Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

Neurobiology of Aging

Volumn 35, Issue 6, 2014, Pages 1442-1452

  Minogue, Aedín M ^a   Jones, Raasay S ^a   Kelly, Ronan J ^a   McDonald, Claire L ^a   Connor, Thomas J ^a   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Alzheimer's disease; Blood brain barrier permeability; Infiltrating immune cells; Interferon ; Microglial activation states

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CD11B ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 4; NERVE GROWTH FACTOR; STAT1 PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; AMYLOID PRECURSOR PROTEIN; AUTACOID; PRESENILIN 1;

AGING; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CELL ACTIVATION; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IMMUNOCOMPETENT CELL; MACROPHAGE; MALE; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PERMEABILITY;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MUTATION; PERMEABILITY; PRESENILIN-1; UP-REGULATION;

EID: 84903371932     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.12.026     Document Type: Article

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