-
1
-
-
47549090432
-
TGFb in cancer
-
J. Massagué, TGFb in cancer. Cell 134, 215-230 (2008).
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
2
-
-
77952896646
-
TGFb signalling: A complex web in cancer progression
-
H. Ikushima, K. Miyazono, TGFb signalling: A complex web in cancer progression. Nat. Rev. Cancer 10, 415-424 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 415-424
-
-
Ikushima, H.1
Miyazono, K.2
-
3
-
-
79951805332
-
Epithelial-mesenchymal interactions in pulmonary fibrosis
-
H. A. Chapman, Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu. Rev. Physiol. 73, 413-435 (2011).
-
(2011)
Annu. Rev. Physiol
, vol.73
, pp. 413-435
-
-
Chapman, H.A.1
-
4
-
-
84903515259
-
TGFb and matrix-regulated epithelial to mesenchymal transition
-
A. Moustakas, P. Heldin, TGFb and matrix-regulated epithelial to mesenchymal transition. Biochim. Biophys. Acta 1840, 2621-2634 (2014).
-
(2014)
Biochim. Biophys. Acta
, vol.1840
, pp. 2621-2634
-
-
Moustakas, A.1
Heldin, P.2
-
5
-
-
2142646426
-
TGF-b signaling and the fibrotic response
-
A. Leask, D. J. Abraham, TGF-b signaling and the fibrotic response. FASEB J. 18, 816-827 (2004).
-
(2004)
FASEB J.
, vol.18
, pp. 816-827
-
-
Leask, A.1
Abraham, D.J.2
-
6
-
-
84871948755
-
TGF-b signaling and epithelial-mesenchymal transition in cancer progression
-
Y. Katsuno, S. Lamouille, R. Derynck, TGF-b signaling and epithelial-mesenchymal transition in cancer progression. Curr. Opin. Oncol. 25, 76-84 (2013).
-
(2013)
Curr. Opin. Oncol.
, vol.25
, pp. 76-84
-
-
Katsuno, Y.1
Lamouille, S.2
Derynck, R.3
-
7
-
-
84888639681
-
The roles of TGFb in the tumour microenvironment
-
M. Pickup, S. Novitskiy, H. L. Moses, The roles of TGFb in the tumour microenvironment. Nat. Rev. Cancer 13, 788-799 (2013).
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 788-799
-
-
Pickup, M.1
Novitskiy, S.2
Moses, H.L.3
-
8
-
-
80052317444
-
The role of TGF-b and epithelial-to mesenchymal transition in diabetic nephropathy
-
C. E. Hills, P. E. Squires, The role of TGF-b and epithelial-to mesenchymal transition in diabetic nephropathy. Cytokine Growth Factor Rev. 22, 131-139 (2011).
-
(2011)
Cytokine Growth Factor Rev
, vol.22
, pp. 131-139
-
-
Hills, C.E.1
Squires, P.E.2
-
9
-
-
84904766568
-
Hyperglycemia to nephropathy via transforming growth factor beta
-
M. S. Garud, Y. A. Kulkarni, Hyperglycemia to nephropathy via transforming growth factor beta. Curr. Diabetes Rev. 10, 182-189 (2014).
-
(2014)
Curr. Diabetes Rev
, vol.10
, pp. 182-189
-
-
Garud, M.S.1
Kulkarni, Y.A.2
-
10
-
-
23044466047
-
Specificity and versatility in TGF-b signaling through Smads
-
X. H. Feng, R. Derynck, Specificity and versatility in TGF-b signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693 (2005).
-
(2005)
Annu. Rev. Cell Dev. Biol.
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
11
-
-
84866742560
-
TGFb signalling in context
-
J. Massagué, TGFb signalling in context. Nat. Rev. Mol. Cell Biol. 13, 616-630 (2012).
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 616-630
-
-
Massagué, J.1
-
12
-
-
58149468095
-
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor b signaling
-
D. Koinuma, S. Tsutsumi, N. Kamimura, H. Taniguchi, K. Miyazawa, M. Sunamura, T. Imamura, K. Miyazono, H. Aburatani, Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor b signaling. Mol. Cell. Biol. 29, 172-186 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 172-186
-
-
Koinuma, D.1
Tsutsumi, S.2
Kamimura, N.3
Taniguchi, H.4
Miyazawa, K.5
Sunamura, M.6
Imamura, T.7
Miyazono, K.8
Aburatani, H.9
-
13
-
-
24944497786
-
Non-Smad TGF-b signals
-
A. Moustakas, C. H. Heldin, Non-Smad TGF-b signals. J. Cell Sci. 118, 3573-3584 (2005).
-
(2005)
J. Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
14
-
-
58149213801
-
Non-Smad pathways in TGF-b signaling
-
Y. E. Zhang, Non-Smad pathways in TGF-b signaling. Cell Res. 19, 128-139 (2009).
-
(2009)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
15
-
-
67649664111
-
TACE-mediated ectodomain shedding of the type I TGF-b receptor downregulates TGF-b signaling
-
C. Liu, P. Xu, S. Lamouille, J. Xu, R. Derynck, TACE-mediated ectodomain shedding of the type I TGF-b receptor downregulates TGF-b signaling. Mol. Cell 35, 26-36 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 26-36
-
-
Liu, C.1
Xu, P.2
Lamouille, S.3
Xu, J.4
Derynck, R.5
-
16
-
-
0033619255
-
Silencing of TGF-b signalling by the pseudoreceptor BAMBI
-
D. Onichtchouk, Y. G. Chen, R. Dosch, V. Gawantka, H. Delius, J. Massagué, C. Niehrs, Silencing of TGF-b signalling by the pseudoreceptor BAMBI. Nature 401, 480-485 (1999).
-
(1999)
Nature
, vol.401
, pp. 480-485
-
-
Onichtchouk, D.1
Chen, Y.G.2
Dosch, R.3
Gawantka, V.4
Delius, H.5
Massagué, J.6
Niehrs, C.7
-
17
-
-
71049139747
-
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-b signaling
-
X. Yan, Z. Lin, F. Chen, X. Zhao, H. Chen, Y. Ning, Y. G. Chen, Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-b signaling. J. Biol. Chem. 284, 30097-30104 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 30097-30104
-
-
Yan, X.1
Lin, Z.2
Chen, F.3
Zhao, X.4
Chen, H.5
Ning, Y.6
Chen, Y.G.7
-
18
-
-
67650225263
-
Essential role of TGF-b signaling in glucose-induced cell hypertrophy
-
L. Wu, R. Derynck, Essential role of TGF-b signaling in glucose-induced cell hypertrophy. Dev. Cell 17, 35-48 (2009).
-
(2009)
Dev. Cell
, vol.17
, pp. 35-48
-
-
Wu, L.1
Derynck, R.2
-
19
-
-
84963625116
-
-
D. R. Spitz, K. J. Dornfeld, K. Krishnan, D. Gius, Eds. (Humana Press, New York, ), chap. 2
-
A. L. Simons, K. P. Orcutt, J. M. Madsen, P. M. Scarbrough, D. R. Spitz, in Oxidative Stress in Cancer Biology and Therapy, D. R. Spitz, K. J. Dornfeld, K. Krishnan, D. Gius, Eds. (Humana Press, New York, 2012), chap. 2, pp. 21-46.
-
(2012)
Oxidative Stress in Cancer Biology and Therapy
, pp. 21-46
-
-
Simons, A.L.1
Orcutt, K.P.2
Madsen, J.M.3
Scarbrough, P.M.4
Spitz, D.R.5
-
20
-
-
0037167920
-
Initial management of glycemia in type 2 diabetes mellitus
-
D. M. Nathan, Initial management of glycemia in type 2 diabetes mellitus. N. Engl. J. Med. 347, 1342-1349 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 1342-1349
-
-
Nathan, D.M.1
-
21
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
C. M. Taniguchi, B. Emanuelli, C. R. Kahn, Critical nodes in signalling pathways: Insights into insulin action. Nat. Rev. Mol. Cell Biol. 7, 85-96 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
22
-
-
84861444859
-
Regulation of glucose transport by insulin: Traffic control of GLUT4
-
D. Leto, A. R. Saltiel, Regulation of glucose transport by insulin: Traffic control of GLUT4. Nat. Rev. Mol. Cell Biol. 13, 383-396 (2012).
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 383-396
-
-
Leto, D.1
Saltiel, A.R.2
-
24
-
-
0029120061
-
Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
-
M. J. Quon, H. Chen, B. L. Ing, M. L. Liu, M. J. Zarnowski, K. Yonezawa, M. Kasuga, S. W. Cushman, S. I. Taylor, Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol. Cell. Biol. 15, 5403-5411 (1995).
-
(1995)
Mol. Cell. Biol
, vol.15
, pp. 5403-5411
-
-
Quon, M.J.1
Chen, H.2
Ing, B.L.3
Liu, M.L.4
Zarnowski, M.J.5
Yonezawa, K.6
Kasuga, M.7
Cushman, S.W.8
Taylor, S.I.9
-
25
-
-
0030734345
-
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
-
L. N. Cong, H. Chen, Y. Li, L. Zhou, M. A. McGibbon, S. I. Taylor, M. J. Quon, Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol. Endocrinol. 11, 1881-1890 (1997).
-
(1997)
Mol. Endocrinol
, vol.11
, pp. 1881-1890
-
-
Cong, L.N.1
Chen, H.2
Li, Y.3
Zhou, L.4
McGibbon, M.A.5
Taylor, S.I.6
Quon, M.J.7
-
26
-
-
77953498775
-
AS160 modulates aldosteronestimulated epithelial sodium channel forward trafficking
-
X. Liang, M. B. Butterworth, K. W. Peters, R. A. Frizzell, AS160 modulates aldosteronestimulated epithelial sodium channel forward trafficking. Mol. Biol. Cell 21, 2024-2033 (2010).
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2024-2033
-
-
Liang, X.1
Butterworth, M.B.2
Peters, K.W.3
Frizzell, R.A.4
-
27
-
-
4344662040
-
PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane
-
P. Viard, A. J. Butcher, G. Halet, A. Davies, B. Nurnberg, F. Heblich, A. C. Dolphin, PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat. Neurosci. 7, 939-946 (2004).
-
(2004)
Nat. Neurosci
, vol.7
, pp. 939-946
-
-
Viard, P.1
Butcher, A.J.2
Halet, G.3
Davies, A.4
Nurnberg, B.5
Heblich, F.6
Dolphin, A.C.7
-
28
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
B. D. Manning, L. C. Cantley, AKT/PKB signaling: Navigating downstream. Cell 129, 1261-1274 (2007).
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
29
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
B. T. Hennessy, D. L. Smith, P. T. Ram, Y. Lu, G. B. Mills, Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4, 988-1004 (2005).
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
30
-
-
0037151026
-
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
-
S. Kane, H. Sano, S. C. Liu, J. M. Asara, W. S. Lane, C. C. Garner, G. E. Lienhard, A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 277, 22115-22118 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 22115-22118
-
-
Kane, S.1
Sano, H.2
Liu, S.C.3
Asara, J.M.4
Lane, W.S.5
Garner, C.C.6
Lienhard, G.E.7
-
31
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
H. Sano, S. Kane, E. Sano, C. P. MÎinea, J. M. Asara, W. S. Lane, C. W. Garner, G. E. Lienhard, Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J. Biol. Chem. 278, 14599-14602 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Mîinea, C.P.4
Asara, J.M.5
Lane, W.S.6
Garner, C.W.7
Lienhard, G.E.8
-
32
-
-
3042530936
-
Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen speciesrelated nuclear factor-kB activation and cyclooxygenase-2 expression in mesangial cells
-
M. L. Sheu, F. M. Ho, K. F. Chao, M. L. Kuo, S. H. Liu, Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen speciesrelated nuclear factor-kB activation and cyclooxygenase-2 expression in mesangial cells. Mol. Pharmacol. 66, 187-196 (2004).
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 187-196
-
-
Sheu, M.L.1
Ho, F.M.2
Chao, K.F.3
Kuo, M.L.4
Liu, S.H.5
-
33
-
-
0038682002
-
Mechanisms of TGF-b signaling from cell membrane to the nucleus
-
Y. Shi, J. Massagué, Mechanisms of TGF-b signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
34
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
L. Zawel, J. L. Dai, P. Buckhaults, S. Zhou, K. W. Kinzler, B. Vogelstein, S. E. Kern, Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
35
-
-
0028894025
-
Disruption of transforming growth factor b signaling by a mutation that prevents transphosphorylation within the receptor complex
-
J. Carcámo, A. Zentella, J. Massagué, Disruption of transforming growth factor b signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol. Cell. Biol. 15, 1573-1581 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1573-1581
-
-
Carcámo, J.1
Zentella, A.2
Massagué, J.3
-
36
-
-
67651155960
-
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: From PI-103 through PI-540, PI-620 to the oral agent GDC-0941
-
F. I. Raynaud, S. A. Eccles, S. Patel, S. Alix, G. Box, I. Chuckowree, A. Folkes, S. Gowan, A. De-Haven-Brandon, F. Di-Stefano, A. Hayes, A. T. Henley, L. Lensun, G. Pergl-Wilson, A. Robson, N. Saghir, A. Zhyvoloup, E. McDonald, P. Sheldrake, S. Shuttleworth, M. Valenti, N. C. Wan, P. A. Clarke, P. Workman, Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: From PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Mol. Cancer Ther. 8, 1725-1738 (2009).
-
(2009)
Mol. Cancer Ther
, vol.8
, pp. 1725-1738
-
-
Raynaud, F.I.1
Eccles, S.A.2
Patel, S.3
Alix, S.4
Box, G.5
Chuckowree, I.6
Folkes, A.7
Gowan, S.8
De-Haven-Brandon, A.9
Di-Stefano, F.10
Hayes, A.11
Henley, A.T.12
Lensun, L.13
Pergl-Wilson, G.14
Robson, A.15
Saghir, N.16
Zhyvoloup, A.17
McDonald, E.18
Sheldrake, P.19
Shuttleworth, S.20
Valenti, M.21
Wan, N.C.22
Clarke, P.A.23
Workman, P.24
more..
-
37
-
-
52449106253
-
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin- 1-ylmethyl)-4-morpholin-4-yl-thieno[3, 2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
-
A. J. Folkes, K. Ahmadi, W. K. Alderton, S. Alix, S. J. Baker, G. Box, I. S. Chuckowree, P. A. Clarke, P. Depledge, S. A. Eccles, L. S. Friedman, A. Hayes, T. C. Hancox, A. Kugendradas, L. Lensun, P. Moore, A. G. Olivero, J. Pang, S. Patel, G. H. Pergl-Wilson, F. I. Raynaud, A. Robson, N. Saghir, L. Salphati, S. Sohal, M. H. Ultsch, M. Valenti, H. J. Wallweber, N. C. Wan, C. Wiesmann, P. Workman, A. Zhyvoloup, M. J. Zvelebil, S. J. Shuttleworth, The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin- 1-ylmethyl)-4-morpholin-4-yl-thieno[3, 2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J. Med. Chem. 51, 5522-5532 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5522-5532
-
-
Folkes, A.J.1
Ahmadi, K.2
Alderton, W.K.3
Alix, S.4
Baker, S.J.5
Box, G.6
Chuckowree, I.S.7
Clarke, P.A.8
Depledge, P.9
Eccles, S.A.10
Friedman, L.S.11
Hayes, A.12
Hancox, T.C.13
Kugendradas, A.14
Lensun, L.15
Moore, P.16
Olivero, A.G.17
Pang, J.18
Patel, S.19
Pergl-Wilson, G.H.20
Raynaud, F.I.21
Robson, A.22
Saghir, N.23
Salphati, L.24
Sohal, S.25
Ultsch, M.H.26
Valenti, M.27
Wallweber, H.J.28
Wan, N.C.29
Wiesmann, C.30
Workman, P.31
Zhyvoloup, A.32
Zvelebil, M.J.33
Shuttleworth, S.J.34
more..
-
38
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
M. P. Scheid, J. R. Woodgett, Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546, 108-112 (2003).
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
39
-
-
20144388779
-
Discovery of 2, 3, 5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
-
Z. Zhao, W. H. Leister, R. G. Robinson, S. F. Barnett, D. Defeo-Jones, R. E. Jones, G. D. Hartman, J. R. Huff, H. E. Huber, M. E. Duggan, C. W. Lindsley, Discovery of 2, 3, 5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorg. Med. Chem. Lett. 15, 905-909 (2005).
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 905-909
-
-
Zhao, Z.1
Leister, W.H.2
Robinson, R.G.3
Barnett, S.F.4
Defeo-Jones, D.5
Jones, R.E.6
Hartman, G.D.7
Huff, J.R.8
Huber, H.E.9
Duggan, M.E.10
Lindsley, C.W.11
-
40
-
-
19944431003
-
Allosteric Akt (PKB) inhibitors: Discovery and SAR of isozyme selective inhibitors
-
C. W. Lindsley, Z. Zhao, W. H. Leister, R. G. Robinson, S. F. Barnett, D. Defeo-Jones, R. E. Jones, G. D. Hartman, J. R. Huff, H. E. Huber, M. E. Duggan, Allosteric Akt (PKB) inhibitors: Discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. 15, 761-764 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 761-764
-
-
Lindsley, C.W.1
Zhao, Z.2
Leister, W.H.3
Robinson, R.G.4
Barnett, S.F.5
Defeo-Jones, D.6
Jones, R.E.7
Hartman, G.D.8
Huff, J.R.9
Huber, H.E.10
Duggan, M.E.11
-
41
-
-
58849120491
-
Role of a novel PH-kinase domain interface in PKB/Akt regulation: Structural mechanism for allosteric inhibition
-
V. Calleja, M. Laguerre, P. J. Parker, B. Larijani, Role of a novel PH-kinase domain interface in PKB/Akt regulation: Structural mechanism for allosteric inhibition. PLOS Biol. 7, e17 (2009).
-
(2009)
PLOS Biol
, vol.7
, pp. e17
-
-
Calleja, V.1
Laguerre, M.2
Parker, P.J.3
Larijani, B.4
-
42
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
M. Andjelković, D. R. Alessi, R. Meier, A. Fernandez, N. J. Lamb, M. Frech, P. Cron, P. Cohen, J. M. Lucocq, B. A. Hemmings, Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272, 31515-31524 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31515-31524
-
-
Andjelković, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
43
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
A. D. Kohn, S. A. Summers, M. J. Birnbaum, R. A. Roth, Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271, 31372-31378 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
44
-
-
67650337799
-
Inhibitor hijacking of Akt activation
-
T. Okuzumi, D. Fiedler, C. Zhang, D. C. Gray, B. Aizenstein, R. Hoffman, K. M. Shokat, Inhibitor hijacking of Akt activation. Nat. Chem. Biol. 5, 484-493 (2009).
-
(2009)
Nat. Chem. Biol
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
Fiedler, D.2
Zhang, C.3
Gray, D.C.4
Aizenstein, B.5
Hoffman, R.6
Shokat, K.M.7
-
45
-
-
66349098674
-
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
-
E. Gonzalez, T. E. McGraw, Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling. Proc. Natl. Acad. Sci. U.S.A. 106, 7004-7009 (2009).
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 7004-7009
-
-
Gonzalez, E.1
McGraw, T.E.2
-
46
-
-
41449087811
-
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes
-
Y. Ng, G. Ramm, J. A. Lopez, D. E. James, Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab. 7, 348-356 (2008).
-
(2008)
Cell Metab
, vol.7
, pp. 348-356
-
-
Ng, Y.1
Ramm, G.2
Lopez, J.A.3
James, D.E.4
-
47
-
-
26844573782
-
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
-
C. P. MÎinea, H. Sano, S. Kane, E. Sano, M. Fukuda, J. Peränen, W. S. Lane, G. E. Lienhard, AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem. J. 391, 87-93 (2005).
-
(2005)
Biochem. J.
, vol.391
, pp. 87-93
-
-
Mîinea, C.P.1
Sano, H.2
Kane, S.3
Sano, E.4
Fukuda, M.5
Peränen, J.6
Lane, W.S.7
Lienhard, G.E.8
-
48
-
-
28544435205
-
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
-
L. Eguez, A. Lee, J. A. Chavez, C. P. Miinea, S. Kane, G. E. Lienhard, T. E. McGraw, Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab. 2, 263-272 (2005).
-
(2005)
Cell Metab
, vol.2
, pp. 263-272
-
-
Eguez, L.1
Lee, A.2
Chavez, J.A.3
Miinea, C.P.4
Kane, S.5
Lienhard, G.E.6
McGraw, T.E.7
-
49
-
-
33847062845
-
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic
-
F. S. L. Thong, P. J. Bilan, A. Klip, The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes 56, 414-423 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 414-423
-
-
Thong, F.S.L.1
Bilan, P.J.2
Klip, A.3
-
50
-
-
27844528870
-
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
-
M. Larance, G. Ramm, J. Stöckli, E. M. van Dam, S. Winata, V. Wasinger, F. Simpson, M. Graham, J. R. Junutula, M. Guilhaus, D. E. James, Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J. Biol. Chem. 280, 37803-37813 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37803-37813
-
-
Larance, M.1
Ramm, G.2
Stöckli, J.3
Van Dam, E.M.4
Winata, S.5
Wasinger, V.6
Simpson, F.7
Graham, M.8
Junutula, J.R.9
Guilhaus, M.10
James, D.E.11
-
51
-
-
80053641164
-
Membrane trafficking of collecting duct water channel protein AQP2 regulated by Akt/AS160
-
H. J. Jung, T. H. Kwon, Membrane trafficking of collecting duct water channel protein AQP2 regulated by Akt/AS160. Electrolyte Blood Press. 8, 59-65 (2010).
-
(2010)
Electrolyte Blood Press
, vol.8
, pp. 59-65
-
-
Jung, H.J.1
Kwon, T.H.2
-
52
-
-
84859387660
-
Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase
-
D. Samovski, X. Su, Y. Xu, N. A. Abumrad, P. D. Stahl, Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase. J. Lipid Res. 53, 709-717 (2012).
-
(2012)
J. Lipid Res
, vol.53
, pp. 709-717
-
-
Samovski, D.1
Su, X.2
Xu, Y.3
Abumrad, N.A.4
Stahl, P.D.5
-
53
-
-
34247148430
-
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1
-
J. A. Chavez, W. G. Roach, C. P. MÎinea, G. E. Lienhard, Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. Biochem. J. 403, 353-358 (2007).
-
(2007)
Biochem. J.
, vol.403
, pp. 353-358
-
-
Chavez, J.A.1
Roach, W.G.2
Mîinea, C.P.3
Lienhard, G.E.4
-
54
-
-
33749395733
-
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
-
G. Ramm, M. Larance, M. Guilhaus, D. E. James, A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160. J. Biol. Chem. 281, 29174-29180 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 29174-29180
-
-
Ramm, G.1
Larance, M.2
Guilhaus, M.3
James, D.E.4
-
55
-
-
78650897555
-
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking
-
S. Chen, D. H. Wasserman, C. MacKintosh, K. Sakamoto, Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab. 13, 68-79 (2011).
-
(2011)
Cell Metab
, vol.13
, pp. 68-79
-
-
Chen, S.1
Wasserman, D.H.2
MacKintosh, C.3
Sakamoto, K.4
-
56
-
-
33645997012
-
Bridging the GAP between insulin signaling and GLUT4 translocation
-
R. T. Watson, J. E. Pessin, Bridging the GAP between insulin signaling and GLUT4 translocation. Trends Biochem. Sci. 31, 215-222 (2006).
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 215-222
-
-
Watson, R.T.1
Pessin, J.E.2
-
57
-
-
84864573006
-
The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation
-
W. Ren, S. Cheema, K. Du, The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation. J. Biol. Chem. 287, 26890-26900 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 26890-26900
-
-
Ren, W.1
Cheema, S.2
Du, K.3
-
58
-
-
0037598870
-
Distinct endocytic pathways regulate TGF-b receptor signalling and turnover
-
G. M. Di-Guglielmo, C. Le-Roy, A. F. Goodfellow, J. L. Wrana, Distinct endocytic pathways regulate TGF-b receptor signalling and turnover. Nat. Cell Biol. 5, 410-421 (2003).
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 410-421
-
-
Di-Guglielmo, G.M.1
Le-Roy, C.2
Goodfellow, A.F.3
Wrana, J.L.4
-
59
-
-
4344606636
-
Ligand-dependent and -independent transforming growth factor-b receptor recycling regulated by clathrin-mediated endocytosis and Rab11
-
H. Mitchell, A. Choudhury, R. E. Pagano, E. B. Leof, Ligand-dependent and -independent transforming growth factor-b receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol. Biol. Cell 15, 4166-4178 (2004).
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 4166-4178
-
-
Mitchell, H.1
Choudhury, A.2
Pagano, R.E.3
Leof, E.B.4
-
60
-
-
0037144841
-
TGFb receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
-
S. Hayes, A. Chawla, S. Corvera, TGFb receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2. J. Cell Biol. 158, 1239-1249 (2002).
-
(2002)
J. Cell Biol
, vol.158
, pp. 1239-1249
-
-
Hayes, S.1
Chawla, A.2
Corvera, S.3
-
61
-
-
69249106881
-
Pathways and mechanisms of endocytic recycling
-
B. D. Grant, J. G. Donaldson, Pathways and mechanisms of endocytic recycling. Nat. Rev. Mol. Cell Biol. 10, 597-608 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 597-608
-
-
Grant, B.D.1
Donaldson, J.G.2
-
62
-
-
0242446165
-
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
-
B. Sönnichsen, S. De-Renzis, E. Nielsen, J. Rietdorf, M. Zerial, Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. J. Cell Biol. 149, 901-913 (2000).
-
(2000)
J. Cell Biol
, vol.149
, pp. 901-913
-
-
Sönnichsen, B.1
De-Renzis, S.2
Nielsen, E.3
Rietdorf, J.4
Zerial, M.5
-
63
-
-
78650468888
-
+-ATPase and mediates the adenosine monophosphate-stimulated protein kinasedependent regulation of sodium pump surface expression
-
+-ATPase and mediates the adenosine monophosphate-stimulated protein kinasedependent regulation of sodium pump surface expression. Mol. Biol. Cell 21, 4400-4408 (2010).
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 4400-4408
-
-
Alves, D.S.1
Farr, G.A.2
Seo-Mayer, P.3
Caplan, M.J.4
-
64
-
-
84862758806
-
Oligomeric interactions of TGF-b and BMP receptors
-
M. Ehrlich, O. Gutman, P. Knaus, Y. I. Henis, Oligomeric interactions of TGF-b and BMP receptors. FEBS Lett. 586, 1885-1896 (2012).
-
(2012)
FEBS Lett
, vol.586
, pp. 1885-1896
-
-
Ehrlich, M.1
Gutman, O.2
Knaus, P.3
Henis, Y.I.4
-
65
-
-
0029010192
-
Phosphorylationdependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-b receptors
-
R. H. Chen, H. L. Moses, E. M. Maruoka, R. Derynck, M. Kawabata, Phosphorylationdependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-b receptors. J. Biol. Chem. 270, 12235-12241 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 12235-12241
-
-
Chen, R.H.1
Moses, H.L.2
Maruoka, E.M.3
Derynck, R.4
Kawabata, M.5
-
66
-
-
0026659016
-
Growth hormone and fibronectin expression in 3T3 preadipose cells
-
S. Guller, D. L. Allen, R. E. Corin, C. J. Lockwood, M. Sonenberg, Growth hormone and fibronectin expression in 3T3 preadipose cells. Endocrinology 130, 2609-2616 (1992).
-
(1992)
Endocrinology
, vol.130
, pp. 2609-2616
-
-
Guller, S.1
Allen, D.L.2
Corin, R.E.3
Lockwood, C.J.4
Sonenberg, M.5
-
67
-
-
0034647770
-
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways
-
C. Miele, J. J. Rochford, N. Filippa, S. Giorgetti-Peraldi, E. Van-Obberghen, Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J. Biol. Chem. 275, 21695-21702 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 21695-21702
-
-
Miele, C.1
Rochford, J.J.2
Filippa, N.3
Giorgetti-Peraldi, S.4
Van-Obberghen, E.5
-
68
-
-
0032720262
-
Insulininduced vascular endothelial growth factor expression in retina
-
M. Lu, S. Amano, K. Miyamoto, R. Garland, K. Keough, W. Qin, A. P. Adamis, Insulininduced vascular endothelial growth factor expression in retina. Invest. Ophthalmol. Vis. Sci. 40, 3281-3286 (1999).
-
(1999)
Invest. Ophthalmol. Vis. Sci.
, vol.40
, pp. 3281-3286
-
-
Lu, M.1
Amano, S.2
Miyamoto, K.3
Garland, R.4
Keough, K.5
Qin, W.6
Adamis, A.P.7
-
69
-
-
0345420481
-
Insulin and TNFa induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways
-
L. M. Grønning, A. Cederberg, N. Miura, S. Enerbäck, K. Taskén, Insulin and TNFa induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways. Mol. Endocrinol. 16, 873-883 (2002).
-
(2002)
Mol. Endocrinol
, vol.16
, pp. 873-883
-
-
Grønning, L.M.1
Cederberg, A.2
Miura, N.3
Enerbäck, S.4
Taskén, K.5
-
70
-
-
84856471735
-
SREBPs: Metabolic integrators in physiology and metabolism
-
T. I. Jeon, T. F. Osborne, SREBPs: Metabolic integrators in physiology and metabolism. Trends Endocrinol. Metab. 23, 65-72 (2012).
-
(2012)
Trends Endocrinol. Metab.
, vol.23
, pp. 65-72
-
-
Jeon, T.I.1
Osborne, T.F.2
-
71
-
-
84921508408
-
Biomechanics of TGFb-induced epithelial-mesenchymal transition: Implications for fibrosis and cancer
-
J. W. O'Connor, E. W. Gomez, Biomechanics of TGFb-induced epithelial-mesenchymal transition: Implications for fibrosis and cancer. Clin. Transl. Med. 3, 23 (2014).
-
(2014)
Clin. Transl. Med
, vol.3
, pp. 23
-
-
O'Connor, J.W.1
Gomez, E.W.2
-
72
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
S. Lamouille, J. Xu, R. Derynck, Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 15, 178-196 (2014).
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
73
-
-
34249289041
-
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
-
H. Peinado, D. Olmeda, A. Cano, Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat. Rev. Cancer 7, 415-428 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 415-428
-
-
Peinado, H.1
Olmeda, D.2
Cano, A.3
-
74
-
-
16844379257
-
Cadherin switching: Essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
-
M. Maeda, K. R. Johnson, M. J. Wheelock, Cadherin switching: Essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J. Cell Sci. 118, 873-887 (2005).
-
(2005)
J. Cell Sci
, vol.118
, pp. 873-887
-
-
Maeda, M.1
Johnson, K.R.2
Wheelock, M.J.3
-
75
-
-
84861448736
-
TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
-
S. Lamouille, E. Connolly, J. W. Smyth, R. J. Akhurst, R. Derynck, TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J. Cell Sci. 125, 1259-1273 (2012).
-
(2012)
J. Cell Sci
, vol.125
, pp. 1259-1273
-
-
Lamouille, S.1
Connolly, E.2
Smyth, J.W.3
Akhurst, R.J.4
Derynck, R.5
-
76
-
-
57749114754
-
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
-
S. Thuault, E. J. Tan, H. Peinado, A. Cano, C. H. Heldin, A. Moustakas, HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283, 33437-33446 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33437-33446
-
-
Thuault, S.1
Tan, E.J.2
Peinado, H.3
Cano, A.4
Heldin, C.H.5
Moustakas, A.6
-
77
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
J. P. Thiery, H. Acloque, R. Y. Huang, M. A. Nieto, Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
78
-
-
60249101233
-
Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing
-
Y. Liu, M. Petreaca, M. Yao, M. Martins-Green, Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing. BMC Cell Biol. 10, 1 (2009).
-
(2009)
BMC Cell Biol
, vol.10
, pp. 1
-
-
Liu, Y.1
Petreaca, M.2
Yao, M.3
Martins-Green, M.4
-
79
-
-
2142765294
-
Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium
-
L. J. Shanley, C. D. McCaig, J. V. Forrester, M. Zhao, Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium. Invest. Ophthalmol. Vis. Sci. 45, 1088-1094 (2004).
-
(2004)
Invest. Ophthalmol. Vis. Sci.
, vol.45
, pp. 1088-1094
-
-
Shanley, L.J.1
McCaig, C.D.2
Forrester, J.V.3
Zhao, M.4
-
80
-
-
33846939295
-
Insulin augments matrix metalloproteinase-9 expression in monocytes
-
A. Fischoeder, H. Meyborg, D. Stibenz, E. Fleck, K. Graf, P. Stawowy, Insulin augments matrix metalloproteinase-9 expression in monocytes. Cardiovasc. Res. 73, 841-848 (2007).
-
(2007)
Cardiovasc. Res.
, vol.73
, pp. 841-848
-
-
Fischoeder, A.1
Meyborg, H.2
Stibenz, D.3
Fleck, E.4
Graf, K.5
Stawowy, P.6
-
81
-
-
0033532205
-
Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion
-
N. Ramos-DeSimone, E. Hahn-Dantona, J. Sipley, H. Nagase, D. L. French, J. P. Quigley, Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J. Biol. Chem. 274, 13066-13076 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 13066-13076
-
-
Ramos-DeSimone, N.1
Hahn-Dantona, E.2
Sipley, J.3
Nagase, H.4
French, D.L.5
Quigley, J.P.6
-
82
-
-
4644300287
-
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160
-
A. Zeigerer, M. K. McBrayer, T. E. McGraw, Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160. Mol. Biol. Cell 15, 4406-4415 (2004).
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 4406-4415
-
-
Zeigerer, A.1
McBrayer, M.K.2
McGraw, T.E.3
-
83
-
-
84871902200
-
The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosinebinding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes
-
S. X. Tan, Y. Ng, J. G. Burchfield, G. Ramm, D. G. Lambright, J. Stöckli, D. E. James, The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosinebinding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol. Cell. Biol. 32, 4946-4959 (2012).
-
(2012)
Mol. Cell. Biol
, vol.32
, pp. 4946-4959
-
-
Tan, S.X.1
Ng, Y.2
Burchfield, J.G.3
Ramm, G.4
Lambright, D.G.5
Stöckli, J.6
James, D.E.7
-
84
-
-
58249106743
-
Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-b
-
R. A. Rahimi, M. Andrianifahanana, M. C. Wilkes, M. Edens, T. J. Kottom, J. Blenis, E. B. Leof, Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-b. Cancer Res. 69, 84-93 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 84-93
-
-
Rahimi, R.A.1
Andrianifahanana, M.2
Wilkes, M.C.3
Edens, M.4
Kottom, T.J.5
Blenis, J.6
Leof, E.B.7
-
85
-
-
0347511753
-
Mediators of diabetic renal disease: The case for TGF-b as the major mediator
-
F. N. Ziyadeh, Mediators of diabetic renal disease: The case for TGF-b as the major mediator. J. Am. Soc. Nephrol. 15 (Suppl. 1), S55-S57 (2004).
-
(2004)
J. Am. Soc. Nephrol.
, vol.15
, pp. S55-S57
-
-
Ziyadeh, F.N.1
-
86
-
-
34547587877
-
Cell size and invasion in TGF-b-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
-
S. Lamouille, R. Derynck, Cell size and invasion in TGF-b-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J. Cell Biol. 178, 437-451 (2007).
-
(2007)
J. Cell Biol
, vol.178
, pp. 437-451
-
-
Lamouille, S.1
Derynck, R.2
-
87
-
-
3242757526
-
TGF-b induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
-
T. Nakagawa, J. Li, G. Garcia, W. Mu, E. Piek, E. P. Böttinger, Y. Chen, H. Zhu, D. Kang, G. Schreiner, H. Lan, R. Johnson, TGF-b induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int. 66, 605-613 (2004).
-
(2004)
Kidney Int.
, vol.66
, pp. 605-613
-
-
Nakagawa, T.1
Li, J.2
Garcia, G.3
Mu, W.4
Piek, E.5
Böttinger, E.P.6
Chen, Y.7
Zhu, H.8
Kang, D.9
Schreiner, G.10
Lan, H.11
Johnson, R.12
-
88
-
-
84888328750
-
VEGF targets the tumour cell
-
H. L. Goel, A. M. Mercurio, VEGF targets the tumour cell. Nat. Rev. Cancer 13, 871-882 (2013).
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 871-882
-
-
Goel, H.L.1
Mercurio, A.M.2
-
89
-
-
0032933626
-
ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
-
M. Foretz, C. Pacot, I. Dugail, P. Lemarchand, C. Guichard, X. Le-Lièpvre, C. Berthelier-Lubrano, B. Spiegelman, J. B. Kim, P. Ferré, F. Foufelle, ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell. Biol. 19, 3760-3768 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 3760-3768
-
-
Foretz, M.1
Pacot, C.2
Dugail, I.3
Lemarchand, P.4
Guichard, C.5
Le-Lièpvre, X.6
Berthelier-Lubrano, C.7
Spiegelman, B.8
Kim, J.B.9
Ferré, P.10
Foufelle, F.11
-
90
-
-
0032853588
-
D-Glucose and insulin stimulate migration and tubular formation of human endothelial cells in vitro
-
S. Shigematsu, K. Yamauchi, K.Nakajima, S. Iijima, T. Aizawa, K. Hashizume, D-Glucose and insulin stimulate migration and tubular formation of human endothelial cells in vitro. Am. J. Physiol. 277, E433-E438 (1999).
-
(1999)
Am. J. Physiol
, vol.277
, pp. E433-E438
-
-
Shigematsu, S.1
Yamauchi, K.2
Nakajima, K.3
Iijima, S.4
Aizawa, T.5
Hashizume, K.6
-
91
-
-
59449090107
-
TGF-b-induced epithelial to mesenchymal transition
-
J. Xu, S. Lamouille, R. Derynck, TGF-b-induced epithelial to mesenchymal transition. Cell Res. 19, 156-172 (2009).
-
(2009)
Cell Res
, vol.19
, pp. 156-172
-
-
Xu, J.1
Lamouille, S.2
Derynck, R.3
-
92
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
93
-
-
23944526062
-
Activation of AKT kinases in cancer: Implications for therapeutic targeting
-
A. Bellacosa, C. C. Kumar, A. Di-Cristofano, J. R. Testa, Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv. Cancer Res. 94, 29-86 (2005).
-
(2005)
Adv. Cancer Res
, vol.94
, pp. 29-86
-
-
Bellacosa, A.1
Kumar, C.C.2
Di-Cristofano, A.3
Testa, J.R.4
-
94
-
-
77957141714
-
Frequent hyperphosphorylation of AS160 in breast cancer
-
X.-H. Jiang, J.-W. Sun, M. Xu, X.-F. Jiang, C.-F. Liu, Y. Lu, Frequent hyperphosphorylation of AS160 in breast cancer. Cancer Biol. Ther. 10, 362-367 (2010).
-
(2010)
Cancer Biol. Ther
, vol.10
, pp. 362-367
-
-
Jiang, X.-H.1
Sun, J.-W.2
Xu, M.3
Jiang, X.-F.4
Liu, C.-F.5
Lu, Y.6
-
95
-
-
84929305819
-
Expression and phosphorylation of the AS160v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma
-
J. C. Cheng, S. K. McBrayer, C. Coarfa, S. Dalva-Aydemir, P. H. Gunaratne, J. D. Carpten, J. K. Keats, S. T. Rosen, M. Shanmugam, Expression and phosphorylation of the AS160v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma. Cancer Metab. 1, 14 (2013).
-
(2013)
Cancer Metab
, vol.1
, pp. 14
-
-
Cheng, J.C.1
McBrayer, S.K.2
Coarfa, C.3
Dalva-Aydemir, S.4
Gunaratne, P.H.5
Carpten, J.D.6
Keats, J.K.7
Rosen, S.T.8
Shanmugam, M.9
-
96
-
-
47349101284
-
The role of insulin receptors and IGF-I receptors in cancer and other diseases
-
F. Frasca, G. Pandini, L. Sciacca, V. Pezzino, S. Squatrito, A. Belfiore, R. Vigneri, The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch. Physiol. Biochem. 114, 23-37 (2008).
-
(2008)
Arch. Physiol. Biochem
, vol.114
, pp. 23-37
-
-
Frasca, F.1
Pandini, G.2
Sciacca, L.3
Pezzino, V.4
Squatrito, S.5
Belfiore, A.6
Vigneri, R.7
-
97
-
-
77955517441
-
Diabetes and cancer: A consensus report
-
E. Giovannucci, D. M. Harlan, M. C. Archer, R. M. Bergenstal, S. M. Gapstur, L. A. Habel, M. Pollak, J. G. Regensteiner, D. Yee, Diabetes and cancer: A consensus report. Diabetes Care 33, 1674-1685 (2010).
-
(2010)
Diabetes Care
, vol.33
, pp. 1674-1685
-
-
Giovannucci, E.1
Harlan, D.M.2
Archer, M.C.3
Bergenstal, R.M.4
Gapstur, S.M.5
Habel, L.A.6
Pollak, M.7
Regensteiner, J.G.8
Yee, D.9
-
98
-
-
77951818071
-
Diabetes, insulin use, and cancer risk: Are observational studies part of the solution-or part of the problem?
-
J. A. Johnson, E. A. Gale, Diabetes, insulin use, and cancer risk: Are observational studies part of the solution-or part of the problem? Diabetes 59, 1129-1131 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 1129-1131
-
-
Johnson, J.A.1
Gale, E.A.2
-
99
-
-
58049192725
-
Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis
-
B. B. Barone, H. C. Yeh, C. F. Snyder, K. S. Peairs, K. B. Stein, R. L. Derr, A. C. Wolff, F. L. Brancati, Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis. JAMA 300, 2754-2764 (2008).
-
(2008)
JAMA
, vol.300
, pp. 2754-2764
-
-
Barone, B.B.1
Yeh, H.C.2
Snyder, C.F.3
Peairs, K.S.4
Stein, K.B.5
Derr, R.L.6
Wolff, A.C.7
Brancati, F.L.8
-
100
-
-
79951960884
-
Diabetes mellitus and breast cancer outcomes: A systematic review and meta-analysis
-
K. S. Peairs, B. B. Barone, C. F. Snyder, H. C. Yeh, K. B. Stein, R. L. Derr, F. L. Brancati, A. C. Wolff, Diabetes mellitus and breast cancer outcomes: A systematic review and meta-analysis. J. Clin. Oncol. 29, 40-46 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 40-46
-
-
Peairs, K.S.1
Barone, B.B.2
Snyder, C.F.3
Yeh, H.C.4
Stein, K.B.5
Derr, R.L.6
Brancati, F.L.7
Wolff, A.C.8
-
101
-
-
0142245613
-
TGF-b signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro
-
J. Larsson, U. Blank, H. Helgadottir, J. M. Bjornsson, M. Ehinger, M. J. Goumans, X. Fan, P. Leveen, S. Karlsson, TGF-b signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood 102, 3129-3135 (2003).
-
(2003)
Blood
, vol.102
, pp. 3129-3135
-
-
Larsson, J.1
Blank, U.2
Helgadottir, H.3
Bjornsson, J.M.4
Ehinger, M.5
Goumans, M.J.6
Fan, X.7
Leveen, P.8
Karlsson, S.9
-
102
-
-
0028972072
-
Transforming growth factor-b (TGF-b)-induced down-regulation of cyclin A expression requires a functional TGF-b receptor complex. Characterization of chimeric and truncated type I and type II receptors
-
X. H. Feng, E. H. Filvaroff, R. Derynck, Transforming growth factor-b (TGF-b)-induced down-regulation of cyclin A expression requires a functional TGF-b receptor complex. Characterization of chimeric and truncated type I and type II receptors. J. Biol. Chem. 270, 24237-24245 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 24237-24245
-
-
Feng, X.H.1
Filvaroff, E.H.2
Derynck, R.3
-
103
-
-
0028328817
-
An assay for transforming growth factor-b using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
-
M. Abe, J. G. Harpel, C. N. Metz, I. Nunes, D. J. Loskutoff, D. B. Rifkin, An assay for transforming growth factor-b using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal. Biochem. 216, 276-284 (1994).
-
(1994)
Anal. Biochem
, vol.216
, pp. 276-284
-
-
Abe, M.1
Harpel, J.G.2
Metz, C.N.3
Nunes, I.4
Loskutoff, D.J.5
Rifkin, D.B.6
-
104
-
-
31944444653
-
Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling
-
O. Thoumine, M. Lambert, R. M. Mège, D. Choquet, Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling. Mol. Biol. Cell 17, 862-875 (2006).
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 862-875
-
-
Thoumine, O.1
Lambert, M.2
Mège, R.M.3
Choquet, D.4
-
105
-
-
33749188859
-
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
-
J. Y. Yang, C. S. Zong, W. Xia, Y. Wei, M. Ali-Seyed, Z. Li, K. Broglio, D. A. Berry, M. C. Hung, MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol. Cell. Biol. 26, 7269-7282 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 7269-7282
-
-
Yang, J.Y.1
Zong, C.S.2
Xia, W.3
Wei, Y.4
Ali-Seyed, M.5
Li, Z.6
Broglio, K.7
Berry, D.A.8
Hung, M.C.9
-
106
-
-
0036121308
-
A c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
-
Y. Fujita, G. Krause, M. Scheffner, D. Zechner, H. E. Leddy, J. Behrens, T. Sommer, W. Birchmeier, Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4, 222-231 (2002).
-
(2002)
Nat. Cell Biol
, vol.4
, pp. 222-231
-
-
Fujita, Y.1
Krause, G.2
Scheffner, M.3
Zechner, D.4
Leddy, H.E.5
Behrens, J.6
Sommer, T.7
Birchmeier, W.8
Hakai9
|