Perturbation of the transcriptome: Implications of the innate immune system in Alzheimer's disease

Current Opinion in Pharmacology

Volumn 26, Issue , 2016, Pages 47-53

  Song, Fuhai ^a,b   Qian, Ying ^a,b   Peng, Xing ^a,b   Han, Guangchun ^a   Wang, Jiajia ^a,b   Bai, Zhouxian ^a,b   Crack, Peter J ^c   Lei, Hongxing ^a,d  

^a Chinese Academy of Sciences   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TRANSCRIPTOME; TREM2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; DISEASE COURSE; FRONTOTEMPORAL DEMENTIA; GENE; GENE CLUSTER; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNE DYSREGULATION; INNATE IMMUNITY; MICROGLIA; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RISK FACTOR; TREM2 GENE; UPREGULATION; ANIMAL; GENETICS; IMMUNOLOGY;

ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; HUMANS; IMMUNITY, INNATE; MEMBRANE GLYCOPROTEINS; MICROGLIA; RECEPTORS, IMMUNOLOGIC; TRANSCRIPTOME;

EID: 84944396178     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.09.015     Document Type: Review

References (58)

1. G. Han, J. Sun, J. Wang, Z. Bai, F. Song, and H. Lei Genomics in neurological disorders Genomics Proteomics Bioinformatics 12 2014 156 163
2. S. Reardon Antibody drugs for Alzheimer's show glimmers of promise Nature 523 2015 509 510
3. C.E. Hanzel, A. Pichet-Binette, L.S. Pimentel, M.F. Iulita, S. Allard, A. Ducatenzeiler, S. Do Carmo, and A.C. Cuello Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease Neurobiol Aging 35 2014 2249 2262
4. M.V. Guillot-Sestier, K.R. Doty, D. Gate, J. Rodriguez Jr., B.P. Leung, K. Rezai-Zadeh, and T. Town Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology Neuron 85 2015 534 548
5. P. Maheshwari, and G.D. Eslick Bacterial infection and Alzheimer's disease: a meta-analysis J Alzheimers Dis 43 2015 957 966
6. A.R. Kamer, E. Pirraglia, W. Tsui, H. Rusinek, S. Vallabhajosula, L. Mosconi, L. Yi, P. McHugh, R.G. Craig, S. Svetcov, and et al. Periodontal disease associates with higher brain amyloid load in normal elderly Neurobiol Aging 36 2015 627 633
7. D.P. Bhatt, K.L. Puig, M.W. Gorr, L.E. Wold, and C.K. Combs A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain PLOS ONE 10 2015 e0127102
8. M.D. Filiou, A.S. Arefin, P. Moscato, and M.B. Graeber 'Neuroinflammation' differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared Neurogenetics 15 2014 201 212
9. T. Raj, K. Rothamel, S. Mostafavi, C. Ye, M.N. Lee, J.M. Replogle, T. Feng, M. Lee, N. Asinovski, I. Frohlich, and et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes Science 344 2014 519 523
10. E.M. Blalock, J.W. Geddes, K.C. Chen, N.M. Porter, W.R. Markesbery, and P.W. Landfield Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses Proc Natl Acad Sci U S A 101 2004 2173 2178
11. K. Bossers, K.T.S. Wirz, G.F. Meerhoff, A.H.W. Essing, J.W. van Dongen, P. Houba, C.G. Kruse, J. Verhaagen, and D.F. Swaab Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease Brain 133 2010 3699 3723
12. W.S. Liang, T. Dunckley, T.G. Beach, A. Grover, D. Mastroeni, K. Ramsey, R.J. Caselli, W.A. Kukull, D. McKeel, J.C. Morris, and et al. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set Physiol Genomics 33 2008 240 256
13. J.A. Webster, J.R. Gibbs, J. Clarke, M. Ray, W. Zhang, P. Holmans, K. Rohrer, A. Zhao, L. Marlowe, M. Kaleem, and et al. Genetic control of human brain transcript expression in Alzheimer disease Am J Hum Genet 84 2009 445 458
14. B. Zhang, C. Gaiteri, L.G. Bodea, Z. Wang, J. McElwee, A.A. Podtelezhnikov, C. Zhang, T. Xie, L. Tran, R. Dobrin, and et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease Cell 153 2013 707 720
15. IGAP Convergent genetic and expression data implicate immunity in Alzheimer's disease Alzheimers Dement 11 2015 658 671
16. E. Gjoneska, A.R. Pfenning, H. Mathys, G. Quon, A. Kundaje, L.H. Tsai, and M. Kellis Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease Nature 518 2015 365 369
17. J. Sun, X. Feng, D. Liang, Y. Duan, and H. Lei Down-regulation of energy metabolism in Alzheimer's disease is a protective response of neurons to the microenvironment J Alzheimers Dis 28 2012 389 402
18. X. Feng, Z. Bai, J. Wang, B. Xie, J. Sun, G. Han, F. Song, P.J. Crack, Y. Duan, and H. Lei Robust gene dysregulation in Alzheimer's disease brains J Alzheimers Dis 41 2014 587 597
19. Z. Bai, G. Han, B. Xie, J. Wang, F. Song, X. Peng, and H. Lei AlzBase: an integrative database for gene dysregulation in Alzheimer's disease Mol Neurobiol 2015 10.1007/s12035-014-9011-3
20. G. Cantarella, G. Di Benedetto, D. Puzzo, L. Privitera, C. Loreto, S. Saccone, S. Giunta, A. Palmeri, and R. Bernardini Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease Brain 138 2015 203 216
21. H. Lian, L. Yang, A. Cole, L. Sun, A.C. Chiang, S.W. Fowler, D.J. Shim, J. Rodriguez-Rivera, G. Taglialatela, J.L. Jankowsky, and et al. NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease Neuron 85 2015 101 115
22. J. Renziehausen, C. Hiebel, H. Nagel, A. Kundu, S. Kins, D. Kogel, C. Behl, and P. Hajieva The cleavage product of amyloid-beta protein precursor sAbetaPPalpha modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity J Alzheimers Dis 44 2015 879 896
23. Z. Lei, C. Brizzee, and G.V. Johnson BAG3 facilitates the clearance of endogenous tau in primary neurons Neurobiol Aging 36 2015 241 248
24. L.T. Nordestgaard, A. Tybjaerg-Hansen, B.G. Nordestgaard, and R. Frikke-Schmidt Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease Alzheimers Dement 2015 10.1016/j.jalz.2015.04.006
25. P.D. Rye, B.B. Booij, G. Grave, T. Lindahl, L. Kristiansen, H.M. Andersen, P.O. Horndalsveen, H.A. Nygaard, M. Naik, D. Hoprekstad, and et al. A novel blood test for the early detection of Alzheimer's disease J Alzheimers Dis 23 2011 121 129
26. L. Roed, G. Grave, T. Lindahl, E. Rian, P.O. Horndalsveen, L. Lannfelt, C. Nilsson, F. Swenson, A. Lonneborg, P. Sharma, and et al. Prediction of mild cognitive impairment that evolves into Alzheimer's disease dementia within two years using a gene expression signature in blood: a pilot study J Alzheimers Dis 35 2013 611 621
27. P. Fehlbaum-Beurdeley, A.C. Jarrige-Le Prado, D. Pallares, J. Carriere, C. Guihal, C. Soucaille, F. Rouet, D. Drouin, O. Sol, H. Jordan, and et al. Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression Alzheimers Dement 6 2010 25 38
28. K. Lunnon, M. Sattlecker, S.J. Furney, G. Coppola, A. Simmons, P. Proitsi, M.K. Lupton, A. Lourdusamy, C. Johnston, H. Soininen, and et al. A blood gene expression marker of early Alzheimer's disease J Alzheimers Dis 33 2013 737 753
29. G. Han, J. Wang, F. Zeng, X. Feng, J. Yu, H.Y. Cao, X. Yi, H. Zhou, L.W. Jin, Y. Duan, and et al. Characteristic transformation of blood transcriptome in Alzheimer's disease J Alzheimers Dis 35 2013 373 386
30. Z. Bai, B. Stamova, H. Xu, B.P. Ander, J. Wang, G.C. Jickling, X. Zhan, D. Liu, G. Han, L.W. Jin, and et al. Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities Alzheimer Dis Assoc Disord 28 2014 226 233
31. H. Luo, G. Han, J. Wang, F. Zeng, Y. Li, S. Shao, F. Song, Z. Bai, X. Peng, Y.J. Wang, and et al. Common aging signature in the peripheral blood of vascular dementia and Alzheimer's disease Mol Neurobiol 2015 10.1007/s12035-015-9288-x
32. P. Talwar, Y. Silla, S. Grover, M. Gupta, R. Agarwal, S. Kushwaha, and R. Kukreti Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease BMC Genomics 15 2014 199
33. M.Y. Liu, S. Wang, W.F. Yao, Z.J. Zhang, X. Zhong, L. Sha, M. He, Z.H. Zheng, and M.J. Wei Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice Neuroscience 273 2014 141 151
34. P. Jin, J.A. Kim, D.Y. Choi, Y.J. Lee, H.S. Jung, and J.T. Hong Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer's disease mice model J Neuroinflammation 10 2013 2
35. Y.B. Joshi, P.F. Giannopoulos, J. Chu, M. Sperow, L.G. Kirby, M.E. Abood, and D. Pratico Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease Hum Mol Genet 23 2014 6894 6902
36. L.M. Grimaldi, G. Zappala, F. Iemolo, A.E. Castellano, S. Ruggieri, G. Bruno, and A. Paolillo A pilot study on the use of interferon beta-1a in early Alzheimer's disease subjects J Neuroinflammation 11 2014 30
37. P.D. Wes, I.R. Holtman, E.W. Boddeke, T. Moller, and B.J. Eggen Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease Glia 2015 10.1002/glia.22866
38. M. Orre, W. Kamphuis, L.M. Osborn, A.H. Jansen, L. Kooijman, K. Bossers, and E.M. Hol Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction Neurobiol Aging 35 2014 2746 2760
39. S. Sekar, J. McDonald, L. Cuyugan, J. Aldrich, A. Kurdoglu, J. Adkins, G. Serrano, T.G. Beach, D.W. Craig, J. Valla, and et al. Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes Neurobiol Aging 36 2015 583 591
40. R. Baron, A.A. Babcock, A. Nemirovsky, B. Finsen, and A. Monsonego Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease Aging cell 13 2014 584 595
41. A.M. Minogue, R.S. Jones, R.J. Kelly, C.L. McDonald, T.J. Connor, and M.A. Lynch Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice Neurobiol Aging 35 2014 1442 1452
42. V. Landel, K. Baranger, I. Virard, B. Loriod, M. Khrestchatisky, S. Rivera, P. Benech, and F. Feron Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease Mol Neurodegener 9 2014 33
43. M.H. Cho, K. Cho, H.J. Kang, E.Y. Jeon, H.S. Kim, H.J. Kwon, H.M. Kim, D.H. Kim, and S.Y. Yoon Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome Autophagy 10 2014 1761 1775
44. M. Orre, W. Kamphuis, S. Dooves, L. Kooijman, E.T. Chan, C.J. Kirk, V. Dimayuga Smith, S. Koot, C. Mamber, A.H. Jansen, and et al. Reactive glia show increased immunoproteasome activity in Alzheimer's disease Brain 136 2013 1415 1431
45. N.S. Woodling, Q. Wang, P.G. Priyam, P. Larkin, J. Shi, J.U. Johansson, I. Zagol-Ikapitte, O. Boutaud, and K.I. Andreasson Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling J Neurosci 34 2014 5882 5894
46. B. Brawek, B. Schwendele, K. Riester, S. Kohsaka, C. Lerdkrai, Y. Liang, and O. Garaschuk Impairment of in vivo calcium signaling in amyloid plaque-associated microglia Acta Neuropathol 127 2014 495 505
47. E. Cudaback, Y. Yang, T.J. Montine, and C.D. Keene APOE genotype-dependent modulation of astrocyte chemokine CCL3 production Glia 63 2015 51 65
48. R. Guerreiro, A. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, E. Majounie, C. Cruchaga, C. Sassi, J.S. Kauwe, S. Younkin, and et al. TREM2 variants in Alzheimer's disease N Engl J Med 368 2012 117 127
49. D. Finelli, S. Rollinson, J. Harris, M. Jones, A. Richardson, A. Gerhard, J. Snowden, D. Mann, and S. Pickering-Brown TREM2 analysis and increased risk of Alzheimer's disease Neurobiol Aging 36 2015 546 e549-513
50. O. Korvatska, J.B. Leverenz, S. Jayadev, P. McMillan, I. Kurtz, X. Guo, M. Rumbaugh, M. Matsushita, S. Girirajan, M.O. Dorschner, and et al. R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study JAMA Neurol 72 2015 920 927
51. S.C. Jin, B.A. Benitez, C.M. Karch, B. Cooper, T. Skorupa, D. Carrell, J.B. Norton, S. Hsu, O. Harari, Y. Cai, and et al. Coding variants in TREM2 increase risk for Alzheimer's disease Hum Mol Genet 23 2014 5838 5846
52. N.C. Berchtold, D.H. Cribbs, P.D. Coleman, J. Rogers, E. Head, R. Kim, T. Beach, C. Miller, J. Troncoso, J.Q. Trojanowski, and et al. Gene expression changes in the course of normal brain aging are sexually dimorphic Proc Natl Acad Sci 105 2008 15605 15610
53. P. Forabosco, A. Ramasamy, D. Trabzuni, R. Walker, C. Smith, J. Bras, A.P. Levine, J. Hardy, J.M. Pocock, R. Guerreiro, and et al. Insights into TREM2 biology by network analysis of human brain gene expression data Neurobiol Aging 34 2013 2699 2714
54. G. Kleinberger, Y. Yamanishi, M. Suarez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, A. Wenninger-Weinzierl, F. Mazaheri, and et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis Sci Transl Med 6 2014 243ra86
55. X. Li, K.S. Montine, C.D. Keene, and T.J. Montine Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia Faseb J 29 2015 1754 1762
56. I. Lefterov, J. Schug, A. Mounier, K.N. Nam, N.F. Fitz, and R. Koldamova RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment Neurobiol Dis 82 2015 132 140
57. T. Jiang, J.T. Yu, X.C. Zhu, M.S. Tan, L.Z. Gu, Y.D. Zhang, and L. Tan Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice Neurobiol Aging 35 2014 1243 1251
58. T.R. Jay, C.M. Miller, P.J. Cheng, L.C. Graham, S. Bemiller, M.L. Broihier, G. Xu, D. Margevicius, J.C. Karlo, G.L. Sousa, and et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models J Exp Med 212 2015 287 295