The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity

Journal of Alzheimer's Disease

Volumn 44, Issue 3, 2015, Pages 879-896

  Renziehausen, Jana ^a   Hiebel, Christof ^a   Nagel, Heike ^a   Kundu, Arpita ^b   Kins, Stefan ^c   Kögel, Donat ^b   Behl, Christian ^a   Hajieva, Parvana ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c University of Koblenz Landau   (Germany)

Author keywords

Alzheimer's disease; autophagy; Bag3 protein; fibroblasts; proteasome; sA PP

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN; PROTEIN BAG 3; PROTEIN LC3; PROTEIN P62; SOLUBLE AMYLOID BETA PROTEIN PRECURSOR ALPHA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAG3 PROTEIN, HUMAN; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYSTEINE PROTEINASE INHIBITOR; GREEN FLUORESCENT PROTEIN; LEUPEPTIN; SECRETASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA;

AGGRESOME; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MACROAUTOPHAGY; MOLECULAR BIOLOGY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; RAT; TRANSCRIPTION REGULATION; ANIMAL; ANIMAL EMBRYO; BRAIN; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT; TIME;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BRAIN; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LEUPEPTINS; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION;

EID: 84922623224     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140600     Document Type: Article

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