Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction

Experimental Gerontology

Volumn 42, Issue 7, 2007, Pages 676-685

  Radovits, Tamás ^a   Seres, Leila ^a   Gero, Domokos ^b   Berger, Irina ^a   Szabó, Csaba ^b,c   Karck, Matthias ^a   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c University of Medicine and Dentistry of New Jersey   (United States)

Author keywords

Aging; Cardiac function; Endothelial function; Immunohistochemistry; Nitro oxidative stress; Poly(ADP ribose) polymerase

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; INO 1001; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITROPRUSSIDE SODIUM; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; HEART CATHETER; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASCULAR RING;

ACETYLCHOLINE; AGING; ANIMALS; ENZYME INHIBITORS; HEART; IMMUNOHISTOCHEMISTRY; INDOLES; MODELS, ANIMAL; MYOCARDIUM; PHENYLEPHRINE; POLY(ADP-RIBOSE) POLYMERASES; RATS; TYROSINE;

ANIMALIA; RATTUS;

EID: 34248584872     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.01.013     Document Type: Article

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