Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Acta Pharmaceutica

Volumn 58, Issue 4, 2008, Pages 407-419

  Ahmad, Farhan Jalees ^a   Alam, Mohd Aftab ^a   Khan, Zeenat Iqbal ^a   Khar, Roop Krishen ^a   Ali, Mushir ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Acid buffering gel; Bioadhesive polymers; Mixed vaginal infections; Vaginal bioadhesion

Indexed keywords

ADHESIVE AGENT; BIOADHESIVE POLYMER; BUFFER; CANDID V; CANESTEN1; CLOTRIMAZOLE; METRONIDAZOLE; POLYMER; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG RETENTION; DRUG STABILITY; GEL; IN VITRO STUDY; LACTOBACILLUS ACIDOPHILUS; NONHUMAN; VAGINA SECRETION; VAGINITIS;

EID: 58149154649     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-008-0023-2     Document Type: Article

References (18)

1. J. Sherrard, European guidelines for the management of vaginal discharge, Int. J. STD AIDS 12 (2001) 73-77.
2. S. Kukner, T. Ergin, N. Cicek, M. Ugur, H. Yesilyurt and O. Gokmen, Treatment of vaginitis, Int. J. Gynecol. Obstet. 52 (1996) 43-47; DOI: 10.1016/0020-7292(95)02531-6.
3. Vaginitis ACOG Technical Bulletin, Int. J. Gynecol. Obstet. 53 (1996) 271-280; DOI: 10.1016/S0020-7292(96)90014-4.
4. P. A. Mardh, K. Tchoudomirova, S. Elshibly and D. Hellberg, Symptoms and signs in single and mixed genital infections, Int. J. Gynecol. Obstet. 63 (1998) 145-152; DOI: 10.1016/S0020-7292(98)00140-4.
5. E. Ozyurt, M. B. Toykuliyeva, I. L. Danilyans, O. Morton and G. Baktir, Efficacy of 7-day treatment with metronidazole + miconazole (Neo-Penotran®) - a triple-active pessary for the treatment of single and mixed vaginal infections, Int. J. Gynecol. Obstet. 74 (2001) 35-43; DOI: 10.1016/S0020-7292(01)00388-5.
6. J. Thinkhamrop, P. Lumbiganon, P. Thongkrajai and C. Chongsomchai, Vaginal pH as a screening test for vaginitis, Int. J. Gynecol. Obstet. 66 (1999) 143-148; DOI: 10.1016/S0020-7292(99) 00057-0.
7. G. C. Ceschel, P. Maffei, S. L. Borgia, C. Ronchi and S. Rossi, Development of a mucoadhesive dosage form for vaginal administration, Drug Dev. Ind. Pharm. 27 (2001) 541-547; DOI: 10.1081/DDC-100105179.
8. K. Vermani and S. Garg, The scope and potential of vaginal drug delivery, Pharm. Sci. Technol. Today 3 (2000) 359-364; DOI: 10.1016/S1461-5347(00)00296-0.
9. R. S. Levinson and D. J. Thompson, VagiSite bioadhesive technology, Drugs Pharm. Sci. 126 (2003) 801-806.
10. C. D. Freeman, N. E. Klutman and K. C. Lamp, Metronidazole, a therapeutic review and update, Drugs 54 (1997) 679-708.
11. P. H. Spiekermann and M. D. Young, Clinical evaluation of clotrimazole. A broad-spectrum antifungal agent, Arch. Dermatol. 112 (1976) 350-352.
12. L. Maggi, P. Mastromarino, S. Macchia, P. Brigidi, F. Pirovano, D. Matteuzzi and U. Conte, Technological and biological evaluation of tablets containing different strains of Lactobacilli for vaginal administration, Eur. J. Pharm. Biopharm. 50 (2000) 389-395; DOI: 10.1016/S0939-6411(00)00121-1.
13. D. H. Owen and D. F. Katz, A vaginal fluid stimulant, Contraception 59 (1999) 91-95; DOI: 10.1016/S0010-7824(99)00010-4.
14. United States Pharmacopoeia 26 - National Formulary 21, Asian Edition, USP Convention, Rockville (MD) 2003, pp. 2155-2156.
15. H-L. Weng and E. L. Parrott, Dissolution apparatus for gels, J. Pharm. Sci. 72 (1983) 186-188; DOI: 10.1002/jps.2600720223.
16. M. A. Alam, F. J. Ahmad, Z. I. Iqubal, R. K. Khar and M. Ali, Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections, AAPS PharmSciTech. 8 (2007) 229-236.
17. I. C. De Paula, G. G. Ortega, V. L. Bassani and P. R. Petrovick, Development of ointment formulations prepared with Achyrocline satureioides spray dried extracts, Drug Dev. Ind. Pharm. 24 (1998) 235-241.
18. L. Kaus, Buffers and Buffering Agents, in Encyclopedia of Pharmaceutical Technology (Eds. J. Swarbrick and J. C. Boylan), Vol. 2, Marcel Dekker, New York 1990, pp. 213-231.