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Volumn 6, Issue 3, 2014, Pages 530-542

Characterization of commercially available vaginal lubricants: A safety perspective

Author keywords

Buffer capacity; Cytotoxicity; Microbicides; Osmolality; Vaginal drug delivery

Indexed keywords

HYDROXYETHYLCELLULOSE; LACTATE DEHYDROGENASE; LUBRICATING AGENT; NONOXINOL 9; PLACEBO; SORBIC ACID; UNCLASSIFIED DRUG; VAGINAL LUBRICANT AGENT;

EID: 84937029060     PISSN: None     EISSN: 19994923     Source Type: Journal    
DOI: 10.3390/pharmaceutics6030530     Document Type: Article
Times cited : (42)

References (45)
  • 3
    • 22944486730 scopus 로고    scopus 로고
    • Preferences and practices related to vaginal lubrication: Implications for microbicide acceptability and clinical testing
    • Braunstein, S.; van de Wijgert, J. Preferences and practices related to vaginal lubrication: Implications for microbicide acceptability and clinical testing. J. Womens Health 2005, 14, 424–433.
    • (2005) J. Womens Health , vol.14 , pp. 424-433
    • Braunstein, S.1    Van De Wijgert, J.2
  • 4
    • 23944494632 scopus 로고    scopus 로고
    • Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis
    • Pavelić, Ž.; Škalko-Basnet, N.; Jalšenjak, I. Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis. Int. J. Pharm. 2005, 301, 140–148.
    • (2005) Int. J. Pharm , vol.301 , pp. 140-148
    • Pavelić, Ž.1    Škalko-Basnet, N.2    Jalšenjak, I.3
  • 5
    • 33745504777 scopus 로고    scopus 로고
    • Gels as vaginal drug delivery systems
    • das Neves, J.; Bahia, M.F. Gels as vaginal drug delivery systems. Int. J. Pharm. 2006, 318, 1–14.
    • (2006) Int. J. Pharm , vol.318 , pp. 1-14
    • Das Neves, J.1    Bahia, M.F.2
  • 6
    • 43249120415 scopus 로고    scopus 로고
    • Performance of an in vitro mucoadhesion testing method for vaginal semisolids: Influence of different testing conditions and instrumental parameters
    • das Neves, J.; Amaral, M.H.; Bahia, M.F. Performance of an in vitro mucoadhesion testing method for vaginal semisolids: Influence of different testing conditions and instrumental parameters. Eur. J. Pharm. Biopharm. 2008, 69, 622–632.
    • (2008) Eur. J. Pharm. Biopharm , vol.69 , pp. 622-632
    • Das Neves, J.1    Amaral, M.H.2    Bahia, M.F.3
  • 8
    • 84887285794 scopus 로고    scopus 로고
    • Condoms and condiments: Compatibility and safety of personal lubricants and their use in Africa
    • Geibel, S. Condoms and condiments: Compatibility and safety of personal lubricants and their use in Africa. J. Int. AIDS Soc. 2013, 16, 18531.
    • (2013) J. Int. AIDS Soc , vol.16 , pp. 18531
    • Geibel, S.1
  • 9
    • 0024510937 scopus 로고
    • Mineral oil lubricants cause rapid deterioration of latex condoms
    • Voeller, B.; Coulson, A.H.; Bernstein, G.S.; Nakamura, R.M. Mineral oil lubricants cause rapid deterioration of latex condoms. Contraception 1989, 39, 95–102.
    • (1989) Contraception , vol.39 , pp. 95-102
    • Voeller, B.1    Coulson, A.H.2    Bernstein, G.S.3    Nakamura, R.M.4
  • 11
    • 84907675378 scopus 로고    scopus 로고
    • A question for women’s health: Chemicals in feminine hygiene products and personal lubricants
    • Nicole, W. A question for women’s health: Chemicals in feminine hygiene products and personal lubricants. Environ. Health Perspect. 2014, 122, A70–A75.
    • (2014) Environ. Health Perspect , vol.122 , pp. A70-A75
    • Nicole, W.1
  • 12
    • 0035039512 scopus 로고    scopus 로고
    • Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization
    • Maguire, R.A.; Bergman, N.; Phillips, D.M. Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization. Sex. Transm. Dis. 2001, 28, 259–265.
    • (2001) Sex. Transm. Dis. , vol.28 , pp. 259-265
    • Maguire, R.A.1    Bergman, N.2    Phillips, D.M.3
  • 13
    • 43449092562 scopus 로고    scopus 로고
    • Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex. Transm
    • Adriaens, E.; Remon, J.P. Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex. Transm. Dis. 2008, 35, 512–516.
    • (2008) Dis , vol.35 , pp. 512-516
    • Adriaens, E.1    Remon, J.P.2
  • 14
    • 78349239340 scopus 로고    scopus 로고
    • Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    • Moench, T.R.; Mumper, R.J.; Hoen, T.E.; Sun, M.; Cone, R.A. Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse. BMC Infect. Dis. 2010, 10, 331.
    • (2010) BMC Infect. Dis , vol.10 , pp. 331
    • Moench, T.R.1    Mumper, R.J.2    Hoen, T.E.3    Sun, M.4    Cone, R.A.5
  • 21
    • 84937055485 scopus 로고    scopus 로고
    • CurveExpert Basic 1.4. Available online, (accessed on 30 June 2014)
    • CurveExpert Basic 1.4. Available online: http://www.curveexpert.net/curveexpert-basic/ (accessed on 30 June 2014).
  • 22
    • 0033023953 scopus 로고    scopus 로고
    • A vaginal fluid simulant
    • Owen, D.H.; Katz, D.F. A vaginal fluid simulant. Contraception 1999, 59, 91–95.
    • (1999) Contraception , vol.59 , pp. 91-95
    • Owen, D.H.1    Katz, D.F.2
  • 23
    • 84862687804 scopus 로고    scopus 로고
    • Sarmento, B. Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine
    • das Neves, J.; Michiels, J.; Ariën, K.K.; Vanham, G.; Amiji, M.; Bahia, M.F.; Sarmento, B. Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine. Pharm. Res. 2012, 29, 1468–1484.
    • (2012) Pharm. Res , vol.29 , pp. 1468-1484
    • Das Neves, J.1    Michiels, J.2    Ariën, K.K.3    Vanham, G.4    Amiji, M.5    Bahia, M.F.6
  • 25
    • 33845485055 scopus 로고    scopus 로고
    • The effect of polycarbophil gel (Replens™) on bacterial vaginosis: A pilot study
    • Wu, J.P.; Fielding, S.L.; Fiscella, K. The effect of polycarbophil gel (Replens™) on bacterial vaginosis: A pilot study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2007, 130, 132–136.
    • (2007) Eur. J. Obstet. Gynecol. Reprod. Biol , vol.130 , pp. 132-136
    • Wu, J.P.1    Fielding, S.L.2    Fiscella, K.3
  • 26
    • 19744375363 scopus 로고    scopus 로고
    • Successful treatment of bacterial vaginosis with a policarbophil-carbopol acidic vaginal gel: Results from a randomised double-blind, placebo-controlled trial
    • Fiorilli, A.; Molteni, B.; Milani, M. Successful treatment of bacterial vaginosis with a policarbophil-carbopol acidic vaginal gel: Results from a randomised double-blind, placebo-controlled trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005, 120, 202–205.
    • (2005) Eur. J. Obstet. Gynecol. Reprod. Biol , vol.120 , pp. 202-205
    • Fiorilli, A.1    Molteni, B.2    Milani, M.3
  • 28
    • 0019960171 scopus 로고
    • pH and the potential irritancy of douche formulations to the vaginal mucosa of the albino rabbit and rat
    • Kaminsky, M.; Willigan, D.A. pH and the potential irritancy of douche formulations to the vaginal mucosa of the albino rabbit and rat. Food Chem. Toxicol. 1982, 20, 193–196.
    • (1982) Food Chem. Toxicol , vol.20 , pp. 193-196
    • Kaminsky, M.1    Willigan, D.A.2
  • 30
    • 84877820852 scopus 로고    scopus 로고
    • Non-hormonal topical treatment of vulvovaginal atrophy
    • Sinha, A.; Ewies, A.A. Non-hormonal topical treatment of vulvovaginal atrophy: An up-to-date overview. Climacteric 2013, 16, 305–312.
    • (2013) An up-to-date overview. Climacteric , vol.16 , pp. 305-312
    • Sinha, A.1    Ewies, A.A.2
  • 31
    • 0034817210 scopus 로고    scopus 로고
    • Origins of vaginal acidity: High D/L lactate ratio is consistent with bacteria being the primary source. Hum
    • Boskey, E.R.; Cone, R.A.; Whaley, K.J.; Moench, T.R. Origins of vaginal acidity: High D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 2001, 16, 1809–1813.
    • (2001) Reprod , vol.16 , pp. 1809-1813
    • Boskey, E.R.1    Cone, R.A.2    Whaley, K.J.3    Moench, T.R.4
  • 32
    • 33846523463 scopus 로고    scopus 로고
    • Chitosan gels for the vaginal delivery of lactic acid: Relevance of formulation parameters to mucoadhesion and release mechanisms
    • Bonferoni, M.C.; Giunchedi, P.; Scalia, S.; Rossi, S.; Sandri, G.; Caramella, C. Chitosan gels for the vaginal delivery of lactic acid: Relevance of formulation parameters to mucoadhesion and release mechanisms. AAPS PharmSciTech 2006, 7, 104.
    • (2006) AAPS PharmSciTech , vol.7 , pp. 104
    • Bonferoni, M.C.1    Giunchedi, P.2    Scalia, S.3    Rossi, S.4    Sandri, G.5    Caramella, C.6
  • 33
    • 78650077732 scopus 로고    scopus 로고
    • Unacceptable side-effects associated with a hyperosmolar vaginal microbicide in a phase 1 trial
    • Lacey, C.J.; Woodhall, S.; Qi, Z.; Sawant, S.; Cowen, M.; McCormack, S.; Jiang, S. Unacceptable side-effects associated with a hyperosmolar vaginal microbicide in a phase 1 trial. Int. J. STD AIDS 2010, 21, 714–717.
    • (2010) Int. J. STD AIDS , vol.21 , pp. 714-717
    • Lacey, C.J.1    Woodhall, S.2    Qi, Z.3    Sawant, S.4    Cowen, M.5    McCormack, S.6    Jiang, S.7
  • 35
    • 38949095688 scopus 로고    scopus 로고
    • Effect of vaginal lubricants on sperm motility and chromatin integrity: A prospective comparative study. Fertil
    • Agarwal, A.; Deepinder, F.; Cocuzza, M.; Short, R.A.; Evenson, D.P. Effect of vaginal lubricants on sperm motility and chromatin integrity: A prospective comparative study. Fertil. Steril. 2008, 89, 375–379.
    • (2008) Steril , vol.89 , pp. 375-379
    • Agarwal, A.1    Deepinder, F.2    Cocuzza, M.3    Short, R.A.4    Evenson, D.P.5
  • 36
    • 79953196872 scopus 로고    scopus 로고
    • Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1. Antimicrob
    • Mahalingam, A.; Simmons, A.P.; Ugaonkar, S.R.; Watson, K.M.; Dezzutti, C.S.; Rohan, L.C.; Buckheit, R.W., Jr.; Kiser, P.F. Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1. Antimicrob. Agents Chemother. 2011, 55, 1650–1660.
    • (2011) Agents Chemother , vol.55 , pp. 1650-1660
    • Mahalingam, A.1    Simmons, A.P.2    Ugaonkar, S.R.3    Watson, K.M.4    Dezzutti, C.S.5    Rohan, L.C.6    Buckheit, R.W.7    Kiser, P.F.8
  • 40
    • 0023738916 scopus 로고
    • Quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
    • Decker, T.; Lohmann-Matthes, M.L. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immunol. Methods 1988, 115, 61–69.
    • (1988) J. Immunol. Methods , vol.115 , pp. 61-69
    • Decker, T.1    Lohmann-Matthes, M.L.A.2
  • 41
    • 84878711961 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of hyaluronic acid vaginal gel to ease vaginal dryness: A multicenter, randomized, controlled, open-label, parallel-group, clinical trial
    • Chen, J.; Geng, L.; Song, X.; Li, H.; Giordan, N.; Liao, Q. Evaluation of the efficacy and safety of hyaluronic acid vaginal gel to ease vaginal dryness: A multicenter, randomized, controlled, open-label, parallel-group, clinical trial. J. Sex. Med. 2013, 10, 1575–1584.
    • (2013) J. Sex. Med. , vol.10 , pp. 1575-1584
    • Chen, J.1    Geng, L.2    Song, X.3    Li, H.4    Giordan, N.5    Liao, Q.6
  • 44
    • 78649640372 scopus 로고    scopus 로고
    • In vitro evaluation of viability, integrity and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides. Antimicrob
    • Gali, Y.; Delezay, O.; Brouwers, J.; Addad, N.; Augustijns, P.; Bourlet, T.; Hamzeh-Cognasse, H.; Ariën, K.K.; Pozzetto, B.; Vanham, G. In vitro evaluation of viability, integrity and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides. Antimicrob. Agents Chemother. 2010, 54, 5105–5114.
    • (2010) Agents Chemother , vol.54 , pp. 5105-5114
    • Gali, Y.1    Delezay, O.2    Brouwers, J.3    Addad, N.4    Augustijns, P.5    Bourlet, T.6    Hamzeh-Cognasse, H.7    Ariën, K.K.8    Pozzetto, B.9    Vanham, G.10
  • 45
    • 0025333045 scopus 로고
    • Final report on the safety assessment of phenoxyethanol
    • Poudrier, J.K. Final report on the safety assessment of phenoxyethanol. J. Am. Coll. Toxicol. 1990, 9, 259–277.
    • (1990) J. Am. Coll. Toxicol , vol.9 , pp. 259-277
    • Poudrier, J.K.1


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