wu, K.5    Zhang, X.6    Li, Z.7    Yao, T.-P.8    Pestell, R.G.9
  • 33
    • 79958254560 scopus 로고    scopus 로고
    • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    • Jirawatnotai S, et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011;474(7350):230- 234.
    • (2011) Nature , vol.474 , Issue.7350 , pp. 230-234
    • Jirawatnotai, S.1
  • 36
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;66(4):649-661. (Pubitemid 121001701)
    • (1991) Cell , vol.66 , Issue.4 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6    Sklar, J.7
  • 37
    • 65349090671 scopus 로고    scopus 로고
    • Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
    • Lee SY, et al. Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci. 2009;100(5):920-926.
    • (2009) Cancer Sci , vol.100 , Issue.5 , pp. 920-926
    • Lee, S.Y.1
  • 39
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101-105.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 101-105
    • Puente, X.S.1
  • 41
    • 79955915582 scopus 로고    scopus 로고
    • A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    • Klinakis A, et al. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011;473(7346):230-233.
    • (2011) Nature , vol.473 , Issue.7346 , pp. 230-233
    • Klinakis, A.1
  • 45
    • 50849104230 scopus 로고    scopus 로고
    • Notch tumor suppressor function
    • Dotto GP. Notch tumor suppressor function. Oncogene. 2008;27(38):5115- 5123.
    • (2008) Oncogene , vol.27 , Issue.38 , pp. 5115-5123
    • Dotto, G.P.1
  • 46
    • 22344436360 scopus 로고    scopus 로고
    • WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
    • DOI 10.1101/gad.341405
    • Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP. p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 2005;19(12):1485-1495. (Pubitemid 41003015)
    • (2005) Genes and Development , vol.19 , Issue.12 , pp. 1485-1495
    • Devgan, V.1    Mammucari, C.2    Millar, S.E.3    Brisken, C.4    Dotto, G.P.5
  • 49
    • 0036024023 scopus 로고    scopus 로고
    • Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    • Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002;9(8):842-855.
    • (2002) Cell Death Differ , vol.9 , Issue.8 , pp. 842-855
    • Nickoloff, B.J.1    Qin, J.Z.2    Chaturvedi, V.3    Denning, M.F.4    Bonish, B.5    Miele, L.6
  • 50
    • 0345166971 scopus 로고    scopus 로고
    • Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    • DOI 10.1083/jcb.200305112
    • Blokzijl A, et al. Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 2003;163(4):723-728. (Pubitemid 37517880)
    • (2003) Journal of Cell Biology , vol.163 , Issue.4 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3    Falk, A.4    Moliner, A.5    Lendahl, U.6    Ibanez, C.F.7
  • 51
    • 33747014859 scopus 로고    scopus 로고
    • Growth suppression induced by Notch1 activation involves Wnt - beta-catenin down-regulation in human tongue carcinoma cells
    • DOI 10.1042/BC20060020
    • Duan L, Yao J, Wu X, Fan M. Growth suppression induced by Notch1 activation involves Wnt-betacatenin down-regulation in human tongue carcinoma cells. Biol Cell. 2006;98(8):479-490. (Pubitemid 44203907)
    • (2006) Biology of the Cell , vol.98 , Issue.8 , pp. 479-490
    • Duan, L.1    Yao, J.2    Wu, X.3    Fan, M.4
  • 53
    • 0036713311 scopus 로고    scopus 로고
    • Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
    • DOI 10.1101/gad.988902
    • Talora C, Sgroi DC, Crum CP, Dotto GP. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 2002;16(17):2252-2263. (Pubitemid 35013088)
    • (2002) Genes and Development , vol.16 , Issue.17 , pp. 2252-2263
    • Talora, C.1    Sgroi, D.C.2    Crum, C.P.3    Paolo, D.G.4
  • 54
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • DOI 10.1038/19531
    • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999; 398(6729):708-713. (Pubitemid 29197649)
    • (1999) Nature , vol.398 , Issue.6729 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.-J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 57
    • 67749093259 scopus 로고    scopus 로고
    • Crosstalk of Notch with p53 and p63 in cancer growth control
    • Dotto GP. Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer. 2009; 9(8):587-595.
    • (2009) Nat Rev Cancer , vol.9 , Issue.8 , pp. 587-595
    • Dotto, G.P.1
  • 58
    • 0042856236 scopus 로고    scopus 로고
    • Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray
    • DOI 10.1007/s00428-003-0859-2
    • Reis-Filho JS, Simpson PT, Martins A, Preto A, Gartner F, Schmitt FC. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch. 2003; 443(2):122-132. (Pubitemid 37056135)
    • (2003) Virchows Archiv , vol.443 , Issue.2 , pp. 122-132
    • Reis-Filho, J.S.1    Simpson, P.T.2    Martins, A.3    Preto, A.4    Gartner, F.5    Schmitt, F.C.6
  • 61
    • 80055035200 scopus 로고    scopus 로고
    • DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance
    • Danilov AV, et al. DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance. PLoS One. 2011;6(10):e26815.
    • (2011) PLoS One , vol.6 , Issue.10
    • Danilov, A.V.1
  • 62
    • 33646385922 scopus 로고    scopus 로고
    • p63 and p73: Life and death in squamous cell carcinoma
    • Rocco JW, Ellisen LW. p63 and p73: life and death in squamous cell carcinoma. Cell Cycle. 2006; 5(9):936-940.
    • (2006) Cell Cycle , vol.5 , Issue.9 , pp. 936-940
    • Rocco, J.W.1    Ellisen, L.W.2
  • 63
    • 30344450404 scopus 로고    scopus 로고
    • p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    • DOI 10.1016/j.ccr.2005.12.013, PII S1535610805003946
    • Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell. 2006;9(1):45-56. (Pubitemid 43069510)
    • (2006) Cancer Cell , vol.9 , Issue.1 , pp. 45-56
    • Rocco, J.W.1    Leong, C.-O.2    Kuperwasser, N.3    DeYoung, M.P.4    Ellisen, L.W.5
  • 64
    • 67650461955 scopus 로고    scopus 로고
    • Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
    • Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J. 2009;28(13):1904-1915.
    • (2009) EMBO J , vol.28 , Issue.13 , pp. 1904-1915
    • Su, X.1    Cho, M.S.2    Gi, Y.J.3    Ayanga, B.A.4    Sherr, C.J.5    Flores, E.R.6
  • 69
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • Berger AH, Knudson AG, Pandolfi PP. A continuum model for tumour suppression. Nature. 2011; 476(7359):163-169.
    • (2011) Nature , vol.476 , Issue.7359 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 70
    • 33645084781 scopus 로고    scopus 로고
    • PIK3CA mutations in head and neck squamous cell carcinoma
    • Qiu W, et al. PIK3CA mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 2006; 12(5):1441-1446.
    • (2006) Clin Cancer Res , vol.12 , Issue.5 , pp. 1441-1446
    • Qiu, W.1
  • 71
    • 38749089046 scopus 로고    scopus 로고
    • Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer
    • DOI 10.1002/ijc.23217
    • Qiu W, Tong GX, Manolidis S, Close LG, Assaad AM, Su GH. Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer. Int J Cancer. 2008;122(5):1189-1194. (Pubitemid 351214020)
    • (2008) International Journal of Cancer , vol.122 , Issue.5 , pp. 1189-1194
    • Qiu, W.1    Tong, G.-X.2    Manolidis, S.3    Close, L.G.4    Assaad, A.M.5    Su, G.H.6
  • 72
    • 79958132520 scopus 로고    scopus 로고
    • PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
    • Henken FE, et al. PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro. Mol Cancer. 2011;10:71.
    • (2011) Mol Cancer , vol.10 , pp. 71
    • Henken, F.E.1
  • 73
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009;9(8):550-562.
    • (2009) Nat Rev Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 74
    • 0025732716 scopus 로고
    • High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India
    • Saranath D, et al. High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. Br J Cancer. 1991;63(4):573-578.
    • (1991) Br J Cancer , vol.63 , Issue.4 , pp. 573-578
    • Saranath, D.1
  • 75
    • 0026474705 scopus 로고
    • Prevalence of RAS oncogene mutation in head and neck carcinomas
    • Anderson JA, Irish JC, Ngan BY. Prevalence of RAS oncogene mutation in head and neck carcinomas. J Otolaryngol. 1992;21(5):321-326.
    • (1992) J Otolaryngol , vol.21 , Issue.5 , pp. 321-326
    • Anderson, J.A.1    Irish, J.C.2    Ngan, B.Y.3
  • 77
    • 33749354957 scopus 로고    scopus 로고
    • Mouse models for human head and neck squamous cell carcinomas
    • DOI 10.1002/hed.20397
    • Lu S-L, Herrington H, Wang X-J. Mouse models for human head and neck squamous cell carcinomas. Head Neck. 2006;28(10):945-954. (Pubitemid 44497871)
    • (2006) Head and Neck , vol.28 , Issue.10 , pp. 945-954
    • Lu, S.-L.1    Herrington, H.2    Wang, X.-J.3
  • 78
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie DA, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009;462(7269):108-112.
    • (2009) Nature , vol.462 , Issue.7269 , pp. 108-112
    • Barbie, D.A.1
  • 79
    • 65849111219 scopus 로고    scopus 로고
    • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
    • Scholl C, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 2009; 137(5):821-834.
    • (2009) Cell , vol.137 , Issue.5 , pp. 821-834
    • Scholl, C.1
  • 80
    • 65649108558 scopus 로고    scopus 로고
    • A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
    • Singh A, et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell. 2009;15(6):489-500.
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 489-500
    • Singh, A.1
  • 81
    • 78649469283 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck
    • Sharafinski ME, Ferris RL, Ferrone S, Grandis JR. Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck. Head Neck. 2010;32(10):1412-1421.
    • (2010) Head Neck , vol.32 , Issue.10 , pp. 1412-1421
    • Sharafinski, M.E.1    Ferris, R.L.2    Ferrone, S.3    Grandis, J.R.4
  • 82
    • 77954706620 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer
    • Taoudi Benchekroun M, et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila). 2010;3(7):800-809.
    • (2010) Cancer Prev Res (Phila) , vol.3 , Issue.7 , pp. 800-809
    • Taoudi Benchekroun, M.1
  • 86
    • 79955496795 scopus 로고    scopus 로고
    • Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study
    • Licitra L, et al. Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study. Ann Oncol. 2011;22(5):1078-1087.
    • (2011) Ann Oncol , vol.22 , Issue.5 , pp. 1078-1087
    • Licitra, L.1
  • 87
    • 28144437798 scopus 로고    scopus 로고
    • Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR
    • Cohen EE, et al. Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR. Clin Cancer Res. 2005;11(22):8105-8108.
    • (2005) Clin Cancer Res , vol.11 , Issue.22 , pp. 8105-8108
    • Cohen, E.E.1
  • 90
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • DOI 10.1200/JCO.2004.06.075
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol. 2004;22(1):77-85. (Pubitemid 41095117)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarvala, S.S.5    Siu, L.L.6
  • 91
    • 27244432279 scopus 로고    scopus 로고
    • Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Wirth LJ, et al. Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2005;23(28):6976-6981.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6976-6981
    • Wirth, L.J.1
  • 93
    • 70349436013 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
    • Hama T, et al. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist. 2009;14(9):900-908.
    • (2009) Oncologist , vol.14 , Issue.9 , pp. 900-908
    • Hama, T.1
  • 95
    • 66149135285 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
    • Seiwert TY, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009;69(7):3021-3031.
    • (2009) Cancer Res , vol.69 , Issue.7 , pp. 3021-3031
    • Seiwert, T.Y.1
  • 97
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693-1703.
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1
  • 99
    • 13444309090 scopus 로고    scopus 로고
    • CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas
    • Soung YH, et al. CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res. 2005;65(3):815-821.
    • (2005) Cancer Res , vol.65 , Issue.3 , pp. 815-821
    • Soung, Y.H.1
  • 100
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    • DOI 10.1016/j.cytogfr.2005.09.009, PII S1359610105001139
    • Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 2006; 17(1-2):41-58. (Pubitemid 43117515)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.1-2 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 101
    • 0031410093 scopus 로고    scopus 로고
    • Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck
    • DOI 10.1093/carcin/18.11.2285
    • Wang D, Song H, Evans JA, Lang JC, Schuller DE, Weghorst CM. Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck. Carcinogenesis. 1997;18(11):2285-2290. (Pubitemid 28134761)
    • (1997) Carcinogenesis , vol.18 , Issue.11 , pp. 2285-2290
    • Wang, D.1    Song, H.2    Evans, J.A.3    Lang, J.C.4    Schuller, D.E.5    Weghorst, C.M.6
  • 102
    • 33845683318 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4
    • DOI 10.1016/j.canlet.2006.01.003, PII S0304383506000279
    • Qiu W, Schonleben F, Li X, Su GH. Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4. Cancer Lett. 2007;245(1-2):163-170. (Pubitemid 44959352)
    • (2007) Cancer Letters , vol.245 , Issue.1-2 , pp. 163-170
    • Qiu, W.1    Schonleben, F.2    Li, X.3    Su, G.H.4
  • 103
    • 70449338760 scopus 로고    scopus 로고
    • Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
    • Bornstein S, et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009;119(11):3408-3419.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3408-3419
    • Bornstein, S.1
  • 104
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factorbeta type II receptor promotes metastatic headand-neck squamous cell carcinoma
    • Lu SL, et al. Loss of transforming growth factorbeta type II receptor promotes metastatic headand-neck squamous cell carcinoma. Genes Dev. 2006;20(10):1331-1342.
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1331-1342
    • Lu, S.L.1
  • 106
    • 34547101487 scopus 로고    scopus 로고
    • Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
    • DOI 10.1038/sj.onc.1210330, PII 1210330
    • Nakaya K, et al. Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene. 2007;26(36):5300-5308. (Pubitemid 47237625)
    • (2007) Oncogene , vol.26 , Issue.36 , pp. 5300-5308
    • Nakaya, K.1    Yamagata, H.D.2    Arita, N.3    Nakashiro, K.-I.4    Nose, M.5    Miki, T.6    Hamakawa, H.7
  • 107
    • 77950280030 scopus 로고    scopus 로고
    • A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
    • Rothenberg SM, et al. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010;70(6):2158-2164.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2158-2164
    • Rothenberg, S.M.1
  • 108
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma
    • Morin RD, et al. Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma. Nature. 2011;476(7360):298-303.
    • (2011) Nature , vol.476 , Issue.7360 , pp. 298-303
    • Morin, R.D.1
  • 109
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van Haaften G, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009;41(5):521-523.
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 521-523
    • Van Haaften, G.1
  • 110
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela I, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 2011;469(7331):539-542.
    • (2011) Nature , vol.469 , Issue.7331 , pp. 539-542
    • Varela, I.1
  • 112
    • 51649107126 scopus 로고    scopus 로고
    • Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas
    • Marme A, et al. Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas. Int J Cancer. 2008;123(9):2048-2056.
    • (2008) Int J Cancer , vol.123 , Issue.9 , pp. 2048-2056
    • Marme, A.1
  • 113
    • 79959873016 scopus 로고    scopus 로고
    • Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival
    • Masica DL, Karchin R. Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival. Cancer Res. 2011;71(13):4550-4561.
    • (2011) Cancer Res , vol.71 , Issue.13 , pp. 4550-4561
    • Masica, D.L.1    Karchin, R.2
  • 114
    • 58149265465 scopus 로고    scopus 로고
    • Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers
    • Yonesaka K, et al. Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers. Clin Cancer Res. 2008;14(21):6963-6973.
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 6963-6973
    • Yonesaka, K.1
  • 116
    • 79955514313 scopus 로고    scopus 로고
    • Survival and human papillomavirus in oropharynx cancer in TAX 324: A subset analysis from an international phase III trial
    • Posner MR, et al. Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol. 2011;22(5):1071-1077.
    • (2011) Ann Oncol , vol.22 , Issue.5 , pp. 1071-1077
    • Posner, M.R.1
  • 118
    • 70449105984 scopus 로고    scopus 로고
    • Suppression of cancer cell growth by promoting cyclin D1 degradation
    • Shan J, Zhao W, Gu W. Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell. 2009;36(3):469-476.
    • (2009) Mol Cell , vol.36 , Issue.3 , pp. 469-476
    • Shan, J.1    Zhao, W.2    Gu, W.3
  • 119
    • 65449144050 scopus 로고    scopus 로고
    • PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
    • Lambert JM, et al. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell. 2009;15(5):376-388.
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 376-388
    • Lambert, J.M.1
  • 120
    • 37549040575 scopus 로고    scopus 로고
    • The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
    • Verdine GL, Walensky LD. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. Clin Cancer Res. 2007;13(24):7264-7270.
    • (2007) Clin Cancer Res , vol.13 , Issue.24 , pp. 7264-7270
    • Verdine, G.L.1    Walensky, L.D.2


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