AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

Cell Cycle

Volumn 14, Issue 15, 2015, Pages 2520-2536

  Chen, Shuyang ^a   Yin, Chengqian ^a   Lao, Taotao ^a,e   Liang, Dongming ^a,f   He, Dan ^a   Wang, Chenguang ^b,c   Sang, Nianli ^a,d  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b INSTITUTE OF RADIATION MEDICINE   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e CHANNING LABORATORY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

AMPK; Deacetylation; HDAC5; HIF 1; Hsp70; Nuclear export

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CARBONATE DEHYDRATASE IX; GLUCOSE; GLUCOSE TRANSPORTER 1; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 6; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROTEASOME; SMALL INTERFERING RNA; TRICHOSTATIN A; HDAC5 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HISTONE DEACETYLASE;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL HYPOXIA; CELL LEVEL; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; DEACETYLATION; DOWN REGULATION; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; ENZYME SYNTHESIS; GENE DELETION; GENE OVEREXPRESSION; GENE SILENCING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GLYCOLYSIS; HELA CELL LINE; HISTONE UBIQUITINATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MCF 7 CELL LINE; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION; STEADY STATE; TRANSACTIVATION; UPREGULATION; ENZYME ACTIVATION; GENETICS; MCF-7 CELL LINE; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOSOL; ENZYME ACTIVATION; HELA CELLS; HISTONE DEACETYLASES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MCF-7 CELLS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84943770063     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1055426     Document Type: Article

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