Mucoadhesive drug delivery system: An overview

Journal of Advanced Pharmaceutical Technology and Research

Volumn 1, Issue 4, 2010, Pages 381-387

  Boddupalli, Bindu M ^a   Mohammed, Zulkar N K ^a   Nath A , Ravinder ^b   Banji, David ^a  

^a Nalanda College of Pharmacy   (India)

^b OSMANIA UNIVERSITY   (India)

Author keywords

Mucoadhesion; mucoadhesive dosage forms; theories

Indexed keywords

CARBOMER; CARBOXYMETHYLCELLULOSE; CHITOSAN; CYANOACRYLATE; GELLAN; GLYCOPROTEIN; HYALURONIC ACID; HYDROXYPROPYLCELLULOSE; MACROGOL; METHACRYLIC ACID DERIVATIVE; MUCIN; POLYACRYLIC ACID; POLYCARBOPHIL; POLYMER; POLYMETHACRYLIC ACID; POLYVINYL ALCOHOL; POVIDONE;

BIOAVAILABILITY; CHEMICAL INTERACTION; CILIARY MOTILITY; CONCENTRATION (PARAMETERS); CONTACT ANGLE; CONTROLLED RELEASE FORMULATION; CROSS LINKING; DIFFUSION; DRUG ABSORPTION; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG TARGETING; ELECTRON TRANSPORT; FILM COATING; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; GEL; HYDRATION; HYDROGEN BOND; INTRAVAGINAL DRUG ADMINISTRATION; MOISTURE; MOLECULAR INTERACTION; MOLECULAR WEIGHT; MOUTH CAVITY; MUCOADHESION; MUCOSA; NOSE CAVITY; OINTMENT; PRIORITY JOURNAL; PROTEIN INTERACTION; RECTAL DRUG ADMINISTRATION; RESPIRATORY SYSTEM; REVIEW; SUBLINGUAL GLAND; TABLET; TABLET PROPERTY; TRANSDERMAL PATCH; VISCOSITY;

EID: 79952979545     PISSN: 22314040     EISSN: 09762094     Source Type: Journal    
DOI: 10.4103/0110-5558.76436     Document Type: Review

References (42)

1. Chickering DE III, Mathiowitz E. Fundamentals of bioadhesion. In: Lehr CM, editor. Bioadhesive drug delivery systems-Fundamentals, Novel Approaches and Development. New York: Marcel Dekker; 1999. p. 1-85.
2. Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997;23:489-515. (Pubitemid 27241128)
3. Veuillez F, Kalia YN, Jacques Y, Deshusses J, Buri P. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 2001;51:93-109. (Pubitemid 32162488)
4. Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system: A review. Int J Res Pharm Sci 2010;1:170-86.
5. Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev 2005;57:1556-68. (Pubitemid 41443469)
6. Hgerstrm H, Edsman K, Strmme M. Low-frequency dielectric spectroscopy as a tool for studying the compatibility between pharmaceutical gels and mucus tissue. J Pharm Sci 2003;92:1869-81. (Pubitemid 37071819)
7. Dodou D, Breedveld P, Wieringa P. Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications. Eur J Pharm Biopharm 2005;60:1-16. (Pubitemid 40545855)
8. Kinloch AJ. The science of adhesion. J Mater Sci 1980;15:2141-66.
9. Jimnez-Castellanos MR, Zia H, Rhodes CT. Mucoadhe-sive drug delivery systems. Drug Dev Ind Pharm 1993;19:143-94.
10. Tiwari D, Goldman D, Sause R, Madan PL. Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations. AAPS Pharm Sci 1999;1:13-21.
11. Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco-and bioadhesion: Tethered structures and site-specific surfaces. J Control Release 2000;65:63-71. (Pubitemid 30122916)
12. Gu JM, Robinson JR, Leung SH. Binding of acrylic polymers to mucin/epithelial surfaces: Structure-property relationships. Crit Rev Ther Drug Carrier Syst 1998;5:21-67.
13. Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985;2:257-75. (Pubitemid 16195943)
14. Park H, Amiji M, Park K. Mucoadhesive hydrogels effective at neutral pH. Proc Int Symp Control Release Bioact Mater 1989;16:217-8.
15. Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 1992;78:43-8.
16. Smart JD, Mortazavi SA. An investigation of the pH within the hydrating gel layer of a poly(acylic acid) compact. J Pharm Pharmacol 1995;47:1099.
17. Solomonidou D, Cremer K, Krumme M, Kreuter J. Effect of carbomer concentration and degree of neutralization on the mucoadhesive properties of polymer films. J Biomater Sci Polym Ed 2001;12:1191-205. (Pubitemid 34134189)
18. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharm Sci 1998;1:15-30.
19. Remun-Lpez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release 1998;55:143-52. (Pubitemid 28477605)
20. Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian J Pharm Sci 2008;70:43-8. (Pubitemid 351670567)
21. Hornof M, Weyenberg W, Ludwig A, Bernkop SA. Mucoadhesive ocular insert based on thiolated poly (acrylic acid): Development and in vivo evaluation in humans. J Control Release 2003;89:419-28. (Pubitemid 36555901)
22. Sultana Y, Aqil M, Ali A. Ocular inserts for controlled delivery of pefloxacin mesylate: Preparation and evaluation. Acta Pharm 2005;55:305-14. (Pubitemid 41495274)
23. Wagh VD, Inamdar B, Samanta MK. Polymers used in ocular dosage form and drug delivery systems. Asian J Pharmaceutics 2008;2:12-7.
24. Elhadi SS, Mortada ND, Awad GA, Zaki NM, Taha RA. Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration. Saudi Pharm J 2003;11:150-71.
25. Neves JD, Amaral MH, Bahia MF. Vaginal drug delivery. In: Gad SC, editor. Pharmaceutical Manufacturing Handbook. NJ: John Willey and Sons Inc; 2007. p. 809-78.
26. Choi HG, Kim CK. In situ gelling and mucoadhesive liquid suppository containing acetaminophen: Enhanced bioavailability. Int J Pharm 1998;165:23-32.
27. Asane GS. Mucoadhesive gastro intestinal drug delivery system: An overview. Pharmainfo.net 2007;5:1-5.
28. Schnrch AB. Mucoadhesive systems in oral drug delivery. Drug Discov Today Technol 2005;2:83-7.
29. Rathbone MJ, Drummond BK, Tucker G. The oral cavity as a site for systemic drug delivery. Adv Drug Deliv Rev 1994;13:1-22. (Pubitemid 24032039)
30. Rajput GC, Majmudar FD, Patel JK, Patel KN, Thakor RS, Patel BP, et al. Stomach specific mucoadhesive tablets as controlled drug delivery system: A review work. Int J Pharm Biol Res 2010;1:30-41.
31. Remeth D, Sfurti S, Kailas M. In-vitro absorption studies of mucoadhesive tablets of acyclovir. Indian J Pharm Educ Res 2010;44:183-8.
32. Shah D, Gaud RS, Misra AN, Parikh R. Formulation of a water soluble mucoadhesive film of lycopene for treatment of leukoplakia. Int J Pharm Sci Rev Res 2010;12:6-11.
33. Biswajit B, Kevin G, Thimmasetty J. Formulation and evaluation of pimozide buccal mucoadhesive patches. Int J Pharm Sci Nanotechnol 2010;2:32-41.
34. Wong CF, Yuen KH, Peh KK. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm 1999;178:11-22. (Pubitemid 29074403)
35. Kumar S, Haglund BO, Himmelstein KJ. In situ-forming gels for ophthalmic drug delivery. J Ocul Pharmacol 1994;10:47-56. (Pubitemid 24119429)
36. Ishida M, Nambu N, Nagai T. Highly viscous gel ointment containing carbopol for application to the oral mucosa. Chem Pharm Bull 1983;31:4561-4. (Pubitemid 14175621)
37. Gurny R, Ryser JE, Tabatabay C, Martenet M, Edman P, Camber O. Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy. Graefes Arch Clin Exp Ophthalmol 1990;228:510-2. (Pubitemid 20362508)
38. Meseguer G, Gurny R, Buri P. Gamma scintigraphic evaluation of precorneal clearance in human volunteers and in rabbits. Eur J Drug Metab Pharmacokinet 1993;18:190-4.
39. Martin L, Wilson CG, Koosha F, Uchegbu IF. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. Eur J Pharm Biopharm 2003;55:35-45. (Pubitemid 36120493)
40. Jones DS, Woolfson AD, Brown AF, Coulter WA, McClelland C, Irwin CR. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Control Release 2000;67:357-68. (Pubitemid 30303848)
41. Vinholis AH, De Figueiredo LC, Marcantonio E, Marcantonio RA, Salvador SL, Goissis G. Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J 2001;12:209-13.
42. Ikinci G, Kenel SS, AkVncVbay H, Kas S, Ercis S, Wilson CG, et al. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis. Int J Pharm 2002;235:121-7. (Pubitemid 34185443)