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Volumn 92, Issue , 2015, Pages 39-52

Mucoadhesive and thermogelling systems for vaginal drug delivery

Author keywords

In situ gel forming systems; Methods for mucoadhesion testing; Methods for thermogelling testing; Mucoadhesive formulations; Vaginal mucosa; Vaginal secretions

Indexed keywords

ALIPHATIC COMPOUNDS; ETHYLENE; MHEALTH; NANOPARTICLES; TARGETED DRUG DELIVERY;

EID: 84943456474     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2015.02.001     Document Type: Review
Times cited : (214)

References (156)
  • 1
    • 85056973355 scopus 로고    scopus 로고
    • Strategies to improve systemic and local availability of drugs administered via vaginal route
    • Taylor and Francis CRC Press, Boca Raton FL, E. Touitou, B.W. Barry (Eds.)
    • Sandri G., Rossi S., Ferrari F., Bonferoni M.C., Caramella C. Strategies to improve systemic and local availability of drugs administered via vaginal route. Enhancement in Drug Delivery 2007, 441-470. Taylor and Francis CRC Press, Boca Raton FL. E. Touitou, B.W. Barry (Eds.).
    • (2007) Enhancement in Drug Delivery , pp. 441-470
    • Sandri, G.1    Rossi, S.2    Ferrari, F.3    Bonferoni, M.C.4    Caramella, C.5
  • 2
    • 0017810686 scopus 로고
    • Human cervical mucus. IV. Viscoelasticity and sperm penetrability during the ovulatory menstrual cycle
    • Wolf D.P., Blasco L., Khan M.A., Litt M. Human cervical mucus. IV. Viscoelasticity and sperm penetrability during the ovulatory menstrual cycle. Fertil. Steril. 1978, 30:163-169.
    • (1978) Fertil. Steril. , vol.30 , pp. 163-169
    • Wolf, D.P.1    Blasco, L.2    Khan, M.A.3    Litt, M.4
  • 3
    • 0033023953 scopus 로고    scopus 로고
    • A vaginal fluid simulant
    • Owen D.H., Katz D.F. A vaginal fluid simulant. Contraception 1999, 59:91-95.
    • (1999) Contraception , vol.59 , pp. 91-95
    • Owen, D.H.1    Katz, D.F.2
  • 4
    • 26844560127 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in vaginal delivery
    • Valenta C. The use of mucoadhesive polymers in vaginal delivery. Adv. Drug Deliv. Rev. 2005, 57:1692-1712.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1692-1712
    • Valenta, C.1
  • 8
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • Smart J.D. The basics and underlying mechanisms of mucoadhesion. Adv. Drug Deliv. Rev. 2005, 57:1556-1568.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1556-1568
    • Smart, J.D.1
  • 9
    • 33745504777 scopus 로고    scopus 로고
    • Gels as vaginal drug delivery systems
    • das Neves J., Bahia M.F. Gels as vaginal drug delivery systems. Int. J. Pharm. 2006, 318:1-14.
    • (2006) Int. J. Pharm. , vol.318 , pp. 1-14
    • das Neves, J.1    Bahia, M.F.2
  • 10
    • 70350762116 scopus 로고    scopus 로고
    • Mucoadhesive vaginal drug delivery systems
    • Acarturk F. Mucoadhesive vaginal drug delivery systems. Recent Pat. Drug Deliv. Formul. 2009, 3:193-205.
    • (2009) Recent Pat. Drug Deliv. Formul. , vol.3 , pp. 193-205
    • Acarturk, F.1
  • 12
    • 84855343151 scopus 로고    scopus 로고
    • To lube or not to lube: experiences and perceptions of lubricant use in women with and without dyspareunia
    • Sutton K.S., Boyer S.C., Goldfinger C., Ezer P., Pukall C.F. To lube or not to lube: experiences and perceptions of lubricant use in women with and without dyspareunia. J. Sex. Med. 2012, 9:240-250.
    • (2012) J. Sex. Med. , vol.9 , pp. 240-250
    • Sutton, K.S.1    Boyer, S.C.2    Goldfinger, C.3    Ezer, P.4    Pukall, C.F.5
  • 13
    • 0028084423 scopus 로고
    • Comparative study: Replens™ versus local estrogen in menopausal women
    • Nachtigall L.E. Comparative study: Replens™ versus local estrogen in menopausal women. Fertil. Steril. 1994, 61:178-180.
    • (1994) Fertil. Steril. , vol.61 , pp. 178-180
    • Nachtigall, L.E.1
  • 14
    • 33845485055 scopus 로고    scopus 로고
    • The effect of polycarbophil gel (Replens™) on bacterial vaginosis: a pilot study
    • Wu J.P., Fielding S.L., Fiscella K. The effect of polycarbophil gel (Replens™) on bacterial vaginosis: a pilot study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2007, 130:132-136.
    • (2007) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.130 , pp. 132-136
    • Wu, J.P.1    Fielding, S.L.2    Fiscella, K.3
  • 15
    • 58149154649 scopus 로고    scopus 로고
    • Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections
    • Ahmad F.J., Alam M.A., Khan Z.I., Khar R.K., Ali M. Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharma. 2008, 58:407-419.
    • (2008) Acta Pharma. , vol.58 , pp. 407-419
    • Ahmad, F.J.1    Alam, M.A.2    Khan, Z.I.3    Khar, R.K.4    Ali, M.5
  • 16
    • 33846523463 scopus 로고    scopus 로고
    • Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms
    • Bonferoni M.C., Giunchedi P., Scalia S., Rossi S., Sandri G., Caramella C. Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms. AAPS PharmSciTech 2006, 7. (Article 104 (http://www.aapspharmscitech.org)).
    • (2006) AAPS PharmSciTech , vol.7
    • Bonferoni, M.C.1    Giunchedi, P.2    Scalia, S.3    Rossi, S.4    Sandri, G.5    Caramella, C.6
  • 17
    • 8444240531 scopus 로고    scopus 로고
    • Postcoital testing after the use of a bio-adhesive acid buffering gel (ACIDFORM) and a 2% nonoxynol-9 product
    • Amaral E., Perdigao A., Souza M.H., Mauck C., Waller D., Zaneveld L., Faundes A. Postcoital testing after the use of a bio-adhesive acid buffering gel (ACIDFORM) and a 2% nonoxynol-9 product. Contraception 2004, 70:492-497.
    • (2004) Contraception , vol.70 , pp. 492-497
    • Amaral, E.1    Perdigao, A.2    Souza, M.H.3    Mauck, C.4    Waller, D.5    Zaneveld, L.6    Faundes, A.7
  • 18
    • 0042666898 scopus 로고    scopus 로고
    • Formulation and evaluation of metronidazole acid gel for vaginal contraception
    • El-Gizawy S.A., Aglan N.I. Formulation and evaluation of metronidazole acid gel for vaginal contraception. J. Pharm. Pharmacol. 2003, 55:903-909.
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 903-909
    • El-Gizawy, S.A.1    Aglan, N.I.2
  • 22
    • 38549137950 scopus 로고    scopus 로고
    • Chitosan citrate as multifunctional polymer for vaginal delivery. Evaluation of penetration enhancement and peptidase inhibition properties
    • Bonferoni M.C., Sandri G., Rossi S., Ferrari F., Gibin S., Caramella C. Chitosan citrate as multifunctional polymer for vaginal delivery. Evaluation of penetration enhancement and peptidase inhibition properties. Eur. J. Pharm. Sci. 2008, 33:166-176.
    • (2008) Eur. J. Pharm. Sci. , vol.33 , pp. 166-176
    • Bonferoni, M.C.1    Sandri, G.2    Rossi, S.3    Ferrari, F.4    Gibin, S.5    Caramella, C.6
  • 23
    • 20544431828 scopus 로고    scopus 로고
    • Erosion of microbicide formulation coating layers: effect of contact and shearing with vaginal fluid or semen
    • Geonnotti A.R., Peters J.J., Katz D.F. Erosion of microbicide formulation coating layers: effect of contact and shearing with vaginal fluid or semen. J. Pharm. Sci. 2005, 94:1705-1712.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 1705-1712
    • Geonnotti, A.R.1    Peters, J.J.2    Katz, D.F.3
  • 24
    • 0037235124 scopus 로고    scopus 로고
    • Effect of temperature and pH on contraceptive gel viscosity
    • Owen D.H., Peters J.J., Lavine M.L., Katz D.F. Effect of temperature and pH on contraceptive gel viscosity. Contraception 2003, 67:57-64.
    • (2003) Contraception , vol.67 , pp. 57-64
    • Owen, D.H.1    Peters, J.J.2    Lavine, M.L.3    Katz, D.F.4
  • 26
    • 8444229398 scopus 로고    scopus 로고
    • In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse
    • Barnhart K.T., Pretorius E.S., Timbers K., Shera D., Shabbout M., Malamud D. In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse. Contraception 2004, 70:498-505.
    • (2004) Contraception , vol.70 , pp. 498-505
    • Barnhart, K.T.1    Pretorius, E.S.2    Timbers, K.3    Shera, D.4    Shabbout, M.5    Malamud, D.6
  • 29
    • 78649436881 scopus 로고    scopus 로고
    • Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets
    • Garg S., Goldman D., Krumme M., Rohan L.C., Smoot S., Friend D.R. Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets. Antivir. Res. 2010, 88S:S19-S29.
    • (2010) Antivir. Res. , vol.88S , pp. S19-S29
    • Garg, S.1    Goldman, D.2    Krumme, M.3    Rohan, L.C.4    Smoot, S.5    Friend, D.R.6
  • 30
    • 84901594342 scopus 로고    scopus 로고
    • Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis
    • Cevher E., Açma A., Sinani G., Aksu B., Zloh M., Mülazimoğlu L. Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis. Int. J. Biol. Macromol. 2014, 69:124-136.
    • (2014) Int. J. Biol. Macromol. , vol.69 , pp. 124-136
    • Cevher, E.1    Açma, A.2    Sinani, G.3    Aksu, B.4    Zloh, M.5    Mülazimoğlu, L.6
  • 31
    • 37549071832 scopus 로고    scopus 로고
    • Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections
    • E 109
    • Alam M.A., Ahmad F.J., Khan Z.I., Khar R.K., Ali M. Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections. AAPS PharmSciTech 2007, 8. (E 109 (http://www.aapspharmscitech.org.)). 10.1208/pt0804109.
    • (2007) AAPS PharmSciTech , vol.8
    • Alam, M.A.1    Ahmad, F.J.2    Khan, Z.I.3    Khar, R.K.4    Ali, M.5
  • 32
    • 38349169237 scopus 로고    scopus 로고
    • A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: design, in vitro and 'in vivo' evaluation
    • Wang L., Tang X. A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: design, in vitro and 'in vivo' evaluation. Int. J. Pharm. 2008, 350:181-187.
    • (2008) Int. J. Pharm. , vol.350 , pp. 181-187
    • Wang, L.1    Tang, X.2
  • 33
    • 76549097076 scopus 로고    scopus 로고
    • Freeze-dried, mucoadhesive systems for vaginal delivery of the HIV microbicide, dapirivine: optimization by an artificial neural network
    • Woolfson A.D., Umrethia M.L., Kett V.L., Malcolm R.K. Freeze-dried, mucoadhesive systems for vaginal delivery of the HIV microbicide, dapirivine: optimization by an artificial neural network. Int. J. Pharm. 2010, 388:136-143.
    • (2010) Int. J. Pharm. , vol.388 , pp. 136-143
    • Woolfson, A.D.1    Umrethia, M.L.2    Kett, V.L.3    Malcolm, R.K.4
  • 35
    • 79961125688 scopus 로고    scopus 로고
    • In vitro evaluation of mucoadhesive vaginal tablets of antifungal drugs prepared with thiolated polymer and development of a new dissolution technique for vaginal formulations
    • Baloglu E., Ay Senyiqit Z., Karavana S.Y., Vetter A., Metin D.Y., Hilmioglu Polat S., Guneri T., Bernkop-Schnurch A. In vitro evaluation of mucoadhesive vaginal tablets of antifungal drugs prepared with thiolated polymer and development of a new dissolution technique for vaginal formulations. Chem. Pharm. Bull. 2011, 59:952-958.
    • (2011) Chem. Pharm. Bull. , vol.59 , pp. 952-958
    • Baloglu, E.1    Ay Senyiqit, Z.2    Karavana, S.Y.3    Vetter, A.4    Metin, D.Y.5    Hilmioglu Polat, S.6    Guneri, T.7    Bernkop-Schnurch, A.8
  • 36
    • 84894229615 scopus 로고    scopus 로고
    • Vaginal chitosan tablets with clotrimazole-design and evaluation of mucoadhesive properties using porcine vaginal mucosa, mucin and gelatine
    • Szymanska E., Winnicka K., Amelian A., Cwalina U. Vaginal chitosan tablets with clotrimazole-design and evaluation of mucoadhesive properties using porcine vaginal mucosa, mucin and gelatine. Chem. Pharm. Bull. 2014, 62:160-167.
    • (2014) Chem. Pharm. Bull. , vol.62 , pp. 160-167
    • Szymanska, E.1    Winnicka, K.2    Amelian, A.3    Cwalina, U.4
  • 42
    • 0029782693 scopus 로고    scopus 로고
    • The in vitro release of some antimuscarinic drugs from monoolein/water lyotropic liquid crystalline gels
    • Geraghty P.B., Attwood D., Collett J.H., Dandiker Y. The in vitro release of some antimuscarinic drugs from monoolein/water lyotropic liquid crystalline gels. Pharm. Res. 1996, 13:1265-1271.
    • (1996) Pharm. Res. , vol.13 , pp. 1265-1271
    • Geraghty, P.B.1    Attwood, D.2    Collett, J.H.3    Dandiker, Y.4
  • 43
    • 0031032381 scopus 로고    scopus 로고
    • An investigation of the parameters influencing the bioadhesive properties of Myverol 18-99/water gels
    • Geraghty P.B., Attwood D., Collett J.H., Sharma H., Dandiker Y. An investigation of the parameters influencing the bioadhesive properties of Myverol 18-99/water gels. Biomaterials 1997, 18:63-67.
    • (1997) Biomaterials , vol.18 , pp. 63-67
    • Geraghty, P.B.1    Attwood, D.2    Collett, J.H.3    Sharma, H.4    Dandiker, Y.5
  • 44
    • 59349094139 scopus 로고    scopus 로고
    • Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate
    • Albertini B., Passerini N., Di Sabatino M., Vitali B., Brigidi P., Rodriguez L. Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate. Eur. J. Pharm. Sci. 2009, 36:591-601.
    • (2009) Eur. J. Pharm. Sci. , vol.36 , pp. 591-601
    • Albertini, B.1    Passerini, N.2    Di Sabatino, M.3    Vitali, B.4    Brigidi, P.5    Rodriguez, L.6
  • 48
    • 0028338775 scopus 로고
    • Evaluation of mucoadhesive properties of hyaluronic acid benzyl esters
    • Sanzgiri Y.D., Topp E.M., Benedetti L., Stella V.J. Evaluation of mucoadhesive properties of hyaluronic acid benzyl esters. Int. J. Pharm. 1994, 107:91-97.
    • (1994) Int. J. Pharm. , vol.107 , pp. 91-97
    • Sanzgiri, Y.D.1    Topp, E.M.2    Benedetti, L.3    Stella, V.J.4
  • 50
    • 84906781659 scopus 로고    scopus 로고
    • Nanoparticle-based drug delivery to the vagina: a review
    • Ensign L., Cone R., Hanes J. Nanoparticle-based drug delivery to the vagina: a review. J. Control. Release 2014, 190:500-514.
    • (2014) J. Control. Release , vol.190 , pp. 500-514
    • Ensign, L.1    Cone, R.2    Hanes, J.3
  • 51
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone R.A. Barrier properties of mucus. Adv. Drug Deliv. Rev. 2009, 61:75-85.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 75-85
    • Cone, R.A.1
  • 53
    • 7044269314 scopus 로고    scopus 로고
    • Real-time multiple-particle tracking: applications to drug and gene delivery
    • Suh J., Dawson M., Hanes J. Real-time multiple-particle tracking: applications to drug and gene delivery. Adv. Drug Deliv. Rev. 2005, 57:63-78.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 63-78
    • Suh, J.1    Dawson, M.2    Hanes, J.3
  • 55
    • 57049085726 scopus 로고    scopus 로고
    • Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the humanmucus barrier
    • Wang Y.Y., Lai S.K., Suk J.S., Pace A., Cone R., Hanes J. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the humanmucus barrier. Angew. Chem. Int. Ed. Engl. 2008, 47:9726-9729.
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , pp. 9726-9729
    • Wang, Y.Y.1    Lai, S.K.2    Suk, J.S.3    Pace, A.4    Cone, R.5    Hanes, J.6
  • 56
    • 78649945616 scopus 로고    scopus 로고
    • Disruption of the mucus barrier by topically applied exogenous particles
    • McGill S., Smyth H. Disruption of the mucus barrier by topically applied exogenous particles. Mol. Pharm. 2010, 7:2280-2288.
    • (2010) Mol. Pharm. , vol.7 , pp. 2280-2288
    • McGill, S.1    Smyth, H.2
  • 57
    • 84862519335 scopus 로고    scopus 로고
    • Mucus penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus
    • Ensign L.M., Tang B.C., Wang Y.Y., Tse T.A., Hoen T., Cone R., Hanes J. Mucus penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci. Transl. Med. 2012, 4:138-179.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 138-179
    • Ensign, L.M.1    Tang, B.C.2    Wang, Y.Y.3    Tse, T.A.4    Hoen, T.5    Cone, R.6    Hanes, J.7
  • 59
    • 78649419410 scopus 로고    scopus 로고
    • Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines
    • Whaley K.J., Hanes J., Shattock R., Cone R.A., Friend D.R. Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines. Antivir. Res. 2010, 88(Suppl. 1):S55-S66.
    • (2010) Antivir. Res. , vol.88 , pp. S55-S66
    • Whaley, K.J.1    Hanes, J.2    Shattock, R.3    Cone, R.A.4    Friend, D.R.5
  • 62
    • 76249115874 scopus 로고    scopus 로고
    • Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
    • Lai S.K., Wang Y.Y., Hida K., Cone R., Hanes J. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:598-603.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 598-603
    • Lai, S.K.1    Wang, Y.Y.2    Hida, K.3    Cone, R.4    Hanes, J.5
  • 63
    • 0035284437 scopus 로고    scopus 로고
    • Synthetic polymers alter the structure of cervical mucus
    • Willits R.K., Saltzman W.M. Synthetic polymers alter the structure of cervical mucus. Biomaterials 2001, 22:445-452.
    • (2001) Biomaterials , vol.22 , pp. 445-452
    • Willits, R.K.1    Saltzman, W.M.2
  • 64
    • 78649748651 scopus 로고    scopus 로고
    • Functionalized positive nanoparticles reduce mucin swelling and dispersion
    • Chen E.Y., Wang Y.C., Chen C.S., Chin W.C. Functionalized positive nanoparticles reduce mucin swelling and dispersion. PLoS One 2010, 5:e15434.
    • (2010) PLoS One , vol.5 , pp. e15434
    • Chen, E.Y.1    Wang, Y.C.2    Chen, C.S.3    Chin, W.C.4
  • 65
    • 33947503596 scopus 로고    scopus 로고
    • Temperature and pH sensitive hydrogels: an approach towards smart semen triggered vaginal microbicidal vehicles
    • Gupta K.M., Barnes S.R., Tangaro R.A., Roberts M.C., Owen D.H., Katz D.F., Kiser P.F. Temperature and pH sensitive hydrogels: an approach towards smart semen triggered vaginal microbicidal vehicles. J. Pharm. Sci. 2007, 96:670-681.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 670-681
    • Gupta, K.M.1    Barnes, S.R.2    Tangaro, R.A.3    Roberts, M.C.4    Owen, D.H.5    Katz, D.F.6    Kiser, P.F.7
  • 66
    • 78650170384 scopus 로고    scopus 로고
    • PH-sensitive Eudragit nanoparticles for mucosal drug delivery
    • Yoo J.W., Giri N., Lee C.H. pH-sensitive Eudragit nanoparticles for mucosal drug delivery. Int. J. Pharm. 2011, 403:262-267.
    • (2011) Int. J. Pharm. , vol.403 , pp. 262-267
    • Yoo, J.W.1    Giri, N.2    Lee, C.H.3
  • 67
    • 70350306659 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus
    • Lai S.K., Hida K., Shukair S., Wang Y.Y., Figueiredo A., Cone R., Hope T.J., Hanes J. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J. Virol. 2009, 83:11196-11200.
    • (2009) J. Virol. , vol.83 , pp. 11196-11200
    • Lai, S.K.1    Hida, K.2    Shukair, S.3    Wang, Y.Y.4    Figueiredo, A.5    Cone, R.6    Hope, T.J.7    Hanes, J.8
  • 69
    • 81255127657 scopus 로고    scopus 로고
    • In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
    • Cu Y., Booth C.J., Saltzman W.M. In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery. J. Control. Release 2011, 156:258-264.
    • (2011) J. Control. Release , vol.156 , pp. 258-264
    • Cu, Y.1    Booth, C.J.2    Saltzman, W.M.3
  • 73
    • 0031390438 scopus 로고    scopus 로고
    • A comparison of different in vitro methods for measuring mucoadhesive performance
    • Tamburic S., Craig D.Q.M. A comparison of different in vitro methods for measuring mucoadhesive performance. Eur. J. Pharm. Biopharm. 1997, 44(2):159-167.
    • (1997) Eur. J. Pharm. Biopharm. , vol.44 , Issue.2 , pp. 159-167
    • Tamburic, S.1    Craig, D.Q.M.2
  • 74
    • 26644434123 scopus 로고    scopus 로고
    • Comparison of the mucoadhesive properties of various polymers
    • Grabovac V., Gucci D., Bernkop-Schnurch A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev. 2005, 57:1713-1723.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1713-1723
    • Grabovac, V.1    Gucci, D.2    Bernkop-Schnurch, A.3
  • 75
    • 11144319352 scopus 로고    scopus 로고
    • Pharmaceutical application of mucoadhesion for the non-oral routes
    • Edsman K., Hägerström H. Pharmaceutical application of mucoadhesion for the non-oral routes. J. Pharm. Pharmacol. 2005, 57:3-22.
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 3-22
    • Edsman, K.1    Hägerström, H.2
  • 76
    • 43249120415 scopus 로고    scopus 로고
    • Performance of in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental apparatus
    • das Neves J., Amaral M.H., Bahia M.F. Performance of in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental apparatus. Eur. J. Pharm. Biopharm. 2008, 69:622-632.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 622-632
    • das Neves, J.1    Amaral, M.H.2    Bahia, M.F.3
  • 77
    • 1242331449 scopus 로고    scopus 로고
    • The importance of gel properties for mucoadhesion measurements: a multivariate analysis approach
    • Hägerström H., Bergström C.A.S., Edsman K. The importance of gel properties for mucoadhesion measurements: a multivariate analysis approach. J. Pharm. Pharmacol. 2004, 56:161-168.
    • (2004) J. Pharm. Pharmacol. , vol.56 , pp. 161-168
    • Hägerström, H.1    Bergström, C.A.S.2    Edsman, K.3
  • 79
    • 0025108791 scopus 로고
    • A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength
    • Hassan E.E., Gallo J.M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 1990, 7:491-495.
    • (1990) Pharm. Res. , vol.7 , pp. 491-495
    • Hassan, E.E.1    Gallo, J.M.2
  • 80
    • 0028000702 scopus 로고
    • Rheological and tensile tests for the assessment of polymer-mucin interactions
    • Caramella C., Bonferoni M.C., Rossi S., Ferrari F. Rheological and tensile tests for the assessment of polymer-mucin interactions. Eur. J. Pharm. Biopharm. 1994, 40:213-217.
    • (1994) Eur. J. Pharm. Biopharm. , vol.40 , pp. 213-217
    • Caramella, C.1    Bonferoni, M.C.2    Rossi, S.3    Ferrari, F.4
  • 81
    • 0002813177 scopus 로고    scopus 로고
    • A rheological approach to explain the mucoadhesive behaviour of polymer hydrogel
    • Marcel Dekker Inc., New York, E. Mathiowitz, D.E. Chickering, C.M. Lehr (Eds.)
    • Caramella C.M., Rossi S., Bonferoni M.C. A rheological approach to explain the mucoadhesive behaviour of polymer hydrogel. Bioadhesive Drug Delivery Systems. Fundamental, Novel Approaches and Development 1999, 25-65. Marcel Dekker Inc., New York. E. Mathiowitz, D.E. Chickering, C.M. Lehr (Eds.).
    • (1999) Bioadhesive Drug Delivery Systems. Fundamental, Novel Approaches and Development , pp. 25-65
    • Caramella, C.M.1    Rossi, S.2    Bonferoni, M.C.3
  • 82
    • 0032837135 scopus 로고    scopus 로고
    • Model-based interpretation of creep profiles for the assessment of polymer-muycin interaction
    • Rossi S., Bonferoni M.C., Caramella C., Ironi L., Tentoni S. Model-based interpretation of creep profiles for the assessment of polymer-muycin interaction. Pharm. Res. 1999, 16:1456-1463.
    • (1999) Pharm. Res. , vol.16 , pp. 1456-1463
    • Rossi, S.1    Bonferoni, M.C.2    Caramella, C.3    Ironi, L.4    Tentoni, S.5
  • 86
    • 0032081252 scopus 로고    scopus 로고
    • A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel
    • Madsen F., Eberth K., Smart J.D. A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel. Biomaterials 1998, 19:1083-1092.
    • (1998) Biomaterials , vol.19 , pp. 1083-1092
    • Madsen, F.1    Eberth, K.2    Smart, J.D.3
  • 87
    • 0034069558 scopus 로고    scopus 로고
    • Characterization of chitosan hydrochloride-mucin interaction by means of viscosimetric and turbidimetric measurements
    • Rossi S., Ferrari F., Bonferoni M.C., Caramella C. Characterization of chitosan hydrochloride-mucin interaction by means of viscosimetric and turbidimetric measurements. Eur. J. Pharm. Sci. 2000, 10:251-257.
    • (2000) Eur. J. Pharm. Sci. , vol.10 , pp. 251-257
    • Rossi, S.1    Ferrari, F.2    Bonferoni, M.C.3    Caramella, C.4
  • 88
    • 0035101451 scopus 로고    scopus 로고
    • Characterization of chitosan hydrochloride-mucin rheological interaction: influence of polymer concentration and polymer:mucin weight ratio
    • Rossi S., Ferrari F., Bonferoni M.C., Caramella C. Characterization of chitosan hydrochloride-mucin rheological interaction: influence of polymer concentration and polymer:mucin weight ratio. Eur. J. Pharm. Sci. 2001, 12:479-485.
    • (2001) Eur. J. Pharm. Sci. , vol.12 , pp. 479-485
    • Rossi, S.1    Ferrari, F.2    Bonferoni, M.C.3    Caramella, C.4
  • 89
    • 0033123016 scopus 로고    scopus 로고
    • Polymeric films as vehicle for buccal delivery: swelling, mechanical and bioadhesive properties
    • Peh K.K., Wong C.F. Polymeric films as vehicle for buccal delivery: swelling, mechanical and bioadhesive properties. J. Pharm. Pharm. Sci. 1999, 2:53-61.
    • (1999) J. Pharm. Pharm. Sci. , vol.2 , pp. 53-61
    • Peh, K.K.1    Wong, C.F.2
  • 90
    • 0346458604 scopus 로고    scopus 로고
    • Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration
    • Abd ElHady S.S., Mortada N.D., Awad G.A.S., Zaki N.M., Taha R.A. Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration. Saudi Pharm. J. 2003, 11:159-171.
    • (2003) Saudi Pharm. J. , vol.11 , pp. 159-171
    • Abd ElHady, S.S.1    Mortada, N.D.2    Awad, G.A.S.3    Zaki, N.M.4    Taha, R.A.5
  • 91
    • 0030724687 scopus 로고    scopus 로고
    • Characterization of rheological and mucoadhesive properties of three grades of chitosan hydrochloride
    • Ferrari F., Rossi S., Bonferoni M.C., Caramella C., Karlsen J. Characterization of rheological and mucoadhesive properties of three grades of chitosan hydrochloride. Farmaco 1997, 52(6-7):493-497.
    • (1997) Farmaco , vol.52 , Issue.6-7 , pp. 493-497
    • Ferrari, F.1    Rossi, S.2    Bonferoni, M.C.3    Caramella, C.4    Karlsen, J.5
  • 93
    • 0041868126 scopus 로고    scopus 로고
    • Development of films and matrices based on chitosan and polyacrylic acid for vaginal delivery of acyclovir
    • Rossi S., Sandri G., Ferrari F., Bonferoni M.C., Caramella C. Development of films and matrices based on chitosan and polyacrylic acid for vaginal delivery of acyclovir. STP Pharma. Sci. 2003, 13:181-189.
    • (2003) STP Pharma. Sci. , vol.13 , pp. 181-189
    • Rossi, S.1    Sandri, G.2    Ferrari, F.3    Bonferoni, M.C.4    Caramella, C.5
  • 94
    • 0021236615 scopus 로고
    • An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
    • Smart J.D., Kellaway I.W., Worthington H.E. An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 1984, 36:295-299.
    • (1984) J. Pharm. Pharmacol. , vol.36 , pp. 295-299
    • Smart, J.D.1    Kellaway, I.W.2    Worthington, H.E.3
  • 95
    • 79959669312 scopus 로고    scopus 로고
    • Comparison of functional and biological properties of chitosan and hyaluronic acid to be used for the treatment of mucositis in cancer patients
    • Puccio A., Ferrari F., Rossi S., Bonferoni M.C., Sandri G., Dacarro C., Grisoli P., Caramella C. Comparison of functional and biological properties of chitosan and hyaluronic acid to be used for the treatment of mucositis in cancer patients. J. Drug Deliv. Sci.Technol. 2011, 21:241-247.
    • (2011) J. Drug Deliv. Sci.Technol. , vol.21 , pp. 241-247
    • Puccio, A.1    Ferrari, F.2    Rossi, S.3    Bonferoni, M.C.4    Sandri, G.5    Dacarro, C.6    Grisoli, P.7    Caramella, C.8
  • 99
    • 0033044564 scopus 로고    scopus 로고
    • A modified Franz diffusion cell for simultaneous assessment of drug release and washability of mucoadhesive gel
    • Bonferoni M.C., Rossi S., Ferrari F., Caramella C. A modified Franz diffusion cell for simultaneous assessment of drug release and washability of mucoadhesive gel. Pharm. Dev. Technol. 1999, 4:45-54.
    • (1999) Pharm. Dev. Technol. , vol.4 , pp. 45-54
    • Bonferoni, M.C.1    Rossi, S.2    Ferrari, F.3    Caramella, C.4
  • 100
    • 0033045229 scopus 로고    scopus 로고
    • Drug release and washability of mucoadhesive gels based on sodium carboxymethylcellulose and polyacrylic acid
    • Rossi S., Bonferoni M.C., Ferrari F., Caramella C. Drug release and washability of mucoadhesive gels based on sodium carboxymethylcellulose and polyacrylic acid. Pharm. Dev. Technol. 1999, 4:55-63.
    • (1999) Pharm. Dev. Technol. , vol.4 , pp. 55-63
    • Rossi, S.1    Bonferoni, M.C.2    Ferrari, F.3    Caramella, C.4
  • 101
    • 34547402940 scopus 로고    scopus 로고
    • Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models
    • Sandri G., Bonferoni M.C., Rossi S., Ferrari F., Gibin S., Zambito Y., Di Colo G., Caramella C. Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models. Eur. J. Pharm. Biopharm. 2007, 65:68-77.
    • (2007) Eur. J. Pharm. Biopharm. , vol.65 , pp. 68-77
    • Sandri, G.1    Bonferoni, M.C.2    Rossi, S.3    Ferrari, F.4    Gibin, S.5    Zambito, Y.6    Di Colo, G.7    Caramella, C.8
  • 102
    • 26644447977 scopus 로고    scopus 로고
    • Novel mucoadhesion tests for polymers and polymer coated particles to design optimal mucoadhesion drug delivery systems
    • Takeuchi H., Thongborisute J., Matsui Y., Sugihara H., Yamamoto H., Kawashima Y. Novel mucoadhesion tests for polymers and polymer coated particles to design optimal mucoadhesion drug delivery systems. Adv. Drug Deliv. Rev. 2005, 57:1583-1594.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1583-1594
    • Takeuchi, H.1    Thongborisute, J.2    Matsui, Y.3    Sugihara, H.4    Yamamoto, H.5    Kawashima, Y.6
  • 103
    • 33745001604 scopus 로고    scopus 로고
    • Mucin structure, aggregation, physiological functions and biomedical applications
    • Bansil R., Turner B.S. Mucin structure, aggregation, physiological functions and biomedical applications. Curr. Opin. Colloid Interface Sci. 2006, 11:164-170.
    • (2006) Curr. Opin. Colloid Interface Sci. , vol.11 , pp. 164-170
    • Bansil, R.1    Turner, B.S.2
  • 104
    • 62149135189 scopus 로고    scopus 로고
    • Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerol of intravesical bladder cancer therapy
    • Mugabe C., Hadaschik B.A., Kainthan R.K., Brooks D.E., So A.I., Gleave M.E., Burt H.M. Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerol of intravesical bladder cancer therapy. BJU Int. 2009, 103:978-986.
    • (2009) BJU Int. , vol.103 , pp. 978-986
    • Mugabe, C.1    Hadaschik, B.A.2    Kainthan, R.K.3    Brooks, D.E.4    So, A.I.5    Gleave, M.E.6    Burt, H.M.7
  • 105
    • 71649103464 scopus 로고    scopus 로고
    • The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake
    • Jintapattanakit A., Junyaprasert V.B., Kissel T. The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake. J. Pharm. Sci. 2009, 998:4818-4830.
    • (2009) J. Pharm. Sci. , vol.998 , pp. 4818-4830
    • Jintapattanakit, A.1    Junyaprasert, V.B.2    Kissel, T.3
  • 106
    • 42149181776 scopus 로고    scopus 로고
    • Interactions between drug delivery particles and mucin in solution and at interfaces
    • Svensson O., Thuresson K., Arnebrant T. Interactions between drug delivery particles and mucin in solution and at interfaces. Langmuir 2008, 24:2573-2579.
    • (2008) Langmuir , vol.24 , pp. 2573-2579
    • Svensson, O.1    Thuresson, K.2    Arnebrant, T.3
  • 107
    • 48949103330 scopus 로고    scopus 로고
    • Interactions between chitosan-modified particles and mucin-coated surfaces
    • Svensson O., Thuresson K., Arnebrant T. Interactions between chitosan-modified particles and mucin-coated surfaces. J. Colloid Interface Sci. 2008, 325:346-350.
    • (2008) J. Colloid Interface Sci. , vol.325 , pp. 346-350
    • Svensson, O.1    Thuresson, K.2    Arnebrant, T.3
  • 109
    • 55849121922 scopus 로고    scopus 로고
    • Triple therapy-based targeted nanoparticles for the treatment of Helicobacter pylori
    • Ramteke S., Ganesh N., Battacharja S., Narendra K.J. Triple therapy-based targeted nanoparticles for the treatment of Helicobacter pylori. J. Drug Target. 2008, 16:694-705.
    • (2008) J. Drug Target. , vol.16 , pp. 694-705
    • Ramteke, S.1    Ganesh, N.2    Battacharja, S.3    Narendra, K.J.4
  • 110
    • 33847251684 scopus 로고    scopus 로고
    • In vitro evaluation of the mucoadhesive properties of polysaccharide-based nanoparticulate oral drug delivery systems
    • Chayed S., Winnik F.M. In vitro evaluation of the mucoadhesive properties of polysaccharide-based nanoparticulate oral drug delivery systems. Eur. J. Pharm. Biopharm. 2007, 65:363-370.
    • (2007) Eur. J. Pharm. Biopharm. , vol.65 , pp. 363-370
    • Chayed, S.1    Winnik, F.M.2
  • 111
    • 78649835810 scopus 로고    scopus 로고
    • Barrier properties of gastrointestinal mucus to nanoparticle transport
    • Crater J.S., Carrier R.L. Barrier properties of gastrointestinal mucus to nanoparticle transport. Macromol. Biosci. 2010, 10:1473-1483.
    • (2010) Macromol. Biosci. , vol.10 , pp. 1473-1483
    • Crater, J.S.1    Carrier, R.L.2
  • 112
    • 33748885473 scopus 로고    scopus 로고
    • Low molecular weight heparin nanoparticles: mucoadhesion and behaviour in Caco-2 cells
    • Lamprecht A., Koenig P., Ubrich N., Maincent P., Neumann D. Low molecular weight heparin nanoparticles: mucoadhesion and behaviour in Caco-2 cells. Nanotechnology 2006, 17:3673-3680.
    • (2006) Nanotechnology , vol.17 , pp. 3673-3680
    • Lamprecht, A.1    Koenig, P.2    Ubrich, N.3    Maincent, P.4    Neumann, D.5
  • 113
    • 0021344079 scopus 로고
    • Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion
    • Park K., Robinson J.R. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int. J. Pharm. 1984, 19:107-127.
    • (1984) Int. J. Pharm. , vol.19 , pp. 107-127
    • Park, K.1    Robinson, J.R.2
  • 114
    • 78651228118 scopus 로고    scopus 로고
    • A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa
    • Makhlof A., Werle M., Tozuka Y., Takeuchi H. A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa. J. Control. Release 2011, 149:81-88.
    • (2011) J. Control. Release , vol.149 , pp. 81-88
    • Makhlof, A.1    Werle, M.2    Tozuka, Y.3    Takeuchi, H.4
  • 115
    • 0036709119 scopus 로고    scopus 로고
    • Lectin-mediated drug delivery: discrimination between cyctoadhesion and cytoinvasion and evidence for lysosomal accumulation of wheat germ agglutinin in the Caco-2 model
    • Wirth M., Kneuer C., Lehr C.M., Gabor F. Lectin-mediated drug delivery: discrimination between cyctoadhesion and cytoinvasion and evidence for lysosomal accumulation of wheat germ agglutinin in the Caco-2 model. J. Drug Target. 2002, 10:439-448.
    • (2002) J. Drug Target. , vol.10 , pp. 439-448
    • Wirth, M.1    Kneuer, C.2    Lehr, C.M.3    Gabor, F.4
  • 116
    • 44949228208 scopus 로고    scopus 로고
    • Fluorescent bionanoprobes to characterize cytoadhesion and cytoinvasion
    • Fillafer C., Friedl D.S., Wirth M., Gabor F. Fluorescent bionanoprobes to characterize cytoadhesion and cytoinvasion. Small 2008, 4:627-633.
    • (2008) Small , vol.4 , pp. 627-633
    • Fillafer, C.1    Friedl, D.S.2    Wirth, M.3    Gabor, F.4
  • 117
    • 3843071010 scopus 로고    scopus 로고
    • In situ-forming hydrogels-review of temperature-sensitive systems
    • Ruel-Gariepy E., Leroux J.C. In situ-forming hydrogels-review of temperature-sensitive systems. Eur. J. Pharm. Biopharm. 2004, 58:409-426.
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 409-426
    • Ruel-Gariepy, E.1    Leroux, J.C.2
  • 118
    • 67349219709 scopus 로고    scopus 로고
    • Effect of carrageenan on poloxamer-based in situ gel for vaginal use: improved in vitro and in vivo sustained-release properties
    • Liu Y., Zhu Y., Wei G., Lu W. Effect of carrageenan on poloxamer-based in situ gel for vaginal use: improved in vitro and in vivo sustained-release properties. Eur. J. Pharm. Sci. 2009, 37:306-312.
    • (2009) Eur. J. Pharm. Sci. , vol.37 , pp. 306-312
    • Liu, Y.1    Zhu, Y.2    Wei, G.3    Lu, W.4
  • 119
    • 84859451972 scopus 로고    scopus 로고
    • Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application
    • Ibrahim E.I., Fetih G., Shaaban O., Hassanein K., Abdellah N.H. Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application. Acta Pharma. 2012, 62:59-70.
    • (2012) Acta Pharma. , vol.62 , pp. 59-70
    • Ibrahim, E.I.1    Fetih, G.2    Shaaban, O.3    Hassanein, K.4    Abdellah, N.H.5
  • 120
    • 77955841493 scopus 로고    scopus 로고
    • A thermosensitive vaginal gel formulation with HP CD for the pH-dependent release and solubilization of amphotericin B
    • Kim Y.T., Shina B.-K., Garripelli V.K., Kimb J.-K., Davaaa E., Jo S., Parka J.-S. A thermosensitive vaginal gel formulation with HP CD for the pH-dependent release and solubilization of amphotericin B. Eur. J. Pharm. Sci. 2010, 41:399-406.
    • (2010) Eur. J. Pharm. Sci. , vol.41 , pp. 399-406
    • Kim, Y.T.1    Shina, B.-K.2    Garripelli, V.K.3    Kimb, J.-K.4    Davaaa, E.5    Jo, S.6    Parka, J.-S.7
  • 121
    • 0032055148 scopus 로고    scopus 로고
    • Rheological evaluation of poloxamer as an in situ gel for ophthalmic use
    • Edsman K., Carlfors J., Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. Eur. J. Pharm. Sci. 1998, 6:105-112.
    • (1998) Eur. J. Pharm. Sci. , vol.6 , pp. 105-112
    • Edsman, K.1    Carlfors, J.2    Petersson, R.3
  • 122
    • 33845351355 scopus 로고    scopus 로고
    • A review of poloxamer 407 pharmaceutical and pharmacological characteristics
    • Dumortier G., Grossiord J.L., Agnely F., Chaumeil J.C. A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm. Res. 2006, 23:2709-2728.
    • (2006) Pharm. Res. , vol.23 , pp. 2709-2728
    • Dumortier, G.1    Grossiord, J.L.2    Agnely, F.3    Chaumeil, J.C.4
  • 124
    • 33846818951 scopus 로고    scopus 로고
    • Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic® F127 hydrogel for subcutaneous administration: in vitro and in vivo characterization
    • Liu Y., Lu W.-L., Wang J.-C., Zhang X., Zhang H., Wang X.-Q., Zhou T.-Y., Zhang Q. Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic® F127 hydrogel for subcutaneous administration: in vitro and in vivo characterization. J. Control. Release 2007, 117:387-395.
    • (2007) J. Control. Release , vol.117 , pp. 387-395
    • Liu, Y.1    Lu, W.-L.2    Wang, J.-C.3    Zhang, X.4    Zhang, H.5    Wang, X.-Q.6    Zhou, T.-Y.7    Zhang, Q.8
  • 125
    • 62849090441 scopus 로고    scopus 로고
    • A novel mixed micelle gel with thermosensitive property for the local delivery of docetaxel
    • Yang Y., Wang J., Zhang X., Lu W., Zhang Q. A novel mixed micelle gel with thermosensitive property for the local delivery of docetaxel. J. Control. Release 2009, 135:175-182.
    • (2009) J. Control. Release , vol.135 , pp. 175-182
    • Yang, Y.1    Wang, J.2    Zhang, X.3    Lu, W.4    Zhang, Q.5
  • 126
    • 77951687808 scopus 로고    scopus 로고
    • Poloxamers: a pharmaceutical excipients with therapeutic behaviors
    • Patel H.R., Patel M.M. Poloxamers: a pharmaceutical excipients with therapeutic behaviors. Int. J. PharmTech Res. 2009, 1(2):299-303.
    • (2009) Int. J. PharmTech Res. , vol.1 , Issue.2 , pp. 299-303
    • Patel, H.R.1    Patel, M.M.2
  • 127
    • 77955188019 scopus 로고    scopus 로고
    • A new vaginal delivery system of amphotericin B: a dispersion of cationic liposomes in a thermosensitive gel
    • Kang J.-W., Davaa E., Kim Y.-T., Park J.-S. A new vaginal delivery system of amphotericin B: a dispersion of cationic liposomes in a thermosensitive gel. J. Drug Target. 2010, 18:637-644.
    • (2010) J. Drug Target. , vol.18 , pp. 637-644
    • Kang, J.-W.1    Davaa, E.2    Kim, Y.-T.3    Park, J.-S.4
  • 128
    • 85006521970 scopus 로고    scopus 로고
    • A novel thermo-sensitive sol-gel reversible buccal adhesive property of fluconazole in situ gel for oral thrush
    • Kumar K.J., Jayachandran E., Srinivas G.M., Giridhar B., Nair R., Jayakandan M. A novel thermo-sensitive sol-gel reversible buccal adhesive property of fluconazole in situ gel for oral thrush. J. Biomed. Sci. Res. 2010, 2:92-101.
    • (2010) J. Biomed. Sci. Res. , vol.2 , pp. 92-101
    • Kumar, K.J.1    Jayachandran, E.2    Srinivas, G.M.3    Giridhar, B.4    Nair, R.5    Jayakandan, M.6
  • 129
    • 79958193506 scopus 로고    scopus 로고
    • Development of thermosensitive injectable hydrogel with sustained release of doxorubicin: rheological characterization and in vivo evaluation in rats
    • Xuan J.-J., Yan Y.D., Oh D.H., Choi Y.K., Yong C.S., Choi H.G. Development of thermosensitive injectable hydrogel with sustained release of doxorubicin: rheological characterization and in vivo evaluation in rats. Drug Deliv. 2011, 18:305-311.
    • (2011) Drug Deliv. , vol.18 , pp. 305-311
    • Xuan, J.-J.1    Yan, Y.D.2    Oh, D.H.3    Choi, Y.K.4    Yong, C.S.5    Choi, H.G.6
  • 130
    • 0037043096 scopus 로고    scopus 로고
    • Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions
    • Chang J.Y., Oh Y.-K., Choi H., Kim Y.B., Kim C.-K. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int. J. Pharm. 2002, 241:155-163.
    • (2002) Int. J. Pharm. , vol.241 , pp. 155-163
    • Chang, J.Y.1    Oh, Y.-K.2    Choi, H.3    Kim, Y.B.4    Kim, C.-K.5
  • 131
    • 9744237249 scopus 로고    scopus 로고
    • In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine
    • Lin H.R., Sung K.C., Vong W.J. In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine. Biomacromolecules 2004, 6:2358-2365.
    • (2004) Biomacromolecules , vol.6 , pp. 2358-2365
    • Lin, H.R.1    Sung, K.C.2    Vong, W.J.3
  • 132
    • 84869298534 scopus 로고    scopus 로고
    • Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole:β-cyclodextrin complex
    • Bilensoy E., Rouf M.A., Vural I., Şen M., Hincal A.A. Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole:β-cyclodextrin complex. AAPS PharmSciTech 2006, 7(2). (Article 38 (http://www.aapspharmscitech.org)).
    • (2006) AAPS PharmSciTech , vol.7 , Issue.2
    • Bilensoy, E.1    Rouf, M.A.2    Vural, I.3    Şen, M.4    Hincal, A.A.5
  • 133
    • 34248571833 scopus 로고    scopus 로고
    • Development of poloxameranalogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin
    • Qi H., Chen W., Huang C., Li L., Chen C., Li W., Wu C. Development of poloxameranalogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. Int. J. Pharm. 2007, 337:178-187.
    • (2007) Int. J. Pharm. , vol.337 , pp. 178-187
    • Qi, H.1    Chen, W.2    Huang, C.3    Li, L.4    Chen, C.5    Li, W.6    Wu, C.7
  • 134
    • 50349102596 scopus 로고    scopus 로고
    • A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties
    • Mayol L., Quaglia F., Borzacchiello A., Ambrosio L., La Rotonda M.I. A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties. Eur. J. Pharm. Biopharm. 2008, 70:199-206.
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 199-206
    • Mayol, L.1    Quaglia, F.2    Borzacchiello, A.3    Ambrosio, L.4    La Rotonda, M.I.5
  • 135
    • 41549104881 scopus 로고    scopus 로고
    • In vitro and in vivo characteristics of a thermogelling and bioadhesive delivery system intended for rectal administration of quinine in children
    • Koffi A.A., Agnely F., Besnard M., Kablan Brou J., Grossiord J.L., Ponchel G. In vitro and in vivo characteristics of a thermogelling and bioadhesive delivery system intended for rectal administration of quinine in children. Eur. J. Pharm. Biopharm. 2008, 69:167-175.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 167-175
    • Koffi, A.A.1    Agnely, F.2    Besnard, M.3    Kablan Brou, J.4    Grossiord, J.L.5    Ponchel, G.6
  • 137
    • 80055017990 scopus 로고    scopus 로고
    • Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel
    • Gratieri T., Gelfuso Martins M., de Freitas O., Melani Rocha E., Lopez R.F.V. Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel. Eur. J. Pharm. Biopharm. 2011, 79:320-327.
    • (2011) Eur. J. Pharm. Biopharm. , vol.79 , pp. 320-327
    • Gratieri, T.1    Gelfuso Martins, M.2    de Freitas, O.3    Melani Rocha, E.4    Lopez, R.F.V.5
  • 138
  • 139
    • 84869212370 scopus 로고    scopus 로고
    • Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis
    • Date A., Shibata A., Goede M., Sanford B., La Bruzzo K., Belshan M., Destache C.J. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis. Antivir. Res. 2012, 96:430-436.
    • (2012) Antivir. Res. , vol.96 , pp. 430-436
    • Date, A.1    Shibata, A.2    Goede, M.3    Sanford, B.4    La Bruzzo, K.5    Belshan, M.6    Destache, C.J.7
  • 140
    • 84930510625 scopus 로고    scopus 로고
    • Development of miconazole nitrate thermosensitive bioadhesive vaginal gel for vaginal candidiasis
    • Hani U., Shivakamuar H.G. Development of miconazole nitrate thermosensitive bioadhesive vaginal gel for vaginal candidiasis. Am. J. Adv. Drug Deliv. 2013, 3:358-368.
    • (2013) Am. J. Adv. Drug Deliv. , vol.3 , pp. 358-368
    • Hani, U.1    Shivakamuar, H.G.2
  • 141
  • 143
    • 0035452921 scopus 로고    scopus 로고
    • Rheological characterization of thermogelling chitosan/glycerophosphate solutions
    • Chenite A., Buschmann M.D., Wang D., Chaput C., Kandani N. Rheological characterization of thermogelling chitosan/glycerophosphate solutions. Carboydr. Polym. 2001, 46:39-47.
    • (2001) Carboydr. Polym. , vol.46 , pp. 39-47
    • Chenite, A.1    Buschmann, M.D.2    Wang, D.3    Chaput, C.4    Kandani, N.5
  • 144
    • 2142714436 scopus 로고    scopus 로고
    • A novel in situ gel for sustained drug delivery and targeting
    • Ganguly S., Dash A.K. A novel in situ gel for sustained drug delivery and targeting. Int. J. Pharm. 2004, 276:83-92.
    • (2004) Int. J. Pharm. , vol.276 , pp. 83-92
    • Ganguly, S.1    Dash, A.K.2
  • 146
    • 39749109326 scopus 로고    scopus 로고
    • Heat-induced transfer of protons from chitosan to glycerol phosphate produces chitosan precipitation and gelation
    • Lavertu M., Filion D., Buschmann M.D. Heat-induced transfer of protons from chitosan to glycerol phosphate produces chitosan precipitation and gelation. Biomacromolecules 2008, 9:640-650.
    • (2008) Biomacromolecules , vol.9 , pp. 640-650
    • Lavertu, M.1    Filion, D.2    Buschmann, M.D.3
  • 149
    • 19744375363 scopus 로고    scopus 로고
    • Successful treatment of bacterial vaginosis with a policarbophil-carbopol acidic vaginal gel: results from a randomised double-blind, placebo-controlled trial
    • Fiorilli A., Molteni B., Milani M. Successful treatment of bacterial vaginosis with a policarbophil-carbopol acidic vaginal gel: results from a randomised double-blind, placebo-controlled trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005, 120:202-205.
    • (2005) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.120 , pp. 202-205
    • Fiorilli, A.1    Molteni, B.2    Milani, M.3
  • 151
    • 33845239887 scopus 로고    scopus 로고
    • Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo
    • Trifonova T.R., Pasicznyk J.-M., Fichorova R.N. Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo. Antimicrob. Agents Chemother. 2006, 50:4005-4010.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 4005-4010
    • Trifonova, T.R.1    Pasicznyk, J.-M.2    Fichorova, R.N.3
  • 152
    • 5444266910 scopus 로고    scopus 로고
    • Biocompatibility of components of a female controlled drug delivery systems
    • Warrier B.K., Kostoryz E., Lee C.H. Biocompatibility of components of a female controlled drug delivery systems. J. Biomed. Mater. Res. A 2004, 71A:209-216.
    • (2004) J. Biomed. Mater. Res. A , vol.71A , pp. 209-216
    • Warrier, B.K.1    Kostoryz, E.2    Lee, C.H.3


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