메뉴 건너뛰기




Volumn 6, Issue 29, 2015, Pages 26675-26689

Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: Implications for aging and neurodegeneration

Author keywords

Dopamine; Gerotarget; Longevity; Neuroinflammation; Parkinson; Resveratrol

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SELISISTAT; SIRTUIN 1; SIRT1 PROTEIN, MOUSE; SIRT1 PROTEIN, RAT; STILBENE DERIVATIVE;

EID: 84944474625     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5596     Document Type: Article
Times cited : (30)

References (79)
  • 1
    • 43749121572 scopus 로고    scopus 로고
    • Therapeutic role of sirtuins in neurodegenerative disease
    • Outeiro TF, Marques O, Kazantsev A. Therapeutic role of sirtuins in neurodegenerative disease. Biochim Biophys Acta. 2008; 1782:363-369.
    • (2008) Biochim Biophys Acta. , vol.1782 , pp. 363-369
    • Outeiro, T.F.1    Marques, O.2    Kazantsev, A.3
  • 3
    • 84937762014 scopus 로고    scopus 로고
    • SIRTain regulators of premature senescence and accelerated aging
    • Ghosh S, Zhou Z. SIRTain regulators of premature senescence and accelerated aging. Protein Cell. 2015; 6:322-333.
    • (2015) Protein Cell. , vol.6 , pp. 322-333
    • Ghosh, S.1    Zhou, Z.2
  • 4
    • 84938417700 scopus 로고    scopus 로고
    • SIRT1 in the brain-connections with aging-associated disorders and lifespan
    • Ng F, Wijaya L, Tang BL. SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci. 2015; 9:64.
    • (2015) Front Cell Neurosci. , vol.9 , pp. 64
    • Ng, F.1    Wijaya, L.2    Tang, B.L.3
  • 6
    • 77950901103 scopus 로고    scopus 로고
    • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
    • Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem. 2010; 285:8375-8382.
    • (2010) J Biol Chem. , vol.285 , pp. 8375-8382
    • Tanno, M.1    Kuno, A.2    Yano, T.3    Miura, T.4    Hisahara, S.5    Ishikawa, S.6    Shimamoto, K.7    Horio, Y.8
  • 8
    • 84897683362 scopus 로고    scopus 로고
    • Aging: it's SIRTainly possible to restore mitochondrial dysfunction
    • Christian BE, Shadel GS. Aging: it's SIRTainly possible to restore mitochondrial dysfunction. Curr Biol. 2014; 24:R206-208.
    • (2014) Curr Biol. , vol.24 , pp. R206-208
    • Christian, B.E.1    Shadel, G.S.2
  • 12
    • 84874709843 scopus 로고    scopus 로고
    • SIRT1 and SIRT2: emerging targets in neurodegeneration
    • Donmez G, Outeiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med. 2013; 5:344-352.
    • (2013) EMBO Mol Med. , vol.5 , pp. 344-352
    • Donmez, G.1    Outeiro, T.F.2
  • 13
    • 84883524497 scopus 로고    scopus 로고
    • Sirtuins: from metabolic regulation to brain aging
    • Duan W. Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci. 2013; 5:36.
    • (2013) Front Aging Neurosci. , vol.5 , pp. 36
    • Duan, W.1
  • 14
    • 84893459319 scopus 로고    scopus 로고
    • SIRT1 in neurodevelopment and brain senescence
    • Herskovits AZ, Guarente L. SIRT1 in neurodevelopment and brain senescence. Neuron. 2014; 81:471-483.
    • (2014) Neuron. , vol.81 , pp. 471-483
    • Herskovits, A.Z.1    Guarente, L.2
  • 15
    • 33845942205 scopus 로고    scopus 로고
    • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    • Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol. 2007; 73:550-560.
    • (2007) Biochem Pharmacol. , vol.73 , pp. 550-560
    • Okawara, M.1    Katsuki, H.2    Kurimoto, E.3    Shibata, H.4    Kume, T.5    Akaike, A.6
  • 16
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microgliadependent amyloid-beta toxicity through inhibiting NFkappaB signaling
    • Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microgliadependent amyloid-beta toxicity through inhibiting NFkappaB signaling. J Biol Chem. 2005; 280:40364-40374.
    • (2005) J Biol Chem. , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 18
    • 77956242222 scopus 로고    scopus 로고
    • Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its antiinflammatory actions
    • Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its antiinflammatory actions. Mol Pharmacol 2010; 78:466-477.
    • (2010) Mol Pharmacol , vol.78 , pp. 466-477
    • Zhang, F.1    Shi, J.S.2    Zhou, H.3    Wilson, B.4    Hong, J.S.5    Gao, H.M.6
  • 20
    • 84873035303 scopus 로고    scopus 로고
    • AT2 receptors: beneficial counterregulatory role in cardiovascular and renal function
    • Padia SH, Carey RM. AT2 receptors: beneficial counterregulatory role in cardiovascular and renal function. Pflugers Arch. 2013; 465: 99-110.
    • (2013) Pflugers Arch. , vol.465 , pp. 99-110
    • Padia, S.H.1    Carey, R.M.2
  • 21
    • 45849086107 scopus 로고    scopus 로고
    • Role of the reninangiotensin system in vascular inflammation
    • Marchesi C, Paradis P, Schiffrin, EL. Role of the reninangiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008; 29: 367-374.
    • (2008) Trends Pharmacol Sci. , vol.29 , pp. 367-374
    • Marchesi, C.1    Paradis, P.2    Schiffrin, E.L.3
  • 22
    • 12344251549 scopus 로고    scopus 로고
    • Vascular inflammation in aging
    • 23
    • Ungvari Z, Csiszar A, Kaley G. Vascular inflammation in aging. Herz. 2004; 29: 733-40 23.
    • (2004) Herz. , vol.29 , pp. 733-740
    • Ungvari, Z.1    Csiszar, A.2    Kaley, G.3
  • 25
    • 84935417692 scopus 로고    scopus 로고
    • Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging Coincidences with calorie restriction and mTOR inhibition
    • de Cavanagh EM, Inserra F, Ferder L. Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging Coincidences with calorie restriction and mTOR inhibition. Am J Physiol Heart Circ Physiol. 2015; 309:H15-44.
    • (2015) Am J Physiol Heart Circ Physiol. , vol.309 , pp. H15-44
    • de Cavanagh, E.M.1    Inserra, F.2    Ferder, L.3
  • 27
    • 62649089147 scopus 로고    scopus 로고
    • The inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease
    • Joglar B, Rodriguez-Pallares J, Rodríguez-Perez AI, Rey P, Guerra MJ, Labandeira-Garcia JL. The inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease. J Neurochem. 2009; 109, 656-669.
    • (2009) J Neurochem , vol.109 , pp. 656-669
    • Joglar, B.1    Rodriguez-Pallares, J.2    Rodríguez-Perez, A.I.3    Rey, P.4    Guerra, M.J.5    Labandeira-Garcia, J.L.6
  • 29
    • 84878860958 scopus 로고    scopus 로고
    • Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin-angiotensin system in the nigra
    • Garrido-Gil P, Valenzuela R, Villar-Cheda B, Lanciego JL, Labandeira-Garcia JL. Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin-angiotensin system in the nigra. Brain Struct Funct. 2013;218: 373-388.
    • (2013) Brain Struct Funct. , vol.218 , pp. 373-388
    • Garrido-Gil, P.1    Valenzuela, R.2    Villar-Cheda, B.3    Lanciego, J.L.4    Labandeira-Garcia, J.L.5
  • 33
    • 81355139581 scopus 로고    scopus 로고
    • Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration
    • Villar-Cheda B, Valenzuela R, Rodriguez-Perez AI, Guerra MJ, Labandeira-Garcia JL. Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration. Neurobiol Aging. 2012; 33: 204e1-11.
    • (2012) Neurobiol Aging. , vol.33 , pp. 204e1-204e11
    • Villar-Cheda, B.1    Valenzuela, R.2    Rodriguez-Perez, A.I.3    Guerra, M.J.4    Labandeira-Garcia, J.L.5
  • 38
  • 40
    • 77956180402 scopus 로고    scopus 로고
    • SIRT1 is a redoxsensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    • Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. SIRT1 is a redoxsensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 2010; 24:3145-3159.
    • (2010) FASEB J. , vol.24 , pp. 3145-3159
    • Caito, S.1    Rajendrasozhan, S.2    Cook, S.3    Chung, S.4    Yao, H.5    Friedman, A.E.6    Brookes, P.S.7    Rahman, I.8
  • 41
    • 33744494576 scopus 로고    scopus 로고
    • Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex
    • Wu A, Ying Z, Gomez-Pinilla F. Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex. Eur J Neurosci. 2006; 23:2573-2580.
    • (2006) Eur J Neurosci. , vol.23 , pp. 2573-2580
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 42
    • 84886831951 scopus 로고    scopus 로고
    • The anteroventral third ventricle region is critical for the behavioral desensitization caused by repeated injections of angiotensin II
    • Vento PJ, Daniels D. The anteroventral third ventricle region is critical for the behavioral desensitization caused by repeated injections of angiotensin II. Behav Brain Res. 2014; 258: 27-33.
    • (2014) Behav Brain Res. , vol.258 , pp. 27-33
    • Vento, P.J.1    Daniels, D.2
  • 43
    • 2342469362 scopus 로고    scopus 로고
    • Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus-a mechanism for desensitization of AngII signaling
    • Torsoni MA, Carvalheira JB, Calegari VC, Bezerra RM, Saad MJ, Gontijo JA, Velloso LA. Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus-a mechanism for desensitization of AngII signaling. J Endocrinol. 2004; 181: 117-128.
    • (2004) J Endocrinol. , vol.181 , pp. 117-128
    • Torsoni, M.A.1    Carvalheira, J.B.2    Calegari, V.C.3    Bezerra, R.M.4    Saad, M.J.5    Gontijo, J.A.6    Velloso, L.A.7
  • 44
    • 0028116924 scopus 로고
    • Desensitization of angiotensin receptor function
    • Sasamura H, Dzau VJ, Pratt RE. Desensitization of angiotensin receptor function. Kidney Int. 1994; 46:1499-14501.
    • (1994) Kidney Int. , vol.46 , pp. 1499-14501
    • Sasamura, H.1    Dzau, V.J.2    Pratt, R.E.3
  • 45
    • 0035465270 scopus 로고    scopus 로고
    • The angiotensin II type 1 receptor and receptor-associated proteins
    • Guo DF, Sun YL, Hamet P, Inagami T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Res. 2001; 11:165-180.
    • (2001) Cell Res. , vol.11 , pp. 165-180
    • Guo, D.F.1    Sun, Y.L.2    Hamet, P.3    Inagami, T.4
  • 46
    • 33748331132 scopus 로고    scopus 로고
    • Scrable H Progressive loss of SIRT1 with cell cycle withdrawal
    • Sasaki T, Maier B, Bartke A. Scrable H Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell. 2006; 5:413-422.
    • (2006) Aging Cell. , vol.5 , pp. 413-422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3
  • 47
    • 54249107873 scopus 로고    scopus 로고
    • The ups and downs of SIRT1
    • Kwon HS, Ott M. The ups and downs of SIRT1. Trends Biochem Sci. 2008; 33:517-525.
    • (2008) Trends Biochem Sci. , vol.33 , pp. 517-525
    • Kwon, H.S.1    Ott, M.2
  • 48
    • 84856748705 scopus 로고    scopus 로고
    • Different dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats. Role of the brain angiotensin system
    • Rodriguez-Perez AI, Valenzuela R, Villar-Cheda B, Guerra MJ, Labandeira-Garcia JL. Different dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats. Role of the brain angiotensin system. Brain 2012; 135: 124-138.
    • (2012) Brain , vol.135 , pp. 124-138
    • Rodriguez-Perez, A.I.1    Valenzuela, R.2    Villar-Cheda, B.3    Guerra, M.J.4    Labandeira-Garcia, J.L.5
  • 49
    • 84857228790 scopus 로고    scopus 로고
    • Involvement of PPAR-? in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
    • Garrido-Gil P, Joglar B, Rodriguez-Perez AI, Guerra MJ, Labandeira-Garcia JL. Involvement of PPAR-? in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease. J Neuroinflammation. 2012; 9: 38.
    • (2012) J Neuroinflammation. , vol.9 , pp. 38
    • Garrido-Gil, P.1    Joglar, B.2    Rodriguez-Perez, A.I.3    Guerra, M.J.4    Labandeira-Garcia, J.L.5
  • 51
    • 77952674793 scopus 로고    scopus 로고
    • Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation
    • Zhang F, Liu J, Shi JS. Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation. Eur J Pharmacol. 2010; 636:1-7.
    • (2010) Eur J Pharmacol. , vol.636 , pp. 1-7
    • Zhang, F.1    Liu, J.2    Shi, J.S.3
  • 54
    • 34548620779 scopus 로고    scopus 로고
    • Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamineinduced degeneration of dopaminergic neurons
    • Rodriguez-Pallares J, Parga JA, Muñoz A, Rey P, Guerra MJ, Labandeira-Garcia JL. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamineinduced degeneration of dopaminergic neurons. J Neurochem. 2007; 103: 145-156.
    • (2007) J Neurochem. , vol.103 , pp. 145-156
    • Rodriguez-Pallares, J.1    Parga, J.A.2    Muñoz, A.3    Rey, P.4    Guerra, M.J.5    Labandeira-Garcia, J.L.6
  • 58
    • 84862215866 scopus 로고    scopus 로고
    • Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
    • Tang Y, Xu J, Qu W, Peng X, Xin P, Yang X, Ying C, Sun X, Hao L. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J Nutr Biochem. 2012; 23:1410-1416.
    • (2012) J Nutr Biochem. , vol.23 , pp. 1410-1416
    • Tang, Y.1    Xu, J.2    Qu, W.3    Peng, X.4    Xin, P.5    Yang, X.6    Ying, C.7    Sun, X.8    Hao, L.9
  • 60
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004; 23: 2369-2380.
    • (2004) EMBO J. , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 64
    • 0037189154 scopus 로고    scopus 로고
    • Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats
    • Ju
    • Sinha KL, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci. 2002 Ju; 71:655-665.
    • (2002) Life Sci , vol.71 , pp. 655-665
    • Sinha, K.L.1    Chaudhary, G.2    Gupta, Y.K.3
  • 65
    • 0035503936 scopus 로고    scopus 로고
    • Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production
    • Gao XL, Xu YX, Janakiraman N, Chapman RA, Gautam SC. Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochem Pharmacol. 2001; 62:1299-108.
    • (2001) Biochem Pharmacol. , vol.62 , pp. 1108-1299
    • Gao, X.L.1    Xu, Y.X.2    Janakiraman, N.3    Chapman, R.A.4    Gautam, S.C.5
  • 66
    • 33646526704 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation
    • Lu KT, Chiou RY, Chen LG, Chen MH, Tseng WT, Hsieh HT, Yang YL. Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. J Agric Food Chem. 2006; 54:3126-3131.
    • (2006) J Agric Food Chem. , vol.54 , pp. 3126-3131
    • Lu, K.T.1    Chiou, R.Y.2    Chen, L.G.3    Chen, M.H.4    Tseng, W.T.5    Hsieh, H.T.6    Yang, Y.L.7
  • 68
    • 0026781572 scopus 로고
    • A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
    • Crawford GD Jr, Le WD, Smith RG, Xie WJ, Stefani E, Appel SH. A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J Neurosci. 1992; 12:3392-3398.
    • (1992) J Neurosci. , vol.12 , pp. 3392-3398
    • Crawford, G.D.1    Le, W.D.2    Smith, R.G.3    Xie, W.J.4    Stefani, E.5    Appel, S.H.6
  • 69
    • 33645221885 scopus 로고    scopus 로고
    • Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
    • Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006; 26: 28-38.
    • (2006) Mol Cell Biol. , vol.26 , pp. 28-38
    • Solomon, J.M.1    Pasupuleti, R.2    Xu, L.3    McDonagh, T.4    Curtis, R.5    DiStefano, P.S.6    Huber, L.J.7
  • 72
    • 1842430489 scopus 로고    scopus 로고
    • Immunohistochemical and mRNA localization of the angiotensin II receptor subtype 2 (AT2) in follicular granulosa cells of the rat ovary
    • Obermüller N, Gentili M, Gauer S, Gretz N, Weigel M, Geiger H, Gassler N. Immunohistochemical and mRNA localization of the angiotensin II receptor subtype 2 (AT2) in follicular granulosa cells of the rat ovary. J Histochem Cytochem. 2004; 52, 545-548.
    • (2004) J Histochem Cytochem , vol.52 , pp. 545-548
    • Obermüller, N.1    Gentili, M.2    Gauer, S.3    Gretz, N.4    Weigel, M.5    Geiger, H.6    Gassler, N.7
  • 74
    • 84874542636 scopus 로고    scopus 로고
    • Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation
    • Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol. 2013; 93:427-435.
    • (2013) J Leukoc Biol. , vol.93 , pp. 427-435
    • Sareila, O.1    Jaakkola, N.2    Olofsson, P.3    Kelkka, T.4    Holmdahl, R.5
  • 76
    • 80053033653 scopus 로고    scopus 로고
    • Modulation of nicotinamide adenine dinucleotide phosphate oxidase activity through sequential posttranslational modifications of p22 phagocytic oxidase during capacitation and acrosome reaction in goat spermatozoa
    • Chandrasekhar A, Laloraya M, Kumar PG.Modulation of nicotinamide adenine dinucleotide phosphate oxidase activity through sequential posttranslational modifications of p22 phagocytic oxidase during capacitation and acrosome reaction in goat spermatozoa. J Anim Sci. 2011; 89:2995-3007.
    • (2011) J Anim Sci. , vol.89 , pp. 2995-3007
    • Chandrasekhar, A.1    Laloraya, M.2    Kumar, P.G.3
  • 78
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25:402-408.
    • (2001) Methods. , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 79
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research. 2001; 29: e45.
    • (2001) Nucleic Acids Research. , vol.29
    • Pfaffl, M.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.