Poloxamers: A pharmaceutical excipients with therapeutic behaviors

International Journal of PharmTech Research

Volumn 1, Issue 2, 2009, Pages 299-303

  Patel, Hitesh R ^a   Patel, Rakesh P ^a   Patel, M M ^b  

^a GANPAT UNIVERSITY   (India)

^b Kalol Institute of Technology   (India)

Author keywords

Copolymers; Pharmaceutical ingredient; Poloxamers; Therapeutic effect

Indexed keywords

EID: 77951687808     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Lin S.-Y. and Y. Kawashima. The influence of three poly (-oxtethylene) poly (oxypropylene), surface-active block copolymers on the solubility behavior of indomethacin. Pharm. Acta. Helv. 1985; 60: 339-344.
2. Kabanov A.V., Batrakova E.V and Miller D.W. Pluronic(R) block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv. Drug Del. Rev. 2003; 55: 151-164.
3. BASF Corporation3000 Continental Drive-North Mount Olive, New Jersey.
4. Cabana A., Abdellatif A.K. and Juhász J., Study of the gelation process of polyethylene oxide-polypropylene oxide-polyethylene oxide copolymer (poloxamer 407) aqueous solutions. J Colloid Interface Sci1997; 190: 307-312.
5. Maynard C., Swenson R., Paris J.A., Martin J.S., Hallstrom A.P., Cerqueira M.D. and Weaver W.D., Randomized, controlled trial of RheothRx (poloxamer 188) in patients with suspected acute myocardial infarction. Rheothrx in myocardial infarction study group. Am Heart J. 1998; 135:797-804.
6. Nalbandian R.M., Henry R.L., Balko K.W., et.al. Pluronic F-127 gel preparation as an artificial skin in the treatment of third-degree burns in pigs, J. Biomed. Mater. Res. 1987; 21:1135-1148.
7. Kim C.K., Lee S.W., Choi H.G., et.al. Trials of in situ gelling and mucoadhesive acetaminophen liquid suppository in human subjects, Int. J. Pharm. 1998;174:201-207. (Pubitemid 28487004)
8. Gilbert P., Jones M.V., Allison D.G., et.al. The use of poloxamer hydrogels for the assessment of biofilm susceptibility towards biocide treatments. J Appl Microbiol. 1998;85:985-990 (Pubitemid 28559729)
9. Feldman L. J., Pastore C. J., Aubailly N., et.al. Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors, gene therapy, 1997;4:189-198. (Pubitemid 27182072)
10. Daniel J. C., David A. W., Raphael C. L., et.al. Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats. 2004;101:16-20.
11. Hartikka J., Sukhu L.,Buchner C., et.al. Electroporation-facilitated delivery of plasmid DNA in skeletal muscle: plasmid dependence of muscle damage and effect of poloxamer 188. Mol Ther. 2001;5:407-415
12. Mullen A., Carter K., and Baillie A. J... Comparison of the efficacies of various formulations of amphotericin B against murine visceral leishmaniasis. Antimicrob. Agents Chemother. 1997;41:2089-2092.
13. Block T.A., Aarsvold J.N., Matthews L., et al., Nonthermally mediated muscle injury and necrosis in electrical trauma. J. Burn Care Rehabil. 1995;16:581-588.
14. Boodhwani M., Feng J., Mieno S., et.al. Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium European Journal of Cardio-Thoracic Surgery 2006;29:736-741.
15. Steinleitner A., Lambert H., Kazensky C., and Cantor B. Poloxamer 407 as an intraperitoneal barrier material for the prevention of postsurgical adhesion formation and reformation in rodent models for reproductive surgery Obstetrics & Gynecology 1991;77:48-52.
16. H. Baskaran, M. Yarmush, F. Berthiaume poloxamer-188 improves capillary blood f'low in the zone of stasis after burn injury Proceedigs of The First Joint BMEEMBS CMlbmce SeMng Humanity, Advancing Technology 1516:39.
17. Guohui W., Jaroslaw M.,Canay E., et.al. Interaction between Lipid Monolayers and Poloxamer 188: An XRay Reflectivity and Diffraction StudyBiophysical Journal 2005 ;89:3159-3173.
18. Han Y. K., Kwon J.W., Kim J. S., et.al. In vitro and in vivo study of lens refilling with poloxamer hydrogel Br J Ophthalmol 2003;87:1399-1402.
19. C. Lee, L.P. River, F.-S. Pan, L. Ji and R.L. Wollmann, Surfactant-induced sealing of electropermeabilized skeletal muscle membranes in vivo. PNAS USA 1992;89:524-4528.