메뉴 건너뛰기




Volumn 69, Issue 2, 2008, Pages 622-632

Performance of an in vitro mucoadhesion testing method for vaginal semisolids: Influence of different testing conditions and instrumental parameters

Author keywords

Detachment force; Mucoadhesion; Semisolid formulations; Texture analyzer; Vaginal drug delivery; Work of adhesion

Indexed keywords

ANTIFUNGAL AGENT; CARBOMER; CLINDAMYCIN; CLOTRIMAZOLE; NONOXINOL 9; POLYCARBOPHIL; ZIDOVAL;

EID: 43249120415     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.12.007     Document Type: Article
Times cited : (68)

References (53)
  • 5
    • 33745504777 scopus 로고    scopus 로고
    • Gels as vaginal drug delivery systems
    • das Neves J., and Bahia M.F. Gels as vaginal drug delivery systems. Int. J. Pharm. 318 (2006) 1-14
    • (2006) Int. J. Pharm. , vol.318 , pp. 1-14
    • das Neves, J.1    Bahia, M.F.2
  • 6
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • Smart J.D. The basics and underlying mechanisms of mucoadhesion. Adv. Drug Deliv. Rev. 57 (2005) 1556-1568
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1556-1568
    • Smart, J.D.1
  • 7
    • 26844560127 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in vaginal delivery
    • Valenta C. The use of mucoadhesive polymers in vaginal delivery. Adv. Drug Deliv. Rev. 57 (2005) 1692-1712
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1692-1712
    • Valenta, C.1
  • 8
    • 0029965810 scopus 로고    scopus 로고
    • Development and evaluation of a mucoadhesive drug delivery system for dual-controlled delivery of nonoxynol-9
    • Lee C.H., and Chien Y.W. Development and evaluation of a mucoadhesive drug delivery system for dual-controlled delivery of nonoxynol-9. J. Control. Release 39 (1996) 93-103
    • (1996) J. Control. Release , vol.39 , pp. 93-103
    • Lee, C.H.1    Chien, Y.W.2
  • 10
    • 0037043096 scopus 로고    scopus 로고
    • Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions
    • Chang J.Y., Oh Y.K., Choi H.G., Kim Y.B., and Kim C.K. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int. J. Pharm. 241 (2002) 155-163
    • (2002) Int. J. Pharm. , vol.241 , pp. 155-163
    • Chang, J.Y.1    Oh, Y.K.2    Choi, H.G.3    Kim, Y.B.4    Kim, C.K.5
  • 11
    • 31544467845 scopus 로고    scopus 로고
    • Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
    • Han I.K., Kim Y.B., Kang H.S., Sul D., Jung W.W., Cho H.J., and Oh Y.K. Thermosensitive and mucoadhesive delivery systems of mucosal vaccines. Methods 38 (2006) 106-111
    • (2006) Methods , vol.38 , pp. 106-111
    • Han, I.K.1    Kim, Y.B.2    Kang, H.S.3    Sul, D.4    Jung, W.W.5    Cho, H.J.6    Oh, Y.K.7
  • 13
    • 0029100666 scopus 로고
    • Factors affecting in vitro gastric mucoadhesion. I. Test conditions and instrumental parameters
    • Tobyn M.J., Johnson J.R., and Dettmar P.W. Factors affecting in vitro gastric mucoadhesion. I. Test conditions and instrumental parameters. Eur. J. Pharm. Biopharm. 41 (1995) 235-241
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , pp. 235-241
    • Tobyn, M.J.1    Johnson, J.R.2    Dettmar, P.W.3
  • 14
    • 0034892282 scopus 로고    scopus 로고
    • In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa
    • Jackson S.J., and Perkings A.C. In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa. Eur. J. Pharm. Biopharm. 52 (2001) 121-127
    • (2001) Eur. J. Pharm. Biopharm. , vol.52 , pp. 121-127
    • Jackson, S.J.1    Perkings, A.C.2
  • 15
    • 34250840641 scopus 로고    scopus 로고
    • Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer
    • Thirawong N., Nunthanid J., Puttipipatkhachorn S., and Sriamornsak P. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur. J. Pharm. Biopharm. 67 (2007) 132-140
    • (2007) Eur. J. Pharm. Biopharm. , vol.67 , pp. 132-140
    • Thirawong, N.1    Nunthanid, J.2    Puttipipatkhachorn, S.3    Sriamornsak, P.4
  • 16
    • 43249105243 scopus 로고    scopus 로고
    • J. das Neves, M.H. Amaral, M.F. Bahia. Mechanical properties of a vaginal gel containing Thymus vulgaris essential oil (1% w/w), 3rd Pharmaceutical Sciences World Congress, Amsterdam, FIP, 2007.
    • J. das Neves, M.H. Amaral, M.F. Bahia. Mechanical properties of a vaginal gel containing Thymus vulgaris essential oil (1% w/w), 3rd Pharmaceutical Sciences World Congress, Amsterdam, FIP, 2007.
  • 17
    • 23144465315 scopus 로고    scopus 로고
    • Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine
    • Gavini E., Sanna V., Juliano C., Bonferoni M.C., and Giunchedi P. Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine. AAPS PharmSciTech 3 (2002) E20
    • (2002) AAPS PharmSciTech , vol.3
    • Gavini, E.1    Sanna, V.2    Juliano, C.3    Bonferoni, M.C.4    Giunchedi, P.5
  • 18
    • 23944494632 scopus 로고    scopus 로고
    • Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis
    • Pavelic Z., Skalko-Basnet N., and Jalsenjak I. Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis. Int. J. Pharm. 301 (2005) 140-148
    • (2005) Int. J. Pharm. , vol.301 , pp. 140-148
    • Pavelic, Z.1    Skalko-Basnet, N.2    Jalsenjak, I.3
  • 21
    • 0037130164 scopus 로고    scopus 로고
    • Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis
    • Chang J.Y., Oh Y.K., Kong H.S., Kim E.J., Jang D.D., Nam K.T., and Kim C.K. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J. Control. Release 82 (2002) 39-50
    • (2002) J. Control. Release , vol.82 , pp. 39-50
    • Chang, J.Y.1    Oh, Y.K.2    Kong, H.S.3    Kim, E.J.4    Jang, D.D.5    Nam, K.T.6    Kim, C.K.7
  • 22
    • 33846523463 scopus 로고    scopus 로고
    • Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms
    • Bonferoni M.C., Giunchedi P., Scalia S., Rossi S., Sandri G., and Caramella C. Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms. AAPS PharmSciTech 7 (2006) E104
    • (2006) AAPS PharmSciTech , vol.7
    • Bonferoni, M.C.1    Giunchedi, P.2    Scalia, S.3    Rossi, S.4    Sandri, G.5    Caramella, C.6
  • 23
    • 0344519699 scopus 로고    scopus 로고
    • An in vitro investigation for vaginal bioadhesive formulations: bioadhesive properties and swelling states of polymer mixtures
    • Baloglu E., Ozyazici M., Hizarcioglu S.Y., and Karavana H.A. An in vitro investigation for vaginal bioadhesive formulations: bioadhesive properties and swelling states of polymer mixtures. Farmaco 58 (2003) 391-396
    • (2003) Farmaco , vol.58 , pp. 391-396
    • Baloglu, E.1    Ozyazici, M.2    Hizarcioglu, S.Y.3    Karavana, H.A.4
  • 24
    • 0033023953 scopus 로고    scopus 로고
    • A vaginal fluid simulant
    • Owen D.H., and Katz D.F. A vaginal fluid simulant. Contraception 59 (1999) 91-95
    • (1999) Contraception , vol.59 , pp. 91-95
    • Owen, D.H.1    Katz, D.F.2
  • 25
    • 0019967909 scopus 로고
    • Vaginal physiology during menstruation
    • Wagner G., and Ottesen B. Vaginal physiology during menstruation. Ann. Intern. Med. 96 (1982) 921-923
    • (1982) Ann. Intern. Med. , vol.96 , pp. 921-923
    • Wagner, G.1    Ottesen, B.2
  • 26
    • 0034817210 scopus 로고    scopus 로고
    • Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source
    • Boskey E.R., Cone R.A., Whaley K.J., and Moench T.R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 16 (2001) 1809-1813
    • (2001) Hum. Reprod. , vol.16 , pp. 1809-1813
    • Boskey, E.R.1    Cone, R.A.2    Whaley, K.J.3    Moench, T.R.4
  • 27
    • 0035991066 scopus 로고    scopus 로고
    • Effects of chelating agents on the rheological property of cervical mucus
    • Lee C.H., Wang Y., Shin S.C., and Chien Y.W. Effects of chelating agents on the rheological property of cervical mucus. Contraception 65 (2002) 435-440
    • (2002) Contraception , vol.65 , pp. 435-440
    • Lee, C.H.1    Wang, Y.2    Shin, S.C.3    Chien, Y.W.4
  • 28
    • 0036410828 scopus 로고    scopus 로고
    • Assemblies for in vitro measurement of bioadhesive strength and retention characteristics in simulated vaginal environment
    • Vermani K., Garg S., and Zaneveld L.J. Assemblies for in vitro measurement of bioadhesive strength and retention characteristics in simulated vaginal environment. Drug Dev. Ind. Pharm. 28 (2002) 1133-1146
    • (2002) Drug Dev. Ind. Pharm. , vol.28 , pp. 1133-1146
    • Vermani, K.1    Garg, S.2    Zaneveld, L.J.3
  • 29
    • 31144448147 scopus 로고    scopus 로고
    • The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system
    • Yoo J.W., Dharmala K., and Lee C.H. The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Int. J. Pharm. 309 (2006) 139-145
    • (2006) Int. J. Pharm. , vol.309 , pp. 139-145
    • Yoo, J.W.1    Dharmala, K.2    Lee, C.H.3
  • 31
    • 0034601173 scopus 로고    scopus 로고
    • Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease
    • Jones D.S., Woolfson A.D., Brown A.F., Coulter W.A., McClelland C., and Irwin C.R. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J. Control. Release 67 (2000) 357-368
    • (2000) J. Control. Release , vol.67 , pp. 357-368
    • Jones, D.S.1    Woolfson, A.D.2    Brown, A.F.3    Coulter, W.A.4    McClelland, C.5    Irwin, C.R.6
  • 32
    • 0031390438 scopus 로고    scopus 로고
    • A comparison of different in vitro methods for measuring mucoadhesive performance
    • Tamburic S., and Craig D.Q.M. A comparison of different in vitro methods for measuring mucoadhesive performance. Eur. J. Pharm. Biopharm. 44 (1997) 159-167
    • (1997) Eur. J. Pharm. Biopharm. , vol.44 , pp. 159-167
    • Tamburic, S.1    Craig, D.Q.M.2
  • 33
    • 2942516875 scopus 로고    scopus 로고
    • Bioadhesive, rheological, lubricant and other aspects of an oral gel formulation intended for the treatment of xerostomia
    • Kelly H.M., Deasy P.B., Busquet M., and Torrance A.A. Bioadhesive, rheological, lubricant and other aspects of an oral gel formulation intended for the treatment of xerostomia. Int. J. Pharm. 278 (2004) 391-406
    • (2004) Int. J. Pharm. , vol.278 , pp. 391-406
    • Kelly, H.M.1    Deasy, P.B.2    Busquet, M.3    Torrance, A.A.4
  • 34
    • 0030955984 scopus 로고    scopus 로고
    • Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers
    • Jones D.S., Woolfson A.D., and Brown A.F. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int. J. Pharm. 151 (1997) 223-233
    • (1997) Int. J. Pharm. , vol.151 , pp. 223-233
    • Jones, D.S.1    Woolfson, A.D.2    Brown, A.F.3
  • 35
    • 0025738301 scopus 로고
    • An in vitro assessment of some mucosa-adhesive dosage forms
    • Smart J.D. An in vitro assessment of some mucosa-adhesive dosage forms. Int. J. Pharm. 73 (1991) 69-74
    • (1991) Int. J. Pharm. , vol.73 , pp. 69-74
    • Smart, J.D.1
  • 37
    • 0027233057 scopus 로고
    • An investigation into the role of water movement and mucus gel dehydration in mucoadhesion
    • Mortazavi S.A., and Smart J.D. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J. Control. Release 25 (1993) 197-203
    • (1993) J. Control. Release , vol.25 , pp. 197-203
    • Mortazavi, S.A.1    Smart, J.D.2
  • 38
    • 0019230584 scopus 로고
    • Composition and function of human cervical mucus
    • Wolf D.P., Sokoloski J.E., and Litt M. Composition and function of human cervical mucus. Biochim. Biophys. Acta 630 (1980) 545-558
    • (1980) Biochim. Biophys. Acta , vol.630 , pp. 545-558
    • Wolf, D.P.1    Sokoloski, J.E.2    Litt, M.3
  • 40
    • 0028950347 scopus 로고
    • The vaginal epithelium in the postmenopause - cytology, histology and pH as methods of assessment
    • Nilsson K., Risberg B., and Heimer G. The vaginal epithelium in the postmenopause - cytology, histology and pH as methods of assessment. Maturitas 21 (1995) 51-56
    • (1995) Maturitas , vol.21 , pp. 51-56
    • Nilsson, K.1    Risberg, B.2    Heimer, G.3
  • 41
    • 20544446960 scopus 로고    scopus 로고
    • A review of the physical and chemical properties of human semen and the formulation of a semen simulant
    • Owen D.H., and Katz D.F. A review of the physical and chemical properties of human semen and the formulation of a semen simulant. J. Androl. 26 (2005) 459-469
    • (2005) J. Androl. , vol.26 , pp. 459-469
    • Owen, D.H.1    Katz, D.F.2
  • 42
    • 84869298534 scopus 로고    scopus 로고
    • Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole:beta-cyclodextrin complex
    • Bilensoy E., Rouf M.A., Vural I., Sen M., and Hincal A.A. Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole:beta-cyclodextrin complex. AAPS PharmSciTech 7 (2006) E38
    • (2006) AAPS PharmSciTech , vol.7
    • Bilensoy, E.1    Rouf, M.A.2    Vural, I.3    Sen, M.4    Hincal, A.A.5
  • 43
    • 33947503596 scopus 로고    scopus 로고
    • Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles
    • Gupta K.M., Barnes S.R., Tangaro R.A., Roberts M.C., Owen D.H., Katz D.F., and Kiser P.F. Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. J. Pharm. Sci. 96 (2007) 670-681
    • (2007) J. Pharm. Sci. , vol.96 , pp. 670-681
    • Gupta, K.M.1    Barnes, S.R.2    Tangaro, R.A.3    Roberts, M.C.4    Owen, D.H.5    Katz, D.F.6    Kiser, P.F.7
  • 44
    • 0023529793 scopus 로고
    • Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels
    • Park H., and Robinson J.R. Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharm. Res. 4 (1987) 457-464
    • (1987) Pharm. Res. , vol.4 , pp. 457-464
    • Park, H.1    Robinson, J.R.2
  • 45
    • 8344252009 scopus 로고    scopus 로고
    • Adhesion of polyether-modified poly(acrylic acid) to mucin
    • Cleary J., Bromberg L., and Magner E. Adhesion of polyether-modified poly(acrylic acid) to mucin. Langmuir 20 (2004) 9755-9762
    • (2004) Langmuir , vol.20 , pp. 9755-9762
    • Cleary, J.1    Bromberg, L.2    Magner, E.3
  • 46
    • 0344551269 scopus 로고    scopus 로고
    • Vaginal algometer: development and application of a device to monitor vaginal wall pressure pain threshold
    • Baguley S.D., Curnow J.S., Morrison G.D., and Barron L.F. Vaginal algometer: development and application of a device to monitor vaginal wall pressure pain threshold. Physiol. Meas. 24 (2003) 833-836
    • (2003) Physiol. Meas. , vol.24 , pp. 833-836
    • Baguley, S.D.1    Curnow, J.S.2    Morrison, G.D.3    Barron, L.F.4
  • 47
    • 0000720174 scopus 로고
    • Influence of some technological parameters on the bioadhesive characteristics of polyacrylic acids matrices
    • Lejoyeux F., Ponchel G., and Duchêne D. Influence of some technological parameters on the bioadhesive characteristics of polyacrylic acids matrices. STP Pharma 5 (1989) 893-898
    • (1989) STP Pharma , vol.5 , pp. 893-898
    • Lejoyeux, F.1    Ponchel, G.2    Duchêne, D.3
  • 48
    • 0035678479 scopus 로고    scopus 로고
    • Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method
    • Hagerstrom H., and Edsman K. Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method. J. Pharm. Pharmacol. 53 (2001) 1589-1599
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1589-1599
    • Hagerstrom, H.1    Edsman, K.2
  • 49
    • 0021236615 scopus 로고
    • An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
    • Smart J.D., Kellaway I.W., and Worthington H.E. An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 36 (1984) 295-299
    • (1984) J. Pharm. Pharmacol. , vol.36 , pp. 295-299
    • Smart, J.D.1    Kellaway, I.W.2    Worthington, H.E.3
  • 50
    • 0036754357 scopus 로고    scopus 로고
    • Bioadhesive controlled release metronidazole vaginal tablet
    • El-Kamel A.H., Sokar M.S., Naggar V.F., and Al Gamal S.S. Bioadhesive controlled release metronidazole vaginal tablet. Acta Pharm. 52 (2002) 171-179
    • (2002) Acta Pharm. , vol.52 , pp. 171-179
    • El-Kamel, A.H.1    Sokar, M.S.2    Naggar, V.F.3    Al Gamal, S.S.4
  • 51
    • 26644434123 scopus 로고    scopus 로고
    • Comparison of the mucoadhesive properties of various polymers
    • Grabovac V., Guggi D., and Bernkop-Schnurch A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev. 57 (2005) 1713-1723
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1713-1723
    • Grabovac, V.1    Guggi, D.2    Bernkop-Schnurch, A.3
  • 52
    • 43249112460 scopus 로고    scopus 로고
    • J. das Neves, Desenvolvimento de um Gel Hidrófilo de Óleo Essencial de Thymus vulgaris L. para o Tratamento da Candidose Vulvovaginal, MSc Thesis, University of Porto, Porto, 2007.
    • J. das Neves, Desenvolvimento de um Gel Hidrófilo de Óleo Essencial de Thymus vulgaris L. para o Tratamento da Candidose Vulvovaginal, MSc Thesis, University of Porto, Porto, 2007.
  • 53
    • 0028810099 scopus 로고
    • An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems
    • Tamburic S., and Craig D.Q.M. An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J. Control. Release 37 (1995) 59-68
    • (1995) J. Control. Release , vol.37 , pp. 59-68
    • Tamburic, S.1    Craig, D.Q.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.