A thermosensitive vaginal gel formulation with HPγCD for the pH-dependent release and solubilization of amphotericin B

European Journal of Pharmaceutical Sciences

Volumn 41, Issue 2, 2010, Pages 399-406

  Kim, Ye Tae ^a   Shin, Baek Ki ^a   Garripelli, Vivek Kumar ^b   Kim, Jin Ki ^b   Davaa, Enkhzaya ^a   Jo, Seongbong ^b   Park, Jeong Sook ^a  

^a Chungnam National University   (South Korea)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Amphotericin B; HP CD; Novel copolymer; PH dependent degradation; PH sensitive polymer; Vaginal gel

Indexed keywords

AMB; AMPHOTERICIN B; COPOLYMER; HYDROXYPROPYL GAMMA CYCLODEXTRIN; MULTIBLOCK COPOLYMER; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BODY TEMPERATURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; GEL; GELATION; HEAT SENSITIVITY; HISTOPATHOLOGY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOUSE; NONHUMAN; PATIENT COMPLIANCE; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; VAGINA CANDIDIASIS; VAGINAL INJURY; X RAY POWDER DIFFRACTION;

AMPHOTERICIN B; CALORIMETRY, DIFFERENTIAL SCANNING; FEMALE; GELS; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VAGINA; X-RAY DIFFRACTION;

EID: 77955841493     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.07.009     Document Type: Article

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