RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

Neurobiology of Disease

Volumn 82, Issue , 2015, Pages 132-140

  Lefterov, Iliya ^a   Schug, Jonathan ^b   Mounier, Anais ^a   Nam, Kyong Nyon ^a   Fitz, Nicholas F ^a   Koldamova, Radosveta ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; APP PS1 transgenic mice; A phagocytosis; Bexarotene; ChIP; MRNA seq; RXR; Trem2; Tyrobp

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BEXAROTENE; PREALBUMIN; RETINOID X RECEPTOR; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TETRALIN DERIVATIVE; TREM2 PROTEIN, MOUSE; TYROBP PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOE GENE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; FEMALE; GENE; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; IMMUNE RESPONSE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; RNA SEQUENCE; TRANSCRIPTION REGULATION; TREM2 GENE; TTR GENE; TYROBP GENE; UPREGULATION; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SEQUENCE ANALYSIS; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYLOID BETA-PEPTIDES; ANIMALS; ANTICARCINOGENIC AGENTS; APOLIPOPROTEINS E; BRAIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC; RETINOID X RECEPTORS; SEQUENCE ANALYSIS, RNA; TETRAHYDRONAPHTHALENES; UP-REGULATION;

EID: 84934964053     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.05.019     Document Type: Article

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