A novel blood test for the early detection of Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 23, Issue 1, 2011, Pages 121-129

  Rye, Phil D ^a,j   Booij, Birgitte Boonstra ^a,k   Grave, Gisle ^a   Lindahl, Torbjørn ^a   Kristiansen, Lena ^a   Andersen, Hilde Marie ^a   Horndalsveen, Peter O ^b   Nygaard, Harald A ^c,d   Naik, Mala ^d,e   Hoprekstad, Dagne ^f   Wetterberg, Peter ^g   Nilsson, Christer ^h   Aarsland, Dag ⁱ   Sharma, Praveen ^a   Lönneborg, Anders ^a  

^a DiaGenic ASA   (Norway)

^b Sanderud Hospital   (Norway)

^c NKS Olaviken Hospital for Old Age Psychiatry   (Norway)

^d UNIVERSITY OF BERGEN   (Norway)

^e Haraldsplass Deaconess Hospital   (Norway)

^f STAVANGER UNIVERSITY HOSPITAL   (Norway)

^g ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^h LUND UNIVERSITY HOSPITAL   (Sweden)

ⁱ UNIVERSITY OF OSLO   (Norway)

^j GE HEALTHCARE   (Norway)

^k Clavis Pharma   (Norway)

more..

Author keywords

Alzheimer's disease; biomarker; blood; diagnostic test; gene expression; RNA

Indexed keywords

RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD EXAMINATION; CEREBROSPINAL FLUID; CLASSIFICATION ALGORITHM; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; EARLY DIAGNOSIS; FEMALE; GENETIC MARKER; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RNA EXTRACTION; SENSITIVITY AND SPECIFICITY; SERIAL ANALYSIS OF GENE EXPRESSION; VALIDATION PROCESS;

EID: 78651371164     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-101521     Document Type: Article

References (38)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112-2117.
2. Wimo A, Winblad B, Jönsson L (2007) An estimate of the total worldwide societalcostsofdementiain2005.Alzheimers Dement 3, 81-91.
3. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
4. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, JichaG,MeguroK,O'BrienJ,PasquierF, RobertP,Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746.
5. Li Y, Rinne JO, Mosconi L, Pirraglia E, Rusinek H, DeSanti S, Kemppainen N, Nagren K, Kim BC, Tsui W, de Leon MJ (2008) Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur J Nucl Med Mol Imaging 35, 2169-2181.
6. Brys M, Glodzik L, Mosconi L, Switalski R, De Santi S, Pirraglia E, Rich K, Kim BC, Mehta P, Zinkowski R, Pratico D, Wallin A, Zetterberg H, Tsui WH, Rusinek H, Blennow K, de Leon MJ (2009) Magnetic resonance imaging improves cerebrospinalfluid biomarkersinthe early detection of Alzheimer's disease. J Alzheimers Dis 16, 351-362.
7. Buchhave P, Blennow K, Zetterberg H, Stomrud E, Londos E, Andreasen N, Minthon L, Hansson O (2009) Longitudinal studyofCSF biomarkersin patients with Alzheimer's disease. PLoS One 4, e6294.
8. Maes OC, Xu S, YuB, Chertkow HM, WangE, Schipper HM (2007) Transcriptional profiling of Alzheimer blood mononu-clear cells by microarray. Neurobiol Aging 28, 1795-1809.
9. Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR (2007) Molecular markers of early Parkinson's disease based on gene expression in blood. Proc Natl Acad Sci USA 104, 955-960.
10. Sharp FR, Xu H, Lit L, Walker W, Apperson M, Gilbert DL, Glauser TA, Wong B, Hershey A, Liu DZ, Pinter J, Zhan X, Liu X, Ran R (2006) The future of genomic profiling of neurological diseases using blood. Arch Neurol 63, 1529-1536.
11. Tang Y, Nee AC, Lu A, Ran R, Sharp FR (2003) Blood genomic expression profile for neuronal injury. J Cereb Blood Flow Metab 23, 310-319.
12. Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR (2004) Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain Res Mol Brain Res 132, 155-167.
13. Lonneborg A (2008) Biomarkers for Alzheimer disease in cerebrospinal fluid, urine, and blood. Mol Diagn Ther 12, 307-320.
14. Winblad B, Lönneborg A (2008) Blood biomarkers for Alzheimer's disease. Eur Neurol Rev 3, 28-30.
15. Fehlbaum-Beurdeley P, Jarrige A-C, Pallares D, Carriere J, Guihal C, Soucaille C, Rouet F, Drouin D, Sol O, Jordan H, Wu D, Lei L, Einstein R, Schweighoffer F, Bracco L (2010) Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression. Alzheimers Dementia 6, 25-38.
16. Grunblatt E, Bartl J, Zehetmayer S, Ringel TM, Bauer P, Riederer P, Jacob CP (2009) Gene expression as peripheral biomarkers for sporadic Alzheimer's disease. J Alzheimers Dis 16, 627-634.
17. Booij BB, LindahlT,WetterbergP,Skaane NV, SaeboS,Feten G, Rye PD, Kristiansen L, Hagen N, Jensen M, Bardsen K, WinbladB, Sharma P,Lönneborg A (2010) Agene expression patternin blood for the early detectionofAlzheimer's disease. J Alzheimers Dis 23, 109-119.
18. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
19. Freedman M (1994) Clock Drawing: A Neuropsychological Analysis, Oxford University Press, New York.
20. Scanlan JM, Brush M, Quijano C, Borson S (2002) Comparing clock tests for dementia screening: naive judgments vs formal systems-what is optimal? Int J Geriatr Psychiatry 17, 14-21.
21. Kendrick DC (1985) Kendrick Cognitive Test for the Elderly, The NFER-NELSON Publishing Company Ltd, Windsor, UK.
22. Welsh K, Butters N, Hughes J, Mohs R, Heyman A (1991) Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Arch Neurol 48, 278-281.
23. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39, 1159-1165.
24. Brown EC, Casey A, Fisch RI, Neuringer C (1958) Trail making testasascreeningdevice forthe detectionofbraindamage. J Consult Psychol 22, 469-474.
25. Morris JC (1993) The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43, 2412-2414.
26. Dasarathy BV (1991) Nearest Neighbor (NN) Norms: NN Pattern Classification Techniques, IEEE Computer Society Press, Los Alamitos, California.
27. Albert PS (2009) Estimating diagnostic accuracy of multiple binary tests with an imperfect reference standard. Stat Med 28, 780-797.
28. Baker SG (1991) Evaluating a new test using a reference test with estimated sensitivity and specificity. Commun Stat Theory Methods 20, 2739-2752.
29. Valenstein PN (1990) Evaluating diagnostic tests with imperfect standards. Am J Clin Pathol 93, 252-258.
30. Mok W, Chow TW, Zheng L, Mack WJ, Miller C (2004) Clinicopathological concordance of dementia diagnoses by community versus tertiary care clinicians. Am J Alzheimers Dis Other Demen 19, 161-165.
31. Zekry D, Duyckaerts C, Belmin J, Geoffre C, Moulias R, Hauw JJ (2002) Alzheimer's disease and brain infarcts in the elderly. Agreement with neuropathology. J Neurol 249, 1529-1534.
32. -(1998) Consensus report of the Working Group on: "Molecular and biochemical markers of Alzheimer's disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol Aging 19, 109-116.
33. U.S. Department of Health and Human Services, Food and Drug Administration, Guidance for Industry and FDA Staff-Statistical Guidance on Reporting Results from Studies Evaluating Diagnostic Tests, http://www.fda.gov/ downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ UCM071287.pdf, Posted 13 March, 2007, Accessed August, 2010.
34. Brunnstrom H, Rawshani N, Zetterberg H, Blennow K, Minthon L, Passant U, Englund E (2010) Cerebrospinal fluid biomarker results in relation to neuropathological dementia diagnoses. Alzheimers Dement 6, 104-109.
35. Liew CC,MaJ, Tang HC, Zheng R, DempseyAA(2006) The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 147, 126-132.
36. Sullivan PF, Fan C, Perou CM (2006) Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet 141, 261-268.
37. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39, 17-23.
38. Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T (2007) Classification and prediction of clinical Alzheimer's diagnosis basedonplasma signaling proteins. Nat Med 13, 1359-1362.