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Volumn 15, Issue 1, 2013, Pages 25-30

Update on the angiotensin AT2 receptor

Author keywords

Ang peptides; Angiotensin II; Angiotensin III; Angiotensin peptides; Antifibrotic; AT2 receptor; AT2R; AT2R agonists; Beta substituted amino acids; Blood pressure; Brain function; C21; Compound 21; Hypertension; Kidney; Neuroprotection; Organ protection; Vascular

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN III; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-9]; ANTIHYPERTENSIVE AGENT; C 21; CARDIOVASCULAR AGENT; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; PD 1233119; UNCLASSIFIED DRUG;

EID: 84872610780     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-012-0321-4     Document Type: Review
Times cited : (54)

References (59)
  • 1
    • 0037527730 scopus 로고    scopus 로고
    • Angiotensin AT1/AT2 receptors: Regulation, signalling and function
    • DOI 10.1080/08037050310001057
    • Kaschina E, Unger T. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press. 2003;12:70-88. (Pubitemid 36700689)
    • (2003) Blood Pressure , vol.12 , Issue.2 , pp. 70-88
    • Kaschina, E.1    Unger, T.2
  • 3
    • 0035725997 scopus 로고    scopus 로고
    • 2 subtype receptor of angiotensin II from large arteries to the microcirculation
    • Henrion D, Kubis N, Levy BI. Physiological and pathophysiological functions of the AT(2) subtype receptor of angiotensin II: from large arteries to the microcirculation. Hypertension. 2001;38:1150-7. (Pubitemid 34252821)
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1150-1157
    • Henrion, D.1    Kubis, N.2    Levy, B.I.3
  • 5
    • 0032576551 scopus 로고    scopus 로고
    • Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases
    • Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res. 1998;83:1182-91. (Pubitemid 29006033)
    • (1998) Circulation Research , vol.83 , Issue.12 , pp. 1182-1191
    • Matsubara, H.1
  • 6
    • 56149096807 scopus 로고    scopus 로고
    • AT2 receptors: Functional relevance in cardiovascular disease
    • 18804122 10.1016/j.pharmthera.2008.08.009 1:CAS:528:DC%2BD1cXhsVWrsL7N
    • Jones ES, Vinh A, McCarthy CA, et al. AT2 receptors: functional relevance in cardiovascular disease. Pharmacol Ther. 2008;120:292-316.
    • (2008) Pharmacol Ther , vol.120 , pp. 292-316
    • Jones, E.S.1    Vinh, A.2    McCarthy, C.A.3
  • 7
    • 0031446688 scopus 로고    scopus 로고
    • 2 receptors: Evidence for selective sorting of receptor and ligand
    • DOI 10.1210/me.11.9.1266
    • Hein L, Meinel L, Pratt RE, et al. Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. Mol Endocrinol. 1997;11:1266-77. (Pubitemid 28041334)
    • (1997) Molecular Endocrinology , vol.11 , Issue.9 , pp. 1266-1277
    • Hein, L.1    Meinel, L.2    Pratt, R.E.3    Dzau, V.J.4    Kobilka, B.K.5
  • 8
    • 0036771844 scopus 로고    scopus 로고
    • AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade
    • 12364356 10.1161/01.HYP.0000033224.99806.8A 1:CAS:528: DC%2BD38Xntlams78%3D
    • Widdop RE, Matrougui K, Levy BI, et al. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension. 2002;40:516-20.
    • (2002) Hypertension , vol.40 , pp. 516-520
    • Widdop, R.E.1    Matrougui, K.2    Levy, B.I.3
  • 9
    • 0028876654 scopus 로고
    • The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells
    • 7860748 10.1172/JCI117710 1:CAS:528:DyaK2MXjsV2rsrs%3D
    • Stoll M, Steckelings UM, Paul M, et al. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 1995;95:651-7.
    • (1995) J Clin Invest , vol.95 , pp. 651-657
    • Stoll, M.1    Steckelings, U.M.2    Paul, M.3
  • 10
    • 63849169364 scopus 로고    scopus 로고
    • The angiotensin II type 2 (AT2) receptor: An enigmatic seven transmembrane receptor
    • 19273111 10.2741/3289 1:CAS:528:DC%2BD1MXltFejtLo%3D
    • Porrello E, Delbridge L, Thomas W. The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor. Front Biosci. 2009;14:958-72.
    • (2009) Front Biosci , vol.14 , pp. 958-972
    • Porrello, E.1    Delbridge, L.2    Thomas, W.3
  • 11
    • 84858257624 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor agonists: Where should they be applied?
    • 22348403 10.1517/13543784.2012.664131 1:CAS:528:DC%2BC38Xjslejsb0%3D
    • Verdonk K, Danser AH, van Esch JH. Angiotensin II type 2 receptor agonists: where should they be applied? Expert Opin Investig Drugs. 2012;21:501-13.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 501-513
    • Verdonk, K.1    Danser, A.H.2    Van Esch, J.H.3
  • 14
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    • 19029468 10.1161/CIRCULATIONAHA.108.784868 1:CAS:528:DC%2BD1cXhsVerur3E
    • Kaschina E, Grzesiak A, Li J, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation. 2008;118:2523-32.
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3
  • 15
    • 84872601514 scopus 로고    scopus 로고
    • Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor {kappa}B
    • 2 receptor stimulation with antiinflammatory effects
    • 2 receptor stimulation with antiinflammatory effects.
    • (2010) Hypertension , vol.109 , pp. 147843
    • Rompe, F.1    Artuc, M.2    Hallberg, A.3
  • 16
    • 3242892150 scopus 로고    scopus 로고
    • 1 receptor blockade in conscious SHR
    • DOI 10.1038/sj.bjp.0705838
    • Li XC, Widdop RE. AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR. Br J Pharmacol. 2004;142:821-30. (Pubitemid 38998096)
    • (2004) British Journal of Pharmacology , vol.142 , Issue.5 , pp. 821-830
    • Li, X.C.1    Widdop, R.E.2
  • 17
    • 0032733920 scopus 로고    scopus 로고
    • AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats
    • 10567191 10.1161/01.HYP.34.5.1112 1:CAS:528:DyaK1MXnvFCisrs%3D
    • Barber MN, Sampey DB, Widdop RE. AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats. Hypertension. 1999;34:1112-6.
    • (1999) Hypertension , vol.34 , pp. 1112-1116
    • Barber, M.N.1    Sampey, D.B.2    Widdop, R.E.3
  • 18
    • 76449117787 scopus 로고    scopus 로고
    • Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats
    • 20128808 10.1111/j.1476-5381.2009.00575.x 1:CAS:528:DC%2BC3cXitlChsr0%3D Comprehensive dose-ranging study of the in vitro and in vivo vascular effects of Compound 21
    • •• Bosnyak S, Welungoda IK, Hallberg A, et al. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol. 2010;159:709-16. Comprehensive dose-ranging study of the in vitro and in vivo vascular effects of Compound 21.
    • (2010) Br J Pharmacol , vol.159 , pp. 709-716
    • Bosnyak, S.1    Welungoda, I.K.2    Hallberg, A.3
  • 19
    • 84865467701 scopus 로고    scopus 로고
    • Compound 21 Induces Vasorelaxation via an Endothelium- and Angiotensin II Type 2 Receptor-Independent Mechanism / Novelty and Significance
    • 2 receptors
    • 2 receptors.
    • (2012) Hypertension , vol.60 , pp. 722-729
    • Verdonk, K.1    Durik, M.2    Abd-Alla, N.3
  • 20
    • 74949119893 scopus 로고    scopus 로고
    • Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: Loss of angiotensin II type 2 receptor-mediated vasodilation
    • 20026759 10.1161/HYPERTENSIONAHA.109.145037 1:CAS:528: DC%2BC3cXotVaiuw%3D%3D
    • Moltzer E, Verkuil AV, van Veghel R, et al. Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. Hypertension. 2010;55:516-22.
    • (2010) Hypertension , vol.55 , pp. 516-522
    • Moltzer, E.1    Verkuil, A.V.2    Van Veghel, R.3
  • 21
    • 84865499511 scopus 로고    scopus 로고
    • Why do we need a selective angiotensin II type 2 receptor agonist?
    • 22802228 10.1161/HYPERTENSIONAHA.112.197046 1:CAS:528:DC%2BC38Xht1SitbrP
    • Henrion D. Why do we need a selective angiotensin II type 2 receptor agonist? Hypertension. 2012;60:616-7.
    • (2012) Hypertension , vol.60 , pp. 616-617
    • Henrion, D.1
  • 22
    • 0016182679 scopus 로고
    • Pharmacology of angiotensin
    • 4371235 1:CAS:528:DyaE2MXltFOqtQ%3D%3D
    • Regoli D, Park WK, Rioux F. Pharmacology of angiotensin. Pharmacol Rev. 1974;26:69-123.
    • (1974) Pharmacol Rev , vol.26 , pp. 69-123
    • Regoli, D.1    Park, W.K.2    Rioux, F.3
  • 23
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology. XXIII. The angiotensin II receptors
    • 10977869
    • de Gasparo M, Catt KJ, Inagami T, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415-72.
    • (2000) Pharmacol Rev , vol.52 , pp. 415-472
    • De Gasparo, M.1    Catt, K.J.2    Inagami, T.3
  • 25
    • 38549150268 scopus 로고    scopus 로고
    • 2 receptor-mediated natriuresis in rats
    • DOI 10.1161/HYPERTENSIONAHA.107.103242, PII 0000426820080200100008
    • Padia SH, Kemp BA, Howell NL, et al. Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor Mediated Natriuresis In Rats. Hypertension. 2008;51:460-5. (Pubitemid 351156433)
    • (2008) Hypertension , vol.51 , Issue.2 PART 2 , pp. 460-465
    • Padia, S.H.1    Kemp, B.A.2    Howell, N.L.3    Fournie-Zaluski, M.-C.4    Roques, B.P.5    Carey, R.M.6
  • 26
    • 33847049473 scopus 로고    scopus 로고
    • Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor-Blocked Rats
    • 17190872 10.1161/01.HYP.0000254833.85106.4d 1:CAS:528: DC%2BD2sXhslCmsL0%3D
    • Padia SH, Kemp BA, Howell NL, et al. Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor-Blocked Rats. Hypertension. 2007;49:625-30.
    • (2007) Hypertension , vol.49 , pp. 625-630
    • Padia, S.H.1    Kemp, B.A.2    Howell, N.L.3
  • 27
    • 33644987169 scopus 로고    scopus 로고
    • Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat
    • DOI 10.1161/01.HYP.0000196950.48596.21
    • Padia SH, Howell NL, Siragy HM, et al. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension. 2006;47:537-44. (Pubitemid 43843872)
    • (2006) Hypertension , vol.47 , Issue.3 , pp. 537-544
    • Padia, S.H.1    Howell, N.L.2    Siragy, H.M.3    Carey, R.M.4
  • 28
    • 18244391184 scopus 로고    scopus 로고
    • Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats
    • DOI 10.1161/01.HYP.0000160325.59323.b8
    • Walters PE, Gaspari TA, Widdop RE. Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats. Hypertension. 2005;45:960-6. (Pubitemid 40628944)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 960-966
    • Walters, P.E.1    Gaspari, T.A.2    Widdop, R.E.3
  • 29
    • 38849168247 scopus 로고    scopus 로고
    • Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice
    • DOI 10.1093/cvr/cvm021
    • Vinh A, Widdop RE, Drummond GR, et al. Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice. Cardiovasc Res. 2008;77:178-87. (Pubitemid 351195149)
    • (2008) Cardiovascular Research , vol.77 , Issue.1 , pp. 178-187
    • Vinh, A.1    Widdop, R.E.2    Drummond, G.R.3    Gaspari, T.A.4
  • 30
    • 84868282338 scopus 로고    scopus 로고
    • Differential mechanisms of Ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats
    • 22187625 1:STN:280:DC%2BC38%2FovF2rtw%3D%3D Striking difference in the vascular phenotype of Ang (1-7) given acutely to either young-adult or aged conscious rats
    • • Bosnyak S, Widdop RE, Denton KM, et al. Differential mechanisms of Ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. Int J Hypertens. 2012;2012:192567. Striking difference in the vascular phenotype of Ang (1-7) given acutely to either young-adult or aged conscious rats.
    • (2012) Int J Hypertens , vol.2012 , pp. 192567
    • Bosnyak, S.1    Widdop, R.E.2    Denton, K.M.3
  • 33
    • 84863240765 scopus 로고    scopus 로고
    • From the first selective non-peptide AT(2) receptor agonist to structurally related antagonists
    • 2 receptor antagonist by minor substitutions to the structure of Compound 21
    • 2 receptor antagonist by minor substitutions to the structure of Compound 21.
    • (2012) J Med Chem , vol.55 , pp. 2265-2278
    • Murugaiah, A.M.1    Wu, X.2    Wallinder, C.3
  • 34
    • 79953216990 scopus 로고    scopus 로고
    • A Single beta-Amino Acid Substitution to Angiotensin II Confers AT(2) Receptor Selectivity and Vascular Function
    • 1 receptor selectivity and function
    • 1 receptor selectivity and function.
    • (2011) Hypertension , vol.57 , pp. 570-576
    • Jones, E.S.1    Del Borgo, M.P.2    Kirsch, J.F.3
  • 35
    • 77951293287 scopus 로고    scopus 로고
    • Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
    • 20411619 10.1097/HJH.0b013e328335d291 1:CAS:528:DC%2BC3cXkslKmsLk%3D
    • Ocaranza MP, Lavandero S, Jalil JE, et al. Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro. J Hypertens. 2010;28:1054-64.
    • (2010) J Hypertens , vol.28 , pp. 1054-1064
    • Ocaranza, M.P.1    Lavandero, S.2    Jalil, J.E.3
  • 36
    • 79951711793 scopus 로고    scopus 로고
    • Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor
    • 21173078 10.1113/jphysiol.2010.203075 1:CAS:528:DC%2BC3MXksFOmsLs%3D
    • Flores-Munoz M, Smith NJ, Haggerty C, et al. Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor. J Physiol. 2011;589:939-51.
    • (2011) J Physiol , vol.589 , pp. 939-951
    • Flores-Munoz, M.1    Smith, N.J.2    Haggerty, C.3
  • 37
    • 84856257062 scopus 로고    scopus 로고
    • Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor
    • 2 receptors, although a contribution by other metabolized Ang peptides and mechanisms needs to be fully ruled out
    • 2 receptors, although a contribution by other metabolized Ang peptides and mechanisms needs to be fully ruled out.
    • (2012) Hypertension , vol.59 , pp. 300-307
    • Flores-Munoz, M.1    Work, L.M.2    Douglas, K.3
  • 38
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin i to angiotensin 1-9
    • 10969042 10.1161/01.RES.87.5.e1 1:CAS:528:DC%2BD3MXhslOisr8%3D
    • Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87:E1-9.
    • (2000) Circ Res , vol.87 , pp. 1-9
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3
  • 39
    • 84856114750 scopus 로고    scopus 로고
    • Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis
    • 22203736 10.1161/HYPERTENSIONAHA.111.184788 1:CAS:528: DC%2BC38Xns1alsA%3D%3D
    • Padia SH, Kemp BA, Howell NL, et al. Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis. Hypertension. 2012;59:437-45.
    • (2012) Hypertension , vol.59 , pp. 437-445
    • Padia, S.H.1    Kemp, B.A.2    Howell, N.L.3
  • 40
    • 33847615585 scopus 로고    scopus 로고
    • Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism
    • DOI 10.1161/01.HYP.0000251881.89610.ee, PII 0000426820070100000030
    • Salomone LJ, Howell NL, McGrath HE, et al. Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism. Hypertension. 2007;49:155-61. (Pubitemid 46360355)
    • (2007) Hypertension , vol.49 , Issue.1 , pp. 155-161
    • Salomone, L.J.1    Howell, N.L.2    McGrath, H.E.3    Kemp, B.A.4    Keller, S.R.5    Gildea, J.J.6    Felder, R.A.7    Carey, R.M.8
  • 41
    • 84864276934 scopus 로고    scopus 로고
    • Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors
    • 22689743 10.1161/HYPERTENSIONAHA.112.191403 1:CAS:528:DC%2BC38XhtVCrs73F Current paper from a series of publications that shows Ang III, but not Ang II or Ang (1-7), causes AT2 receptor mediated natriuresis
    • •• Kemp BA, Bell JF, Rottkamp DM, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012;60:387-95. Current paper from a series of publications that shows Ang III, but not Ang II or Ang (1-7), causes AT2 receptor mediated natriuresis.
    • (2012) Hypertension , vol.60 , pp. 387-395
    • Kemp, B.A.1    Bell, J.F.2    Rottkamp, D.M.3
  • 42
    • 83655193396 scopus 로고    scopus 로고
    • Sex Differences in the Pressor and Tubuloglomerular Feedback Response to Angiotensin II
    • 22124434 10.1161/HYPERTENSIONAHA.111.178715 1:CAS:528:DC%2BC3MXhs1WksrvL
    • Brown RD, Hilliard LM, Head GA, et al. Sex Differences in the Pressor and Tubuloglomerular Feedback Response to Angiotensin II. Hypertension. 2012;59:129-35.
    • (2012) Hypertension , vol.59 , pp. 129-135
    • Brown, R.D.1    Hilliard, L.M.2    Head, G.A.3
  • 43
    • 54749085871 scopus 로고    scopus 로고
    • Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats
    • 18711010 10.1161/HYPERTENSIONAHA.108.114058 1:CAS:528:DC%2BD1cXhtV2jsr3I
    • Sampson AK, Moritz KM, Jones ES, et al. Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats. Hypertension. 2008;52:666-71.
    • (2008) Hypertension , vol.52 , pp. 666-671
    • Sampson, A.K.1    Moritz, K.M.2    Jones, E.S.3
  • 44
    • 79551499015 scopus 로고    scopus 로고
    • Gender Differences in Pressure-Natriuresis and Renal Autoregulation Role of the Angiotensin Type 2 Receptor
    • 2 receptors in renal vasculature in female, as compared to male, rats
    • 2 receptors in renal vasculature in female, as compared to male, rats.
    • (2011) Hypertension , vol.57 , pp. 275-282
    • Hilliard, L.M.1    Nematbakhsh, M.2    Kett, M.M.3
  • 45
    • 84856097765 scopus 로고    scopus 로고
    • Sex-Specific Influence of Angiotensin Type 2 Receptor Stimulation on Renal Function
    • 2 receptor-mediated renal vasodilator response to Compound 21 in female, as compared to male, rats
    • 2 receptor-mediated renal vasodilator response to Compound 21 in female, as compared to male, rats.
    • (2012) Hypertension , vol.59 , pp. 409-414
    • Hilliard, L.M.1    Jones, E.S.2    Steckelings, U.M.3
  • 46
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats
    • 2 receptor antagonist PD123319 was not examined
    • 2 receptor antagonist PD123319 was not examined.
    • (2012) Hypertension , vol.59 , pp. 291-299
    • Rehman, A.1    Leibowitz, A.2    Yamamoto, N.3
  • 47
    • 84856201427 scopus 로고    scopus 로고
    • Direct Angiotensin II Type 2 Receptor Stimulation in N-Nitro-l-Arginine- Methyl Ester- Induced Hypertension
    • 2 receptor antagonist PD123319 was not examined
    • 2 receptor antagonist PD123319 was not examined.
    • (2012) Hypertension , vol.59 , pp. 485-492
    • Paulis, L.1    Becker, S.T.R.2    Lucht, K.3
  • 48
    • 79551505061 scopus 로고    scopus 로고
    • Angiotensin AT2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension
    • 21189405 10.1161/HYPERTENSIONAHA.110.164202 1:CAS:528: DC%2BC3MXnvVWmuw%3D%3D One of the first studies to show anti-inflammatory effects of Compound 21 in the kidney after short-term treatment with Compound 21
    • • Matavelli LC, Huang J, Siragy HM. Angiotensin AT2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension. Hypertension. 2011;57:308-13. One of the first studies to show anti-inflammatory effects of Compound 21 in the kidney after short-term treatment with Compound 21.
    • (2011) Hypertension , vol.57 , pp. 308-313
    • Matavelli, L.C.1    Huang, J.2    Siragy, H.M.3
  • 49
    • 73649119592 scopus 로고    scopus 로고
    • Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: Focus on renal damage
    • 19680135 10.1097/HJH.0b013e3283311ba1 1:CAS:528:DC%2BD1MXhsVanu7jL
    • Gelosa P, Pignieri A, Fändriks L, et al. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens. 2009;27:2444-51.
    • (2009) J Hypertens , vol.27 , pp. 2444-2451
    • Gelosa, P.1    Pignieri, A.2    Fändriks, L.3
  • 50
    • 84870523200 scopus 로고    scopus 로고
    • Impact of the AT(2) receptor agonist C21 on blood pressure and beyond
    • 22836386 10.1007/s11906-012-0291-6 1:CAS:528:DC%2BC38XhtlWlurzL
    • Foulquier S, Steckelings UM, Unger T. Impact of the AT(2) receptor agonist C21 on blood pressure and beyond. Curr Hypertens Rep. 2012;14:403-9.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 403-409
    • Foulquier, S.1    Steckelings, U.M.2    Unger, T.3
  • 51
    • 84859885811 scopus 로고    scopus 로고
    • A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice
    • 22157261 10.1097/FJC.0b013e3182444110 1:CAS:528:DC%2BC38XlsVaku7w%3D
    • Jehle AB, Xu Y, Dimaria JM, et al. A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice. J Cardiovasc Pharmacol. 2012;59:363-8.
    • (2012) J Cardiovasc Pharmacol , vol.59 , pp. 363-368
    • Jehle, A.B.1    Xu, Y.2    Dimaria, J.M.3
  • 52
    • 65249180615 scopus 로고    scopus 로고
    • Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke
    • 19246705 10.1161/STROKEAHA.108.531509 1:CAS:528:DC%2BD1MXjsVOntb0%3D
    • McCarthy CA, Vinh A, Callaway JK, et al. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482-9.
    • (2009) Stroke , vol.40 , pp. 1482-1489
    • McCarthy, C.A.1    Vinh, A.2    Callaway, J.K.3
  • 53
    • 84870245689 scopus 로고    scopus 로고
    • Angiotensin II Type 2 Receptor Stimulation Initiated after Stroke Causes Neuroprotection in Conscious Rats
    • Oct 22 [Epub ahead of print]. Proof-of-principle report showing that CGP42112, given centrally 6 hours after stroke in conscious spontaneously hypertensive rats, still evoked neuroprotection
    • •• McCarthy CA, Vinh A, Broughton BR, et al. Angiotensin II Type 2 Receptor Stimulation Initiated After Stroke Causes Neuroprotection in Conscious Rats. Hypertension. 2012, Oct 22 [Epub ahead of print]. Proof-of-principle report showing that CGP42112, given centrally 6 hours after stroke in conscious spontaneously hypertensive rats, still evoked neuroprotection.
    • (2012) Hypertension
    • McCarthy, C.A.1    Vinh, A.2    Broughton, B.R.3
  • 54
    • 84868694549 scopus 로고    scopus 로고
    • Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo
    • 4: Aug 24 [Epub ahead of print]. Proof-of-principle report showing that CGP42112, given peripherally at the time of ischaemia/reperfusion in anaesthetised mice, evoked neuroprotection
    • •• Lee S, Brait V, Arumugam T, et al. Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo. Exp Transl Stroke Med. 2012, 4: Aug 24 [Epub ahead of print]. Proof-of-principle report showing that CGP42112, given peripherally at the time of ischaemia/reperfusion in anaesthetised mice, evoked neuroprotection.
    • (2012) Exp Transl Stroke Med.
    • Lee, S.1    Brait, V.2    Arumugam, T.3
  • 55
    • 81055156294 scopus 로고    scopus 로고
    • Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT2 receptor agonist, to the striatum in rats
    • 21723321 10.1016/j.jneumeth.2011.06.009 1:CAS:528:DC%2BC3MXhsVOhtrfO
    • Shraim N, Mertens B, Clinckers R, et al. Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT2 receptor agonist, to the striatum in rats. J Neurosci Methods. 2011;202:137-42.
    • (2011) J Neurosci Methods , vol.202 , pp. 137-142
    • Shraim, N.1    Mertens, B.2    Clinckers, R.3
  • 56
    • 80052853007 scopus 로고    scopus 로고
    • Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke
    • 21685445 1:CAS:528:DC%2BC3MXhtlOnt7bE First report showing that Ang (1-7) can also evoke neuroprotective effects
    • • Mecca AP, Regenhardt RW, O'Connor TE, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol. 2011;96:1084-96. First report showing that Ang (1-7) can also evoke neuroprotective effects.
    • (2011) Exp Physiol , vol.96 , pp. 1084-1096
    • Mecca, A.P.1    Regenhardt, R.W.2    O'Connor, T.E.3
  • 57
    • 84864474059 scopus 로고    scopus 로고
    • Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function
    • 10.1007/s00213-012-2639-7 1:CAS:528:DC%2BC38XivVSjurs%3D
    • Tota S, Hanif K, Kamat PK, et al. Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function. Psychopharmacology (Berl). 2012;222:185-202.
    • (2012) Psychopharmacology (Berl) , vol.222 , pp. 185-202
    • Tota, S.1    Hanif, K.2    Kamat, P.K.3
  • 58
    • 84856479413 scopus 로고    scopus 로고
    • Direct stimulation of angiotensin II type 2 receptor enhances spatial memory
    • 21971355 10.1038/jcbfm.2011.133 1:CAS:528:DC%2BC38XhslOksLk%3D First report on the improved cognitive effects of Compound 21
    • •• Jing F, Mogi M, Sakata A, et al. Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab. 2012;32:248-55. First report on the improved cognitive effects of Compound 21.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 248-255
    • Jing, F.1    Mogi, M.2    Sakata, A.3
  • 59
    • 84862322861 scopus 로고    scopus 로고
    • Regulation of angiotensin II receptors beyond the classical pathway
    • 22548405 10.1042/CS20110677 1:CAS:528:DC%2BC38Xhs1Wqt7nI An excellent recent review summarising a number of aspects of nonclassical Ang signaling that are not covered in the current update
    • • Horiuchi M, Iwanami J, Mogi M. Regulation of angiotensin II receptors beyond the classical pathway. Clin Sci. 2012;123:193-203. An excellent recent review summarising a number of aspects of nonclassical Ang signaling that are not covered in the current update.
    • (2012) Clin Sci , vol.123 , pp. 193-203
    • Horiuchi, M.1    Iwanami, J.2    Mogi, M.3


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