Development of thermo-sensitive injectable hydrogel with sustained release of doxorubicin: Rheological characterization and in vivo evaluation in rats

Drug Delivery

Volumn 18, Issue 5, 2011, Pages 305-311

  Xuan, Jing Ji ^a   Yan, Yi Dong ^a   Oh, Dong Hoon ^a   Choi, Young Keun ^a   Yong, Chul Soon ^a   Choi, Han Gon ^b  

^a Yeungnam University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Doxorubicin; gelation time; injectable gel; poloxamer; rat; sustained release; thermosensitive

Indexed keywords

DOXORUBICIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COLD TREATMENT; CONTROLLED STUDY; DIFFUSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; GELATION; HEAT SENSITIVITY; HYDROGEL; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; VISCOSITY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; EXCIPIENTS; HYDROCHLORIC ACID; HYDROGELS; INJECTIONS, INTRAMUSCULAR; MALE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SOLUBILITY; TEMPERATURE; TIME FACTORS; VISCOSITY;

EID: 79958193506     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2010.544690     Document Type: Article

References (30)

1. Álvarez-Cedrón, L., Sayalero, M.L., Lanao, J.M. (1999). Highperformance liquid chromatographic validated assay of doxorubicin in rat plasma and tissues. J Chromatogr. 721: 271-8 (Pubitemid 29142349)
2. Arnold, R., Slack, J.E., Straubinger, R.M. (2004). Quantification of Doxorubicin and metabilites in rat plasma and small volume tissue samples by liquid chromatography/ electrospray tandem mass spectroscopy. J Chromatogr B. 808:141-52 (Pubitemid 38952908)
3. Bhattarai, N., Ramay, H.R., Gunn, J., Matsen, F.A., Zhang, M. (2005). PEG-grafted chitosan as an injectable thermo-sensitive hydrogel for sustained protein release. J Contr Rel. 103:609-24 (Pubitemid 40471019)
4. Cabana, A., Ait-kadi, A., Juhasz, J. (1997). Study of the gelation process of polyethylene oxide-polypropylene oxide-polyethylene oxide copolymer (poloxamer 407) aqueous solution. J Colloid Interface Sci. 190:307-12 (Pubitemid 27470860)
5. Choi, H.G., Jung, J.H., Ryu, J.M., Yoon, S.J., Sung Oh, Y.K., Kim, C.K. (1998a). Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository. Int J Pharm. 165:33-44
6. Choi, H.G., Kim, M.H., Lee, M.K., Kim, C.K. (1999). Effect of additives on the physicochemical properties of liquid suppository. Int J Pharm. 190:13-19
7. Choi, H.G., Oh, Y.K., Kim, C.K. (1998b). In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability. Int J Pharm. 165;23-32
8. Dumortier, G., Zumer, M., Courarraze, G., Chaumeil, J.C., Grossiord, J.L. (1991). Rheological study of a thermoreversible morphine gel. Drug Dev Ind Pharm. 17:1255-65
9. Fan, H., Dash, A.K. (2001). Effect of cross-linking on the in vitro release kinetics of doxorubicin from gelatin implants. Int J Pharm. 213:103-16 (Pubitemid 32119466)
10. Fundarò, A., Cavalli, R., Bargoni, A., Vighetto, D., Zara, G.P., Gasco, M.R. (2000). Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. Pharm Res. 42:337-43
11. Gibaldi, M., Perrier, D. (1982). Pharmacokinetics. 2nd ed. New York: Marcel-Dekker
12. Jeong, B., Gutowska, A. (2002). Lessons from nature: stimuliresponsive polymers and their biomedical applications. Trends Biotechnol. 20:305-11 (Pubitemid 34626726)
13. Kakinoki, S., Taguchi, T., Saito, H., Tanaka, J., Tateishi, T. (2007). Injectable in situ forming drug delivery system for cancer chemotherapy using a novel tissue adhesive: characterization and in vitro evaluation. Eur J Pharm Biopharm. 66:383-90 (Pubitemid 46756224)
14. Kang, G.D., Cheon, S.H., Khang, G., Song, S.C. (2006b). Thermosensitive poly (organophosphazene) hydrogels for a controlled drug delivery. Eur J Pharm Biopharm. 63:340-6 (Pubitemid 43776232)
15. Kang, G.D., Cheon, S.H., Song, S.C. (2006a). Controlled release of doxorubicin from thermosensitive poly(organophosphazene) hydrogels. Int J Pharm. 319:29-36 (Pubitemid 44051797)
16. Klein-Szanto, A.J. (1992). Carcinogenic effects of chemotherapeutic compounds. Prog Clin. 374:167-74
17. Lee, S.Y., Tae, G. (2007). Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection. J Contr Rel. 119:313-9 (Pubitemid 46770880)
18. Lenarets, V., Triqueneaux, C., Quarton, M., Falson, F.R., Couvreur, P. (1987). Temperature-dependent rheological behavior of Pluronic F-127 aqueous solutions. Int J Pharm. 31:121-7 (Pubitemid 17130782)
19. Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., Gianni, L. (2004). Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 56:185-229 (Pubitemid 38720829)
20. Paavola, A., Kilpelainen, I., Yliruusi, J., Rosenberg, P. (2000). Controlled release injectable liposomal gel of ibuprofen for epidural analgesia. Int J Pharm. 199:85-93 (Pubitemid 30224508)
21. Raymond, J., Metcalfe, A., Salazkin, I., Schwarz, A. (2004). Temporary vascular occlusion with poloxamer 407. Biomaterials. 25:3983-9 (Pubitemid 38388564)
22. Ricci, E.J., Bentley, M.V., Farah, M., Bretas, R.E., Marchetti, J.M. (2002). Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels. Eur J Pharm Sci. 17:161-7 (Pubitemid 35248270)
23. Schmolka, I.R. (1972). Artificial skin I. Preparation and properties of Pluronic F-127 gels for treatment of burns. J Biomed Mat Res. 6:571-82
24. Society of Toxicology (SOT), December 2008). Guiding principles in the use of animals in toxicology. Available online at www. toxicology.org/AI/FA/ guidingprinciples.pdf, accessed
25. Tan, E.C., Lin, R., Wang, C.H. (2005). Fabrication of double-walled microspheres for the sustained release of doxorubicin. J Colloid Interf Sci. 291:135-43 (Pubitemid 41392917)
26. Veyries, M.L., Couarraze, G., Geiger, S., Agnely, F., Massias, L., Kunzli, B., Faurisson, F., Rouveix, B. (1999). Controlled release of vancomycin from poloxamer 407 gels. Int J Pharm. 192:183-93 (Pubitemid 29531552)
27. Yong, C.S., Choi, J.S., Quan, Q.Z., Rhee, J.D., Kim, C.K., Lim, S.J., Kim, K.M., Choi, H.G. (2001). Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. Int J Pharm. 226:195-205 (Pubitemid 32800794)
28. Yong, C.S., Yang, C.H., Rhee, J.D., Lee, B.J., Kim, D.C., Kim, D.D., Kim, C.K., Choi, J.S., Choi, H.G. (2004). Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol. Int J Pharm. 269:169-76 (Pubitemid 38032832)
29. Yun, M.O., Choi, H.G., Jung, J.H., Kim, C.K. (1999). Development of thermoreversible insulin liquid suppository with sodium salicylate. Int J Pharm. 189:137-45
30. Zhao, P., Dash, A.K. (1999). A simple HPLC method using a microbore column for the analysis of doxorubicin. J Pharmaceut Biomed. 20:543-8 (Pubitemid 29253860)