Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Neurobiology of Aging

Volumn 36, Issue 2, 2015, Pages 583-591

  Sekar, Shobana ^a,b   McDonald, Jacquelyn ^a,b   Cuyugan, Lori ^a,b   Aldrich, Jessica ^a   Kurdoglu, Ahmet ^a   Adkins, Jonathan ^a,b   Serrano, Geidy ^b,c   Beach, Thomas G ^b,c   Craig, David W ^a   Valla, Jonathan ^b,d   Reiman, Eric M ^a,b,c,e   Liang, Winnie S ^a,b  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^b ARIZONA ALZHEIMER S CONSORTIUM   (United States)

^c SUN HEALTH RESEARCH INSTITUTE   (United States)

^d MIDWESTERN UNIVERSITY   (United States)

^e BANNER ALZHEIMER S INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Astrocytes; Immune response; Mitochondria; Posterior cingulate; RNA sequencing

Indexed keywords

CD74 ANTIGEN; COMPLEMENT COMPONENT C3; TRANSCRIPTOME; AMYLOID BETA PROTEIN; B LYMPHOCYTE ANTIGEN; C3 PROTEIN, HUMAN; CLU PROTEIN, HUMAN; CLUSTERIN; CYTOCHROME C OXIDASE; FASTKD2 PROTEIN, HUMAN; HLA ANTIGEN CLASS 2; INVARIANT CHAIN; NDUFA4 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TRANSFER RNA METHYLTRANSFERASE; TRMT61B PROTEIN, HUMAN;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; C3 GENE; CD74 GENE; CELL ASSAY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLU GENE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FASTKD2 GENE; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; IMMUNE RESPONSE; IMMUNE RESPONSE GENE; MALE; MITOCHONDRIAL RELATED GENE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NDUFA4L2 GENE; OUTCOME ASSESSMENT; POSTERIOR CINGULATE; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRMT61B GENE; VERY ELDERLY; BRAIN; CELLULAR IMMUNITY; CYTOLOGY; ENERGY METABOLISM; GENETICS; IMMUNOLOGY; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ASTROCYTES; BRAIN; CLUSTERIN; COMPLEMENT C3; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, CELLULAR; MALE; MITOCHONDRIA; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ANALYSIS, RNA; TRNA METHYLTRANSFERASES;

EID: 84922787347     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.09.027     Document Type: Article

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