The physiological significance of mitochondrial proton leak in animal cells and tissues

Bioscience Reports

Volumn 17, Issue 1, 1997, Pages 9-16

  Rolfe, David F S ^a   Brand, Martin D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Carbon flux control; Metabolic sensitivity; Mitochondria; Proton leak; Reactive oxygen species; Standard Metabolic Rate; Thermogenesis

Indexed keywords

PROTON; REACTIVE OXYGEN METABOLITE; THYROID HORMONE;

CELL METABOLISM; METABOLIC RATE; MITOCHONDRIAL RESPIRATION; NONHUMAN; REVIEW; THERMOGENESIS;

ANIMALS; BASAL METABOLISM; BODY MASS INDEX; MAMMALS; MITOCHONDRIA; PROTONS; REACTIVE OXYGEN SPECIES; THYROID HORMONES;

ANIMALIA;

EID: 0030995005     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027327015957     Document Type: Review

References (36)

1. Ambrosio, G., Zweier, J. L., Duilio, C., Kuppsamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P., Condorelli, M., Chiarello, M. and Flaherty, J. T. (1993) J. Biol. Chem. 268:18532-18541.
2. Berry, M. N., Edwards, A. M. and Barritt, G. J. (1991) in: Isolated Hepatocytes: Preparation, Properties and Applications. Elsevier, The Netherlands.
3. Brand, M. D., Couture, P., Else, P. L., Withers, K. W. & Hulbert, A. J. (1991) Biochem. J. 275:81-86.
4. Brand, M. D., Chien, L.-F. and Rolfe, D. F. S. (1993) Biochem Soc. Trans. 21:757-762.
5. Brand, M. D. Chien, L.-F., Ainscow, E. K., Rolfe, D. F. S. and Porter, R. K. (1994a) Biochim. Biophys. Acta 1187, 132-139.
6. Brand, M. D., Chien, L.-F. and Diolez, P. (1994b) Biochem. J. 297:27-29.
7. Brown, G. C. (1989) J. Biol. Chem. 264:14704-14709.
8. Brown, G. C., Lakin-Thomas, P. L. & Brand, M. D. (1990) Eur. J. Biochem. 192:355-362.
9. Buttgereit, F., Brand, M. D. and Muller, M. (1992) Biosci. Rep. 12:381-386.
10. Buttgereit, F., Muller, M. and Rapoport, S. M. (1991) Biochem. Int. 24:59-67.
11. Challoner, D. R. (1968) Nature 217:78-79.
12. Diolez, P., Kesseler, A. K., Haraux, F., Valerio, M., Brinkmann, K. and Brand, M. D. (1993) Biochem. Soc. Trans. 21:769-773.
13. Girardier, L. (1977) Experiment 33:1121-1122.
14. Hafner, R. P., Nobes, C. D., McGown, A. D. and Brand, M. D. (1988) EJB 178:511-518.
15. Hafner, R. P. & Brand, M. D. (1991) Biochem. J. 275:75-80.
16. Halliwell, B. (1992) in: Free Radicals and the Brain (Packer, L., Prilipko, L. and Christen, Y., eds.) Springer-Verlag, Berlin.
17. Halliwell, B. and Gutteridge, J. M. C. (1989) in: Free Radicals in Biology and Medicine. Clarendon, Oxford.
18. Harper, M.-E. and Brand, M. D. (1993) J. Biol. Chem. 268:14850-14860.
19. Hulbert, A. J. and Williams, C. A. (1988) Comp. Biochem. Physiol. 90A:41-48.
20. Jansky, L. (1965). Acta Univ. Carol. Biol. 1:1-91.
21. Kesseler, A. K., Diolez, P., Brinkmann, K. and Brand, M. D. (1992) Eur. J. Biochem. 210:775-784.
22. Kesseler, A. K. and Brand, M. D. (1995) Plant Physiol. Biochem. 33:519-528.
23. Larsson, M., Pettersson, T. and Carlstrom, A. (1985) Gen. Comp. Endocrinol. 58:360-375.
24. Newsholme, E. A. and Underwood, A. H. (1966) Biochem. J. 99:24-26.
25. Nicholls, D. G. (1974) Eur. J. Biochem. 50:305-315.
26. Nobes, C. D., Brown, G. C., Olive, P. N. & Brand, M. D. (1990) J. Biol. Chem. 265:12903-12909.
27. Porter, R. K. and Brand, M. D. (1993) Nature 362:628-630.
28. Porter, R. K. and Brand, M. D. (1995a) Biochem. J. 310:379-382.
29. Porter, R. K. and Brand, M. D. (1995b) Am. J. Physiol. 269:R226-R228.
30. Porter, R. K. and Brand, M. D. (1995c) Am. J. Physiol. 269:R1213-R1224.
31. Rabkin, M. & Blum, J. J. (1985) Biochem. J. 225:761-786.
32. Rolfe, D. F. S., Hulbert, A. J. and Brand, M. D. (1994) Biochim. Biophys. Acta 1188:405-416.
33. Rolfe, D. F. S. and Brand, M. D. (1996) Am. J. Physiol. 270:C1380-C1389.
34. Skulachev, V. P. (1996) Q. Rev. Biophys. 29:169-202.
35. Turrens, J. F., Alexandre, A. and Lehninger, A. L. (1985) Arch. Biochem. Biophys. 237:408-414.
36. Zolkiewska, A., Zablocka, B., Duszynski, J. and Wojtczak, L. (1989) Arch. Biochem. Biophys. 275:580-590.